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  1. Article: Inversion of soil water and salt information based on UAV hyperspectral remote sensing and machine lear-ning.

    Wang, Yi-Jing / Ding, Qi-Dong / Zhang, Jun-Hua / Chen, Ruihua / Jia, Keli / Li, Xiao-Lin

    Ying yong sheng tai xue bao = The journal of applied ecology

    2023  Volume 34, Issue 11, Page(s) 3045–3052

    Abstract: Accurate diagnosis of water and salt information in saline agricultural lands is crucial for long-term soil quality improvement and arable land conservation. In this study, we extracted field-scale vegetation canopy spectral information by UAV ... ...

    Title translation 基于无人机高光谱遥感和机器学习的土壤水盐信息反演.
    Abstract Accurate diagnosis of water and salt information in saline agricultural lands is crucial for long-term soil quality improvement and arable land conservation. In this study, we extracted field-scale vegetation canopy spectral information by UAV hyperspectral information, transforming the reflectance (R) to standard normal variate transformation (SNV), multiplicative scatter correction (MSC), first derivative of reflectance (FDR) and second derivative of reflectance (SDR). We determined the optimal spectral transformation forms of soil water content (SWC), soil pH, and soil salt content (SSC) by the maximum absolute correlation coefficient (MACC), and extracted the feature bands by competitive adaptive reweighted sampling (CARS). We constructed an inversion model of soil water and salt information by partial least squares regression (PLSR), random forest (RF), and extreme gradient boosting (XGBoost). The results showed that R, FDR and MSC were the best spectral transformation types for soil water content, soil pH, and soil salt content, and the corresponding MACC were 0.730, 0.472 and 0.654, respectively. The CARS algorithm effectively eliminated the irrelevant variables, optimally selecting 16-17 feature bands from 150 spectral bands. Both soil water content and soil pH performed best with XGBoost model, achieving determination coefficient of validation (
    MeSH term(s) Soil/chemistry ; Hyperspectral Imaging ; Water ; Sodium Chloride ; Remote Sensing Technology
    Chemical Substances Soil ; Water (059QF0KO0R) ; Sodium Chloride (451W47IQ8X)
    Language English
    Publishing date 2023-11-21
    Publishing country China
    Document type Journal Article
    ZDB-ID 2881809-X
    ISSN 1001-9332
    ISSN 1001-9332
    DOI 10.13287/j.1001-9332.202311.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The pulmonary biopharmaceutics and anti-inflammatory effects after intratracheal and intravenous administration of Re-Du-Ning injection.

    Jia-Xing, Wei / Chao-Yi, Li / Wei-Ya, Chen / Yi-Jun, Cong / Chun-Yu, Liu / Fei-Fei, Yang / Yong-Hong, Liao

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2023  Volume 160, Page(s) 114335

    Abstract: Background: Re-Du-Ning injection (RDN) is a renowned heat-clearing traditional Chinese medicine ...

    Abstract Background: Re-Du-Ning injection (RDN) is a renowned heat-clearing traditional Chinese medicine for the treatment of respiratory diseases owing to its anti-inflammatory effects. However, very little is known about the pulmonary distribution and lung exposure-efficacy relationships. This study aimed to investigate the pulmonary distribution and biopharmaceutics concerning lung penetrability and affinity and the local anti-inflammatory effects after intravenous and pulmonary administration of RDN.
    Methods: Two iridoids and seven phenolic acid components were selected as the chemical markers in RDN. The in vitro pulmonary distribution and biopharmaceutics were conducted by evaluating the binding and disassociation kinetics of chemical markers in lung tissue explants whereas the in vivo evaluation was performed by determining the time-dependent concentrations of chemical markers in plasma, lung epithelial lining fluid (ELF), lung tissues and immune cells in the ELF after intratracheal and intravenous administrations of RDN. The inhibitory effects on tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) production were used to evaluate the anti-inflammatory effect of RDN on lung tissues in vitro and on mice with LPS-induced lung inflammation.
    Results: The chemical markers of RDN exhibited excellent lung penetrability but poor lung affinity in vitro and in vivo. After intravenous administration, the chemical markers appeared to rapidly penetrate through the lung tissue to reach the ELF, leading to markedly higher drug exposure to ELF and immune cells in the ELF than to lung tissues. Compared to intravenous injection, the intratracheal instillation of RDN increased drug exposure to lung tissue and immune cells in the ELF by up to > 80-fold, leading to improved anti-inflammatory potency and prolonged duration of action.
    Conclusion: The drug exposure to immune cells in the ELF was correlated with the lung-targeted anti-inflammatory effects of RDN and pulmonary delivery has the potential to replace intravenous injection of RDN for the treatment of respiratory diseases.
    MeSH term(s) Animals ; Mice ; Biopharmaceutics ; Administration, Intravenous ; Injections, Intravenous ; Medicine, Chinese Traditional ; Lung
    Language English
    Publishing date 2023-01-30
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2023.114335
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Efficacy and Safety of the Shouzu Ning Decoction Treatment Versus Halometasone Plus Celecoxib Treatment in Patients With Grade 2 HFSR: A Randomized Clinical Trial.

    Shou, Liumei / Shao, Tianyu / Chen, Jialu / Zhang, Yao / Shu, Qijin

    Integrative cancer therapies

    2023  Volume 22, Page(s) 15347354231168796

    Abstract: Objectives: To compare the effects of the Shouzu Ning Decoction (SND) and Halometasone plus ...

    Abstract Objectives: To compare the effects of the Shouzu Ning Decoction (SND) and Halometasone plus Celecoxib (Hal/Cxb) as therapy in patients with grade 2 hand-foot skin reaction (HFSR).
    Materials and methods: Fifty patients with grade 2 HFSR participated in a randomized, single-center, open-label study. Patients were randomly assigned in a 1:1 ratio to receive the SND or Hal/Cxb treatment, twice daily for 4 weeks, followed by 4 weeks of post-treatment follow-up. The primary endpoint was clinical remission of HFSR at the end of the fourth week (W4). The secondary endpoints were recurrence rate, quality of life (QoL), pain intensity, and safety.
    Results: In this study, 46 patients successfully completed the study, and 4 patients were excluded. There was no statistically significant difference between the 2 groups on demographic and baseline clinical characteristics. In the SND group, 56.52% of patients showed clinical remission at W4, which was significantly superior to that achieved in the Hal/Cxb group (26.09%,
    Conclusion: In the present study, SND treatment has been observed to be effective and well tolerated for patients with grade 2 HFSR. Thus, SND treatment could be considered a suitable option for HFSR patients.
    Trial registration: Chinese Clinical Trial Registry, ChiCTR1900027518. Registered on 17 Nov 2019.
    MeSH term(s) Humans ; Quality of Life ; Celecoxib/adverse effects ; Treatment Outcome ; Skin
    Chemical Substances Celecoxib (JCX84Q7J1L) ; halometasone (J69Z9UU41Z)
    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2182320-0
    ISSN 1552-695X ; 1534-7354
    ISSN (online) 1552-695X
    ISSN 1534-7354
    DOI 10.1177/15347354231168796
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Mechanisms of Lian-Gui-Ning-Xin-Tang in the treatment of arrhythmia: Integrated pharmacology and in vivo pharmacological assessment.

    Chen, Jinhong / Liu, Zhichao / Deng, Fangjun / Liang, Jiayu / Fan, Boya / Zhen, Xin / Tao, Rui / Sun, Lili / Zhang, Shaoqiang / Cong, Zidong / Li, Xiaofeng / Du, Wuxun

    Phytomedicine : international journal of phytotherapy and phytopharmacology

    2022  Volume 99, Page(s) 153989

    Abstract: Background: Lian-Gui-Ning-Xin-Tang (LGNXT), a classical traditional Chinese medicine (TCM) formula ...

    Abstract Background: Lian-Gui-Ning-Xin-Tang (LGNXT), a classical traditional Chinese medicine (TCM) formula, has been widely used in clinical practice and has shown satisfactory efficacy in the treatment of arrhythmias. However, its mechanism of action in the treatment of arrhythmias is still unknown. Moreover, the complex chemical composition and therapeutic targets of LGNXT pose a challenge in pharmacological research.
    Purpose: To analyze the active compounds and action mechanisms of LGNXT for the treatment of arrhythmias.
    Methods: Here, we used an integrated pharmacology approach to identify the potential active compounds and mechanisms of action of LGNXT in treating arrhythmias. Potential active compounds in LGNXT were identified using ultra-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry (UPLC-Q-TOF/MS) and the potential related targets of these compounds were predicted using an integrated in silico approach. The obtained targets were mapped onto relevant databases to identify their corresponding pathways, following the experiments that were conducted to confirm whether the presumptive results of systemic pharmacology were correct.
    Results: Eighty-three components were identified in herbal materials and in animal plasma using UPLC-Q-TOF/MS and were considered the potential active components of LGNXT. Thirty key targets and 57 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were identified as possible targets and pathways involved in LGNXT-mediated treatment using network pharmacology, with the cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA)/Ca
    Conclusions: The findings of this study revealed that preventing intracellular Ca
    Language English
    Publishing date 2022-02-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2022.153989
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Bu-Shen-Ning-Xin decoction alleviates premature ovarian insufficiency (POI) by regulating autophagy of granule cells through activating PI3K/AKT/mTOR pathway.

    Dou, Xiaoqing / Jin, Xin / Chen, Xingbei / Zhou, Qun / Chen, Hanyu / Wen, Mingxiao / Chen, Wenjun

    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

    2022  Volume 38, Issue 9, Page(s) 754–764

    Abstract: Purpose: To explore the therapeutic effects of Bu-Shen-Ning-Xin decoction (BSNXD) on POI and ...

    Abstract Purpose: To explore the therapeutic effects of Bu-Shen-Ning-Xin decoction (BSNXD) on POI and the underlying mechanism.
    Methods: VCD was used to induce the
    Results: Decreased primary follicles in the ovarian tissues, elevated concentration of FSH, and LH, suppressed concentration of E2 and AMH in the serum, reduced number of oocytes, and mitochondrial dysfunction in oocytes induced by VCD were significantly reversed by BSNXD. Activated autophagy state and inhibited PI3K/AKT/mTOR pathway stimulated by VCD in both ovarian tissues and GCs were dramatically reversed by BSNXD. The protective effect of BSNXD on VCD-treated GCs was abolished by LY294002, an inhibitor of the PI3K/AKT/mTOR pathway.
    Conclusion: Our data revealed that BSNXD alleviated POI by regulating autophagy of granule cells through activating PI3K/AKT/mTOR pathway.
    MeSH term(s) Animals ; Apoptosis ; Autophagy ; Beclin-1/pharmacology ; Drugs, Chinese Herbal ; Female ; Follicle Stimulating Hormone/therapeutic use ; Humans ; Menopause, Premature ; Phosphatidylinositol 3-Kinases/metabolism ; Primary Ovarian Insufficiency/chemically induced ; Proto-Oncogene Proteins c-akt/metabolism ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Rats ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism
    Chemical Substances Beclin-1 ; Drugs, Chinese Herbal ; Proto-Oncogene Proteins c-bcl-2 ; bu-shen-ning-xin ; Follicle Stimulating Hormone (9002-68-0) ; MTOR protein, human (EC 2.7.1.1) ; mTOR protein, rat (EC 2.7.1.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2022-08-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 639237-4
    ISSN 1473-0766 ; 0951-3590
    ISSN (online) 1473-0766
    ISSN 0951-3590
    DOI 10.1080/09513590.2022.2112941
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Stevens-Johnson syndrome/toxic epidermal necrolysis successfully treated with Chinese herbal medicine Pi-Yan-Ning: A case report.

    Chen, Shu-Yi / Chen, Qun-Wei / Shou, Liu-Mei / Pan, Hong / Ruan, Shan-Ming / Liang, Zhe-Hao / Shu, Qi-Jin

    Journal of integrative medicine

    2021  Volume 19, Issue 6, Page(s) 555–560

    Abstract: ... Ning which was applied externally for 20 min twice a day. After 7 days of treatment, the dead skin ... In this case, SJS/TEN was successfully treated with Pi-Yan-Ning, suggesting that there might be tremendous ... potential for the use of Pi-Yan-Ning in the treatment of severe skin reactions to drug treatments. Further ...

    Abstract Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a rare adverse cutaneous reaction with a low incidence and high mortality. Despite posing a serious threat to patients' health and lives, there is no high-quality evidence for a standard treatment regimen. Here we report the case of a 62-year-old man with stage IV pancreatic cancer who experienced immunotherapy-induced SJS/TEN. After consensus-based regular treatments at a local hospital, his symptoms became worse. Thus, he consented to receive Chinese herbal medicine (CHM) therapy. The affected parts of the patient were treated with the CHM Pi-Yan-Ning which was applied externally for 20 min twice a day. After 7 days of treatment, the dead skin began peeling away from the former lesions that had covered his hands, feet, and lips, indicating that skin had regenerated. After 12 days of treatment, the patient's skin was completely recovered. In this case, SJS/TEN was successfully treated with Pi-Yan-Ning, suggesting that there might be tremendous potential for the use of Pi-Yan-Ning in the treatment of severe skin reactions to drug treatments. Further basic investigations and clinical trials to explore the mechanism and efficacy are needed.
    MeSH term(s) Drugs, Chinese Herbal/therapeutic use ; Humans ; Immunologic Factors ; Incidence ; Male ; Middle Aged ; Skin ; Stevens-Johnson Syndrome/drug therapy ; Stevens-Johnson Syndrome/etiology
    Chemical Substances Drugs, Chinese Herbal ; Immunologic Factors
    Language English
    Publishing date 2021-10-11
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2705612-0
    ISSN 2095-4964
    ISSN 2095-4964
    DOI 10.1016/j.joim.2021.10.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The Efficacy and Safety of the Shouzu Ning Decoction Treatment for Multi-Kinase Inhibitors-Associated Severe Hand-Foot Skin Reaction.

    Shou, Liumei / Shao, Tianyu / Zhao, Fangmin / Chen, Shuyi / Chen, Qunwei / Shu, Qijin

    Cancer management and research

    2021  Volume 13, Page(s) 45–53

    Abstract: ... with the Shouzu Ning Decoction (SND) twice a day, in addition to the MKIs treatment. Grading of HFSR was assessed ...

    Abstract Background: Multi-kinase inhibitors (MKIs) treatment plays an important role in cancer therapy, but still suffers from a high incidence of hand-foot skin reaction (HFSR), leading to MKIs dose modification or termination. Thus, there is a high need for therapeutic strategy for HFSR.
    Patients and methods: This prospective analysis included twenty patients, who were continuously administered with MKIs treatment and presented with a grade 3 HFSR during January 2018 to December 2019. All the patients were treated with the Shouzu Ning Decoction (SND) twice a day, in addition to the MKIs treatment. Grading of HFSR was assessed by National Cancer Institute Common Terminology Criteria for Adverse Events version 5.0. Pain intensity was evaluated using the numerical rating scale (NRS). Quality of life was assessed using the Hand-Foot Quality of Life Scale (HF-QoLS).
    Results: The median time from MKIs initiation to onset of grade 3 HFSR was 26.2 days. Following the SND treatment, seventeen (17/20) patients displayed grade 2 HFSR with a median time of 5.1 days. Among whom, seven (7/17) finally transformed to grade 1 with a median time of 9.9 days. While all of the grade 1 patients (7/7) had local recurrence, and retreatment of the SND was effective. In addition, after the SND treatment, the score of NRS and HF-QoLS decreased to 1.60 ± 1.14 (
    Conclusion: The SND treatment could alleviate symptoms, relieve pain and improve quality of life in HFSR patients. The SND treatment was proved to be an effective and well-tolerated treatment for MKIs-associated grade 3 HFSR patients for the first time. Indeed, further randomized controlled trails with large-scale, multi-center are require to fully determine the clinical application of the SND in MKIs-associated HFSR.
    Language English
    Publishing date 2021-01-07
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2508013-1
    ISSN 1179-1322
    ISSN 1179-1322
    DOI 10.2147/CMAR.S285002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Mechanisms of Lian-Gui-Ning-Xin-Tang in the treatment of arrhythmia: Integrated pharmacology and in vivo pharmacological assessment

    Chen, Jinhong / Liu, Zhichao / Deng, Fangjun / Liang, Jiayu / Fan, Boya / Zhen, Xin / Tao, Rui / Sun, Lili / Zhang, Shaoqiang / Cong, Zidong / Li, Xiaofeng / Du, Wuxun

    Phytomedicine. 2022 May, v. 99

    2022  

    Abstract: Lian-Gui-Ning-Xin-Tang (LGNXT), a classical traditional Chinese medicine (TCM) formula, has been ...

    Abstract Lian-Gui-Ning-Xin-Tang (LGNXT), a classical traditional Chinese medicine (TCM) formula, has been widely used in clinical practice and has shown satisfactory efficacy in the treatment of arrhythmias. However, its mechanism of action in the treatment of arrhythmias is still unknown. Moreover, the complex chemical composition and therapeutic targets of LGNXT pose a challenge in pharmacological research. To analyze the active compounds and action mechanisms of LGNXT for the treatment of arrhythmias. Here, we used an integrated pharmacology approach to identify the potential active compounds and mechanisms of action of LGNXT in treating arrhythmias. Potential active compounds in LGNXT were identified using ultra-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry (UPLC-Q-TOF/MS) and the potential related targets of these compounds were predicted using an integrated in silico approach. The obtained targets were mapped onto relevant databases to identify their corresponding pathways, following the experiments that were conducted to confirm whether the presumptive results of systemic pharmacology were correct. Eighty-three components were identified in herbal materials and in animal plasma using UPLC-Q-TOF/MS and were considered the potential active components of LGNXT. Thirty key targets and 57 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were identified as possible targets and pathways involved in LGNXT-mediated treatment using network pharmacology, with the cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA)/Ca²⁺ system pathway being the most significantly affected. This finding was validated using an adrenaline (Adr)-induced rat model of arrhythmias. Pretreatment with LGNXT delayed the occurrence, shortened the duration, and reduced the severity of arrhythmias. LGNXT exerted antiarrhythmic effects by inhibiting cAMP, PKA, CACNA1C, and RyR2. The findings of this study revealed that preventing intracellular Ca²⁺ overload and maintaining intracellular Ca²⁺ homeostasis may be the primary mechanisms of LGNXT in alleviating arrhythmias. Thus, we suggest that the β-adrenergic receptor (AR)/cAMP/PKA/Ca²⁺ system signaling hub may constitute a promising molecular target for the development of novel antiarrhythmic therapeutic interventions. Additionally, we believe that the approach of investigation of the biological effects of a multi-herbal formula by the combination of metabolomics and network pharmacology, as used in this study, could serve as a systematic model for TCM research.
    Keywords Oriental traditional medicine ; animal models ; animals ; arrhythmia ; calcium ; computer simulation ; cyclic AMP ; epinephrine ; homeostasis ; mass spectrometry ; mechanism of action ; metabolomics ; pharmacology ; therapeutics
    Language English
    Dates of publication 2022-05
    Publishing place Elsevier GmbH
    Document type Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2022.153989
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Treatment with Tang-luo-ning altered the microRNA expression profile in rats with diabetic peripheral neuropathy.

    Li, Yixiao / Gao, Yanbin / Gong, Yanbing / Guo, Yuxin / Wang, Liying / Liu, Qin / Chen, Feng / Zhang, Taojing

    Bioengineered

    2020  Volume 11, Issue 1, Page(s) 841–851

    Abstract: Tang-luo-ning (TLN) is a traditional Chinese herbal recipe that has been used to treat diabetic ...

    Abstract Tang-luo-ning (TLN) is a traditional Chinese herbal recipe that has been used to treat diabetic peripheral neuropathy (DPN); nevertheless, the underlying mechanism remains unclear. This study was aimed to investigate the microRNA (miRNA) expression profile in diabetic rats treated with TLN, and the target genes were predicted. Male Sprague-Dawley rats were randomly divided into control, diabetes, and TLN-treated diabetes groups. Diabetes was induced with streptozotocin, and TLN (5 g/kg/day) was orally given for eight weeks. Then, the sciatic nerves were harvested for miRNA microarray analyses. The differentially expressed miRNAs and their target genes were analyzed. Compared with the control rats, 24 miRNAs were significantly upregulated, and 59 were downregulated in the sciatic nerves of the diabetic rats by more than two folds (all
    MeSH term(s) Animals ; Cluster Analysis ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/genetics ; Diabetes Mellitus, Experimental/metabolism ; Diabetic Neuropathies/drug therapy ; Diabetic Neuropathies/genetics ; Diabetic Neuropathies/metabolism ; Drugs, Chinese Herbal/therapeutic use ; Male ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/drug effects ; Signal Transduction/genetics
    Chemical Substances Drugs, Chinese Herbal ; MicroRNAs
    Language English
    Publishing date 2020-07-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2737830-5
    ISSN 2165-5987 ; 2165-5979
    ISSN (online) 2165-5987
    ISSN 2165-5979
    DOI 10.1080/21655979.2020.1797282
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Investigation of the Cellular Pharmacological Mechanism and Clinical Evidence of the Multi-Herbal Antiarrhythmic Chinese Medicine Xin Su Ning.

    Ma, Yu-Ling / Hu, Rou-Mu / Yang, Xinchun / Wang, Taiyi / Noble, Penelope J / Wilkins, Robert / Ellory, Clive / Carr, Carolyn / Noble, Denis / Yang, Jiefu / Lu, Weixing / Zhang, Junhua / Hu, Hongde / Guo, Xiaomei / Chen, Min / Wu, Yang / Wei, Meng / Mao, Jingyuan / Ma, Xiaochang /
    Qin, Ling / Wu, Huanlin / Lu, Feng / Cao, Ying / Gao, Sheng / Gu, Wanli

    Frontiers in pharmacology

    2020  Volume 11, Page(s) 600

    Abstract: Xin Su Ning (XSN), a China patented and certified multi-herbal medicine, has been available ...

    Abstract Xin Su Ning (XSN), a China patented and certified multi-herbal medicine, has been available in China since 2005 for treating cardiac ventricular arrhythmia including arrhythmia induced by ischemic heart diseases and viral myocarditis, without adverse reactions being reported. It is vitally important to discover pharmacologically how XSN as a multicomponent medicine exerts its clinical efficacy, and whether the therapeutic effect of XSN can be verified by standard clinical trial studies. In this paper we report our discoveries in a cellular electrophysiological study and in a three-armed, randomized, double-blind, placebo-controlled, parallel-group, multicenter trial. Conventional electrophysiological techniques were used to study the cellular antiarrhythmic mechanism of XSN. Data was then modeled with computational simulation of human action potential (AP) of the cardiac ventricular myocytes. The clinical trial was conducted with a total of 861 eligible participants randomly assigned in a ratio of 2:2:1 to receive XSN, mexiletine, or the placebo for 4 weeks. The primary and secondary endpoint was the change of premature ventricular contraction (PVC) counts and PVC-related symptoms, respectively. This trial was registered in the Chinese Clinical Trial Register Center (ChiCTR-TRC-14004180). We found that XSN prolonged AP duration of the ventricular myocytes in a dose-dependent, reversible manner and blocked potassium channels. Patients in XSN group exhibited significant total effective responses in the reduction of PVCs compared to those in the placebo group (65.85% vs. 27.27%, P < 0.0001). No severe adverse effects attributable to XSN were observed. In conclusion, XSN is an effective multicomponent antiarrhythmic medicine to treat PVC without adverse effect in patients, which is convincingly supported by its class I & III pharmacological antiarrhythmic mechanism of blocking hERG potassium channels and hNaV1.5 sodium channel reported in our earlier publication and prolongs AP duration both in ventricular myocytes and with computational simulation of human AP presented in this report.
    Language English
    Publishing date 2020-05-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2020.00600
    Database MEDical Literature Analysis and Retrieval System OnLINE

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