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  1. Article ; Online: M-LASH: Hydrological and computational enhancements of the LASH model

    Vargas, Marcelle Martins / Beskow, Samuel / de Mello, Carlos Rogério / de Moura, Maíra Martim / da Cunha, Zandra Almeida / Beskow, Tamara Leitzke Caldeira / Timm, Luís Carlos

    Environmental Modelling and Software. 2023 Sept., v. 167 p.105774-

    2023  

    Abstract: ... The main contributions of this study were the implementation of the model in MATLAB® language (M-LASH ... the script, which is the major differential in the implementation of M-LASH. ...

    Abstract Hydrological models have been strongly recommended for supporting water resources management and, among the models, the Lavras Simulation of Hydrology (LASH) has been successfully used in Brazilian watersheds. The main contributions of this study were the implementation of the model in MATLAB® language (M-LASH), improving its characteristics associated with streamflow routing, calibration and processing time, and its evaluation based on four Brazilian watersheds located in different biomes. In short, the results allowed us to verify the gains of structuring the model in MATLAB® language, mainly with regard to: i) river routing module based on the Kinematic Wave, adding a structure with more hydraulic bias to the model; ii) the ease of coupling the AMALGAM multi-objective calibration algorithm; iii) the computational devices implemented to optimize the model's processing time; and iv) the ease of altering, updating and expanding the script, which is the major differential in the implementation of M-LASH.
    Keywords algorithms ; computer software ; models ; rivers ; stream flow ; Hydrology ; Hydrological modeling ; AMALGAM ; MATLAB®
    Language English
    Dates of publication 2023-09
    Publishing place Elsevier Ltd
    Document type Article ; Online
    ISSN 1364-8152
    DOI 10.1016/j.envsoft.2023.105774
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Is the post-COVID-19 syndrome a severe impairment of acetylcholine-orchestrated neuromodulation that responds to nicotine administration?

    Leitzke, Marco

    Bioelectronic medicine

    2023  Volume 9, Issue 1, Page(s) 2

    Abstract: Following a SARS-CoV-2 infection, many individuals suffer from post-COVID-19 syndrome. It makes them unable to proceed with common everyday activities due to weakness, memory lapses, pain, dyspnea and other unspecific physical complaints. Several ... ...

    Abstract Following a SARS-CoV-2 infection, many individuals suffer from post-COVID-19 syndrome. It makes them unable to proceed with common everyday activities due to weakness, memory lapses, pain, dyspnea and other unspecific physical complaints. Several investigators could demonstrate that the SARS-CoV-2 related spike glycoprotein (SGP) attaches not only to ACE-2 receptors but also shows DNA sections highly affine to nicotinic acetylcholine receptors (nAChRs). The nAChR is the principal structure of cholinergic neuromodulation and is responsible for coordinated neuronal network interaction. Non-intrinsic viral nAChR attachment compromises integrative interneuronal communication substantially. This explains the cognitive, neuromuscular and mood impairment, as well as the vegetative symptoms, characterizing post-COVID-19 syndrome. The agonist ligand nicotine shows an up to 30-fold higher affinity to nACHRs than acetylcholine (ACh). We therefore hypothesize that this molecule could displace the virus from nAChR attachment and pave the way for unimpaired cholinergic signal transmission. Treating several individuals suffering from post-COVID-19 syndrome with a nicotine patch application, we witnessed improvements ranging from immediate and substantial to complete remission in a matter of days.
    Language English
    Publishing date 2023-01-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2929561-0
    ISSN 2332-8886 ; 2332-8886
    ISSN (online) 2332-8886
    ISSN 2332-8886
    DOI 10.1186/s42234-023-00104-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Breakdown of Phospholipid Asymmetry Triggers ADAM17-Mediated Rescue Events in Cells Undergoing Apoptosis.

    Sperrhacke, Maria / Leitzke, Sinje / Ahrens, Björn / Reiss, Karina

    Membranes

    2023  Volume 13, Issue 8

    Abstract: ADAM17, a prominent member of the "Disintegrin and Metalloproteinase" (ADAM) family, controls vital cellular functions through the cleavage of transmembrane substrates, including epidermal growth factor receptor (EGFR) ligands such as transforming growth ...

    Abstract ADAM17, a prominent member of the "Disintegrin and Metalloproteinase" (ADAM) family, controls vital cellular functions through the cleavage of transmembrane substrates, including epidermal growth factor receptor (EGFR) ligands such as transforming growth factor (TGF)-alpha and Epiregulin (EREG). Several ADAM17 substrates are relevant to oncogenesis and tumor growth. We have presented evidence that surface exposure of phosphatidylserine (PS) is pivotal for ADAM17 to exert sheddase activity. The scramblase Xkr8 is instrumental for calcium-independent exposure of PS in apoptotic cells. Xkr8 can be dually activated by caspase-3 and by kinases. In this investigation, we examined whether Xkr8 would modulate ADAM17 activity under apoptotic and non-apoptotic conditions. Overexpression of Xkr8 in HEK293T cells led to significantly increased caspase-dependent as well as PMA-induced release of EREG and TGF-alpha. Conversely, siRNA-mediated downregulation of Xkr8 in colorectal Caco-2 cancer cells led to decreased PS externalization upon induction of apoptosis, which was accompanied by reduced shedding of endogenously expressed EREG and reduced cell survival. We conclude that Xkr8 shares with conventional scramblases the propensity to upmodulate the ADAM-sheddase function. Liberation of growth factors could serve a rescue function in cells on the pathway to apoptotic death.
    Language English
    Publishing date 2023-08-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2614641-1
    ISSN 2077-0375
    ISSN 2077-0375
    DOI 10.3390/membranes13080720
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Thesis: Kniegelenkendoprothetik beim jugendlichen Patienten

    Leitzke, Marco

    (eine Standortbestimmung in der Literatur)

    1999  

    Author's details eingereicht von: Marco Leitzke
    Language German
    Size 112 Bl. : Ill.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Leipzig, Univ., Diss., 1999
    HBZ-ID HT011082709
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    99 E 2171 order for loan Magazin

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  5. Article: Scramblases as Regulators of Proteolytic

    Reiss, Karina / Leitzke, Sinje / Seidel, Jana / Sperrhacke, Maria / Bhakdi, Sucharit

    Membranes

    2022  Volume 12, Issue 2

    Abstract: Proteolytic ectodomain release is a key mechanism for regulating the function of many cell surface proteins. The ... ...

    Abstract Proteolytic ectodomain release is a key mechanism for regulating the function of many cell surface proteins. The sheddases
    Language English
    Publishing date 2022-02-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2614641-1
    ISSN 2077-0375
    ISSN 2077-0375
    DOI 10.3390/membranes12020185
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Liposomal amikacin for treatment of M. avium infections in clinically relevant experimental settings.

    Ehlers, S / Bucke, W / Leitzke, S / Fortmann, L / Smith, D / Hänsch, H / Hahn, H / Bancroff, G / Müller, R

    Zentralblatt fur Bakteriologie : international journal of medical microbiology

    1996  Volume 284, Issue 2-3, Page(s) 218–231

    Abstract: In an effort to optimize rational chemotherapy against M. avium infections in a clinically ... and late stages of intravenous infection, and (iii) immunocompetent mice with pulmonary M. avium ... infection. Although complete eradication of M. avium was never achieved following intravenous ...

    Abstract In an effort to optimize rational chemotherapy against M. avium infections in a clinically meaningful context, we tested whether liposome-encapsulated amikacin would effectively reduce the bacterial load in (i) intravenously infected immunodeficient SCID mice, (ii) immunocompetent mice in both early and late stages of intravenous infection, and (iii) immunocompetent mice with pulmonary M. avium infection. Although complete eradication of M. avium was never achieved following intravenous infection, mycobacterial CFUs decreased by 3 to 4 logs in the spleens and livers of mice treated for three weeks with twice-weekly intravenous injections of liposomal amikacin and continued to stay low in the liver, even in the absence of specific immunity. Mice treated in the chronic stage of infection equally benefited from therapy and showed signs of attenuated granulomatous inflammation in the liver. Even moribund mice responded to liposomal amikacin by significantly gaining weight and survived their infected untreated littermates by at least 4 months. In contrast, during pulmonary M. avium infection, treatment with liposome-encapsulated amikacin only resulted in a transient plateau of bacterial proliferation in the lungs, and the infection exacerbated immediately after cessation of therapy.
    MeSH term(s) Amikacin/administration & dosage ; Animals ; Body Weight ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drug Carriers ; Granuloma/drug therapy ; Injections, Intravenous ; Liposomes ; Liver Diseases/drug therapy ; Male ; Mice ; Mice, Inbred C57BL ; Mice, SCID ; Mycobacterium avium ; Time Factors ; Tuberculosis/drug therapy ; Tuberculosis/pathology
    Chemical Substances Drug Carriers ; Liposomes ; Amikacin (84319SGC3C)
    Language English
    Publishing date 1996-07
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1002479-7
    ISSN 0934-8840
    ISSN 0934-8840
    DOI 10.1016/s0934-8840(96)80097-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Role of ADAM10 and ADAM17 in Regulating CD137 Function.

    Seidel, Jana / Leitzke, Sinje / Ahrens, Björn / Sperrhacke, Maria / Bhakdi, Sucharit / Reiss, Karina

    International journal of molecular sciences

    2021  Volume 22, Issue 5

    Abstract: Human CD137 (4-1BB), a member of the TNF receptor family, and its ligand CD137L (4-1BBL), are expressed on immune cells and tumor cells. CD137/CD137L interaction mediates bidirectional cellular responses of potential relevance in inflammatory diseases, ... ...

    Abstract Human CD137 (4-1BB), a member of the TNF receptor family, and its ligand CD137L (4-1BBL), are expressed on immune cells and tumor cells. CD137/CD137L interaction mediates bidirectional cellular responses of potential relevance in inflammatory diseases, autoimmunity and oncology. A soluble form of CD137 exists, elevated levels of which have been reported in patients with rheumatoid arthritis and various malignancies. Soluble CD137 (sCD137) is considered to represent a splice variant of CD137. In this report, however, evidence is presented that A Disintegrin and Metalloproteinase (ADAM)10 and potentially also ADAM17 are centrally involved in its generation. Release of sCD137 by transfected cell lines and primary T cells was uniformly inhibitable by ADAM10 inhibition. The shedding function of ADAM10 can be blocked through inhibition of its interaction with surface exposed phosphatidylserine (PS), and this effectively inhibited sCD137 generation. The phospholipid scramblase Anoctamin-6 (ANO6) traffics PS to the outer membrane and thus modifies ADAM10 function. Overexpression of ANO6 increased stimulated shedding, and hyperactive ANO6 led to maximal constitutive shedding of CD137. sCD137 was functionally active and augmented T cell proliferation. Our findings shed new light on the regulation of CD137/CD137L immune responses with potential impact on immunotherapeutic approaches targeting CD137.
    MeSH term(s) ADAM10 Protein/metabolism ; ADAM17 Protein/metabolism ; Amyloid Precursor Protein Secretases/metabolism ; Anoctamins/metabolism ; Arthritis, Rheumatoid/metabolism ; Arthritis, Rheumatoid/pathology ; Cell Membrane/metabolism ; HEK293 Cells ; HT29 Cells ; Humans ; Membrane Proteins/metabolism ; Neoplasm Proteins/metabolism ; Neoplasms/metabolism ; Neoplasms/pathology ; Phospholipid Transfer Proteins/metabolism ; T-Lymphocytes/metabolism ; T-Lymphocytes/pathology ; Tumor Necrosis Factor Receptor Superfamily, Member 9/metabolism
    Chemical Substances ANO6 protein, human ; Anoctamins ; Membrane Proteins ; Neoplasm Proteins ; Phospholipid Transfer Proteins ; Tumor Necrosis Factor Receptor Superfamily, Member 9 ; Amyloid Precursor Protein Secretases (EC 3.4.-) ; ADAM10 Protein (EC 3.4.24.81) ; ADAM10 protein, human (EC 3.4.24.81) ; ADAM17 Protein (EC 3.4.24.86) ; ADAM17 protein, human (EC 3.4.24.86)
    Language English
    Publishing date 2021-03-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22052730
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Influence of Anoctamin-4 and -9 on ADAM10 and ADAM17 Sheddase Function.

    Leitzke, Sinje / Seidel, Jana / Ahrens, Björn / Schreiber, Rainer / Kunzelmann, Karl / Sperrhacke, Maria / Bhakdi, Sucharit / Reiss, Karina

    Membranes

    2022  Volume 12, Issue 2

    Abstract: ... ...

    Abstract Ca
    Language English
    Publishing date 2022-01-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2614641-1
    ISSN 2077-0375
    ISSN 2077-0375
    DOI 10.3390/membranes12020123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Autonomic balance determines the severity of COVID-19 courses.

    Leitzke, M / Stefanovic, D / Meyer, J-J / Schimpf, S / Schönknecht, P

    Bioelectronic medicine

    2020  Volume 6, Issue 1, Page(s) 22

    Abstract: COVID-19 has left mankind desperately seeking how to manage dramatically rising infection rates associated with severe disease progressions. COVID-19 courses range from mild symptoms up to multiple organ failure and death, triggered by excessively high ... ...

    Abstract COVID-19 has left mankind desperately seeking how to manage dramatically rising infection rates associated with severe disease progressions. COVID-19 courses range from mild symptoms up to multiple organ failure and death, triggered by excessively high serum cytokine levels (IL 1β, IL 6, TNF α, IL 8). The vagally driven cholinergic anti-inflammatory pathway (CAP) stops the action of nuclear factor κB (NF-κB), the transcriptional factor of pro-inflammatory cytokines. Thus, well-balanced cytokine release depends on adequate vagal signaling. Coronaviruses replicate using NF-κB transcriptional factor as well. By degrading the cytoplasmatic inhibitor of NF-κB subunits (IκB), coronaviruses induce unrestricted NF-κB expression accelerating both, virus replication and cytokine transcription.We hypothesize that CAP detriment due to depressed vagal tone critically determines the severity of COVID-19.
    Language English
    Publishing date 2020-11-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2929561-0
    ISSN 2332-8886 ; 2332-8886
    ISSN (online) 2332-8886
    ISSN 2332-8886
    DOI 10.1186/s42234-020-00058-0
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  10. Article ; Online: Can't Take My Eyes Off of You: Eye Tracking Reveals How Ruminating Young Adolescents Get Stuck.

    Hilt, Lori M / Leitzke, Brian T / Pollak, Seth D

    Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53

    2017  Volume 46, Issue 6, Page(s) 858–867

    Abstract: Rumination, a cognitive process that involves passively, repetitively focusing on negative feelings and their meaning, is a transdiagnostic risk factor for psychopathology. Research with adults has suggested that attentional control difficulties may ... ...

    Abstract Rumination, a cognitive process that involves passively, repetitively focusing on negative feelings and their meaning, is a transdiagnostic risk factor for psychopathology. Research with adults has suggested that attentional control difficulties may underlie rumination, but questions remain about the nature of these processes. Furthermore, the relationship between attentional control and rumination in youth has received little empirical examination. In the present study, 92 youth (ages 9-14; 72% girls; 74% Caucasian) reported on their trait rumination and internalizing symptoms. They also completed a 1,500 ms emotional-faces dot-probe task while their eye movements were measured to examine overt visual attention with high temporal precision. Youth's rumination was associated with greater dwell on emotional faces but not with initial orientation. These findings suggest that rumination is associated with increased attention to emotional information during the later stages of selective attention rather than earlier orienting to emotional cues. Implications for prevention and treatment of psychopathology are discussed.
    Language English
    Publishing date 2017-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2073310-0
    ISSN 1537-4424 ; 1537-4416
    ISSN (online) 1537-4424
    ISSN 1537-4416
    DOI 10.1080/15374416.2015.1121824
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1943: Show issues Location:
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