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  1. Article ; Online: Untangling the CD4 T cell response to the microbiota.

    Mayassi, Toufic / Xavier, Ramnik J

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 16, Page(s) e2303351120

    MeSH term(s) CD4-Positive T-Lymphocytes ; Microbiota ; Gastrointestinal Microbiome
    Language English
    Publishing date 2023-04-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2303351120
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    Zs.A 1148: Show issues Location:
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  2. Article ; Online: Translating the human microbiome: a path to improving health.

    Xavier, Ramnik J

    Genome medicine

    2021  Volume 13, Issue 1, Page(s) 78

    MeSH term(s) Diet ; Disease Susceptibility ; Energy Metabolism ; Homeostasis ; Host Microbial Interactions ; Humans ; Metagenome ; Metagenomics/methods ; Microbiota/physiology ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism
    Language English
    Publishing date 2021-05-05
    Publishing country England
    Document type Editorial ; Introductory Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2484394-5
    ISSN 1756-994X ; 1756-994X
    ISSN (online) 1756-994X
    ISSN 1756-994X
    DOI 10.1186/s13073-021-00896-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Cytotoxic Th1 cells mushroom after fungal exposures in Crohn's disease.

    Stražar, Martin / Xavier, Ramnik J

    Immunity

    2023  Volume 56, Issue 12, Page(s) 2679–2681

    Abstract: Fungi are consistently enriched in inflamed intestines, with elusive effects on host immunity. In a recent issue of Nature Medicine, Martini et al. identify a subset of Th1 cells able to lyse the epithelium, enriched in Crohn's disease patient samples ... ...

    Abstract Fungi are consistently enriched in inflamed intestines, with elusive effects on host immunity. In a recent issue of Nature Medicine, Martini et al. identify a subset of Th1 cells able to lyse the epithelium, enriched in Crohn's disease patient samples after fungal exposure.
    MeSH term(s) Humans ; Crohn Disease ; Th1 Cells ; Agaricales ; Intestines/microbiology
    Language English
    Publishing date 2023-12-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2023.11.012
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    Zs.A 4227: Show issues Location:
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  4. Article ; Online: Conditioning of the immune system by the microbiome.

    Graham, Daniel B / Xavier, Ramnik J

    Trends in immunology

    2023  Volume 44, Issue 7, Page(s) 499–511

    Abstract: The human intestinal microbiome has coevolved with its host to establish a stable homeostatic relationship with hallmark features of mutualistic symbioses, yet the mechanistic underpinnings of host-microbiome interactions are incompletely understood. ... ...

    Abstract The human intestinal microbiome has coevolved with its host to establish a stable homeostatic relationship with hallmark features of mutualistic symbioses, yet the mechanistic underpinnings of host-microbiome interactions are incompletely understood. Thus, it is an opportune time to conceive a common framework for microbiome-mediated regulation of immune function. We propose the term conditioned immunity to describe the multifaceted mechanisms by which the microbiome modulates immunity. In this regard, microbial colonization is a conditioning exposure that has durable effects on immune function through the action of secondary metabolites, foreign molecular patterns, and antigens. Here, we discuss how spatial niches impact host exposure to microbial products at the level of dose and timing, which elicit diverse conditioned responses.
    MeSH term(s) Humans ; Microbiota ; Intestines ; Gastrointestinal Microbiome ; Immune System ; Symbiosis
    Language English
    Publishing date 2023-05-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2036831-8
    ISSN 1471-4981 ; 1471-4906
    ISSN (online) 1471-4981
    ISSN 1471-4906
    DOI 10.1016/j.it.2023.05.002
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  5. Article ; Online: Growth and the Microbiome - Integrating Global Health with Basic Science.

    Xavier, Ramnik J

    The New England journal of medicine

    2020  Volume 383, Issue 4, Page(s) 391–393

    MeSH term(s) Child ; Duodenum ; Global Health ; Humans ; Intestinal Diseases ; Microbiota
    Language English
    Publishing date 2020-07-24
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe2017496
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  6. Article ; Online: Translating the human microbiome

    Ramnik J. Xavier

    Genome Medicine, Vol 13, Iss 1, Pp 1-

    a path to improving health

    2021  Volume 4

    Keywords Medicine ; R ; Genetics ; QH426-470
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Gut microbiome lipid metabolism and its impact on host physiology.

    Brown, Eric M / Clardy, Jon / Xavier, Ramnik J

    Cell host & microbe

    2023  Volume 31, Issue 2, Page(s) 173–186

    Abstract: Metabolites produced by commensal gut microbes impact host health through their recognition by the immune system and their influence on numerous metabolic pathways. Notably, the gut microbiota can both transform and synthesize lipids as well as break ... ...

    Abstract Metabolites produced by commensal gut microbes impact host health through their recognition by the immune system and their influence on numerous metabolic pathways. Notably, the gut microbiota can both transform and synthesize lipids as well as break down dietary lipids to generate secondary metabolites with host modulatory properties. Although lipids have largely been consigned to structural roles, particularly in cell membranes, recent research has led to an increased appreciation of their signaling activities, with potential impacts on host health and physiology. This review focuses on studies that highlight the functions of bioactive lipids in mammalian physiology, with a special emphasis on immunity and metabolism.
    MeSH term(s) Animals ; Gastrointestinal Microbiome/physiology ; Lipid Metabolism ; Immune System ; Lipids ; Mammals
    Chemical Substances Lipids
    Language English
    Publishing date 2023-02-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2278004-X
    ISSN 1934-6069 ; 1931-3128
    ISSN (online) 1934-6069
    ISSN 1931-3128
    DOI 10.1016/j.chom.2023.01.009
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    Zs.A 6578: Show issues Location:
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  8. Article ; Online: Author Correction: Systemic sclerosis gastrointestinal dysmotility: risk factors, pathophysiology, diagnosis and management.

    McMahan, Zsuzsanna H / Kulkarni, Subhash / Chen, Joan / Chen, Jiande Z / Xavier, Ramnik J / Pasricha, P Jay / Khanna, Dinesh

    Nature reviews. Rheumatology

    2023  Volume 19, Issue 3, Page(s) 191

    Language English
    Publishing date 2023-02-15
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2491532-4
    ISSN 1759-4804 ; 1759-4790
    ISSN (online) 1759-4804
    ISSN 1759-4790
    DOI 10.1038/s41584-023-00929-1
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  9. Article ; Online: Tuning in to inflammation: A path forward for precise and efficacious microbiome medicines?

    Subramanian, Sathish / Xavier, Ramnik J

    Med (New York, N.Y.)

    2020  Volume 2, Issue 8, Page(s) 892–894

    Abstract: Gut microbes sense various external cues, including those found in inflammatory conditions, yielding possibilities for connecting sensory circuits to effector pathways to engineer precise and scaled interventions to target pathway activity. Scott et al. ... ...

    Abstract Gut microbes sense various external cues, including those found in inflammatory conditions, yielding possibilities for connecting sensory circuits to effector pathways to engineer precise and scaled interventions to target pathway activity. Scott et al. combined directed evolution and a synthetic gene circuit in yeast to fine-tune sensing of extracellular ATP, showing promise as a live therapeutic in two murine models of chemical colitis and a murine model of antibody-mediated enteritis.
    MeSH term(s) Animals ; Colitis/chemically induced ; Enteritis ; Inflammation/drug therapy ; Mice ; Microbiota ; Time
    Language English
    Publishing date 2020-07-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ISSN 2666-6340
    ISSN (online) 2666-6340
    DOI 10.1016/j.medj.2021.07.006
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  10. Article ; Online: Beth Cindy Levine (1960-2020).

    Virgin, Herbert W / Cuervo, Ana Maria / Xavier, Ramnik J

    Science (New York, N.Y.)

    2020  Volume 369, Issue 6502, Page(s) 378

    Language English
    Publishing date 2020-07-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abd6216
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