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  1. Article ; Online: A Cytokine Circus with a Viral Ringleader: SARS-CoV-2-Associated Cytokine Storm Syndromes.

    Cabler, Stephanie S / French, Anthony R / Orvedahl, Anthony

    Trends in molecular medicine

    2020  Volume 26, Issue 12, Page(s) 1078–1085

    Abstract: An unbridled host immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is likely to underlie severe cases of the disease and has been labeled a 'cytokine storm syndrome' (CSS). Here, we emphasize that categorization ... ...

    Abstract An unbridled host immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is likely to underlie severe cases of the disease and has been labeled a 'cytokine storm syndrome' (CSS). Here, we emphasize that categorization of syndromes triggered by a completely novel pathogen based on other seemingly similar, but potentially distinct, known entities is an inherently risky endeavor.
    MeSH term(s) Adolescent ; COVID-19/complications ; COVID-19/etiology ; COVID-19/immunology ; COVID-19/virology ; Child ; Child, Preschool ; Cytokine Release Syndrome/etiology ; Cytokine Release Syndrome/immunology ; Cytokine Release Syndrome/virology ; Cytokines/blood ; Host Microbial Interactions/immunology ; Humans ; Models, Immunological ; Pandemics ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity ; Systemic Inflammatory Response Syndrome/etiology ; Systemic Inflammatory Response Syndrome/immunology ; Systemic Inflammatory Response Syndrome/virology ; Young Adult
    Chemical Substances Cytokines
    Keywords covid19
    Language English
    Publishing date 2020-09-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2036490-8
    ISSN 1471-499X ; 1471-4914
    ISSN (online) 1471-499X
    ISSN 1471-4914
    DOI 10.1016/j.molmed.2020.09.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Myeloid autophagy genes protect mice against fatal TNF- and LPS-induced cytokine storm syndromes.

    Wang, Ya-Ting / Sansone, Amy / Smirnov, Asya / Stallings, Christina L / Orvedahl, Anthony

    Autophagy

    2022  Volume 19, Issue 4, Page(s) 1114–1127

    Abstract: Abbreviations: ATG5: autophagy related 5; ATG7: autophagy related 7; ATG14: autophagy related 14; ATG16L1: autophagy related 16-like 1 (S. cerevisiae); BECN1: beclin 1, autophagy related; CASP1: caspase 1; CASP4/CASP11: caspase 4, apoptosis-related ... ...

    Abstract Abbreviations: ATG5: autophagy related 5; ATG7: autophagy related 7; ATG14: autophagy related 14; ATG16L1: autophagy related 16-like 1 (S. cerevisiae); BECN1: beclin 1, autophagy related; CASP1: caspase 1; CASP4/CASP11: caspase 4, apoptosis-related cysteine peptidase; CIM: conditionally immortalized macrophage; CLP: cecal ligation and puncture; CSS: cytokine storm syndrome; DC: dendritic cell; IFNG/IFNγ: interferon gamma; IFNGR1: interferon gamma receptor 1; ip: intraperitoneal; iv: intravenous; IL12/p70: interleukin 12, p70 heterodimer; IL18: Interleukin 18; ITGAX/CD11c: integrin alpha X; LAP: LC3-associated phagocytosis; LPS: lipopolysaccharide; LYZ2/LYSM: lysozyme 2; MAP1LC3A/LC3: microtubule-associated protein 1 light chain 3 alpha; RB1CC1/FIP200: RB1-inducible coiled-coil 1; S100A8/MRP8: S100 calcium binding protein A8 (calgranulin A); TICAM1/TRIF: TIR domain containing adaptor molecule 1; TLR4: toll-like receptor 4; TNF: tumor necrosis factor.
    MeSH term(s) Animals ; Mice ; Autophagy/genetics ; Lipopolysaccharides/pharmacology ; Cytokine Release Syndrome ; Saccharomyces cerevisiae ; Phagocytosis/genetics
    Chemical Substances Lipopolysaccharides
    Language English
    Publishing date 2022-09-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2022.2116675
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  3. Article ; Online: A Cytokine Circus with a Viral Ringleader

    Cabler, Stephanie S. / French, Anthony R. / Orvedahl, Anthony

    Trends in Molecular Medicine ; ISSN 1471-4914

    SARS-CoV-2-Associated Cytokine Storm Syndromes

    2020  

    Keywords Molecular Medicine ; Molecular Biology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/j.molmed.2020.09.012
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: A Cytokine Circus with a Viral Ringleader: SARS-CoV-2-Associated Cytokine Storm Syndromes

    Cabler, Stephanie S / French, Anthony R / Orvedahl, Anthony

    Trends mol. med

    Abstract: An unbridled host immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is likely to underlie severe cases of the disease and has been labeled a 'cytokine storm syndrome' (CSS). Here, we emphasize that categorization ... ...

    Abstract An unbridled host immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is likely to underlie severe cases of the disease and has been labeled a 'cytokine storm syndrome' (CSS). Here, we emphasize that categorization of syndromes triggered by a completely novel pathogen based on other seemingly similar, but potentially distinct, known entities is an inherently risky endeavor.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #807615
    Database COVID19

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  5. Article ; Online: Autophagy gene-dependent intracellular immunity triggered by interferon-γ.

    McAllaster, Michael R / Bhushan, Jaya / Balce, Dale R / Orvedahl, Anthony / Park, Arnold / Hwang, Seungmin / Sullender, Meagan E / Sibley, L David / Virgin, Herbert W

    mBio

    2023  , Page(s) e0233223

    Abstract: Genes required for the lysosomal degradation pathway of autophagy play key roles in topologically distinct and physiologically important cellular processes. Some functions ... ...

    Abstract Genes required for the lysosomal degradation pathway of autophagy play key roles in topologically distinct and physiologically important cellular processes. Some functions of
    Language English
    Publishing date 2023-10-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.02332-23
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  6. Article ; Online: Successful treatment of fulminant neonatal enteroviral myocarditis in monochorionic diamniotic twins with cardiopulmonary support, intravenous immunoglobulin and pocapavir.

    Amdani, Shahnawaz M / Kim, Hannah S / Orvedahl, Anthony / John, Audrey Odom / Said, Ahmed / Simpson, Kathleen

    BMJ case reports

    2018  Volume 2018

    Abstract: Neonatal cardiogenic shock most commonly occurs due to critical congenital heart disease, sepsis, metabolic disorder or arrhythmias. In particular, enterovirus infections are common in the neonatal period, and patients can present with fulminant ... ...

    Abstract Neonatal cardiogenic shock most commonly occurs due to critical congenital heart disease, sepsis, metabolic disorder or arrhythmias. In particular, enterovirus infections are common in the neonatal period, and patients can present with fulminant myocarditis. Early recognition is imperative due to its high morbidity and mortality without prompt and aggressive treatment. We present the successful treatment of fulminant neonatal enteroviral myocarditis in a pair of monochorionic diamniotic twins with cardiopulmonary support, intravenous immunoglobulin and pocapavir, an enteroviral capsid inhibitor. The twins took an almost exact parallel hospital course, including day of extracorporeal membrane oxygenation (ECMO) cannulation, day of ECMO decannulation, improvement of cardiac function, discharge and status at follow-up. While it was difficult to assess the relative contribution of each intervention, our case shows promise in the use of pocapavir for treatment of severe enteroviral infections. Remarkably, both twins demonstrated remarkable recovery within 2 weeks, underscoring that early aggressive cardiopulmonary support, and potentially pocapavir, contributed to their recovery.
    MeSH term(s) Antiviral Agents/therapeutic use ; Combined Modality Therapy ; Diseases in Twins/therapy ; Diseases in Twins/virology ; Enterovirus Infections/complications ; Enterovirus Infections/therapy ; Extracorporeal Membrane Oxygenation/methods ; Heart/virology ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Infant, Newborn ; Male ; Myocarditis/therapy ; Myocarditis/virology ; Phenyl Ethers/therapeutic use ; Shock, Cardiogenic/therapy ; Shock, Cardiogenic/virology ; Treatment Outcome ; Twins, Monozygotic
    Chemical Substances Antiviral Agents ; Immunoglobulins, Intravenous ; Phenyl Ethers ; pocapavir (4ILA3VOV97)
    Language English
    Publishing date 2018-05-18
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2017-224133
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A 12-Year-Old Girl With Encephalopathy and Acute Flaccid Paralysis: A Neuropathological Correlation and Cohort Review.

    Kim, Young-Min / Orvedahl, Anthony / Morris, Stephanie / Schmidt, Robert / Mar, Soe

    Pediatric neurology

    2017  Volume 66, Page(s) 5–11

    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639164-3
    ISSN 1873-5150 ; 0887-8994
    ISSN (online) 1873-5150
    ISSN 0887-8994
    DOI 10.1016/j.pediatrneurol.2016.08.004
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  8. Article: Autophagy in Mammalian antiviral immunity.

    Orvedahl, Anthony / Levine, Beth

    Current topics in microbiology and immunology

    2009  Volume 335, Page(s) 267–285

    Abstract: Autophagy plays diverse roles in cellular adaptation to stress and promotes vital housekeeping functions by recycling unused or damaged organelles and proteins. As an innate immune defense pathway, autophagy also protects against infection with diverse ... ...

    Abstract Autophagy plays diverse roles in cellular adaptation to stress and promotes vital housekeeping functions by recycling unused or damaged organelles and proteins. As an innate immune defense pathway, autophagy also protects against infection with diverse pathogens, including viruses. Autophagy combats infections with both RNA and DNA viruses, and may function by degrading viral components, by promoting the survival of virally infected cells, and/or by activating innate and adaptive immunity. Viruses have evolved counter-mechanisms to evade host autophagy in order to promote their own survival. This chapter will highlight recent advances and unanswered questions relating to autophagy in mammalian antiviral immunity.
    MeSH term(s) Alphavirus Infections/immunology ; Animals ; Autophagy/immunology ; Herpes Simplex/immunology ; Herpesvirus 1, Human/immunology ; Host-Pathogen Interactions/immunology ; Humans ; Sindbis Virus/immunology ; Virus Diseases/immunology ; Virus Diseases/virology
    Language English
    Publishing date 2009
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ISSN 0070-217X
    ISSN 0070-217X
    DOI 10.1007/978-3-642-00302-8_13
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  9. Article ; Online: Autophagy and viral neurovirulence.

    Orvedahl, Anthony / Levine, Beth

    Cellular microbiology

    2008  Volume 10, Issue 9, Page(s) 1747–1756

    Abstract: As terminally differentiated vital cells, neurons may be specialized to fight viral infections without undergoing cellular self-destruction. The cellular lysosomal degradation pathway, autophagy, is emerging as one such mechanism of neuronal antiviral ... ...

    Abstract As terminally differentiated vital cells, neurons may be specialized to fight viral infections without undergoing cellular self-destruction. The cellular lysosomal degradation pathway, autophagy, is emerging as one such mechanism of neuronal antiviral defence. Autophagy has diverse physiological functions, such as cellular adaptation to stress, routine organelle and protein turnover, and innate immunity against intracellular pathogens, including viruses. Most of the in vivo evidence for an antiviral role of autophagy is related to viruses that specifically target neurons, including the prototype alphavirus, Sindbis virus, and the alpha-herpesvirus, herpes simplex virus type 1 (HSV-1). In the case of HSV-1, viral evasion of autophagy is essential for lethal encephalitis. As basal autophagy is important in preventing neurodegeneration, and induced autophagy is important in promoting cellular survival during stress, viral antagonism of autophagy in neurons may lead to neuronal dysfunction and/or neuronal cell death. This review provides background information on the roles of autophagy in immunity and neuroprotection, and then discusses the relationships between autophagy and viral neurovirulence.
    MeSH term(s) Alphavirus Infections/immunology ; Alphavirus Infections/pathology ; Alphavirus Infections/virology ; Animals ; Autophagy ; Encephalitis, Viral/immunology ; Encephalitis, Viral/pathology ; Encephalitis, Viral/virology ; Herpes Simplex/immunology ; Herpes Simplex/pathology ; Herpes Simplex/virology ; Herpesvirus 1, Human/immunology ; Herpesvirus 1, Human/pathogenicity ; Humans ; Immunity, Innate ; Neurodegenerative Diseases/immunology ; Neurodegenerative Diseases/pathology ; Neurodegenerative Diseases/virology ; Neurons/immunology ; Neurons/ultrastructure ; Neurons/virology ; Sindbis Virus/immunology ; Sindbis Virus/pathogenicity ; Virulence/immunology
    Language English
    Publishing date 2008-05-22
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1468320-9
    ISSN 1462-5822 ; 1462-5814
    ISSN (online) 1462-5822
    ISSN 1462-5814
    DOI 10.1111/j.1462-5822.2008.01175.x
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  10. Article: 2007 Keystone Symposium on Autophagy in Health and Disease.

    He, Congcong / Orvedahl, Anthony

    Autophagy

    2007  Volume 3, Issue 5, Page(s) 527–536

    Abstract: The first Keystone Symposium on Autophagy in Health and Disease was held in Monterey, a scenic city on the Pacific coast in central California, April 15-20, 2007. The symposium brought together approximately 280 participants, from basic researchers to ... ...

    Abstract The first Keystone Symposium on Autophagy in Health and Disease was held in Monterey, a scenic city on the Pacific coast in central California, April 15-20, 2007. The symposium brought together approximately 280 participants, from basic researchers to physicians and journalists. The meeting was composed of a joint keynote session with the meeting "Apoptotic and Non-Apoptotic Cell Death Pathways" and eight plenary sessions, covering the molecular mechanisms of autophagy and many emerging concepts and functions of autophagy in organelle degradation, physiological regulation, cell death and survival, and disease. Three afternoon workshops focused on short talks selected from the posters, and a special discussion session led by experts dealt with techniques and concerns regarding experimental detection of autophagy. The symposium highlighted autophagy as a potential therapeutic target in a wide range of diseases, including cancer, microbial infection, myopathies and neurodegenerative disorders.
    MeSH term(s) Animals ; Apoptosis/physiology ; Autophagy/immunology ; Autophagy/physiology ; Cell Death/physiology ; Cell Survival/physiology ; Humans ; Infection/pathology ; Models, Biological ; Neoplasms/pathology ; Neoplasms/therapy ; Nerve Degeneration/pathology ; Nerve Degeneration/therapy ; Organelles/pathology ; Signal Transduction
    Language English
    Publishing date 2007-06-18
    Publishing country United States
    Document type Congress ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.4161/auto.4595
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