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  1. Article ; Online: Diversification of IgA Antibody Specificities by Mild Chemical Modification?

    Gorochov, Guy / von Gunten, Stephan

    Pharmacology

    2022  Volume 107, Issue 7-8, Page(s) 339–340

    MeSH term(s) Antibody Specificity ; Immunoglobulin A
    Chemical Substances Immunoglobulin A
    Language English
    Publishing date 2022-03-31
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 206671-3
    ISSN 1423-0313 ; 0031-7012
    ISSN (online) 1423-0313
    ISSN 0031-7012
    DOI 10.1159/000524041
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  2. Article ; Online: Secondary-Type Carbohydrate Modification as a Driver of Epithelial-Mesenchymal Transition and Features of Cancer Stem Cells.

    von Gunten, Stephan

    Pharmacology

    2020  Volume 105, Issue 5-6, Page(s) 244–245

    MeSH term(s) Carbohydrates ; Epithelial-Mesenchymal Transition ; Neoplasms ; Neoplastic Stem Cells
    Chemical Substances Carbohydrates
    Language English
    Publishing date 2020-04-28
    Publishing country Switzerland
    Document type Editorial ; Comment
    ZDB-ID 206671-3
    ISSN 1423-0313 ; 0031-7012
    ISSN (online) 1423-0313
    ISSN 0031-7012
    DOI 10.1159/000507003
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  3. Article ; Online: Inflamm-Aging: Arginase-II as Stage Setter in Age-Related Adipose Tissue Inflammation.

    von Gunten, Stephan

    Pharmacology

    2020  Volume 105, Issue 9-10, Page(s) 489–490

    MeSH term(s) Adipose Tissue/pathology ; Aging ; Arginase ; Humans ; Inflammation
    Chemical Substances Arginase (EC 3.5.3.1)
    Language English
    Publishing date 2020-09-04
    Publishing country Switzerland
    Document type Editorial ; Comment
    ZDB-ID 206671-3
    ISSN 1423-0313 ; 0031-7012
    ISSN (online) 1423-0313
    ISSN 0031-7012
    DOI 10.1159/000510515
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  4. Article ; Online: The Future of Pharmacology: Towards More Personalized Pharmacotherapy and Reverse Translational Research.

    von Gunten, Stephan

    Pharmacology

    2019  Volume 105, Issue 1-2, Page(s) 1–2

    Language English
    Publishing date 2019-12-10
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 206671-3
    ISSN 1423-0313 ; 0031-7012
    ISSN (online) 1423-0313
    ISSN 0031-7012
    DOI 10.1159/000505216
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  5. Article ; Online: Targeting the Laminated Layer of Echinococcus multilocularis as a Potential Therapeutic Strategy.

    Cummings, Richard D / von Gunten, Stephan

    Pharmacology

    2021  Volume 106, Issue 1-2, Page(s) 1–2

    Language English
    Publishing date 2021-01-18
    Publishing country Switzerland
    Document type Editorial ; Comment
    ZDB-ID 206671-3
    ISSN 1423-0313 ; 0031-7012
    ISSN (online) 1423-0313
    ISSN 0031-7012
    DOI 10.1159/000512769
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  6. Article ; Online: Antibody diversity in IVIG: Therapeutic opportunities for novel immunotherapeutic drugs.

    von Gunten, Stephan / Schneider, Christoph / Imamovic, Lejla / Gorochov, Guy

    Frontiers in immunology

    2023  Volume 14, Page(s) 1166821

    Abstract: Significant progress has been made in the elucidation of human antibody repertoires. Furthermore, non-canonical functions of antibodies have been identified that reach beyond classical functions linked to protection from pathogens. Polyclonal ... ...

    Abstract Significant progress has been made in the elucidation of human antibody repertoires. Furthermore, non-canonical functions of antibodies have been identified that reach beyond classical functions linked to protection from pathogens. Polyclonal immunoglobulin preparations such as IVIG and SCIG represent the IgG repertoire of the donor population and will likely remain the cornerstone of antibody replacement therapy in immunodeficiencies. However, novel evidence suggests that pooled IgA might promote orthobiotic microbial colonization in gut dysbiosis linked to mucosal IgA immunodeficiency. Plasma-derived polyclonal IgG and IgA exhibit immunoregulatory effects by a diversity of different mechanisms, which have inspired the development of novel drugs. Here we highlight recent insights into IgG and IgA repertoires and discuss potential implications for polyclonal immunoglobulin therapy and inspired drugs.
    MeSH term(s) Humans ; Immunoglobulins, Intravenous/therapeutic use ; Immunoglobulin G/therapeutic use ; Antibody Diversity ; Immunologic Deficiency Syndromes ; Immunization, Passive ; Immunoglobulin A/therapeutic use
    Chemical Substances Immunoglobulins, Intravenous ; Immunoglobulin G ; Immunoglobulin A
    Language English
    Publishing date 2023-03-28
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1166821
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The Choice between Intravenous and Subcutaneous Immunoglobulins: Aspects for Consideration.

    von Achenbach, Caroline / Hevia Hernandez, Giselle / von Gunten, Stephan

    Pharmacology

    2022  Volume 107, Issue 11-12, Page(s) 556–563

    Abstract: Background: Intravenous immunoglobulin and subcutaneous immunoglobulin preparations are used to treat primary and secondary immunodeficiencies, as well as autoimmune and inflammatory conditions.: Summary: For certain indications, only defined ... ...

    Abstract Background: Intravenous immunoglobulin and subcutaneous immunoglobulin preparations are used to treat primary and secondary immunodeficiencies, as well as autoimmune and inflammatory conditions.
    Summary: For certain indications, only defined formulations or routes of administration are approved by health authorities. However, for other diseases, there are more options, and treatment decisions may be based on different aspects, such as patient conditions and preferences, pharmacokinetics, or pharmacoeconomic considerations.
    Key messages: Understanding the two different treatment modalities may support the decision-making for the optimal therapeutic option for individual patients. This review summarizes the latest insights into the direct and indirect comparison between the two types of products.
    MeSH term(s) Humans ; Immunoglobulins/therapeutic use ; Immunoglobulins, Intravenous/therapeutic use ; Immunologic Deficiency Syndromes/drug therapy ; Administration, Intravenous
    Chemical Substances Immunoglobulins ; Immunoglobulins, Intravenous
    Language English
    Publishing date 2022-11-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 206671-3
    ISSN 1423-0313 ; 0031-7012
    ISSN (online) 1423-0313
    ISSN 0031-7012
    DOI 10.1159/000527655
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Targeting sialylation to treat central nervous system diseases.

    Lünemann, Jan D / von Gunten, Stephan / Neumann, Harald

    Trends in pharmacological sciences

    2021  Volume 42, Issue 12, Page(s) 998–1008

    Abstract: Sialic acid-binding immunoglobulin-type lectins (SIGLECs) are membrane receptors that are preferentially expressed on immune cells and recognize sialylated proteins, lipids, and RNA. Sialic acids and signaling through SIGLECs are increasingly recognized ... ...

    Abstract Sialic acid-binding immunoglobulin-type lectins (SIGLECs) are membrane receptors that are preferentially expressed on immune cells and recognize sialylated proteins, lipids, and RNA. Sialic acids and signaling through SIGLECs are increasingly recognized for their essential roles in immune system homeostasis as well as nervous system development, plasticity, and repair. Dysregulated sialylation and SIGLEC dysfunctions contribute to several chronic diseases of the central nervous system (CNS) in which current therapeutic options are very limited. While only a few therapies targeting SIGLECs are currently being tested in clinical trials, the area emerged as one of the most dynamic and active fields in glycobiology and drug development. This review highlights recent insights into sialic acid and SIGLEC function in CNS pathologies and illustrates opportunities and challenges for the development of sialic acid-based and SIGLEC-targeted therapies for neurological diseases.
    MeSH term(s) Central Nervous System/metabolism ; Central Nervous System Diseases/drug therapy ; Humans ; N-Acetylneuraminic Acid/metabolism ; Sialic Acid Binding Immunoglobulin-like Lectins/metabolism
    Chemical Substances Sialic Acid Binding Immunoglobulin-like Lectins ; N-Acetylneuraminic Acid (GZP2782OP0)
    Language English
    Publishing date 2021-10-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 282846-7
    ISSN 1873-3735 ; 0165-6147
    ISSN (online) 1873-3735
    ISSN 0165-6147
    DOI 10.1016/j.tips.2021.09.002
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  9. Article ; Online: IgE glycosylation is essential for the function of omalizumab.

    Plattner, Kevin / Augusto, Gilles / Muerner, Lukas / von Gunten, Stephan / Jörg, Lukas / Engeroff, Paul / Bachmann, Martin F / Vogel, Monique

    Allergy

    2023  Volume 78, Issue 9, Page(s) 2546–2549

    MeSH term(s) Humans ; Omalizumab/therapeutic use ; Glycosylation ; Hypersensitivity/drug therapy ; Anti-Allergic Agents/therapeutic use ; Immunoglobulin E/therapeutic use
    Chemical Substances Omalizumab (2P471X1Z11) ; Anti-Allergic Agents ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2023-04-28
    Publishing country Denmark
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.15748
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  10. Article ; Online: Allergy and Atopic Diseases: An Update on Experimental Evidence.

    Verschoor, Daniëlle / von Gunten, Stephan

    International archives of allergy and immunology

    2019  Volume 180, Issue 4, Page(s) 235–243

    Abstract: Over the last decades, an increasing appearance of allergies and atopic disorders, such as asthma, dermatitis, and rhinitis, has been observed. The mechanisms of these disorders remain unclear, and therefore the development of novel therapies is limited. ...

    Abstract Over the last decades, an increasing appearance of allergies and atopic disorders, such as asthma, dermatitis, and rhinitis, has been observed. The mechanisms of these disorders remain unclear, and therefore the development of novel therapies is limited. Current treatments are often symptomatic, nonspecific, or may have severe side effects. Further insights into the mechanisms of the underlying disease pathogenesis could reveal novel targets for treatment. In this review, we provide an update on recent basic and translational studies that offer novel insights and opportunities for the treatment of patients with atopic disorders.
    MeSH term(s) Allergens/immunology ; Asthma/etiology ; Asthma/genetics ; Asthma/therapy ; Dermatitis, Atopic/etiology ; Dermatitis, Atopic/genetics ; Dermatitis, Atopic/therapy ; Food Hypersensitivity/etiology ; Food Hypersensitivity/genetics ; Food Hypersensitivity/therapy ; Genetic Predisposition to Disease/genetics ; Humans ; Rhinitis, Allergic/etiology ; Rhinitis, Allergic/genetics ; Rhinitis, Allergic/therapy ; Risk Factors
    Chemical Substances Allergens
    Language English
    Publishing date 2019-11-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1108932-5
    ISSN 1423-0097 ; 1018-2438
    ISSN (online) 1423-0097
    ISSN 1018-2438
    DOI 10.1159/000504439
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