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Article ; Online: Monotropein Induced Apoptosis and Suppressed Cell Cycle Progression in Colorectal Cancer Cells.

Gao, Quan / Li, Lin / Zhang, Qi-Man / Sheng, Qin-Song / Zhang, Ji-Liang / Jin, Li-Jun / Shang, Rui-Yan

2023 Volume 30, Issue 1, Page(s) 25–33

Abstract: Objective: To determine whether monotropein has an anticancer effect and explore its potential mechanisms against colorectal cancer (CRC) through network pharmacology and molecular docking combined with experimental verification.: Methods: Network ... ...

Abstract	Objective: To determine whether monotropein has an anticancer effect and explore its potential mechanisms against colorectal cancer (CRC) through network pharmacology and molecular docking combined with experimental verification. Methods: Network pharmacology and molecular docking were used to predict potential targets of monotropein against CRC. Cell counting kit assay, plate monoclonal assay and microscopic observation were used to investigate the antiproliferative effects of monotropein on CRC cells HCT116, HT29 and LoVo. Flow cytometry and scratch assay were used to analyze apoptosis and cell cycle, as well as cell migration, respectively in HCT116, HT29, and LoVo cells. Western blotting was used to detect the expression of proteins related to apoptosis, cell cycle, and cell migration, and the expression of proteins key to the Akt pathway. Results: The Gene Ontology and Reactome enrichment analyses indicated that the anticancer potential of monotropein against CRC might be involved in multiple cancer-related signaling pathways. Among these pathways, RAC-beta serine/threonine-protein kinase (Akt1, Akt2), cyclin-dependent kinase 6 (CDK6), matrix metalloproteinase-9 (MMP9), epidermal growth factor receptor (EGFR), cell division control protein 42 homolog (CDC42) were shown as the potential anticancer targets of monotropein against CRC. Molecular docking suggested that monotropein may interact with the 6 targets (Akt1, Akt2, CDK6, MMP9, EGFR, CDC42). Subsequently, cell activity of HCT116, HT29 and LoVo cell lines were significantly suppressed by monotropein (P<0.05). Furthermore, our research revealed that monotropein induced cell apoptosis by inhibiting Bcl-2 and increasing Bax, induced G Conclusion: Monotropein exerts its antitumor effects primarily by arresting the cell cycle, causing cell apoptosis, and inhibiting cell migration. This indicates a high potential for developing novel medication for treating CRC.
MeSH term(s)	Humans ; Proto-Oncogene Proteins c-akt/metabolism ; Cell Proliferation ; Matrix Metalloproteinase 9 ; Molecular Docking Simulation ; Cell Cycle ; ErbB Receptors ; Apoptosis ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/pathology ; Cell Line, Tumor
Chemical Substances	Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Matrix Metalloproteinase 9 (EC 3.4.24.35) ; monotropein (0Y61M84O2T) ; ErbB Receptors (EC 2.7.10.1)
Language	English
Publishing date	2023-09-26
Publishing country	China
Document type	Journal Article
ZDB-ID	2171254-2
ISSN	1993-0402 ; 1672-0415
ISSN (online)	1993-0402
ISSN	1672-0415
DOI	10.1007/s11655-023-3710-4
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Zs.A 5823: Show issues

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Article: Comparison of Gut Microbiome in Human Colorectal Cancer in Paired Tumor and Adjacent Normal Tissues.

Sheng, Qin-Song / He, Kang-Xin / Li, Jian-Jiong / Zhong, Zi-Feng / Wang, Fei-Xia / Pan, Le-Lin / Lin, Jian-Jiang

OncoTargets and therapy

2020 Volume 13, Page(s) 635–646

Abstract: Background: To understand the biological effect of gut microbiome on the progression of colorectal cancer (CRC), we sequenced the V3-V4 region of the 16S rRNA gene to illustrate the overall structure of microbiota in the CRC patients.: Methods: In ... ...

Abstract	Background: To understand the biological effect of gut microbiome on the progression of colorectal cancer (CRC), we sequenced the V3-V4 region of the 16S rRNA gene to illustrate the overall structure of microbiota in the CRC patients. Methods: In this study, a total of 66 CRC patients were dichotomized into different groups based on the following characteristics: paired tumor and adjacent normal tissues, distal and proximal CRC segments, MMR (-) and MMR (+), different TNM staging and clinic tumor staging. Results: By sequencing and comparing the microbial assemblages, our results indicated that 7 microbe genus ( Conclusion: All these findings implied a better understanding of the alteration in the gut microbiome, which may offer new insight into diagnosing and therapying for CRC patients.
Language	English
Publishing date	2020-01-21
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2495130-4
ISSN	1178-6930
ISSN	1178-6930
DOI	10.2147/OTT.S218004
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Article: Fitness and Hard Seededness of F

Liang, Rong / Liu, Jia-Li / Ji, Xue-Qin / Olsen, Kenneth M / Qiang, Sheng / Song, Xiao-Ling

Plants (Basel, Switzerland)

2023 Volume 12, Issue 21

Abstract: The commercial cultivation of herbicide-resistant (HR) transgenic soybeans ( ...

Abstract	The commercial cultivation of herbicide-resistant (HR) transgenic soybeans (
Language	English
Publishing date	2023-10-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants12213671
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Article ; Online: A study of using carbon nanoparticles to improve lymph nodes staging for laparoscopic-assisted radical right hemicolectomy in colon cancer.

Pan, Lelin / Ye, Feng / Liu, Jing-Jing / Ba, Xiao-Qun / Sheng, Qin-Song

International journal of colorectal disease

2018 Volume 33, Issue 8, Page(s) 1131–1134

Abstract: Purpose: This study aimed to analyze and evaluate the feasibility of using carbon nanoparticles (CNs) to track lymph nodes (LNs) metastases in right colon tumors, especially for patients who underwent laparoscopic-assisted radical right hemicolectomy.!## ...

Abstract	Purpose: This study aimed to analyze and evaluate the feasibility of using carbon nanoparticles (CNs) to track lymph nodes (LNs) metastases in right colon tumors, especially for patients who underwent laparoscopic-assisted radical right hemicolectomy. Method: A total of 99 patients were enrolled in this retrospective study between November 2015 and September 2017 (control group n = 47). One day before surgery, 1 ml of CNs suspension was injected into the submucosal layer around the site of the primary lesions by colonoscopy. Then complete mesocolic excision (CME) of laparoscopic right hemicolectomy was performed. CNs-stained LNs were identified and counted from all dissected LNs after surgery. Results: The dates showed that the number of total harvested LNs and the number of positive patients in the experimental group increased significantly compared with the control group (respectively, P < 0.01 and P < 0.05). The increase of positive percentage shifted some patients toward higher stage, although the total number of positive LNs changed a little bit. In addition, the duration for pathologist to dissect LNs became shorter (26.4 vs. 31.1 min, P < 0.05). Conclusion: Therefore, the CNs are not only a good tattoo in laparoscopic-assisted operation, but could be regarded as a better pathological evaluating tool for tumor treatment.
MeSH term(s)	Carbon ; China ; Colectomy ; Colonic Neoplasms/diagnosis ; Colonic Neoplasms/pathology ; Humans ; Laparoscopy ; Lymph Node Excision ; Lymph Nodes ; Lymphatic Metastasis/diagnosis ; Nanoparticles ; Neoplasm Staging ; Retrospective Studies
Chemical Substances	Carbon (7440-44-0)
Language	English
Publishing date	2018-04-16
Publishing country	Germany
Document type	Journal Article
ZDB-ID	84975-3
ISSN	1432-1262 ; 0179-1958
ISSN (online)	1432-1262
ISSN	0179-1958
DOI	10.1007/s00384-018-3050-6
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Zs.A 2121: Show issues

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Article: Corrigendum: Impact of intestinal microbiota on metabolic toxicity and potential detoxification of amygdalin.

Wen, Qiuyu / Yu, Shen / Wang, Shanshan / Qin, Yan / Xia, Quan / Wang, Sheng / Chen, Guanjun / Shen, Chenlin / Song, Shuai

Frontiers in microbiology

2023 Volume 14, Page(s) 1303273

Abstract: This corrects the article DOI: 10.3389/fmicb.2022.1030516.]. ...

Abstract	[This corrects the article DOI: 10.3389/fmicb.2022.1030516.].
Language	English
Publishing date	2023-11-01
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2023.1303273
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Article ; Online: Models for evaluating glioblastoma invasion along white matter tracts.

Li, Yao / Wang, Jun / Song, Si-Rong / Lv, Sheng-Qing / Qin, Jian-Hua / Yu, Shi-Cang

Trends in biotechnology

2023 Volume 42, Issue 3, Page(s) 293–309

Abstract: White matter tracts (WMs) are one of the main invasion paths of glioblastoma multiforme (GBM). The lack of ideal research models hinders our understanding of the details and mechanisms of GBM invasion along WMs. To date, many potential in vitro models ... ...

Abstract	White matter tracts (WMs) are one of the main invasion paths of glioblastoma multiforme (GBM). The lack of ideal research models hinders our understanding of the details and mechanisms of GBM invasion along WMs. To date, many potential in vitro models have been reported; nerve fiber culture models and nanomaterial models are biocompatible, and the former have electrically active neurons. Brain slice culture models, organoid models, and microfluidic chip models can simulate the real brain and tumor microenvironment (TME), which contains a variety of cell types. These models are closer to the real in vivo environment and are helpful for further studying not only invasion along WMs by GBM, but also perineural invasion and brain metastasis by solid tumors.
MeSH term(s)	Humans ; Glioblastoma/metabolism ; Glioblastoma/pathology ; White Matter/metabolism ; White Matter/pathology ; Neoplasm Invasiveness ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Cell Line, Tumor ; Tumor Microenvironment
Language	English
Publishing date	2023-10-06
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	47474-5
ISSN	1879-3096 ; 0167-7799
ISSN (online)	1879-3096
ISSN	0167-7799
DOI	10.1016/j.tibtech.2023.09.005
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Zs.A 2750: Show issues

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Article ; Online: GRACE-based groundwater drought in the Indochina Peninsula during 1979-2020: Changing properties and possible teleconnection mechanisms.

Song, Xuanhua / Chen, Hao / Chen, Tan / Qin, Zhihao / Chen, Sheng / Yang, Ni / Deng, Shulin

The Science of the total environment

2023 Volume 908, Page(s) 168423

Abstract: Groundwater is very important for human productivity and daily life, hydrological cycle regulation, and ecosystem stability. However, due to the complex mechanisms of groundwater drought, the spatial and temporal variations of groundwater drought and its ...

Abstract	Groundwater is very important for human productivity and daily life, hydrological cycle regulation, and ecosystem stability. However, due to the complex mechanisms of groundwater drought, the spatial and temporal variations of groundwater drought and its driving mechanisms are still not fully understood, especially in Indochina Peninsula. In this work, we used a reconstructed long-term terrestrial water storage dataset from the Gravity Recovery and Climate Experiment (GRACE) emission and a GRACE-based groundwater drought index to investigate the spatial and temporal characteristics of groundwater drought during 1979-2020 in the Indochina Peninsula. The possible teleconnection mechanisms between groundwater drought and the Indian Ocean Dipole (IOD), El Niño-Southern Oscillation (ENSO), and El Niño Modoki (ENSO_M) were also investigated using cross wavelet transform method. The results show that groundwater drought worsens significantly during 1979-2020, and becomes much more frequent and intensified after 2000 in the southern Indochina Peninsula. Both univariate and bivariate (logic 'or' and 'and') return periods for duration, severity, and peak of groundwater drought are short in the southern Indochina Peninsula, and thus the risk of groundwater drought is high. The IOD, ENSO, and ENSO_M can reduce the intensity of groundwater drought to a certain extent during the warm phases, but only ENSO_M tends to significantly exacerbate the intensity of groundwater drought during the cold phases in the southern Indochina Peninsula. The variations in groundwater drought are dominated by ENSO_M, and are also coupled influenced by the IOD and ENSO in the southern Indochina Peninsula. The results provide valuable information for the sustainable ecological environment and socioeconomic development, especially development of groundwater drought early warning and prediction models in the Indochina Peninsula.
Language	English
Publishing date	2023-11-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.168423
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Zs.A 949: Show issues

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Article ; Online: Predicting Demands of COVID-19 Prevention and Control Materials via Co-Evolutionary Transfer Learning.

Song, Qin / Zheng, Yu-Jun / Yang, Jun / Huang, Yu-Jiao / Sheng, Wei-Guo / Chen, Sheng-Yong

IEEE transactions on cybernetics

2023 Volume 53, Issue 6, Page(s) 3859–3872

Abstract: The novel coronavirus pneumonia (COVID-19) has created great demands for medical resources. Determining these demands timely and accurately is critically important for the prevention and control of the pandemic. However, even if the infection rate has ... ...

Abstract	The novel coronavirus pneumonia (COVID-19) has created great demands for medical resources. Determining these demands timely and accurately is critically important for the prevention and control of the pandemic. However, even if the infection rate has been estimated, the demands of many medical materials are still difficult to estimate due to their complex relationships with the infection rate and insufficient historical data. To alleviate the difficulties, we propose a co-evolutionary transfer learning (CETL) method for predicting the demands of a set of medical materials, which is important in COVID-19 prevention and control. CETL reuses material demand knowledge not only from other epidemics, such as severe acute respiratory syndrome (SARS) and bird flu but also from natural and manmade disasters. The knowledge or data of these related tasks can also be relatively few and imbalanced. In CETL, each prediction task is implemented by a fuzzy deep contractive autoencoder (CAE), and all prediction networks are cooperatively evolved, simultaneously using intrapopulation evolution to learn task-specific knowledge in each domain and using interpopulation evolution to learn common knowledge shared across the domains. Experimental results show that CETL achieves high prediction accuracies compared to selected state-of-the-art transfer learning and multitask learning models on datasets during two stages of COVID-19 spreading in China.
MeSH term(s)	Animals ; Humans ; COVID-19/prevention & control ; COVID-19/epidemiology ; SARS-CoV-2 ; Pandemics/prevention & control ; Learning ; Machine Learning
Language	English
Publishing date	2023-05-17
Publishing country	United States
Document type	Journal Article
ISSN	2168-2275
ISSN (online)	2168-2275
DOI	10.1109/TCYB.2022.3164412
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Article ; Online: Charlson Comorbidity Index is correlated with all-cause readmission within six months in patients with heart failure: a retrospective cohort study in China.

Sheng, Song / Xu, Feng-Qin / Zhang, Yan-Hong / Huang, Ye

BMC cardiovascular disorders

2023 Volume 23, Issue 1, Page(s) 111

Abstract: Background: Charlson Comorbidity Index (CCI) is positively associated with all-cause readmission in patients with heart failure (HF) in western countries. However, there is a scarcity of strong scientific evidence supporting the correlation in China. ... ...

Abstract	Background: Charlson Comorbidity Index (CCI) is positively associated with all-cause readmission in patients with heart failure (HF) in western countries. However, there is a scarcity of strong scientific evidence supporting the correlation in China. This study aimed at testing this hypothesis in Chinese. METHODS: We conducted a secondary analysis of 1,946 patients with HF in Zigong Fourth People's Hospital in China between December 2016 to June 2019. Logistic regression models were used to study the hypotheses, with adjustments for the four regression models. We also explore the linear trend and possible nonlinear relationship between CCI and readmission within six months. We further conducted subgroup analysis and tests for interaction to examine the possible interaction between CCI and the endpoint. Additionally, CCI alone and several combinations of variables based on CCI were used to predict the endpoint. Under the curve (AUC), sensitivity and specificity were reported to evaluate the performance of the predicted model. Results: In the adjusted II model, CCI was an independent prognostic factor for readmission within six months in patients with HF (OR = 1.14, 95% CI: 1.03-1.26, P = 0.011). Trend tests revealed that there was a significant linear trend for the association. A nonlinear association was identified between them and the inflection point of CCI was 1. Subgroup analyses and tests for interaction indicated that cystatin played an interactive role in the association. ROC analysis indicated neither CCI alone nor combinations of variables based on CCI were adequate for prediction. Conclusion: CCI was independently positively correlated with readmission within six months in patients with HF in Chinese population. However, CCI has limited value on predicting readmission within six months in patients with HF.
MeSH term(s)	Humans ; Patient Readmission ; Retrospective Studies ; Heart Failure/diagnosis ; Heart Failure/epidemiology ; Heart Failure/therapy ; China/epidemiology ; Comorbidity
Language	English
Publishing date	2023-03-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2059859-2
ISSN	1471-2261 ; 1471-2261
ISSN (online)	1471-2261
ISSN	1471-2261
DOI	10.1186/s12872-023-03151-9
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Article ; Online: Effects of budesonide on the expression of the glucocorticoid receptor-α in nasal polyp epithelial cells.

Wang, De-Sheng / Liu, Qin-Song / Lai, Hai-Chun

American journal of rhinology & allergy

2013 Volume 27, Issue 2, Page(s) 123–127

Abstract: Background: This study explores effects of budesonide on the proliferation of nasal polyp epithelial cells and expression of the glucocorticoid receptor (GR) alpha in nasal polyp epithelial cells.: Methods: Primary cultured, purified, and identified ... ...

Abstract	Background: This study explores effects of budesonide on the proliferation of nasal polyp epithelial cells and expression of the glucocorticoid receptor (GR) alpha in nasal polyp epithelial cells. Methods: Primary cultured, purified, and identified the epithelial cells collected from nasal polyps. The proliferation of nasal polyp epithelial cells was examined by a cell counting kit, and expression of GR-alpha mRNA in nasal polyp epithelial cells was examined by reverse transcription polymerase chain reaction, after training nasal polyp epithelial cells in budesonide solution. Results: The average survival rate of nasal polyp epithelial cells was the lowest in 1 × 10(-6) M budesonide solution (29.284 ± 0.311%), compared with other concentrations. Budesonide at 1 × 10(-8) M caused down-regulation of GR-alpha mRNA expression levels at 6 and 12 ours, compared with the 0-hour group (p < 0.001); compared with the 0-hour group, there were significantly lower expression levels of GR-alpha mRNA at both 24 and 48 hours (p < 0.001); Expression of GR-alpha mRNA at either 48 or 12 hours was not significantly different from that at 24 hours. Conclusion: Budesonide can significantly inhibit the proliferation of nasal polyp epithelial cells, down-regulate the expression of GR-alpha mRNA in nasal polyp epithelial cells with time dependence.
MeSH term(s)	Anti-Inflammatory Agents/pharmacology ; Budesonide/pharmacology ; Cell Proliferation/drug effects ; Cells, Cultured ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Gene Expression Regulation/drug effects ; Humans ; Nasal Polyps/metabolism ; Primary Cell Culture ; RNA, Messenger/analysis ; Receptors, Glucocorticoid/genetics ; Receptors, Glucocorticoid/metabolism ; Reverse Transcriptase Polymerase Chain Reaction
Chemical Substances	Anti-Inflammatory Agents ; RNA, Messenger ; Receptors, Glucocorticoid ; glucocorticoid receptor alpha ; Budesonide (51333-22-3)
Language	English
Publishing date	2013-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2482804-X
ISSN	1945-8932 ; 1945-8924
ISSN (online)	1945-8932
ISSN	1945-8924
DOI	10.2500/ajra.2013.27.3862
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