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  1. Article ; Online: Update on autoinflammatory diseases.

    Ashari, Kosar Asna / Hausmann, Jonathan S / Dedeoglu, Fatma

    Current opinion in rheumatology

    2023  Volume 35, Issue 5, Page(s) 285–292

    Abstract: Purpose of review: Although the concept of systemic autoinflammatory diseases (SAIDs) is still very young, our knowledge about them is exponentially growing. In the current review, we aim to discuss novel SAIDs and autoinflammatory pathways discovered ... ...

    Abstract Purpose of review: Although the concept of systemic autoinflammatory diseases (SAIDs) is still very young, our knowledge about them is exponentially growing. In the current review, we aim to discuss novel SAIDs and autoinflammatory pathways discovered in the last couple of years.
    Recent findings: Advances in immunology and genetics have led to the discovery of new pathways involved in autoinflammation, as well as several new SAIDs, including retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and migraine headache (ROSAH syndrome), vacuoles, E1 enzyme, X-linked autoinflammatory somatic (VEXAS) syndrome, TBK1 deficiency, NEMO deleted exon 5 autoinflammatory syndrome (NDAS), and disabling pansclerotic morphea. Progress in immunobiology and genetics has also brought forth novel treatments for SAIDs. Personalized medicine has made significant progress in areas such as cytokine-targeted therapies and gene therapies. However, much work remains, especially in measuring and improving the quality of life in patients with SAIDs.
    Summary: In the current review, we discuss the novelties in the world of SAIDs, including mechanistic pathways of autoinflammation, pathogenesis, and treatment. We hope this review helps rheumatologists to gain an updated understanding of SAIDs.
    MeSH term(s) Animals ; Humans ; Quality of Life ; Simian Acquired Immunodeficiency Syndrome ; Hereditary Autoinflammatory Diseases/genetics ; Hereditary Autoinflammatory Diseases/therapy ; Mutation
    Language English
    Publishing date 2023-07-06
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1045317-9
    ISSN 1531-6963 ; 1040-8711
    ISSN (online) 1531-6963
    ISSN 1040-8711
    DOI 10.1097/BOR.0000000000000953
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  2. Article ; Online: The Promises and Perils of Social Media for Pediatric Rheumatology.

    Hausmann, Jonathan S / Weitzman, Elissa R

    Rheumatic diseases clinics of North America

    2021  Volume 48, Issue 1, Page(s) 233–243

    Abstract: The advent of social media has revolutionized and empowered communities of people living with rare diseases. Social media has enabled families of children with similar pediatric rheumatic diseases (PRDs) to meet regardless of geographic distance, ... ...

    Abstract The advent of social media has revolutionized and empowered communities of people living with rare diseases. Social media has enabled families of children with similar pediatric rheumatic diseases (PRDs) to meet regardless of geographic distance, allowing them to support each other and join together to advocate on behalf of their children. Researchers have also leveraged social media to learn about the health of patients and their communities. This article reviews the promises and perils of social media related to health, focusing on its potential use to support research and care of children with PRD.
    MeSH term(s) Child ; Humans ; Rheumatic Diseases/therapy ; Rheumatology ; Social Media
    Language English
    Publishing date 2021-11-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 92118-x
    ISSN 1558-3163 ; 0889-857X
    ISSN (online) 1558-3163
    ISSN 0889-857X
    DOI 10.1016/j.rdc.2021.09.005
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  3. Article ; Online: Targeting cytokines to treat autoinflammatory diseases.

    Hausmann, Jonathan S

    Clinical immunology (Orlando, Fla.)

    2018  Volume 206, Page(s) 23–32

    Abstract: Autoinflammatory diseases are rare group of conditions manifested by recurrent fevers, systemic inflammation, and dysfunctions of the innate immune system. These conditions are characterized by overproduction or lack of inhibition of various cytokines, ... ...

    Abstract Autoinflammatory diseases are rare group of conditions manifested by recurrent fevers, systemic inflammation, and dysfunctions of the innate immune system. These conditions are characterized by overproduction or lack of inhibition of various cytokines, and the advent of biologic drugs that block specific cytokines involved in these conditions has revolutionized their treatment. In this review, I will discuss the most common autoinflammatory conditions of adulthood including familial Mediterranean fever (FMF), cryopyrin-associated periodic syndrome (CAPS), mevalonate kinase deficiency/hyperimmunoglobulinemia D Syndrome (MKD/HIDS), TNF receptor-associated autoinflammatory syndrome (TRAPS), and systemic juvenile idiopathic arthritis/adult-onset Still's disease (SJIA/AOSD). I will discuss how IL-1, IL-6, IL-18, and TNF play pathogenic roles in these conditions and will review the evidence behind cytokine blockade for these diseases. Throughout the paper, I will reflect on gaps in knowledge of autoinflammatory diseases and will highlight the latest advances and newest drugs in development.
    MeSH term(s) Antibodies, Monoclonal/therapeutic use ; Autoimmune Diseases/drug therapy ; Cytokines/antagonists & inhibitors ; Gene Expression Regulation/drug effects ; Humans ; Inflammation/drug therapy ; Inflammation/immunology
    Chemical Substances Antibodies, Monoclonal ; Cytokines
    Language English
    Publishing date 2018-10-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2018.10.016
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  4. Article ; Online: Removing barriers and disparities in health: lessons from the COVID-19 pandemic.

    Sirotich, Emily / Hausmann, Jonathan S

    Nature reviews. Rheumatology

    2020  Volume 17, Issue 3, Page(s) 125–126

    MeSH term(s) COVID-19/epidemiology ; COVID-19/psychology ; Global Health ; Healthcare Disparities/statistics & numerical data ; Humans ; Pandemics ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-10-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2491532-4
    ISSN 1759-4804 ; 1759-4790
    ISSN (online) 1759-4804
    ISSN 1759-4790
    DOI 10.1038/s41584-020-00524-8
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  5. Article ; Online: Engaging trainees within the virtual classroom: Teaching strategies for rheumatologists in a pandemic.

    Wade, Stefanie D / Hausmann, Jonathan S / Freed, Jason A

    European journal of rheumatology

    2022  Volume 9, Issue 3, Page(s) 148–152

    Abstract: Social distancing during the COVID-19 pandemic has led to unprecedented challenges in medical education, including for rheumatology training programs. Many programs have adapted by transitioning educational curricula into virtual classrooms. Herein, we ... ...

    Abstract Social distancing during the COVID-19 pandemic has led to unprecedented challenges in medical education, including for rheumatology training programs. Many programs have adapted by transitioning educational curricula into virtual classrooms. Herein, we review strategies to optimize learning within the virtual classroom. We introduce the flipped virtual classroom as a framework for facilitating higher-order thinking and improving long-term learning. We provide recommendations to maximize interactions between learners, elevate group discussions, and encourage problem solving. Once implemented, these techniques can lead to more productive teaching and learning experiences while maintaining a sense of community for rheumatology training programs.
    MeSH term(s) COVID-19 ; Curriculum ; Humans ; Pandemics/prevention & control ; Problem Solving ; Rheumatologists
    Language English
    Publishing date 2022-02-12
    Publishing country Turkey
    Document type Journal Article ; Review
    ZDB-ID 2873727-1
    ISSN 2148-4279 ; 2147-9720
    ISSN (online) 2148-4279
    ISSN 2147-9720
    DOI 10.5152/eujrheum.2022.20236
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  6. Article ; Online: Case 3-2023: A 16-Year-Old Girl with Abdominal Pain and Bloody Diarrhea.

    Kahn, Stacy A / Leonard, Maureen M / Westra, Sjirk J / Hausmann, Jonathan S / Mueller, Sarah B

    The New England journal of medicine

    2023  Volume 388, Issue 4, Page(s) 358–368

    MeSH term(s) Adolescent ; Female ; Humans ; Abdominal Pain/etiology ; Diarrhea/etiology ; Gastrointestinal Hemorrhage/etiology
    Language English
    Publishing date 2023-01-31
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMcpc2211367
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  7. Article ; Online: A piece of my mind. One stroke at a time.

    Hausmann, Jonathan S

    JAMA

    2014  Volume 312, Issue 9, Page(s) 893–894

    MeSH term(s) Education, Medical ; Goals ; Humans ; Physicians/psychology ; Sports
    Language English
    Publishing date 2014-09-03
    Publishing country United States
    Document type Journal Article ; Personal Narratives
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2014.8148
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  9. Article ; Online: Using Questions to Enhance Rheumatology Education.

    Hausmann, Jonathan S / Schwartzstein, Richard M

    Arthritis care & research

    2018  Volume 71, Issue 10, Page(s) 1304–1309

    MeSH term(s) Education, Medical, Graduate/methods ; Education, Medical, Graduate/trends ; Humans ; Musculoskeletal Diseases/diagnosis ; Musculoskeletal Diseases/therapy ; Rheumatology/education ; Rheumatology/methods ; Rheumatology/trends
    Language English
    Publishing date 2018-08-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 645059-3
    ISSN 2151-4658 ; 0893-7524 ; 2151-464X
    ISSN (online) 2151-4658
    ISSN 0893-7524 ; 2151-464X
    DOI 10.1002/acr.23753
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  10. Article ; Online: Implementing a Virtual Flipped Classroom in a Rheumatology Fellowship Program.

    Wade, Stefanie D / Freed, Jason A / Kyttaris, Vasileios C / Saunders, Staci / Hausmann, Jonathan S

    Arthritis care & research

    2022  Volume 75, Issue 3, Page(s) 634–639

    Abstract: Objective: Active learning opportunities within graduate medical education may be underused. We aimed to assess whether active learning strategies increase after implementing a faculty development workshop and transitioning rheumatology fellowship ... ...

    Abstract Objective: Active learning opportunities within graduate medical education may be underused. We aimed to assess whether active learning strategies increase after implementing a faculty development workshop and transitioning rheumatology fellowship didactics to a virtual flipped classroom.
    Methods: We measured baseline faculty use of active learning strategies during lectures within the Introductory Rheumatology Curriculum by calculating an "active learning score" from a cognitive learning theory assessment tool. We held a faculty development workshop demonstrating active teaching strategies and encouraged using a flipped classroom for fellowship didactics. Because of the COVID-19 pandemic, the strategies were discussed in a virtual classroom setting where the intervention phase would occur. We compared active learning scores before and after the intervention for lectures within the Introductory Rheumatology Curriculum. The primary outcome was the change in active teaching scores preintervention versus postintervention.
    Results: Active learning scores increased in 14 of the 16 lectures, with a mean score increase of 4.7 of 24 points (95% confidence interval 2.3-7.2). Paired t-test analyses comparing active learning scores preintervention and postintervention for each lecture confirmed that results were highly statistically significant (P < 0.001). Despite faculty hesitancy to teach within a virtual environment, faculty satisfaction remained high postintervention.
    Conclusion: A virtual flipped classroom increased the use of active learning strategies within the Introductory Rheumatology Curriculum. Faculty satisfaction remained high despite modest increases in time spent updating their presentations. Fellows and faculty reported a largely positive experience within the virtual classroom.
    MeSH term(s) Humans ; Rheumatology/education ; Fellowships and Scholarships ; Pandemics ; COVID-19 ; Problem-Based Learning/methods ; Curriculum
    Language English
    Publishing date 2022-11-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 645059-3
    ISSN 2151-4658 ; 0893-7524 ; 2151-464X
    ISSN (online) 2151-4658
    ISSN 0893-7524 ; 2151-464X
    DOI 10.1002/acr.24791
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