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Article: Imaging of the Liver and Pancreas: The Added Value of MRI.

Morana, Giovanni / Beleù, Alessandro / Geraci, Luca / Tomaiuolo, Luisa / Venturini, Silvia

2024 Volume 14, Issue 7

Abstract: MR is a powerful diagnostic tool in the diagnosis and management of most hepatic and pancreatic diseases. Thanks to its multiple sequences, the use of dedicated contrast media and special techniques, it allows a multiparametric approach able to provide ... ...

Abstract	MR is a powerful diagnostic tool in the diagnosis and management of most hepatic and pancreatic diseases. Thanks to its multiple sequences, the use of dedicated contrast media and special techniques, it allows a multiparametric approach able to provide both morphological and functional information for many pathological conditions. The knowledge of correct technique is fundamental in order to obtain a correct diagnosis. In this paper, different MR sequences will be illustrated in the evaluation of liver and pancreatic diseases, especially those sequences which provide information not otherwise obtainable with other imaging techniques. Practical MR protocols with the most common indications of MR in the study of the liver and pancreas are provided.
Language	English
Publishing date	2024-03-26
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics14070693
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Article ; Online: Radiology-based diagnosis of fungal pulmonary infections in high-risk hematology patients: are we making progress?

Lewis, Russell E / Stanzani, Marta / Morana, Giovanni / Sassi, Claudia

Current opinion in infectious diseases

2023 Volume 36, Issue 4, Page(s) 250–256

Abstract: Purpose of review: In patients with hematological malignancies, high-resolution computed tomography (CT) is the recommended imaging approach for diagnosis, staging and monitoring of invasive fungal disease (IFD) but lacks specificity. We examined the ... ...

Abstract	Purpose of review: In patients with hematological malignancies, high-resolution computed tomography (CT) is the recommended imaging approach for diagnosis, staging and monitoring of invasive fungal disease (IFD) but lacks specificity. We examined the status of current imaging modalities for IFD and possibilities for more effective applications of current technology for improving the specificity of IFD diagnosis. Recent findings: Although CT imaging recommendations for IFD are largely unchanged in the last 20 years, improvements in CT scanner technology and image processing algorithms now allow for technically adequate examinations at much lower radiation doses. CT pulmonary angiography can improve both the sensitivity and specificity of CT imaging for angioinvasive molds in both neutropenic and nonneutropenic patients, through detection of the vessel occlusion sign (VOS). MRI-based approaches also show promise not only for early detection of small nodules and alveolar hemorrhage but can also be used to detect pulmonary vascular occlusion without radiation and iodinated contrast media. 18F-fluorodeoxyglucose (FDG) PET/computed tomography (FDG-PET/CT) is increasingly used to monitor long-term treatment response for IFD, but could become a more powerful diagnostic tool with the development of fungal-specific antibody imaging tracers. Summary: High-risk hematology patients have a considerable medical need for more sensitive and specific imaging approaches for IFD. This need may be addressable, in part, by better exploiting recent progress in CT/MRI imaging technology and algorithms to improve the specificity of radiological diagnosis for IFD.
MeSH term(s)	Humans ; Hematologic Neoplasms ; Invasive Fungal Infections/diagnostic imaging ; Risk Assessment ; Sensitivity and Specificity ; Technology, Radiologic ; Lung Diseases, Fungal/diagnostic imaging
Language	English
Publishing date	2023-06-09
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	645085-4
ISSN	1473-6527 ; 1535-3877 ; 0951-7375 ; 1355-834X
ISSN (online)	1473-6527 ; 1535-3877
ISSN	0951-7375 ; 1355-834X
DOI	10.1097/QCO.0000000000000937
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Zs.A 2462: Show issues

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Article ; Online: Fetal brain MR angiography at 1.5 T: a feasible study.

Sampaio, Luísa / Morana, Giovanni / Gonçalves, Hernâni / Rossi, Andrea / Ramalho, Carla

Neuroradiology

2023 Volume 66, Issue 2, Page(s) 271–278

Abstract: Purpose: The use of magnetic resonance angiography (MRA) for assessing CNS fetal vasculature has been limited. The aim of this study was to determine the feasibility and added value of 2D time-of-flight (TOF) MRA of the fetal brain vasculature with a 1 ... ...

Abstract	Purpose: The use of magnetic resonance angiography (MRA) for assessing CNS fetal vasculature has been limited. The aim of this study was to determine the feasibility and added value of 2D time-of-flight (TOF) MRA of the fetal brain vasculature with a 1.5 T scanner. Methods: We conducted a prospective study (September 2018 to October 2022) by consecutively selecting pregnant women (≥ 18 years) with clinical indication to fetal brain MRI. On a 1.5 T scanner, a 2D TOF MRA acquisition was obtained at the end of the clinical protocol. Two neuroradiologists independently reviewed all MRIs; a qualitative scale of motion artifacts was applied to MRA images; represented vessels in MRA and T2 images were registered. Results: Thirty-five fetal brain MRIs. Mean maternal age: 32 years; mean fetal gestational age (GA): 31 weeks. Artifacts were found in 74% of MRA. The number of MRAs performed without artifacts increased with GA. On MRA, the identification of the majority of vessels increased with GA; statistical significance was reached in the identification of torcular Herophili (p = 0.026), vein of Galen (p < 0.001), internal cerebral veins (p = 0.002), basilar artery (p = 0.027), vertebral arteries (p = 0.025), and middle cerebral arteries (p = 0.044). Significantly, MRA depicted the sigmoid sinuses and internal jugular veins more frequently. Vascular pathology was found in 3/35 fetal brain MRIs. Conclusion: Although artifacts were found in 74% of cases, MRA acquisitions were informative and of sufficient diagnostic quality in most studies. This technique may represent a valuable complimentary tool in CNS prenatal vascular studies.
MeSH term(s)	Pregnancy ; Humans ; Female ; Adult ; Magnetic Resonance Angiography/methods ; Cerebral Angiography/methods ; Cerebral Arteries ; Prospective Studies ; Feasibility Studies ; Brain/diagnostic imaging ; Brain/blood supply
Language	English
Publishing date	2023-11-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	123305-1
ISSN	1432-1920 ; 0028-3940
ISSN (online)	1432-1920
ISSN	0028-3940
DOI	10.1007/s00234-023-03243-5
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Zs.A 658: Show issues

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Article ; Online: Intimal hyperplasia detection after aneurysm treatment by flow diversion using magnetic resonance vessel wall imaging.

Russo, Riccardo / Mistretta, Francesco / Bergui, Mauro / Morana, Giovanni

The neuroradiology journal

2022 Volume 35, Issue 6, Page(s) 780–783

Abstract: In-stent caliber reduction due to neo-intimal hyperplasia (NIH) is an underestimated event that may follow flow diverter stent (FDS) implantation. Although mostly asymptomatic, this vascular reaction is a well-known risk factor for delayed ischemic ... ...

Abstract	In-stent caliber reduction due to neo-intimal hyperplasia (NIH) is an underestimated event that may follow flow diverter stent (FDS) implantation. Although mostly asymptomatic, this vascular reaction is a well-known risk factor for delayed ischemic strokes. Here we report on the contribution of magnetic resonance vessel wall imaging (MR-VWI), performed on a 1.5 T scanner, to detect in-stent stenosis and mural inflammation in a 40-year-old woman with cerebral aneurysm previously treated with FDS and presenting with motor disturbances on follow-up. Digital subtraction angiography and cone-beam CT confirmed 1.5 T MRVWI findings, highlighting the potential value of this non-invasive imaging technique in investigating and detecting NIH.
MeSH term(s)	Female ; Humans ; Adult ; Cerebral Angiography/methods ; Hyperplasia/diagnostic imaging ; Intracranial Aneurysm/diagnostic imaging ; Intracranial Aneurysm/surgery ; Angiography, Digital Subtraction/methods ; Stents ; Magnetic Resonance Imaging/methods ; Magnetic Resonance Spectroscopy ; Treatment Outcome
Language	English
Publishing date	2022-05-09
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2257770-1
ISSN	2385-1996 ; 1971-4009 ; 1120-9976
ISSN (online)	2385-1996
ISSN	1971-4009 ; 1120-9976
DOI	10.1177/19714009221096818
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Zs.A 2823: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article: Now online: Imaging of the Pancreas: Technique and Clinical Applications

Morana, Giovanni

Magnetom flash

2017 Volume -, Issue 3 = Nr. 69, Page(s) 70

Language	English
Document type	Article
ZDB-ID	2465783-9
Database	Current Contents Medicine

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Zs.A 6925: Show issues

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Article: Chest MRI: Morphological Imaging and Beyond

Morana, Giovanni

Magnetom flash

2017 Volume -, Issue 2 = Nr. 68 ISMRM Ed., Page(s) 102

Language	English
Document type	Article
ZDB-ID	2465783-9
Database	Current Contents Medicine

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Article: Cystic pancreatic lesions: MR imaging findings and management.

Morana, Giovanni / Ciet, Pierluigi / Venturini, Silvia

Insights into imaging

2021 Volume 12, Issue 1, Page(s) 115

Abstract: Cystic pancreatic lesions (CPLs) are frequently casual findings in radiological examinations performed for other reasons in patients with unrelated symptoms. As they require different management according to their histological nature, differential ... ...

Abstract	Cystic pancreatic lesions (CPLs) are frequently casual findings in radiological examinations performed for other reasons in patients with unrelated symptoms. As they require different management according to their histological nature, differential diagnosis is essential. Radiologist plays a key role in the diagnosis and management of these lesions as imaging is able to correctly characterize most of them and thus address to a correct management. The first step for a correct characterization is to look for a communication between the CPLs and the main pancreatic duct, and then, it is essential to evaluate the morphology of the lesions. Age, sex and a history of previous pancreatic pathologies are important information to be used in the differential diagnosis. As some CPLs with different pathologic backgrounds can show the same morphological findings, differential diagnosis can be difficult, and thus, the final diagnosis can require other techniques, such as endoscopic ultrasound, endoscopic ultrasound-fine needle aspiration and endoscopic ultrasound-through the needle biopsy, and multidisciplinary management is important for a correct management.
Language	English
Publishing date	2021-08-10
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2543323-4
ISSN	1869-4101
ISSN	1869-4101
DOI	10.1186/s13244-021-01060-z
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Article ; Online: Pancreatic cancer detection with a non-contrast MR protocol: is it reliable?

Maio, Francesca / Pasqualino, Vincenzo / Bertana, Luca / Venturini, Silvia / Cantoni, Valeria / Fusaro, Michele / Morana, Giovanni

La Radiologia medica

2023 Volume 128, Issue 9, Page(s) 1035–1046

Abstract: Purpose: The pancreatic cancer (PC) is the 4th leading cancer-related death, becoming the second one by 2030, with a 5 year survival rate of 8%. Considering its increased incidence in high-risk categories compared to the general population, we aimed to ... ...

Abstract	Purpose: The pancreatic cancer (PC) is the 4th leading cancer-related death, becoming the second one by 2030, with a 5 year survival rate of 8%. Considering its increased incidence in high-risk categories compared to the general population, we aimed to validate a non-contrast MR protocol, to detect PC in its earliest phase, which could be suitable as a screening tool in high-risk patients. Materials and methods: In this retrospective study, we selected 200 patients (> 40 years) from our radiological database, which performed upper abdominal MRI between 2012 and 2017. 100 were negative for pancreatic lesions and 100 positive for pancreatic lesion (< 30 mm). The latter group included: 40 PDAC (pancreatic adenocarcinoma), 42 BD-IPMN (Branch Duct- Intraductal Papillary Mucinous Neoplasm), 10 PNET(pancreatic neuroendocrine tumor), 4 SCN(serous cystic neoplasm), 3 IPS(intrapancreatic spleen), 1 MCN(mucinous cystic neoplasm). Three readers (R1, R2 and R3) with a high, medium and low experience, respectively, analysed, first, the non-contrast MR sequences (single-shot T2w breath-hold, GE T1w FS, DWI and 2D/3D MRCP), and then the standard MR protocol, independently, randomly and anonymously. Readers identified or excluded the presence of pancreatic lesion, in both reading sessions. These results were compared with the histopathological diagnosis, and then divided into 3 different classes of lesions: all lesions, pancreatic adenocarcinoma and solid lesion. Mcnemar's test was used to compare the results. The inter-observer agreement was determined according to the kappa statistic in both protocols, and then the inter-protocol agreement was calculated. Results: The non-contrast MR protocol has reached statistical parameters values ranging between 83% in SE (sensitivity) by R3 and 99% in NPV (negative predictive value) by R1. The standard MR protocol has reported slight increasing statistical parameters compared to those of the proposed one. However, there are not significant statistical differences between the both protocols. The proposed non-contrast MR protocol has reported the highest NPVs in the PDAC group detection (R1: 99%, R2: 99%, R3: 98%). In all groups of lesions, the agreement between the two protocols was excellent for each Reader ranging from 96 to 98%. Conclusion: The proposed non-contrast MR protocol showed high PC detection values and a time execution ≤ 20 min. Therefore, it can be proposed as a screening tool in high-risk patients.
MeSH term(s)	Humans ; Pancreatic Neoplasms/diagnostic imaging ; Adenocarcinoma/diagnostic imaging ; Retrospective Studies ; Magnetic Resonance Imaging/methods ; Carcinoma, Pancreatic Ductal/diagnostic imaging ; Carcinoma, Pancreatic Ductal/pathology ; Pancreatic Neoplasms
Language	English
Publishing date	2023-07-29
Publishing country	Italy
Document type	Journal Article
ZDB-ID	205751-7
ISSN	1826-6983 ; 0033-8362
ISSN (online)	1826-6983
ISSN	0033-8362
DOI	10.1007/s11547-023-01680-z
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Article: Towards an Automated Approach to the Semi-Quantification of [

Peira, Enrico / Sensi, Francesco / Rei, Luca / Gianeri, Ruben / Tortora, Domenico / Fiz, Francesco / Piccardo, Arnoldo / Bottoni, Gianluca / Morana, Giovanni / Chincarini, Andrea

Journal of clinical medicine

2023 Volume 12, Issue 8

Abstract: Background: This study aims to evaluate the use of a computer-aided, semi-quantification approach to [: Methods: A total of 18 pediatric patients with PDGs underwent magnetic resonance imaging and [: Results: High Pearson correlation coefficients ... ...

Abstract	Background: This study aims to evaluate the use of a computer-aided, semi-quantification approach to [ Methods: A total of 18 pediatric patients with PDGs underwent magnetic resonance imaging and [ Results: High Pearson correlation coefficients resulted between the ratios calculated with the two approaches: ρ = 0.93 ( Conclusions: This study suggested that the proposed computer-aided approach could yield similar results to the manual procedure in terms of diagnostic and prognostic information.
Language	English
Publishing date	2023-04-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12082765
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Article ; Online: Cystic pancreatic lesions

Giovanni Morana / Pierluigi Ciet / Silvia Venturini

Insights into Imaging, Vol 12, Iss 1, Pp 1-

MR imaging findings and management

2021 Volume 26

Abstract: Abstract Cystic pancreatic lesions (CPLs) are frequently casual findings in radiological examinations performed for other reasons in patients with unrelated symptoms. As they require different management according to their histological nature, ... ...

Abstract	Abstract Cystic pancreatic lesions (CPLs) are frequently casual findings in radiological examinations performed for other reasons in patients with unrelated symptoms. As they require different management according to their histological nature, differential diagnosis is essential. Radiologist plays a key role in the diagnosis and management of these lesions as imaging is able to correctly characterize most of them and thus address to a correct management. The first step for a correct characterization is to look for a communication between the CPLs and the main pancreatic duct, and then, it is essential to evaluate the morphology of the lesions. Age, sex and a history of previous pancreatic pathologies are important information to be used in the differential diagnosis. As some CPLs with different pathologic backgrounds can show the same morphological findings, differential diagnosis can be difficult, and thus, the final diagnosis can require other techniques, such as endoscopic ultrasound, endoscopic ultrasound-fine needle aspiration and endoscopic ultrasound-through the needle biopsy, and multidisciplinary management is important for a correct management.
Keywords	Pancreatic cyst ; Pancreatic neoplasms ; Pancreatic intraductal neoplasms ; Cystadenoma ; Serous ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	610
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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