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Article: A cross-sectional observational study for ethno-geographical disparities in sleep quality, brain morphometry and cognition (a SOLACE study) in Indians residing in India, and South Asians and Europeans residing in the UK - a study protocol.

Soni, Rishabh / Dale, Caroline / Garfield, Victoria / Akhtar, Nasreen

2024 Volume 16, Page(s) 1294681

Abstract: Introduction: As individuals age, their sleep patterns change, and sleep disturbances can increase the risk of dementia. Poor sleep quality can be a risk factor for mild cognitive impairment (MCI) and dementia. Epidemiological studies show a connection ... ...

Abstract	Introduction: As individuals age, their sleep patterns change, and sleep disturbances can increase the risk of dementia. Poor sleep quality can be a risk factor for mild cognitive impairment (MCI) and dementia. Epidemiological studies show a connection between sleep quality and cognitive changes, with brain imaging revealing grey matter volume reduction and amyloid beta accumulation in Alzheimer's disease. However, most research has focused on Europeans, with little attention to other ethnic groups. Methods: This is a cross sectional study comparing effects across countries and ethnicities. Group 1 ( Discussion: Racial and ethnic differences can impact the relationships of cognitive function, sleep quality and brain structure in older adults. Earlier studies have highlighted higher prevalence of poor sleep among black individuals compared to white individuals. Genetic or epigenetic mechanisms may contribute to these variations. Socio-cultural and environmental factors, such as neighbourhood, migration, lifestyle, stress and perceived discrimination may influence sleep patterns. The aim of the study is to examine the ethnogeographic variations in sleep quality, cognitive performance and brain morphometry among Indians living in India, and South Asians and Europeans residing in the UK.
Language	English
Publishing date	2024-02-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2558898-9
ISSN	1663-4365
ISSN	1663-4365
DOI	10.3389/fnagi.2024.1294681
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Article ; Online: Kinetics and Mechanism of Azole n-π*-Catalyzed Amine Acylation.

Dale, Harvey J A / Hodges, George R / Lloyd-Jones, Guy C

Journal of the American Chemical Society

2023 Volume 145, Issue 32, Page(s) 18126–18140

Abstract: Azole anions are highly competent in the activation of weak acyl donors, but, unlike neutral (aprotic) Lewis bases, are not yet widely applied as acylation catalysts. Using a combination ... ...

Abstract	Azole anions are highly competent in the activation of weak acyl donors, but, unlike neutral (aprotic) Lewis bases, are not yet widely applied as acylation catalysts. Using a combination of
Language	English
Publishing date	2023-08-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.3c06258
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Article ; Online: Pyrantel resistance in canine hookworms in Queensland, Australia.

Dale, Ashley / Xu, Geoffrey / Kopp, Steven R / Jones, Malcolm K / Kotze, Andrew C / Abdullah, Swaid

Veterinary parasitology, regional studies and reports

2024 Volume 48, Page(s) 100985

Abstract: Hookworms are the most common intestinal nematode parasites of dogs in Australia. The control of these parasites relies mostly on regular deworming with anthelmintics, with pyrantel-based dewormers being a relatively low cost and readily-available option ...

Abstract	Hookworms are the most common intestinal nematode parasites of dogs in Australia. The control of these parasites relies mostly on regular deworming with anthelmintics, with pyrantel-based dewormers being a relatively low cost and readily-available option for dog owners. Pyrantel resistance in canine hookworms in Australia was first reported in 2007, however pyrantel-based dewormers are still used against hookworm infection in dogs across Australia. The present study was conducted to evaluate the efficacy of pyrantel against hookworms infecting dogs housed in a shelter facility in Southeast Queensland which receives rescued or surrendered animals from greyhound rescue centres and dog shelters across this region. A total of 10 dogs were examined using the faecal egg count reduction test (FECRT). There was no reduction in FEC in any of the dogs following pyrantel treatment, with drug efficacies ranging from -0.9% to -283.3%. Given that these dogs originated from various sites across Southeast Queensland, the present study suggests that pyrantel resistance is widespread in this region, and hence this anthelmintic may not be a useful option for treatment of hookworm infections in dogs.
MeSH term(s)	Dogs ; Animals ; Pyrantel/pharmacology ; Pyrantel/therapeutic use ; Ancylostomatoidea ; Queensland/epidemiology ; Parasite Egg Count/veterinary ; Anthelmintics/pharmacology ; Anthelmintics/therapeutic use ; Hookworm Infections/drug therapy ; Hookworm Infections/epidemiology ; Hookworm Infections/veterinary ; Intestinal Diseases, Parasitic/veterinary ; Australia/epidemiology ; Dog Diseases/drug therapy ; Dog Diseases/parasitology
Chemical Substances	Pyrantel (4QIH0N49E7) ; Anthelmintics
Language	English
Publishing date	2024-01-10
Publishing country	Netherlands
Document type	Journal Article
ISSN	2405-9390
ISSN (online)	2405-9390
DOI	10.1016/j.vprsr.2024.100985
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Article ; Online: Modelled and observed plastic pollution on remote Scottish beaches: The importance of local marine sources.

Allison, Nicole L / Dale, Andrew C / Turrell, William R / Narayanaswamy, Bhavani E

Marine pollution bulletin

2023 Volume 194, Issue Pt A, Page(s) 115341

Abstract: Beach-cleans conducted on the west coast of Scotland investigated the distribution of land- and marine-sourced litter and compared these with a particle tracking model representing the presumed principal land-based source. Modelled particles dispersed ... ...

Abstract	Beach-cleans conducted on the west coast of Scotland investigated the distribution of land- and marine-sourced litter and compared these with a particle tracking model representing the presumed principal land-based source. Modelled particles dispersed widely, even reaching the remote northwest coast, with 'hotspots' and 'coldspots' on windward and leeward coasts respectively. In beach sampling, however, land-sourced litter represented only 19% of items by count and 8% by weight, while marine-sourced litter represented 46% by count and 62% by weight. The source of the remainder could not be identified. Windward coasts had an average count of 1859 litter items per 100 m, and weight of 14,862 g per 100 m. Leeward coasts had an average count of 32 litter items per 100 m and weight of 738 g per 100 m. Field observations and model predictions were consistent in many respects for land-sourced litter, however marine-sourced litter is dominant on many coastlines.
MeSH term(s)	Environmental Pollution ; Plastics ; Scotland
Chemical Substances	Plastics
Language	English
Publishing date	2023-08-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2001296-2
ISSN	1879-3363 ; 0025-326X
ISSN (online)	1879-3363
ISSN	0025-326X
DOI	10.1016/j.marpolbul.2023.115341
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Article ; Online: Origins and immunopathogenesis of autoimmune central nervous system disorders.

Ramanathan, Sudarshini / Brilot, Fabienne / Irani, Sarosh R / Dale, Russell C

Nature reviews. Neurology

2023 Volume 19, Issue 3, Page(s) 172–190

Abstract: The field of autoimmune neurology is rapidly evolving, and recent discoveries have advanced our understanding of disease aetiologies. In this article, we review the key pathogenic mechanisms underlying the development of CNS autoimmunity. First, we ... ...

Abstract	The field of autoimmune neurology is rapidly evolving, and recent discoveries have advanced our understanding of disease aetiologies. In this article, we review the key pathogenic mechanisms underlying the development of CNS autoimmunity. First, we review non-modifiable risk factors, such as age, sex and ethnicity, as well as genetic factors such as monogenic variants, common variants in vulnerability genes and emerging HLA associations. Second, we highlight how interactions between environmental factors and epigenetics can modify disease onset and severity. Third, we review possible disease mechanisms underlying triggers that are associated with the loss of immune tolerance with consequent recognition of self-antigens; these triggers include infections, tumours and immune-checkpoint inhibitor therapies. Fourth, we outline how advances in our understanding of the anatomy of lymphatic drainage and neuroimmune interfaces are challenging long-held notions of CNS immune privilege, with direct relevance to CNS autoimmunity, and how disruption of B cell and T cell tolerance and the passage of immune cells between the peripheral and intrathecal compartments have key roles in initiating disease activity. Last, we consider novel therapeutic approaches based on our knowledge of the immunopathogenesis of autoimmune CNS disorders.
MeSH term(s)	Humans ; Central Nervous System ; Central Nervous System Diseases ; Autoimmune Diseases ; Autoimmunity ; Autoantigens
Chemical Substances	Autoantigens
Language	English
Publishing date	2023-02-14
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2491514-2
ISSN	1759-4766 ; 1759-4758
ISSN (online)	1759-4766
ISSN	1759-4758
DOI	10.1038/s41582-023-00776-4
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Article ; Online: Bioelectrical Impedance Changes of the Trunk are Opposite the Limbs Following Acute Hydration Change.

Wagner, Dale R

Journal of electrical bioimpedance

2022 Volume 13, Issue 1, Page(s) 25–30

Abstract: ... a heat chamber of 40 °C and 60% relative humidity. Hyperhydration was achieved by drinking lightly ...

Abstract	This study aimed to evaluate the changes in impedance and estimates of body composition variables obtained from segmental multi-frequency bioelectrical impedance analysis (SMFBIA) following acute hydration change. All participants (N = 11 active adults) had SMFBIA measurements at baseline (euhydration), post-dehydration, and post-hyperhydration in an experimental repeated-measures design. Dehydration and hyperhydration trials were randomized with the opposite treatment given 24 h later. Dehydration was achieved via a heat chamber of 40 °C and 60% relative humidity. Hyperhydration was achieved by drinking lightly-salted water (30 mmol·L
Language	English
Publishing date	2022-06-25
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2580506-X
ISSN	1891-5469 ; 1891-5469
ISSN (online)	1891-5469
ISSN	1891-5469
DOI	10.2478/joeb-2022-0005
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Article ; Online: CTC service heterogeneity and design of a workforce calculator.

Britton, I / Bradbury, C / Srinivas, S / Balasubramaniam, R / Dale, M / Morley-Davies, A / Bednall, R

Clinical radiology

2023 Volume 78, Issue 7, Page(s) e510–e515

Abstract: Aim: To determine the level of heterogeneity in delivery of computed tomography (CT) colonography services and develop a workforce calculator that accommodates the variation identified.: Materials and methods: A national survey, based on the "WHO ... ...

Abstract	Aim: To determine the level of heterogeneity in delivery of computed tomography (CT) colonography services and develop a workforce calculator that accommodates the variation identified. Materials and methods: A national survey, based on the "WHO workforce indicators of staffing need", established activity standards for essential tasks in delivery of the service. From these data a workforce calculator was designed to guide the required staffing and equipment resource by service size. Results: Activity standards were established as mode responses >70%. Service homogeneity was greater in areas where professional standards and guidance were available. The mean service size was 1,101. Did not attend (DNA) rates were lower where direct booking was available (p<0.0001). Service sizes were larger where radiographer reporting was embedded in reporting paradigms (p<0.024). Conclusion: The survey identified benefits of radiographer-led direct booking and reporting. The workforce calculator derived from the survey provides a framework to guide the resourcing of expansion while maintaining standards.
MeSH term(s)	Humans ; Workforce ; Colonography, Computed Tomographic
Language	English
Publishing date	2023-04-24
Publishing country	England
Document type	Journal Article
ZDB-ID	391227-9
ISSN	1365-229X ; 0009-9260
ISSN (online)	1365-229X
ISSN	0009-9260
DOI	10.1016/j.crad.2023.03.020
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Article: Outpatient cross-titration to buprenorphine for chronic pain: A retrospective analysis.

Ito, Satoru / Welsh, Mackenzie / Bockman, Christina / Dale, Rebecca / Pilkington, David / Peperzak, Katherin

Journal of opioid management

2024 Volume 19, Issue 6, Page(s) 543–554

Abstract: Objective: To determine the effectiveness and safety of the University of Washington's buprenorphine cross-titration protocol for chronic pain in the outpatient setting.: Methods: Retrospective chart review was performed on 150 patients transitioned ... ...

Abstract	Objective: To determine the effectiveness and safety of the University of Washington's buprenorphine cross-titration protocol for chronic pain in the outpatient setting. Methods: Retrospective chart review was performed on 150 patients transitioned from full µ-opioid agonist therapy to buprenorphine using the University of Washington Medical Center Pain Clinic's cross-titration protocol between September 1, 2020, and December 31, 2021, in an outpatient setting. Primary outcome was to determine the percentage of patients who completed the cross-titration and continued buprenorphine without full µ-opioid agonists 4 weeks after completion. Secondary outcomes included final buprenorphine dose, days needed to complete cross-titration, deviation rates from the protocol, and opioid-related adverse events. Results: Fifteen of 31 (48.4 percent) included patients successfully converted to buprenorphine. Median duration of successful cross-titration was 29 days (interquartile range 19-57). Average end-titration dose for patients on buprenorphine/naloxone sublingual films was 7.9 ± 5.7 mg/day, while for buprenorphine transdermal (TD) patches, it was 11.9 ± 4.8 mcg/h. Morphine equivalent daily dose (MEDD) prior to induction varied widely. All patients transitioned to TD buprenorphine were taking ≤30 mg MEDD. Patients previously taking >120 mg MEDD stabilized on 8-16 mg/day buprenorphine. Most common reasons for cross-titration failure were inadequate pain control and intolerable adverse effects. Discussion: The University of Washington's buprenorphine cross-titration protocol for chronic pain was successful in about half of included patients undergoing conversion from chronic full µ-opioid agonist therapy and generally well tolerated. Clinical responses were widely variable, and many required slower taper and higher end-titration buprenorphine dose than anticipated. Although protocols provide structure for cross-titration, each course should be monitored closely and individualized.
MeSH term(s)	Humans ; Outpatients ; Buprenorphine/adverse effects ; Analgesics, Opioid/adverse effects ; Chronic Pain/diagnosis ; Chronic Pain/drug therapy ; Retrospective Studies ; Morphine
Chemical Substances	Buprenorphine (40D3SCR4GZ) ; Analgesics, Opioid ; Morphine (76I7G6D29C)
Language	English
Publishing date	2024-01-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2397614-7
ISSN	1551-7489
ISSN	1551-7489
DOI	10.5055/jom.0839
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Article ; Online: Programming Rapid Functional Group Diversification into a Solid-State Reaction: Aryl Nitriles for Self-Assembly, Click Reactivity, and Discovery of Coexisting Supramolecular Synthons.

Li, Changan / Swenson, Dale C / MacGillivray, Leonard R

Chemistry (Weinheim an der Bergstrasse, Germany)

2022 Volume 28, Issue 37, Page(s) e202200978

Abstract: A method to rapidly diversify the molecules formed in organic crystals is introduced, with aryl nitriles playing a novel dual role as both hydrogen-bond acceptors and modifiable organic groups. The discovery of coexisting supramolecular synthons in the ... ...

Abstract	A method to rapidly diversify the molecules formed in organic crystals is introduced, with aryl nitriles playing a novel dual role as both hydrogen-bond acceptors and modifiable organic groups. The discovery of coexisting supramolecular synthons in the same crystal is also described. The general concept is demonstrated by using a bis(aryl nitrile) alkene that undergoes a hydrogen-bond-directed intermolecular [2+2] photodimerization to form a tetra(aryl nitrile)cyclobutane. The product is readily converted by click reactivity to a tetra(aryl tetrazole) and by hydrolysis to a tetra(aryl carboxylic acid). The integration of aryl nitriles into solid-state reactions opens broad avenues to post-modify products formed in crystalline solids for rapid diversification.
MeSH term(s)	Carboxylic Acids/chemistry ; Cyclobutanes ; Hydrogen ; Hydrogen Bonding ; Nitriles/chemistry
Chemical Substances	Carboxylic Acids ; Cyclobutanes ; Nitriles ; Hydrogen (7YNJ3PO35Z)
Language	English
Publishing date	2022-05-31
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202200978
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Article: The Role of Medication Beliefs in COVID-19 Vaccine and Booster Uptake in Healthcare Workers: An Exploratory Study.

Dale, Carys / Seage, Catherine Heidi / Phillips, Rhiannon / James, Delyth

Healthcare (Basel, Switzerland)

2023 Volume 11, Issue 13

Abstract: Illness and medication beliefs have shown to predict COVID-19 vaccination behaviour in the general population, but this relationship has yet to be demonstrated in healthcare staff. This research aimed to explore the potential explanatory value of illness ...

Abstract	Illness and medication beliefs have shown to predict COVID-19 vaccination behaviour in the general population, but this relationship has yet to be demonstrated in healthcare staff. This research aimed to explore the potential explanatory value of illness and medication beliefs on the COVID-19 vaccination uptake of a sample of patient-facing healthcare workers (HCWs). A web-based questionnaire-measuring beliefs about vaccinations (the BMQ), perceptions of COVID-19 (the BIPQ), vaccine hesitancy, and vaccine uptake-was targeted to HCWs via social media platforms between May-July 2022. Open text responses allowed participants to provide explanations for any delay in vaccine uptake. A total of 91 participants completed the questionnaire. Most respondents (77.1%,
Language	English
Publishing date	2023-07-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare11131967
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