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  1. Article: Transcriptional and Epigenetic Regulation of Context-Dependent Plasticity in T-Helper Lineages.

    Friedman, Meyer J / Lee, Haram / Lee, June-Yong / Oh, Soohwan

    Immune network

    2023  Volume 23, Issue 1, Page(s) e5

    Abstract: Th cell lineage determination and functional specialization are tightly linked to the activation of lineage-determining transcription factors (TFs) that ... ...

    Abstract Th cell lineage determination and functional specialization are tightly linked to the activation of lineage-determining transcription factors (TFs) that bind
    Language English
    Publishing date 2023-02-23
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2536191-0
    ISSN 2092-6685 ; 1598-2629
    ISSN (online) 2092-6685
    ISSN 1598-2629
    DOI 10.4110/in.2023.23.e5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Enhancer-promoter specificity in gene transcription: molecular mechanisms and disease associations.

    Friedman, Meyer J / Wagner, Tobias / Lee, Haram / Rosenfeld, Michael G / Oh, Soohwan

    Experimental & molecular medicine

    2024  Volume 56, Issue 4, Page(s) 772–787

    Abstract: Although often located at a distance from their target gene promoters, enhancers are the primary genomic determinants of temporal and spatial transcriptional specificity in metazoans. Since the discovery of the first enhancer element in simian virus 40, ... ...

    Abstract Although often located at a distance from their target gene promoters, enhancers are the primary genomic determinants of temporal and spatial transcriptional specificity in metazoans. Since the discovery of the first enhancer element in simian virus 40, there has been substantial interest in unraveling the mechanism(s) by which enhancers communicate with their partner promoters to ensure proper gene expression. These research efforts have benefited considerably from the application of increasingly sophisticated sequencing- and imaging-based approaches in conjunction with innovative (epi)genome-editing technologies; however, despite various proposed models, the principles of enhancer-promoter interaction have still not been fully elucidated. In this review, we provide an overview of recent progress in the eukaryotic gene transcription field pertaining to enhancer-promoter specificity. A better understanding of the mechanistic basis of lineage- and context-dependent enhancer-promoter engagement, along with the continued identification of functional enhancers, will provide key insights into the spatiotemporal control of gene expression that can reveal therapeutic opportunities for a range of enhancer-related diseases.
    MeSH term(s) Enhancer Elements, Genetic ; Promoter Regions, Genetic ; Humans ; Animals ; Transcription, Genetic ; Gene Expression Regulation
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1328915-9
    ISSN 2092-6413 ; 1226-3613 ; 0378-8512
    ISSN (online) 2092-6413
    ISSN 1226-3613 ; 0378-8512
    DOI 10.1038/s12276-024-01233-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4775: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: Dynamics of Viral and Host 3D Genome Structure upon Infection.

    Friedman, Meyer J / Lee, Haram / Kwon, Young-Chan / Oh, Soohwan

    Journal of microbiology and biotechnology

    2022  Volume 32, Issue 12, Page(s) 1515–1526

    Abstract: Eukaryotic chromatin is highly organized in the 3D nuclear space and dynamically regulated in response to environmental stimuli. This genomic organization is arranged in a hierarchical fashion to support various cellular functions, including ... ...

    Abstract Eukaryotic chromatin is highly organized in the 3D nuclear space and dynamically regulated in response to environmental stimuli. This genomic organization is arranged in a hierarchical fashion to support various cellular functions, including transcriptional regulation of gene expression. Like other host cellular mechanisms, viral pathogens utilize and modulate host chromatin architecture and its regulatory machinery to control features of their life cycle, such as lytic versus latent status. Combined with previous research focusing on individual loci, recent global genomic studies employing conformational assays coupled with high-throughput sequencing technology have informed models for host and, in some cases, viral 3D chromosomal structure re-organization during infection and the contribution of these alterations to virus-mediated diseases. Here, we review recent discoveries and progress in host and viral chromatin structural dynamics during infection, focusing on a subset of DNA (human herpesviruses and HPV) as well as RNA (HIV, influenza virus and SARS-CoV-2) viruses. An understanding of how host and viral genomic structure affect gene expression in both contexts and ultimately viral pathogenesis can facilitate the development of novel therapeutic strategies.
    MeSH term(s) Humans ; Gene Expression Regulation, Viral ; COVID-19 ; SARS-CoV-2/genetics ; Virus Diseases/genetics ; Chromatin/genetics ; Genome, Viral ; Virus Replication ; Herpesvirus 8, Human/genetics
    Chemical Substances Chromatin
    Language English
    Publishing date 2022-09-30
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2412195-2
    ISSN 1738-8872 ; 1738-8872
    ISSN (online) 1738-8872
    ISSN 1738-8872
    DOI 10.4014/jmb.2208.08020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Overexpression of

    Hwang, Geonhee / Park, Jeeyoon / Kim, Soohwan / Park, Jeonghyang / Seo, Dain / Oh, Eunkyoo

    Frontiers in plant science

    2021  Volume 12, Page(s) 782352

    Abstract: Thermomorphogenesis is the morphological response of plants to an elevation in the ambient temperature, which is mediated by the bHLH transcription factor PIF4. The evening-expressed clock component, PRR5, directly represses the expression ... ...

    Abstract Thermomorphogenesis is the morphological response of plants to an elevation in the ambient temperature, which is mediated by the bHLH transcription factor PIF4. The evening-expressed clock component, PRR5, directly represses the expression of
    Language English
    Publishing date 2021-11-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2021.782352
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  5. Article ; Online: Direct observation of surface charge and stiffness of human metaphase chromosomes.

    Roh, Seokbeom / Lee, Taeha / Cheong, Da Yeon / Kim, Yeonjin / Oh, Soohwan / Lee, Gyudo

    Nanoscale advances

    2022  Volume 5, Issue 2, Page(s) 368–377

    Abstract: Metaphase chromosomes in which both polynucleotides and proteins are condensed with hierarchies are closely related to life phenomena such as cell division, cancer development, and cellular senescence. Nevertheless, their nature is rarely revealed, owing ...

    Abstract Metaphase chromosomes in which both polynucleotides and proteins are condensed with hierarchies are closely related to life phenomena such as cell division, cancer development, and cellular senescence. Nevertheless, their nature is rarely revealed, owing to their structural complexity and technical limitations in analytical methods. In this study, we used surface potential and nanomechanics mapping technology based on atomic force microscopy to measure the surface charge and intrinsic stiffness of metaphase chromosomes. We found that extra materials covering the chromosomes after the extraction process were positively charged. With the covering materials, the chromosomes were positively charged (
    Language English
    Publishing date 2022-12-20
    Publishing country England
    Document type Journal Article
    ISSN 2516-0230
    ISSN (online) 2516-0230
    DOI 10.1039/d2na00620k
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Pt cocatalyst morphology on semiconductor nanorod photocatalysts enhances charge trapping and water reduction.

    Park, Bumjin / Park, Won-Woo / Choi, Ji Yong / Choi, Woong / Sung, Young Mo / Sul, Soohwan / Kwon, Oh-Hoon / Song, Hyunjoon

    Chemical science

    2023  Volume 14, Issue 27, Page(s) 7553–7558

    Abstract: In photocatalysis, metal-semiconductor hybrid structures have been proposed for ideal photocatalytic systems. In this study, we investigate the effect of morphology and surface nature of Pt cocatalysts on photocatalytic hydrogen evolution activity in Pt- ... ...

    Abstract In photocatalysis, metal-semiconductor hybrid structures have been proposed for ideal photocatalytic systems. In this study, we investigate the effect of morphology and surface nature of Pt cocatalysts on photocatalytic hydrogen evolution activity in Pt-tipped CdSe nanorods. Three distinct morphologies of Pt cocatalysts were synthesized and employed as visible light photocatalysts. The rough tips exhibit the highest activity, followed by the round and cubic tips. Kinetic investigations using transient absorption spectroscopy reveal that the cubic tips exhibit lower charge-separated states feasible for reacting with water and water reduction rates due to their defectless surface facets. In contrast, the rough tips show a similar charge-separation value but a two-fold higher surface reaction rate than the round tips, resulting in a significant enhancement of hydrogen evolution. These findings highlight the importance of rational design on metal cocatalysts in addition to the main semiconductor bodies for maximizing photocatalytic activities.
    Language English
    Publishing date 2023-06-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d3sc01429k
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  7. Article ; Online: Experimental evaluation of

    Kim, SooHwan / Oh, Taehwan / Yang, Siyeon / Cho, Hyejean / Chae, Chanhee

    Canadian journal of veterinary research = Revue canadienne de recherche veterinaire

    2021  Volume 85, Issue 1, Page(s) 77–81

    Abstract: The objective of this study was to evaluate the efficacy of a ... ...

    Abstract The objective of this study was to evaluate the efficacy of a new
    MeSH term(s) Animals ; Antibodies, Bacterial/blood ; Bacterial Vaccines/immunology ; Enzyme-Linked Immunosorbent Assay/veterinary ; Mycoplasma hyopneumoniae ; Pneumonia of Swine, Mycoplasmal/prevention & control ; Swine
    Chemical Substances Antibodies, Bacterial ; Bacterial Vaccines
    Language English
    Publishing date 2021-01-01
    Publishing country Canada
    Document type Journal Article ; Randomized Controlled Trial, Veterinary
    ZDB-ID 632814-3
    ISSN 1928-9022 ; 0830-9000
    ISSN (online) 1928-9022
    ISSN 0830-9000
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 570: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Corrigendum to: SOMNUS, a CCCH-Type Zinc Finger Protein in Arabidopsis, Negatively Regulates Light-Dependent Seed Germination Downstream of PIL5.

    Kim, Dong Hwan / Yamaguchi, Shinjiro / Lim, Soohwan / Oh, Eunkyoo / Park, Jeongmu / Hanada, Atsushi / Kamiya, Yuji / Choi, Giltsu

    The Plant cell

    2021  Volume 33, Issue 6, Page(s) 2093–2095

    Language English
    Publishing date 2021-03-25
    Publishing country England
    Document type Published Erratum
    ZDB-ID 623171-8
    ISSN 1532-298X ; 1040-4651
    ISSN (online) 1532-298X
    ISSN 1040-4651
    DOI 10.1093/plcell/koab086
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    In stock of ZB MED Bonn / Germany

    Z 4952: Show issues

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  9. Article ; Online: Long-distance association of topological boundaries through nuclear condensates.

    Gamliel, Amir / Meluzzi, Dario / Oh, Soohwan / Jiang, Nan / Destici, Eugin / Rosenfeld, Michael G / Nair, Sreejith J

    Proceedings of the National Academy of Sciences of the United States of America

    2022  Volume 119, Issue 32, Page(s) e2206216119

    Abstract: The eukaryotic genome is partitioned into distinct topological domains separated by boundary elements. Emerging data support the concept that several well-established nuclear compartments are ribonucleoprotein condensates assembled through the physical ... ...

    Abstract The eukaryotic genome is partitioned into distinct topological domains separated by boundary elements. Emerging data support the concept that several well-established nuclear compartments are ribonucleoprotein condensates assembled through the physical process of phase separation. Here, based on our demonstration that chemical disruption of nuclear condensate assembly weakens the insulation properties of a specific subset (∼20%) of topologically associated domain (TAD) boundaries, we report that the disrupted boundaries are characterized by a high level of transcription and striking spatial clustering. These topological boundary regions tend to be spatially associated, even interchromosomally, segregate with nuclear speckles, and harbor a specific subset of "housekeeping" genes widely expressed in diverse cell types. These observations reveal a previously unappreciated mode of genome organization mediated by conserved boundary elements harboring highly and widely expressed transcription units and associated transcriptional condensates.
    MeSH term(s) Cell Compartmentation ; Cell Nucleus/chemistry ; Cell Nucleus/genetics ; Cell Nucleus/metabolism ; Chromosomes/genetics ; Eukaryota/cytology ; Eukaryota/genetics ; Genes, Essential ; Genome/genetics ; Nuclear Speckles/genetics ; Ribonucleoproteins/metabolism ; Transcription, Genetic
    Chemical Substances Ribonucleoproteins
    Language English
    Publishing date 2022-08-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2206216119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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  10. Article: Experimental evaluation of Mycoplasma hyopneumoniae bacterin against a Korean M. hyopneumoniae challenge

    Kim, SooHwan / Oh, Taehwan / Yang, Siyeon / Cho, Hyejean / Chae, Chanhee

    Canadian journal of veterinary research. 2021 Jan., v. 85, no. 1

    2021  

    Abstract: The objective of this study was to evaluate the efficacy of a new Mycoplasma hyopneumoniae bacterin against a Korean M. hyopneumoniae challenge under experimental conditions. Fifteen pigs were allocated randomly into 3 groups (5 pigs per group) that were ...

    Abstract The objective of this study was to evaluate the efficacy of a new Mycoplasma hyopneumoniae bacterin against a Korean M. hyopneumoniae challenge under experimental conditions. Fifteen pigs were allocated randomly into 3 groups (5 pigs per group) that were designated in 1 of 3 ways: vaccinated-challenged, unvaccinated-challenged, or unvaccinated-unchallenged. The pigs in the vaccinated-challenged group were immunized with an M. hyopneumoniae whole-cell bacterin at a 1.0 mL dose-level at 21 d old. At 42 d old (0 d post-challenge), the pigs in the vaccinated-challenged and unvaccinated-challenged groups were inoculated intranasally with a strain of Korean M. hyopneumoniae. Vaccinated-challenged pigs elicited a strong cell-mediated immunity as measured by M. hyopneumoniae-specific interferon-γ secreting cells when compared with unvaccinated-challenged pigs. Vaccination of pigs with this new M. hyopneumoniae bacterin reduced nasal shedding and lung lesions. The evaluated vaccine was therefore considered effective in controlling M. hyopneumoniae infection.
    Keywords Mycoplasma hyopneumoniae ; cell-mediated immunity ; lungs ; nose ; vaccination ; vaccines ; veterinary medicine
    Language English
    Dates of publication 2021-01
    Size p. 77-81.
    Publishing place Canadian Veterinary Medical Association = Association canadienne des vétérinaires
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 632814-3
    ISSN 0830-9000
    ISSN 0830-9000
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 570: Show issues Location:
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