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  1. Article: Acute Effects of Growth Hormone on the Cellular Immunologic Landscape in Pediatric Patients.

    Gujral, Jasmine / Kidd, Brian A / Becker, Christine / Golden, Eddye / Lee, Hao-Chih / Kim-Schulze, Seunghee / Yau, Mabel / Dudley, Joel / Rapaport, Robert

    Cureus

    2024  Volume 16, Issue 4, Page(s) e57383

    Abstract: Introduction: Growth hormone (GH) and the immune system have multiple bidirectional interactions. Data about the acute effects of GH on the immune system are lacking. The objective of our study was to evaluate the acute effects of GH on the immune ... ...

    Abstract Introduction: Growth hormone (GH) and the immune system have multiple bidirectional interactions. Data about the acute effects of GH on the immune system are lacking. The objective of our study was to evaluate the acute effects of GH on the immune system using time-of-flight mass cytometry.
    Methods: This was a prospective study of pediatric patients who were being evaluated for short stature and underwent a GH stimulation test at a tertiary care center. Blood samples for immunologic markers, i.e., complete blood count (CBC) and time of flight mass cytometry (CyTOF), were collected at baseline (T0) and over the course of three hours (T3) of the test. Differences in immune profiling in patients by timepoint (T0, T3) and GH response (growth hormone sufficient (GHS) versus growth hormone deficient (GHD)) were calculated using a two-way ANOVA test.  Results: A total of 54 patients (39 boys and 15 girls) aged five to 18 years were recruited. Twenty-two participants tested GHD (peak GH <10 ng/ml). The CyTOF analysis showed a significant increase from T0 to T3 in granulocyte percentage, monocyte count, and dendritic cell (DC) count; in contrast, a significant decrease was seen in T lymphocytes (helper and cytotoxic) and IgD+ B lymphocytes. The CBC analysis supported these findings: an increase in total white blood cell count, absolute neutrophil count, and neutrophil percentage; a decrease in absolute lymphocyte count, lymphocyte percentage, absolute eosinophil count, and absolute monocyte count. No significant differences were found between CBC/CyTOF measurements and GH status at either time.
    Conclusions: This study provides the first high-resolution map of acute changes in the immune system with GH stimulation. This implies a key role for GH in immunomodulatory function.
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.57383
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Time-restricted feeding makes the mouse run like a pro.

    Chalom, Mayer M / Lee, Chih-Hao

    Nature metabolism

    2023  Volume 5, Issue 7, Page(s) 1082–1083

    MeSH term(s) Mice ; Animals ; Circadian Rhythm ; Feeding Behavior ; Intermittent Fasting
    Language English
    Publishing date 2023-06-26
    Publishing country Germany
    Document type Journal Article ; Comment
    ISSN 2522-5812
    ISSN (online) 2522-5812
    DOI 10.1038/s42255-023-00833-8
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  3. Article ; Online: Young eosinophils rejuvenate ageing adipose tissues.

    Lee, Chih-Hao

    Nature metabolism

    2020  Volume 2, Issue 8, Page(s) 655–656

    Language English
    Publishing date 2020-03-30
    Publishing country Germany
    Document type Journal Article
    ISSN 2522-5812
    ISSN (online) 2522-5812
    DOI 10.1038/s42255-020-0230-9
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  4. Article ; Online: Risk stratification in patients with hypertrophic cardiomyopathy: Looking beyond the left side myocardial function.

    Chang, Hao-Chih / Cheng, Hao-Min / Kuo, Ling / Lee, Dan-Ying / Sung, Shih-Hsien / Chen, Chen-Huan / Yu, Wen-Chung

    Journal of the Chinese Medical Association : JCMA

    2022  Volume 86, Issue 1, Page(s) 19–25

    Abstract: Background: Patients with hypertrophic cardiomyopathy (HCM) have heterogeneous outcomes. As risk stratification mostly focuses on left-side myocardial function, we sought to investigate the prognostic value of right ventricular (RV) function in patients ...

    Abstract Background: Patients with hypertrophic cardiomyopathy (HCM) have heterogeneous outcomes. As risk stratification mostly focuses on left-side myocardial function, we sought to investigate the prognostic value of right ventricular (RV) function in patients with HCM.
    Methods: This retrospective cohort study included patients with HCM. Conventional ventricular functional parameters, including left ventricular ejection fraction (LVEF), tricuspid annular plane systolic excursion (TAPSE), and fractional area change were obtained. The longitudinal strain was analyzed using the speckle tracking method. The primary endpoint was defined as a composite of hospitalization for heart failure, sustained ventricular tachycardia, or all-cause death.
    Results: A total of 56 patients with HCM (aged 58.0 ± 14.9 years, 64.3% male) were included. After a mean follow-up duration of 30.1 ± 17.4 months, primary endpoints developed in 10 (20%) of 50 patients who were treated medically. Patients with cardiovascular events had a more reduced LV thickest segmental strain, worse TAPSE, and more impaired RV free wall strain. After adjusting for age, sex, and LVEF, TAPSE (hazard ratio [HR], 95% confidence intervals [CIs]: 0.24, 0.06-0.93) and RV free wall strain (HR, 95% CIs:1.12, 1.03-1.21) remained independent prognostic predictors. Incorporating either TAPSE or RV free wall strain provides incremental prognostic value to the LV strain alone (net reclassification improvement by 31.4% and 34.1%, respectively, both p < 0.05).
    Conclusion: RV function assessed by TAPSE or RV free wall strain is predictive of subsequent cardiac events, suggesting that a comprehensive evaluation of RV function is useful for risk stratification in patients with HCM.
    MeSH term(s) Humans ; Male ; Female ; Retrospective Studies ; Stroke Volume ; Ventricular Function, Left ; Cardiomyopathy, Hypertrophic ; Risk Assessment ; Prognosis
    Language English
    Publishing date 2022-10-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2107283-8
    ISSN 1728-7731 ; 1726-4901
    ISSN (online) 1728-7731
    ISSN 1726-4901
    DOI 10.1097/JCMA.0000000000000825
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2699: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: Association between spirometry pattern, left ventricular diastolic function, and mortality.

    Huang, Wei-Ming / Chang, Hao-Chih / Lee, Ching-Wei / Huang, Chi-Jung / Yu, Wen-Chung / Cheng, Hao-Min / Guo, Chao-Yu / Chiang, Chern-En / Chen, Chen-Huan / Sung, Shih-Hsien

    European journal of clinical investigation

    2023  Volume 53, Issue 10, Page(s) e14043

    Abstract: Background: Spirometric abnormalities have been related to incident heart failure in general population, who generally have preserved left ventricular ejection fraction (LVEF). We aimed to investigate the association between spirometric indices, cardiac ...

    Abstract Background: Spirometric abnormalities have been related to incident heart failure in general population, who generally have preserved left ventricular ejection fraction (LVEF). We aimed to investigate the association between spirometric indices, cardiac functions and clinical outcomes.
    Methods: Subjects presenting with exertional dyspnoea and received spirometry and echocardiography were eligible for this study. Forced vital capacity (FVC) and forced expiratory volume in the first second (FEV1)/FVC ratio were measured to define the spirometry patterns: normal (FEV1/FVC ≥ 70%, FVC ≥ 80%), obstructive (FEV1/FVC < 70%, FVC ≥ 80%), restrictive pattern (FEV1/FVC ≥ 70%, FVC < 80%) and mixed (FEV1/FVC < 70%, FVC < 80%). The diastolic dysfunction index (DDi) was the counts of the indicators, including septal e' velocity <7 cm/s, septal E/e' > 15, pulmonary artery systolic pressure > 35 mmHg and left atrial dimension >40 mm.
    Results: Among a total of 8669 participants (65.8 ± 16.3 years, 56% men), 3739 (43.1%), 829 (9.6%), 3050 (35.2%) and 1051 (12.1%) had normal, obstructive, restrictive and mixed spirometry pattern, respectively. Subjects with restrictive or mixed spirometry pattern had higher DDi and worse long-term survival than those with obstructive or normal ventilation. FVC but not FEV1/FVC was predictive of 5-year mortality, independent of age, sex, renal function, LVEF, DDi, body mass index, and comorbidities (hazard ratio, 95% confidence intervals: .981, .977-.985). Furthermore, there was an inverse nonlinear relationship between FVC and DDi, suggesting the declined FVC may mediate 43% of the prognostic hazard of left ventricular diastolic dysfunction.
    Conclusions: The restrictive spirometry pattern or the declined FVC was associated with left ventricular diastolic dysfunction, which aggravated the long-term mortality in the ambulatory dyspnoeic subjects.
    MeSH term(s) Male ; Humans ; Female ; Ventricular Function, Left ; Stroke Volume ; Spirometry ; Vital Capacity ; Forced Expiratory Volume ; Ventricular Dysfunction, Left ; Lung ; Pulmonary Disease, Chronic Obstructive
    Language English
    Publishing date 2023-06-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.14043
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 677: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: High Daily Diastolic Blood Pressure Predicts Incident Stroke, Lacune, and Cerebral Microbleeds in CADASIL.

    Chen, Chih-Hao / Liao, Yi-Chu / Cheng, Yu-Wen / Chung, Chih-Ping / Lee, Yi-Chung / Tang, Sung-Chun

    Journal of stroke

    2024  Volume 26, Issue 1, Page(s) 112–115

    Language English
    Publishing date 2024-01-22
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2814366-8
    ISSN 2287-6405 ; 2287-6391
    ISSN (online) 2287-6405
    ISSN 2287-6391
    DOI 10.5853/jos.2023.02880
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  7. Article: Injectable Thermosensitive Hyaluronic Acid Hydrogels for Chondrocyte Delivery in Cartilage Tissue Engineering.

    Chen, Chih-Hao / Kao, Hao-Hsi / Lee, Yen-Chen / Chen, Jyh-Ping

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 9

    Abstract: In this study, we synthesize a hyaluronic acid- ...

    Abstract In this study, we synthesize a hyaluronic acid-
    Language English
    Publishing date 2023-09-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16091293
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  8. Article ; Online: Scaling structural learning with NO-BEARS to infer causal transcriptome networks.

    Lee, Hao-Chih / Danieletto, Matteo / Miotto, Riccardo / Cherng, Sarah T / Dudley, Joel T

    Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing

    2020  Volume 25, Page(s) 391–402

    Abstract: Constructing gene regulatory networks is a critical step in revealing disease mechanisms from transcriptomic data. In this work, we present NO-BEARS, a novel algorithm for estimating gene regulatory networks. The NO-BEARS algorithm is built on the basis ... ...

    Abstract Constructing gene regulatory networks is a critical step in revealing disease mechanisms from transcriptomic data. In this work, we present NO-BEARS, a novel algorithm for estimating gene regulatory networks. The NO-BEARS algorithm is built on the basis of the NO-TEARS algorithm with two improvements. First, we propose a new constraint and its fast approximation to reduce the computational cost of the NO-TEARS algorithm. Next, we introduce a polynomial regression loss to handle non-linearity in gene expressions. Our implementation utilizes modern GPU computation that can decrease the time of hours-long CPU computation to seconds. Using synthetic data, we demonstrate improved performance, both in processing time and accuracy, on inferring gene regulatory networks from gene expression data.
    MeSH term(s) Algorithms ; Animals ; Computational Biology ; Gene Regulatory Networks ; Humans ; Transcriptome ; Ursidae
    Language English
    Publishing date 2020-01-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2335-6936
    ISSN (online) 2335-6936
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: 1,3-Alternate Calix[4]arene Functionalized With Pyrazole and Triazole Ligands as a Highly Selective Fluorescent Sensor for Hg

    Chen, Yin-Ju / Chen, Meng-Yu / Lee, Kun-Ti / Shen, Li-Ching / Hung, Hao-Chih / Niu, Hao-Che / Chung, Wen-Sheng

    Frontiers in chemistry

    2020  Volume 8, Page(s) 593261

    Abstract: We report here the synthesis of a 1,3-alternate calix[4] ... ...

    Abstract We report here the synthesis of a 1,3-alternate calix[4]arene
    Language English
    Publishing date 2020-11-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711776-5
    ISSN 2296-2646
    ISSN 2296-2646
    DOI 10.3389/fchem.2020.593261
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  10. Article ; Online: Orthokeratinized odontogenic cyst at the periapical area of the left maxillary third molar.

    Hwang, Ming-Jay / Lee, Yi-Pang / Huang, Chih-Hao / Chiang, Chun-Pin

    Journal of dental sciences

    2023  Volume 18, Issue 4, Page(s) 1936–1938

    Language English
    Publishing date 2023-06-25
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2213-8862
    ISSN (online) 2213-8862
    DOI 10.1016/j.jds.2023.06.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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