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Article ; Online: Endotheliopathy of liver sinusoidal endothelial cells in liver disease.

Kondo, Reiichiro / Iwakiri, Yasuko / Kage, Masayoshi / Yano, Hirohisa

2023 Volume 73, Issue 9, Page(s) 381–393

Abstract: Liver is the largest solid organ in the abdominal cavity, with sinusoid occupying about half of its volume. Under liver disease, hemodynamics in the liver tissue dynamically change, resulting in injury to liver sinusoidal endothelial cells (LSECs). We ... ...

Abstract	Liver is the largest solid organ in the abdominal cavity, with sinusoid occupying about half of its volume. Under liver disease, hemodynamics in the liver tissue dynamically change, resulting in injury to liver sinusoidal endothelial cells (LSECs). We discuss the injury of LSECs in liver diseases in this article. Generally, in noninflamed tissues, vascular endothelial cells maintain quiescence of circulating leukocytes, and unnecessary blood clotting is inhibited by multiple antithrombotic factors produced by the endothelial cells. In the setting of inflammation, injured endothelial cells lose these functions, defined as inflammatory endotheliopathy. In chronic hepatitis C, inflammatory endotheliopathy in LSECs contributes to platelet accumulation in the liver tissue, and the improvement of thrombocytopenia by splenectomy is attenuated in cases with severe hepatic inflammation. In COVID-19, LSEC endotheliopathy induced by interleukin (IL)-6 trans-signaling promotes neutrophil accumulation and platelet microthrombosis in the liver sinusoids, resulting in liver injury. IL-6 trans-signaling promotes the expression of intercellular adhesion molecule-1, chemokine (C-X-C motif) ligand (CXCL1), and CXCL2, which are the neutrophil chemotactic mediators, and P-selectin, E-selectin, and von Willebrand factor, which are involved in platelet adhesion to endothelial cells, in LSECs. Restoring LSECs function is important for ameliorating liver injury. Prevention of endotheliopathy is a potential therapeutic strategy in liver disease.
MeSH term(s)	Humans ; Endothelial Cells ; COVID-19 ; Liver Diseases ; Hepatic Veins
Language	English
Publishing date	2023-08-17
Publishing country	Australia
Document type	Journal Article ; Review
ZDB-ID	1194850-4
ISSN	1440-1827 ; 1320-5463
ISSN (online)	1440-1827
ISSN	1320-5463
DOI	10.1111/pin.13361
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Article ; Online: A safer method for disinfection of Bacillus Calmette-Guerin-containing urine: a prospective, randomized study.

Kameda, Tomohiro / Kondo, Yoshimasa / Fukataki, Yasuko / Hinotsu, Shiro / Fujimura, Tetsuya / Takayama, Tatsuya

Urologia internationalis

2024

Abstract: Introduction: To examine whether disinfection of Bacillus Calmette-Guerin -containing urine with etaprocohol® (Ethanol 76.9-81.4 vol % and isopropanol as an additive) is safer than disinfection with sodium hypochlorite.: Method: In prospective ... ...

Abstract	Introduction: To examine whether disinfection of Bacillus Calmette-Guerin -containing urine with etaprocohol® (Ethanol 76.9-81.4 vol % and isopropanol as an additive) is safer than disinfection with sodium hypochlorite. Method: In prospective research, safety, and efficacy was analyzed in five patients in the etaprocohol® disinfection group and five patients in the sodium hypochlorite disinfection group. The primary endpoint was the temperature change after disinfection and the secondary endpoint was the unpleasantness of the odor caused by disinfection. Additionally, concentration of gas produced was also examined. Sensory tests were taken from staff who performed urine disinfection and the odor generated by disinfection was evaluated. As a safety protocol, post-BCG-treated urine is cultured to verify the negative for Mycobacteria. Results: Mycobacteria was disinfected in all cases. The temperature rise following disinfection was significantly higher in the sodium hypochlorite group. The sensory test outcomes were significantly worse in the group disinfected with sodium hypochlorite. The concentration of gas generated immediately after disinfection in both groups reached the maximum value and declined quickly. Conclusions: Disinfection of Bacillus Calmette-Guerin -containing urine with etaprocohol® was safer than disinfection with sodium hypochlorite, and an equivalent disinfection effect was achieved.
Language	English
Publishing date	2024-04-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	204045-1
ISSN	1423-0399 ; 0042-1138
ISSN (online)	1423-0399
ISSN	0042-1138
DOI	10.1159/000538758
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Article ; Online: The lymphatic system in alcohol-associated liver disease.

Kondo, Reiichiro / Iwakiri, Yasuko

Clinical and molecular hepatology

2020 Volume 26, Issue 4, Page(s) 633–638

Abstract: The lymphatic system plays vital roles in interstitial fluid balance and immune cell surveillance. The effect of alcohol on the lymphatic system is poorly understood. This review article explores the role of the lymphatic system in the pathogenesis of ... ...

Abstract	The lymphatic system plays vital roles in interstitial fluid balance and immune cell surveillance. The effect of alcohol on the lymphatic system is poorly understood. This review article explores the role of the lymphatic system in the pathogenesis of alcohol-related disease including alcoholic liver disease (ALD) and the therapeutic potential of targeting hepatic lymphatics for the treatment of ALD.
MeSH term(s)	Humans ; Liver Diseases, Alcoholic ; Lymphangiogenesis ; Lymphatic System ; Lymphatic Vessels
Language	English
Publishing date	2020-09-21
Publishing country	Korea (South)
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	2672560-5
ISSN	2287-285X ; 2287-2728
ISSN (online)	2287-285X
ISSN	2287-2728
DOI	10.3350/cmh.2020.0179
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Article: [End-of-Life Care at Nursing Facilities].

Kondo, Seiji / Kondo, Yasuko

Gan to kagaku ryoho. Cancer & chemotherapy

2019 Volume 46, Issue Suppl 1, Page(s) 79–80

Abstract: In Japan, it has been more common for elderly people to die in a hospital than at home. However, recently, increasingly more elderly people want to die where they have been living for a long time, such as their homes or nursing care facilities. We have ... ...

Abstract	In Japan, it has been more common for elderly people to die in a hospital than at home. However, recently, increasingly more elderly people want to die where they have been living for a long time, such as their homes or nursing care facilities. We have been visiting patients at various types of nursing care facilities for ten years, including terminal care services followed by confirming death for 152 patients. Our study showed that 87 patients died of old age, which was the top cause of death. We also found that nursing care facilities, where nurses work full-time, provided terminal care for the greatest number of residents, which was 124 patients. The average period between admission to a facility and death was 3 years 3 months. The number of patients who receive terminal nursing care at a facility is increasing annually. The number of elderly people who die at home or a nursing care facility, rather than a hospital, will keep increasing in the near future.
MeSH term(s)	Humans ; Japan ; Terminal Care
Language	Japanese
Publishing date	2019-06-12
Publishing country	Japan
Document type	Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Article ; Online: Spatio-temporal imaging of cell fate dynamics in single plant cells using luminescence microscope.

Shimadzu, Shunji / Furuya, Tomoyuki / Ozawa, Yasuko / Fukuda, Hiroo / Kondo, Yuki

Quantitative plant biology

2022 Volume 3, Page(s) e15

Abstract: Stem cell fates are spatio-temporally regulated during plant development. Time-lapse imaging of fluorescence reporters is the most widely used method for spatio-temporal analysis of biological processes. However, excitation light for imaging fluorescence ...

Abstract	Stem cell fates are spatio-temporally regulated during plant development. Time-lapse imaging of fluorescence reporters is the most widely used method for spatio-temporal analysis of biological processes. However, excitation light for imaging fluorescence reporters causes autofluorescence and photobleaching. Unlike fluorescence reporters, luminescence proteins do not require excitation light, and therefore offer an alternative reporter for long-term and quantitative spatio-temporal analysis. We established an imaging system for luciferase, which enabled monitoring cell fate marker dynamics during vascular development in a vascular cell induction system called VISUAL. Single cells expressing the cambium marker,
Language	English
Publishing date	2022-07-18
Publishing country	England
Document type	Journal Article
ISSN	2632-8828
ISSN (online)	2632-8828
DOI	10.1017/qpb.2022.12
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Article: [Association of the Types of Dementia and the Incidence of Hypertension, Diabetes Mellitus, or Bone Fracture].

Kondo, Seiji / Kondo, Yasuko

Gan to kagaku ryoho. Cancer & chemotherapy

2018 Volume 45, Issue Suppl 1, Page(s) 25–26

Abstract: Patients with dementia tend to have other chronic diseases, such as hypertension or diabetes mellitus. As dementia progresses, patients tend to decline to a frail state, resulting in bone fracture. In this study, we examined the relationship of the types ...

Abstract	Patients with dementia tend to have other chronic diseases, such as hypertension or diabetes mellitus. As dementia progresses, patients tend to decline to a frail state, resulting in bone fracture. In this study, we examined the relationship of the types of dementia and the incidence of other diseases and bone fracture.
MeSH term(s)	Dementia/complications ; Diabetes Complications ; Diabetes Mellitus ; Diabetes Mellitus, Type 2 ; Fractures, Bone/complications ; Humans ; Hypertension/complications ; Incidence ; Risk Factors
Language	Japanese
Publishing date	2018-04-12
Publishing country	Japan
Document type	Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Article ; Online: Deep learning-based classification of adequate sonographic images for self-diagnosing deep vein thrombosis.

Nakayama, Yusuke / Sato, Mitsuru / Okamoto, Masashi / Kondo, Yohan / Tamura, Manami / Minagawa, Yasuko / Uchiyama, Mieko / Horii, Yosuke

PloS one

2023 Volume 18, Issue 3, Page(s) e0282747

Abstract: Background: Pulmonary thromboembolism is a serious disease that often occurs in disaster victims evacuated to shelters. Deep vein thrombosis is the most common reason for pulmonary thromboembolism, and early prevention is important. Medical technicians ... ...

Abstract	Background: Pulmonary thromboembolism is a serious disease that often occurs in disaster victims evacuated to shelters. Deep vein thrombosis is the most common reason for pulmonary thromboembolism, and early prevention is important. Medical technicians often perform ultrasonography as part of mobile medical screenings of disaster victims but reaching all isolated and scattered shelters is difficult. Therefore, deep vein thrombosis medical screening methods that can be easily performed by anyone are needed. The purpose of this study was to develop a method to automatically identify cross-sectional images suitable for deep vein thrombosis diagnosis so disaster victims can self-assess their risk of deep vein thrombosis. Methods: Ultrasonographic images of the popliteal vein were acquired in 20 subjects using stationary and portable ultrasound diagnostic equipment. Images were obtained by frame split from video. Images were classified as "Satisfactory," "Moderately satisfactory," and "Unsatisfactory" according to the level of popliteal vein visualization. Fine-tuning and classification were performed using ResNet101, a deep learning model. Results: Acquiring images with portable ultrasound diagnostic equipment resulted in a classification accuracy of 0.76 and an area under the receiver operating characteristic curve of 0.89. Acquiring images with stationary ultrasound diagnostic equipment resulted in a classification accuracy of 0.73 and an area under the receiver operating characteristic curve of 0.88. Conclusion: A method for automatically identifying appropriate diagnostic cross-sectional ultrasonographic images of the popliteal vein was developed. This elemental technology is sufficiently accurate to automatically self-assess the risk of deep vein thrombosis by disaster victims.
MeSH term(s)	Humans ; Deep Learning ; Allied Health Personnel ; Disaster Victims ; Ultrasonography ; Venous Thrombosis/diagnostic imaging
Language	English
Publishing date	2023-03-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0282747
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Covid-19 and Liver Injury: Role of Inflammatory Endotheliopathy, Platelet Dysfunction, and Thrombosis.

McConnell, Matthew J / Kondo, Reiichiro / Kawaguchi, Nao / Iwakiri, Yasuko

Hepatology communications

2021 Volume 6, Issue 2, Page(s) 255–269

Abstract: Liver injury, characterized predominantly by elevated aspartate aminotransferase and alanine aminotransferase, is a common feature of coronavirus disease 2019 (COVID-19) symptoms caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). ... ...

Abstract	Liver injury, characterized predominantly by elevated aspartate aminotransferase and alanine aminotransferase, is a common feature of coronavirus disease 2019 (COVID-19) symptoms caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). Additionally, SARS-CoV-2 infection is associated with acute-on-chronic liver failure in patients with cirrhosis and has a notably elevated mortality in patients with alcohol-related liver disease compared to other etiologies. Direct viral infection of the liver with SARS-CoV-2 remains controversial, and alternative pathophysiologic explanations for its hepatic effects are an area of active investigation. In this review, we discuss the effects of SARS-CoV-2 and the inflammatory environment it creates on endothelial cells and platelets more generally and then with a hepatic focus. In doing this, we present vascular inflammation and thrombosis as a potential mechanism of liver injury and liver-related complications in COVID-19.
MeSH term(s)	Blood Platelet Disorders/immunology ; Blood Platelet Disorders/physiopathology ; Blood Platelet Disorders/virology ; COVID-19/immunology ; COVID-19/physiopathology ; Endothelium, Vascular/immunology ; Endothelium, Vascular/physiopathology ; Endothelium, Vascular/virology ; Humans ; Inflammation/immunology ; Inflammation/physiopathology ; Inflammation/virology ; Liver Diseases/immunology ; Liver Diseases/physiopathology ; Liver Diseases/virology ; Thrombosis/immunology ; Thrombosis/physiopathology ; Thrombosis/virology
Language	English
Publishing date	2021-11-10
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2471-254X
ISSN (online)	2471-254X
DOI	10.1002/hep4.1843
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Deep learning-based classification of adequate sonographic images for self-diagnosing deep vein thrombosis.

Yusuke Nakayama / Mitsuru Sato / Masashi Okamoto / Yohan Kondo / Manami Tamura / Yasuko Minagawa / Mieko Uchiyama / Yosuke Horii

PLoS ONE, Vol 18, Iss 3, p e

2023 Volume 0282747

Abstract: Background Pulmonary thromboembolism is a serious disease that often occurs in disaster victims evacuated to shelters. Deep vein thrombosis is the most common reason for pulmonary thromboembolism, and early prevention is important. Medical technicians ... ...

Abstract	Background Pulmonary thromboembolism is a serious disease that often occurs in disaster victims evacuated to shelters. Deep vein thrombosis is the most common reason for pulmonary thromboembolism, and early prevention is important. Medical technicians often perform ultrasonography as part of mobile medical screenings of disaster victims but reaching all isolated and scattered shelters is difficult. Therefore, deep vein thrombosis medical screening methods that can be easily performed by anyone are needed. The purpose of this study was to develop a method to automatically identify cross-sectional images suitable for deep vein thrombosis diagnosis so disaster victims can self-assess their risk of deep vein thrombosis. Methods Ultrasonographic images of the popliteal vein were acquired in 20 subjects using stationary and portable ultrasound diagnostic equipment. Images were obtained by frame split from video. Images were classified as "Satisfactory," "Moderately satisfactory," and "Unsatisfactory" according to the level of popliteal vein visualization. Fine-tuning and classification were performed using ResNet101, a deep learning model. Results Acquiring images with portable ultrasound diagnostic equipment resulted in a classification accuracy of 0.76 and an area under the receiver operating characteristic curve of 0.89. Acquiring images with stationary ultrasound diagnostic equipment resulted in a classification accuracy of 0.73 and an area under the receiver operating characteristic curve of 0.88. Conclusion A method for automatically identifying appropriate diagnostic cross-sectional ultrasonographic images of the popliteal vein was developed. This elemental technology is sufficiently accurate to automatically self-assess the risk of deep vein thrombosis by disaster victims.
Keywords	Medicine ; R ; Science ; Q
Subject code	571
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Re-discovery of MS-347a as a fungicide candidate through a new drug discovery platform with a multidrug-sensitive Saccharomyces cerevisiae screening system and the introduction of a global secondary metabolism regulator, laeA gene.

Honma, Sota / Kimishima, Aoi / Kimishima, Atsushi / Honsho, Masako / Kojima, Hiroki / Tokiwa, Toshiyuki / Nishitomi, Atsuka / Kato, Satoshi / Kondo, Naozumi / Araki, Yasuko / Takahashi, Tadashi / Chinen, Takumi / Usui, Takeo / Fuji, Shin-Ichi / Ito, Kotaro / Asami, Yukihiro

Bioscience, biotechnology, and biochemistry

2024

Abstract: We found that the culture broth of fungi showed anti-fungal activity against multidrug-sensitive budding yeast. However, we could not identify the anti-fungal compound due to the small quantity. Therefore, we attempted to increase the productivity of the ...

Abstract	We found that the culture broth of fungi showed anti-fungal activity against multidrug-sensitive budding yeast. However, we could not identify the anti-fungal compound due to the small quantity. Therefore, we attempted to increase the productivity of the target compound by the introduction of a global secondary metabolism regulator, laeA to the strain, which led to the successful isolation of ten-folds greater amount of MS-347a (1) than Aspergillus sp. FKI-5362. Compound 1 was not effective against Candida albicans and the detailed anti-fungal activity of 1 remains unverified. After our anti-fungal activity screening, 1 was found to inhibit the growth of broad plant pathogenic fungal species belonging to the Ascomycota. It is noteworthy that 1 showed little insecticidal activity against silkworms, suggesting its selective biological activity against plant pathogenic fungi. Our study implies that the combination strategy of multidrug-sensitive yeast and the introduction of laeA is useful for new anti-fungal drug discovery.
Language	English
Publishing date	2024-04-25
Publishing country	England
Document type	Journal Article
ZDB-ID	1106450-x
ISSN	1347-6947 ; 0916-8451
ISSN (online)	1347-6947
ISSN	0916-8451
DOI	10.1093/bbb/zbae050
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