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Article ; Online: Suppression of academics and school training in Iran during the "Woman, Life, Freedom" revolution.

Shojaei, Shahla / Taefehshokr, Nima / Ghavami, Saeid

Biochemistry and cell biology = Biochimie et biologie cellulaire

2023 Volume 101, Issue 6, Page(s) 496–500

Abstract: For the past 6 months, there has been an ongoing revolution in Iran after the brutal death of Zhina (Mahsa) Amini in morality police custody. Iranian universities' professors and students have been on the frontline of this revolution and have been fired ... ...

Abstract	For the past 6 months, there has been an ongoing revolution in Iran after the brutal death of Zhina (Mahsa) Amini in morality police custody. Iranian universities' professors and students have been on the frontline of this revolution and have been fired or sentenced. On the other hand, Iranian high schools and primary schools have been under suspected toxic gas attack. In the current article, the latest status of oppression of the university students and professors and toxic gas attack on primary and high schools in Iran has been evaluated.
MeSH term(s)	Female ; Humans ; Iran ; Schools ; Universities
Language	English
Publishing date	2023-05-19
Publishing country	Canada
Document type	Journal Article
ZDB-ID	54104-7
ISSN	1208-6002 ; 0829-8211
ISSN (online)	1208-6002
ISSN	0829-8211
DOI	10.1139/bcb-2023-0100
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Article ; Online: Correction: Dastghaib et al. Simvastatin Induces Unfolded Protein Response and Enhances Temozolomide-Induced Cell Death in Glioblastoma Cells.

Dastghaib, Sanaz / Shojaei, Shahla / Mostafavi-Pour, Zohreh / Sharma, Pawan / Patterson, John B / Samali, Afshin / Mokarram, Pooneh / Ghavami, Saeid

Cells

2024 Volume 13, Issue 8

Abstract: In the original publication [ ... ]. ...

Abstract	In the original publication [...].
Language	English
Publishing date	2024-04-22
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells13080722
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Article: Autophagy and Biomaterials: A Brief Overview of the Impact of Autophagy in Biomaterial Applications.

Pirmoradi, Leila / Shojaei, Shahla / Ghavami, Saeid / Zarepour, Atefeh / Zarrabi, Ali

Pharmaceutics

2023 Volume 15, Issue 9

Abstract: Macroautophagy (hereafter autophagy), a tightly regulated physiological process that obliterates dysfunctional and damaged organelles and proteins, has a crucial role when biomaterials are applied for various purposes, including diagnosis, treatment, ... ...

Abstract	Macroautophagy (hereafter autophagy), a tightly regulated physiological process that obliterates dysfunctional and damaged organelles and proteins, has a crucial role when biomaterials are applied for various purposes, including diagnosis, treatment, tissue engineering, and targeted drug delivery. The unparalleled physiochemical properties of nanomaterials make them a key component of medical strategies in different areas, such as osteogenesis, angiogenesis, neurodegenerative disease treatment, and cancer therapy. The application of implants and their modulatory effects on autophagy have been known in recent years. However, more studies are necessary to clarify the interactions and all the involved mechanisms. The advantages and disadvantages of nanomaterial-mediated autophagy need serious attention in both the biological and bioengineering fields. In this mini-review, the role of autophagy after biomaterial exploitation and the possible related mechanisms are explored.
Language	English
Publishing date	2023-09-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics15092284
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Article: Prevalence and Associated Factors of Anxiety and Depression Among Patients with Type 2 Diabetes in Kerman, Southern Iran.

Dehesh, Tania / Dehesh, Paria / Shojaei, Shahla

Diabetes, metabolic syndrome and obesity : targets and therapy

2020 Volume 13, Page(s) 1509–1517

Abstract: Purpose: Depression and anxiety are common disorders in patients suffering from type 2 diabetes. These disorders can lead to premature morbidity, exacerbate disease complications, make patients suffer more, and increase health-care costs. As diabetes ... ...

Abstract	Purpose: Depression and anxiety are common disorders in patients suffering from type 2 diabetes. These disorders can lead to premature morbidity, exacerbate disease complications, make patients suffer more, and increase health-care costs. As diabetes has increased worldwide recently, it is necessary to reduce the prevalence of factors that are associated with depression and anxiety in diabetes patients. This study aimed to assess the prevalence of anxiety and depression and to identify their associated factors, including metabolic components among people with type 2 diabetes. Patients and methods: We performed a cross-sectional study in 1500 patients with type 2 diabetes in Kerman, in the southern part of Iran. The prevalence of depression and anxiety was estimated using the Beck Depression Inventory and the Hamilton Anxiety questionnaires, respectively. After calculating the proportions of depression and anxiety, univariate logistic regression was performed. Factors whose Results: The rates of depression and anxiety were 59% (95% CI: 54.48-63.12) and 62% (95% CI: 59.51-66.27), respectively. Factors found to be independently associated with anxiety were high FBS, high LDL-C, high TG, hypertension, complications, low physical activity. Factors found to be independently associated with depression were female gender, older age, high BMI, high FBS, high LDL-C, low HDL-C, high TG, high HbA1c, hypertension, and low physical activity. Complications were independently associated with anxiety but not with depression. Female gender, older age, high BMI, low HDL-C, and high HbA1c were independently associated with depression but not with anxiety. Conclusion: Current findings demonstrated that a large proportion of patients with type 2 diabetes suffer from depression and anxiety. This study also identified factors associated with these disorders. Controlling some metabolic variables will decrease the prevalence of these disorders and improves clinical remedy and quality of life in patients with type 2 diabetes.
Language	English
Publishing date	2020-05-05
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494854-8
ISSN	1178-7007
ISSN	1178-7007
DOI	10.2147/DMSO.S249385
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Article ; Online: Autophagy and cancer research in Iran.

Mokarram, Pooneh / Ahmadi, Mazaher / Shojaei, Shahla / Ghavami, Saeid

Autophagy

2019 Volume 15, Issue 11, Page(s) 2039–2042

Abstract: In August 2018, three events were held in Iran on clinical biochemistry, molecular biology, cancer/autophagy, laboratory management, and proteomics. On August 25-28 at the Isfahan University of Medical Sciences, the 15th National Biochemistry Congress ... ...

Abstract	In August 2018, three events were held in Iran on clinical biochemistry, molecular biology, cancer/autophagy, laboratory management, and proteomics. On August 25-28 at the Isfahan University of Medical Sciences, the 15th National Biochemistry Congress and the 6th International Congress on Biochemistry and Molecular Biology were held, gathering together international professors from Canada, USA, Germany, Australia, Italy, France, and Sweden, as well as Iran to discuss mainly the roles of autophagy in cancer therapy. On August 29, a one-day 'Autophagy' symposium was held at the Shiraz University of Medical Sciences. The symposium was a place for specialist talks and discussions on the double-edged role of autophagy in cancer biology, which brought together approximately 200 participants, from basic and clinical fields who are interested in the autophagy field. Furthermore, the opening ceremony for the Autophagy Research Center was held on the same day, and the establishment of the center was announced in Shiraz.
MeSH term(s)	Apoptosis/genetics ; Autophagy ; Humans ; Iran ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/therapy ; Neoplastic Stem Cells/metabolism ; Pluripotent Stem Cells/cytology ; Pluripotent Stem Cells/metabolism ; Unfolded Protein Response/genetics
Language	English
Publishing date	2019-04-23
Publishing country	United States
Document type	Congress ; Research Support, Non-U.S. Gov't
ZDB-ID	2454135-7
ISSN	1554-8635 ; 1554-8627
ISSN (online)	1554-8635
ISSN	1554-8627
DOI	10.1080/15548627.2019.1606638
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Article ; Online: Placental Nanoparticle Uptake-On-a-Chip: The Impact of Trophoblast Syncytialization and Shear Stress.

Abostait, Amr / Tyrrell, Jack / Abdelkarim, Mahmoud / Shojaei, Shahla / Tse, Wai Hei / El-Sherbiny, Ibrahim M / Keijzer, Richard / Labouta, Hagar I

Molecular pharmaceutics

2022 Volume 19, Issue 11, Page(s) 3757–3769

Abstract: The placenta is a dynamic and complex organ that plays an essential role in the health and development of the fetus. Placental disorders can affect the health of both the mother and the fetus. There is currently an unmet clinical need to develop ... ...

Abstract	The placenta is a dynamic and complex organ that plays an essential role in the health and development of the fetus. Placental disorders can affect the health of both the mother and the fetus. There is currently an unmet clinical need to develop nanoparticle-based therapies to target and treat placental disorders. However, little is known about the interaction of nanoparticles (NPs) with the human placenta under biomimetic conditions. Specifically, the impact of shear stress exerted on the trophoblasts (placental epithelial cells) by the maternal blood flow, the gradual fusion of the trophoblasts along the gestation period (syncytialization), and the impact of microvilli formation on the cell uptake of NPs is not known. To this end, we designed dynamic placenta-on-a-chip models using BeWo cells to recapitulate the micro-physiological environment, and we induced different degrees of syncytialization via chemical induction with forskolin. We characterized the degree of syncytialization quantitatively by measuring beta human chorionic gonadotropin (β-hCG) secretion, as well as qualitatively by immunostaining the tight junction protein, ZO-1, and counter nuclear staining. We also characterized microvilli formation under static and dynamic conditions via F-actin staining. We used these models to measure the cell uptake of chondroitin sulfate a binding protein (CSA) conjugated and control liposomes using confocal microscopy, followed by image analysis. Interestingly, exposure of the cells to a dynamic flow of media intrinsically induced syncytialization and microvilli formation compared to static controls. Under dynamic conditions, BeWo cells produced more β-hCG in conditions that increased the cell exposure time to forskolin (
MeSH term(s)	Female ; Pregnancy ; Humans ; Trophoblasts/metabolism ; Placenta/metabolism ; Colforsin/pharmacology ; Colforsin/metabolism ; Liposomes/metabolism ; Lab-On-A-Chip Devices ; Carrier Proteins/metabolism ; Nanoparticles
Chemical Substances	Colforsin (1F7A44V6OU) ; Liposomes ; Carrier Proteins
Language	English
Publishing date	2022-09-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2138405-8
ISSN	1543-8392 ; 1543-8384
ISSN (online)	1543-8392
ISSN	1543-8384
DOI	10.1021/acs.molpharmaceut.2c00216
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Article ; Online: Autophagy and SARS-CoV-2 infection: Apossible smart targeting of the autophagy pathway.

Shojaei, Shahla / Suresh, Madhumita / Klionsky, Daniel J / Labouta, Hagar Ibrahim / Ghavami, Saeid

Virulence

2020 Volume 11, Issue 1, Page(s) 805–810

Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak resulted in 5,993,317 confirmed cases worldwide with 365,394 confirmed deaths (as of May ... ...

Abstract	The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak resulted in 5,993,317 confirmed cases worldwide with 365,394 confirmed deaths (as of May 29
MeSH term(s)	Autophagy ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/pathology ; Coronavirus Infections/virology ; Humans ; Pandemics ; Pneumonia, Viral/pathology ; Pneumonia, Viral/virology ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-07-07
Publishing country	United States
Document type	Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2657572-3
ISSN	2150-5608 ; 2150-5594
ISSN (online)	2150-5608
ISSN	2150-5594
DOI	10.1080/21505594.2020.1780088
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Article ; Online: Ceramides and ceramide synthases in cancer: Focus on apoptosis and autophagy.

Alizadeh, Javad / da Silva Rosa, Simone C / Weng, Xiaohui / Jacobs, Joadi / Lorzadeh, Shahrokh / Ravandi, Amir / Vitorino, Rui / Pecic, Stevan / Zivkovic, Aleksandra / Stark, Holger / Shojaei, Shahla / Ghavami, Saeid

European journal of cell biology

2023 Volume 102, Issue 3, Page(s) 151337

Abstract: Different studies corroborate a role for ceramide synthases and their downstream products, ceramides, in modulation of apoptosis and autophagy in the context of cancer. These mechanisms of regulation, however, appear to be context dependent in terms of ... ...

Abstract	Different studies corroborate a role for ceramide synthases and their downstream products, ceramides, in modulation of apoptosis and autophagy in the context of cancer. These mechanisms of regulation, however, appear to be context dependent in terms of ceramides' fatty acid chain length, subcellular localization, and the presence or absence of their downstream targets. Our current understanding of the role of ceramide synthases and ceramides in regulation of apoptosis and autophagy could be harnessed to pioneer the development of new treatments to activate or inhibit a single type of ceramide synthase, thereby regulating the apoptosis induction or cross talk of apoptosis and autophagy in cancer cells. Moreover, the apoptotic function of ceramide suggests that ceramide analogues can pave the way for the development of novel cancer treatments. Therefore, in the current review paper we discuss the impact of ceramide synthases and ceramides in regulation of apoptosis and autophagy in context of different types of cancers. We also briefly introduce the latest information on ceramide synthase inhibitors, their application in diseases including cancer therapy, and discuss approaches for drug discovery in the field of ceramide synthase inhibitors. We finally discussed strategies for developing strategies to use lipids and ceramides analysis in biological fluids for developing early biomarkers for cancer.
MeSH term(s)	Humans ; Ceramides/pharmacology ; Neoplasms ; Apoptosis ; Autophagy
Chemical Substances	Ceramides ; dihydroceramide desaturase (EC 1.3.1.-)
Language	English
Publishing date	2023-06-26
Publishing country	Germany
Document type	Review ; Journal Article
ZDB-ID	391967-5
ISSN	1618-1298 ; 0070-2463 ; 0171-9335
ISSN (online)	1618-1298
ISSN	0070-2463 ; 0171-9335
DOI	10.1016/j.ejcb.2023.151337
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Article ; Online: Dynamic placenta-on-a-chip model for fetal risk assessment of nanoparticles intended to treat pregnancy-associated diseases.

Shojaei, Shahla / Ali, Moustafa S / Suresh, Madhumita / Upreti, Tushar / Mogourian, Victoria / Helewa, Michael / Labouta, Hagar I

Biochimica et biophysica acta. Molecular basis of disease

2021 Volume 1867, Issue 7, Page(s) 166131

Abstract: Pregnant women often have to take medication either for pregnancy-related diseases or for previously existing medical conditions. Current maternal medications pose fetal risks due to off target accumulation in the fetus. Nanoparticles, engineered ... ...

Abstract	Pregnant women often have to take medication either for pregnancy-related diseases or for previously existing medical conditions. Current maternal medications pose fetal risks due to off target accumulation in the fetus. Nanoparticles, engineered particles in the nanometer scale, have been used for targeted drug delivery to the site of action without off-target effects. This has opened new avenues for treatment of pregnancy-associated diseases while minimizing risks on the fetus. It is therefore instrumental to study the potential transfer of nanoparticles from the mother to the fetus. Due to limitations of in vivo and ex vivo models, an in vitro model mimicking the in vivo situation is essential. Placenta-on-a-chip provides a microphysiological recapitulation of the human placenta. Here, we reviewed the fetal risks associated with current therapeutic approaches during pregnancy, analyzed the advantages and limitations of current models used for nanoparticle assessment, and highlighted the current need for using dynamic placenta-on-a-chip models for assessing the safety of novel nanoparticle-based therapies during pregnancy.
MeSH term(s)	Drug Delivery Systems/methods ; Female ; Fetus/drug effects ; Fetus/metabolism ; Humans ; Lab-On-A-Chip Devices/statistics & numerical data ; Maternal-Fetal Exchange ; Nanoparticles/administration & dosage ; Nanoparticles/adverse effects ; Placenta/drug effects ; Placenta/metabolism ; Pregnancy ; Pregnancy Complications/drug therapy ; Pregnancy Complications/etiology ; Pregnancy Complications/pathology ; Risk Assessment/methods
Language	English
Publishing date	2021-03-22
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	60-7
ISSN	1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbadis.2021.166131
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Article ; Online: Vitamin D3 and estradiol alter PAD2 expression and activity levels in C6 glioma cells.

Ghasempour, Ghasem / Zamani-Garmsiri, Fahimeh / Shojaei, Shahla / Rahmani-Fard, Soheil / Bagherieh, Molood / Rashno, Sajjad / Najafi, Mohammad

Multiple sclerosis and related disorders

2021 Volume 56, Page(s) 103221

Abstract: Multiple Sclerosis (MS) is known as a chronic demyelinating disease with multifactorial etiology. It is suggested that the deimination of myelin basic proteins (MBPs) by peptidyl arginine deiminase 2 (PAD2) may increase citrulline residues resulting in ... ...

Abstract	Multiple Sclerosis (MS) is known as a chronic demyelinating disease with multifactorial etiology. It is suggested that the deimination of myelin basic proteins (MBPs) by peptidyl arginine deiminase 2 (PAD2) may increase citrulline residues resulting in the reduction of myelin sheath density and the progression of multiple sclerosis. The aim of this study was to investigate the effects of vitamin D (25-hydroxy cholecalciferol (D3)) and estradiol on PAD2 gene expression level and its catalytic activity in rat C6 glioma cells. C6 glioma cells were cultured in DMEM medium and were treated with vitamin D (10 and 100 ng/ml) and estradiol (10 and 100 µM) based on the cellular viability. Then, the PAD2 gene expression and catalytic activity were evaluated using real-time qRT-PCR and spectrophotometry techniques, respectively. The PAD2 gene expression level and its catalytic activity increased significantly in estradiol-treated cells (P = 0.0435 and P = 0.0015, respectively). Conversely, vitamin D downregulated significantly the PAD2 gene expression level (P < 0.015) and its activity (P < 0.017). The study results suggested that estradiol conversely with vitamin D increases the activity of the PAD2 enzyme so that it might develop multiple sclerosis, especially in women.
MeSH term(s)	Animals ; Cholecalciferol/pharmacology ; Citrulline ; Estradiol/pharmacology ; Glioma/genetics ; Hydrolases ; Rats
Chemical Substances	Cholecalciferol (1C6V77QF41) ; Citrulline (29VT07BGDA) ; Estradiol (4TI98Z838E) ; Hydrolases (EC 3.-)
Language	English
Publishing date	2021-08-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2645330-7
ISSN	2211-0356 ; 2211-0348
ISSN (online)	2211-0356
ISSN	2211-0348
DOI	10.1016/j.msard.2021.103221
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