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  1. Article: Editorial: Genetic research into neurodegenerative disorders.

    Zheng, Xiaoting / Chen, Jianhai / Li, Chunyu

    Frontiers in neurology

    2024  Volume 15, Page(s) 1367627

    Language English
    Publishing date 2024-01-29
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2024.1367627
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  2. Article ; Online: Correction: 1-3-7 surveillance and response approach in malaria elimination: China's practice and global adaptions.

    Yi, Boyu / Zhang, Li / Yin, Jianhai / Zhou, Shuisen / Xia, Zhigui

    Malaria journal

    2023  Volume 22, Issue 1, Page(s) 179

    Language English
    Publishing date 2023-06-08
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2091229-8
    ISSN 1475-2875 ; 1475-2875
    ISSN (online) 1475-2875
    ISSN 1475-2875
    DOI 10.1186/s12936-023-04608-0
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  3. Article ; Online: Patient's Healthy-Limb Motion Characteristic-Based Assist-As-Needed Control Strategy for Upper-Limb Rehabilitation Robots.

    Guo, Bingjing / Li, Zhenzhu / Huang, Mingxiang / Li, Xiangpan / Han, Jianhai

    Sensors (Basel, Switzerland)

    2024  Volume 24, Issue 7

    Abstract: The implementation of a progressive rehabilitation training model to promote patients' motivation efforts can greatly restore damaged central nervous system function in patients. Patients' active engagement can be effectively stimulated by assist-as- ... ...

    Abstract The implementation of a progressive rehabilitation training model to promote patients' motivation efforts can greatly restore damaged central nervous system function in patients. Patients' active engagement can be effectively stimulated by assist-as-needed (AAN) robot rehabilitation training. However, its application in robotic therapy has been hindered by a simple determination method of robot-assisted torque which focuses on the evaluation of only the affected limb's movement ability. Moreover, the expected effect of assistance depends on the designer and deviates from the patient's expectations, and its applicability to different patients is deficient. In this study, we propose a control method with personalized treatment features based on the idea of estimating and mapping the stiffness of the patient's healthy limb. This control method comprises an interactive control module in the task-oriented space based on the quantitative evaluation of motion needs and an inner-loop position control module for the pneumatic swing cylinder in the joint space. An upper-limb endpoint stiffness estimation model was constructed, and a parameter identification algorithm was designed. The upper limb endpoint stiffness which characterizes the patient's ability to complete training movements was obtained by collecting surface electromyographic (sEMG) signals and human-robot interaction forces during patient movement. Then, the motor needs of the affected limb when completing the same movement were quantified based on the performance of the healthy limb. A stiffness-mapping algorithm was designed to dynamically adjust the rehabilitation training trajectory and auxiliary force of the robot based on the actual movement ability of the affected limb, achieving AAN control. Experimental studies were conducted on a self-developed pneumatic upper limb rehabilitation robot, and the results showed that the proposed AAN control method could effectively estimate the patient's movement needs and achieve progressive rehabilitation training. This rehabilitation training robot that simulates the movement characteristics of the patient's healthy limb drives the affected limb, making the intensity of the rehabilitation training task more in line with the patient's pre-morbid limb-use habits and also beneficial for the consistency of bilateral limb movements.
    MeSH term(s) Humans ; Robotics ; Upper Extremity ; Motion ; Movement ; Algorithms
    Language English
    Publishing date 2024-03-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s24072082
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  4. Article ; Online: Correction

    Boyu Yi / Li Zhang / Jianhai Yin / Shuisen Zhou / Zhigui Xia

    Malaria Journal, Vol 22, Iss 1, Pp 1-

    1-3-7 surveillance and response approach in malaria elimination: China’s practice and global adaptions

    2023  Volume 3

    Keywords Arctic medicine. Tropical medicine ; RC955-962 ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Retraction: Colon cancer-induced interleukin-35 inhibits beta-catenin-mediated pro-oncogenic activity.

    Jiang, Yueqiang / Ma, Yanling / Li, RuiChao / Sun, JianHai

    Oncotarget

    2022  Volume 13, Page(s) 1322

    Language English
    Publishing date 2022-12-17
    Publishing country United States
    Document type Journal Article ; Retraction of Publication
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.28325
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  6. Article ; Online: PM

    Cheng, Peiyong / Chen, Yongqi / Wang, Jianhai / Han, Ziyu / Hao, De / Li, Yu / Feng, Feifei / Duan, Xuexin / Chen, Huaiyong

    Environmental pollution (Barking, Essex : 1987)

    2024  Volume 347, Page(s) 123686

    Abstract: ... ...

    Abstract PM
    MeSH term(s) Mice ; Animals ; Alveolar Epithelial Cells/metabolism ; Lung/metabolism ; Cell Differentiation ; Cellular Senescence ; Particulate Matter/metabolism
    Chemical Substances Particulate Matter
    Language English
    Publishing date 2024-02-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2024.123686
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2599: Show issues Location:
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  7. Article ; Online: Penaeid Shrimp Chromosome Studies Entering the Post-Genomic Era.

    Zhang, Xiaojun / Xiang, Jianhai / Yuan, Jianbo / Li, Fuhua

    Genes

    2023  Volume 14, Issue 11

    Abstract: Chromosome studies provide the foundation for comprehending inheritance, variation, systematics, and evolution. Penaeid shrimps are a group of crustaceans with great economic importance. Basic cytogenetic information obtained from these shrimps can be ... ...

    Abstract Chromosome studies provide the foundation for comprehending inheritance, variation, systematics, and evolution. Penaeid shrimps are a group of crustaceans with great economic importance. Basic cytogenetic information obtained from these shrimps can be used to study their genome structure, chromosome relationships, chromosome variation, polyploidy manipulation, and breeding. The study of shrimp chromosomes experienced significant growth in the 1990s and has been closely linked to the progress of genome research since the application of next-generation sequencing technology. To date, the genome sequences of five penaeid shrimp species have been published. The availability of these genomes has ushered the study of shrimp chromosomes into the post-genomic era. Currently, research on shrimp cytogenetics not only involves chromosome counting and karyotyping, but also extends to investigating submicroscopic changes; exploring genome structure and regulation during various cell divisions; and contributing to the understanding of mechanisms related to growth, sexual control, stress resistance, and genome evolution. In this article, we provide an overview of the progress made in chromosome research on penaeid shrimp. We emphasize the mutual promotion between studies on chromosome structure and genome research and highlight the impact of chromosome-level assembly on studies of genome structure and function. Additionally, we summarize the emerging trends in post-genomic-era shrimp chromosome research.
    MeSH term(s) Animals ; Penaeidae/genetics ; Genome ; Genomics ; Chromosomes/genetics ; Decapoda/genetics
    Language English
    Publishing date 2023-11-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes14112050
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  8. Article ; Online: Osteomodulin contributes to keloid development by regulating p38 MAPK signaling.

    Li, Qiuchen / Chen, Huaxia / Liu, Yanxin / Bi, Jianhai

    The Journal of dermatology

    2023  Volume 50, Issue 7, Page(s) 895–905

    Abstract: A keloid is a classic fibrotic skin disease characterized by excessive deposition of extracellular matrix (ECM). Osteomodulin (OMD) is a heterologous protein that is a part of osteoadherin and plays a role in modulating ECM deposition. In this study, we ... ...

    Abstract A keloid is a classic fibrotic skin disease characterized by excessive deposition of extracellular matrix (ECM). Osteomodulin (OMD) is a heterologous protein that is a part of osteoadherin and plays a role in modulating ECM deposition. In this study, we investigated the effects of OMD on ECM synthesis and the tumor-like phenotype of keloid fibroblasts. We enrolled 10 patients with keloids and 10 age- and sex-matched healthy individuals, whose keloid or normal skin tissues were collected during surgery. Real-time quantitative polymerase chain reaction (qRT-PCR), western blotting, and immunohistochemical staining were performed to analyze OMD expression in skin tissues. Cell transfection, CCK-8 assay, EdU staining, Transwell assay, qRT-PCR, western blotting, and immunofluorescence were performed to study the effects of OMD on primary keloid-derived fibroblasts (KFs). OMD exhibited greater expression in human keloid specimens than in normal skin tissues. Consistently, higher expression of OMD was observed in KFs, compared to that in normal fibroblasts. Silencing OMD expression in transforming growth factor (TGF)-β1-treated KFs inhibited cell proliferation and migration, as well as collagen and fibronectin expression; however, overexpression of OMD had the opposite effect. p38 mitogen-activated protein kinase (MAPK) was activated in keloid tissues but not in normal skin. OMD was positively correlated with p38 MAPK activation. Adding SB203580, p38 MAPK inhibitor, significantly reversed the effects of OMD on the regulation of KF phenotype. The high expression of OMD may contribute to hyperproliferation of KFs, their migration, and excess ECM synthesis in KFs via regulation of the p38 MAPK signaling pathway.
    MeSH term(s) Humans ; Cell Proliferation ; Cells, Cultured ; Extracellular Matrix Proteins/genetics ; Extracellular Matrix Proteins/metabolism ; Extracellular Matrix Proteins/pharmacology ; Fibroblasts/pathology ; Keloid/pathology ; p38 Mitogen-Activated Protein Kinases/metabolism ; p38 Mitogen-Activated Protein Kinases/pharmacology ; Signal Transduction ; Transforming Growth Factor beta1/metabolism ; Transforming Growth Factor beta1/pharmacology
    Chemical Substances Extracellular Matrix Proteins ; osteoadherin ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Transforming Growth Factor beta1
    Language English
    Publishing date 2023-04-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.16777
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1950: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  9. Article ; Online: Aged polystyrene microplastics exacerbate alopecia associated with tight junction injuries and apoptosis via oxidative stress pathway in skin.

    Li, Qian / Jiang, Lehua / Feng, Jianhai / Wang, Xinhui / Wang, Xusheng / Xu, Xuejuan / Chu, Weiwei

    Environment international

    2024  Volume 186, Page(s) 108638

    Abstract: Microplastics (MPs) are pervasive pollutants in the natural environment and contribute to increased levels of illness in both animals and humans. However, thespecific impacts of MPs on skin damage and alopeciaare not yet well understood. In this study, ... ...

    Abstract Microplastics (MPs) are pervasive pollutants in the natural environment and contribute to increased levels of illness in both animals and humans. However, thespecific impacts of MPs on skin damage and alopeciaare not yet well understood. In this study, we have examined the effects of two types of polystyrene MPs (pristine and aged) on skin and hair follicle damage in mice. UV irradiation changed the chemical and physical properties of the aged MPs, including functional groups, surface roughness, and contact angles. In both in vivo and in vitro experiments, skin and cell injuries related to oxidative stress, apoptosis, tight junctions (TJs), alopecia, mitochondrial dysfunction, and other damages were observed. Mechanistically, MPs and aged MPs can induce TJs damage via the oxidative stress pathway and inhibition of antioxidant-related proteins, and this can lead to alopecia. The regulation of cell apoptosis was also observed, and this is involved in the ROS-mediated mitochondrial signaling pathway. Importantly, aged MPs showed exacerbated toxicity, which may be due to their elevated surface irregularities and altered chemical compositions. Collectively, this study suggests a potential therapeutic approach for alopecia and hair follicle damage caused by MPs pollution.
    MeSH term(s) Alopecia/chemically induced ; Microplastics/toxicity ; Oxidative Stress/drug effects ; Apoptosis/drug effects ; Animals ; Mice ; Polystyrenes/toxicity ; Tight Junctions/drug effects ; Tight Junctions/metabolism ; Skin/drug effects ; Skin/pathology ; Hair Follicle/drug effects ; Reactive Oxygen Species/metabolism
    Chemical Substances Microplastics ; Polystyrenes ; Reactive Oxygen Species
    Language English
    Publishing date 2024-04-07
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 554791-x
    ISSN 1873-6750 ; 0160-4120
    ISSN (online) 1873-6750
    ISSN 0160-4120
    DOI 10.1016/j.envint.2024.108638
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3131: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article: Delayed Inflammatory Reactions After Hyaluronic Acid Filling of Neck Lines: A Case Report.

    Li, Zhiyu / Zhao, Pu / Xu, Qing / Bi, Jianhai / Huo, Ran

    Clinical, cosmetic and investigational dermatology

    2023  Volume 16, Page(s) 99–102

    Abstract: The incidence of adverse events after hyaluronic acid filling is gradually increasing. In addition to acute reactions in the early postoperative period, there have been some cases of delayed inflammatory reactions. However, such events are rarely ... ...

    Abstract The incidence of adverse events after hyaluronic acid filling is gradually increasing. In addition to acute reactions in the early postoperative period, there have been some cases of delayed inflammatory reactions. However, such events are rarely reported in Asia, which may be due to atypical symptoms, long intervals, and misidentification of the product quality. Herein, we present a case in which erythema of the neck appeared three weeks after hyaluronic acid injection into the neck lines and a delayed inflammatory reaction was diagnosed. Watchful waiting was performed, and the erythema subsided spontaneously after two weeks. This case suggests that in patients with a history of hyaluronic acid injections who develop allergic and inflammatory reactions after an interval, it is important to consider whether the reaction is a delayed inflammatory reaction, and if aggressive intervention is necessary.
    Language English
    Publishing date 2023-01-14
    Publishing country New Zealand
    Document type Case Reports
    ZDB-ID 2494852-4
    ISSN 1178-7015
    ISSN 1178-7015
    DOI 10.2147/CCID.S394141
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