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  1. Article ; Online: Atg8ylation as a host-protective mechanism against

    Deretic, Vojo

    Frontiers in tuberculosis

    2023  Volume 1

    Abstract: Nearly two decades have passed since the first report on autophagy acting as a cell-autonomous defense ... ...

    Abstract Nearly two decades have passed since the first report on autophagy acting as a cell-autonomous defense against
    Language English
    Publishing date 2023-09-29
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2813-7868
    ISSN (online) 2813-7868
    DOI 10.3389/ftubr.2023.1275882
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Autophagosome and phagosome

    Deretic, Vojo

    (Methods in molecular biology ; 445)

    2008  

    Author's details ed. by Vojo Deretic
    Series title Methods in molecular biology ; 445
    Collection
    Language English
    Size XVII, 455 S. : Ill., graph. Darst., 24cm
    Publisher Humana Press
    Publishing place Totowa, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT015543246
    ISBN 1-58829-853-1 ; 978-1-58829-853-9
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2008 A 3152 order for loan Magazin

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  3. Article ; Online: An expanding repertoire of E3 ligases in membrane Atg8ylation.

    Deretic, Vojo / Klionsky, Daniel J

    Nature cell biology

    2024  Volume 26, Issue 3, Page(s) 307–308

    MeSH term(s) Ubiquitin-Protein Ligases/metabolism ; Ubiquitination
    Chemical Substances Ubiquitin-Protein Ligases (EC 2.3.2.27)
    Language English
    Publishing date 2024-01-16
    Publishing country England
    Document type Letter
    ZDB-ID 1474722-4
    ISSN 1476-4679 ; 1465-7392
    ISSN (online) 1476-4679
    ISSN 1465-7392
    DOI 10.1038/s41556-023-01329-z
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    Zs.A 5169: Show issues Location:
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    Zs.MG 12: Show issues

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  4. Book: Autophagy in immunity and infection

    Deretic, Vojo

    a novel immune effector

    2006  

    Author's details ed. by Vojo Deretic
    Keywords Autophagie ; Cytologie ; Immunologie ; Infektiologie
    Subject Autophagozytose ; Autophagocytose ; Infektionslehre ; Klinische Immunologie ; Zellbiologie ; Zellenlehre ; Zellforschung ; Zellkunde ; Zelluologie ; Zytologie ; Zelle
    Language English
    Size XXXVI, 250 S. : Ill., graph. Darst., 240 mm x 170 mm
    Publisher WILEY-VCH
    Publishing place Weinheim
    Publishing country Germany
    Document type Book
    HBZ-ID HT014783333
    ISBN 3-527-31450-4 ; 978-3-527-31450-8
    Database Catalogue ZB MED Medicine, Health

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  5. Article ; Online: Autophagy in inflammation, infection, and immunometabolism.

    Deretic, Vojo

    Immunity

    2021  Volume 54, Issue 3, Page(s) 437–453

    Abstract: Autophagy is a quality-control, metabolic, and innate immunity process. Normative autophagy affects many cell types, including hematopoietic as well as non-hematopoietic, and promotes health in model organisms and humans. When autophagy is perturbed, ... ...

    Abstract Autophagy is a quality-control, metabolic, and innate immunity process. Normative autophagy affects many cell types, including hematopoietic as well as non-hematopoietic, and promotes health in model organisms and humans. When autophagy is perturbed, this has repercussions on diseases with inflammatory components, including infections, autoimmunity and cancer, metabolic disorders, neurodegeneration, and cardiovascular and liver diseases. As a cytoplasmic degradative pathway, autophagy protects from exogenous hazards, including infection, and from endogenous sources of inflammation, including molecular aggregates and damaged organelles. The focus of this review is on the role of autophagy in inflammation, including type I interferon responses and inflammasome outputs, from molecules to immune cells. A special emphasis is given to the intersections of autophagy with innate immunity, immunometabolism, and functions of organelles such as mitochondria and lysosomes that act as innate immunity and immunometabolic signaling platforms.
    MeSH term(s) Animals ; Autoimmunity ; Autophagy/immunology ; Humans ; Immune System/metabolism ; Immunity, Innate ; Infections/immunology ; Inflammation/immunology ; Lysosomes/metabolism ; Signal Transduction
    Language English
    Publishing date 2021-02-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2021.01.018
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    Zs.MG 69: Show issues

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  6. Article ; Online: Autophagy is part of the answer to tuberculosis.

    Deretic, Vojo / Wang, Fulong

    Nature microbiology

    2022  Volume 8, Issue 5, Page(s) 762–763

    MeSH term(s) Humans ; Tuberculosis ; Mycobacterium tuberculosis/genetics ; Autophagy
    Language English
    Publishing date 2022-11-16
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2058-5276
    ISSN (online) 2058-5276
    DOI 10.1038/s41564-023-01373-3
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  7. Article ; Online: Autophagy in metabolism and quality control: opposing, complementary or interlinked functions?

    Deretic, Vojo / Kroemer, Guido

    Autophagy

    2021  Volume 18, Issue 2, Page(s) 283–292

    Abstract: ... ...

    Abstract The
    MeSH term(s) Autophagy/physiology ; Lysosomes/metabolism ; Macroautophagy ; Mitochondria/metabolism ; Peroxisomes/metabolism
    Language English
    Publishing date 2021-06-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2021.1933742
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  8. Article ; Online: A guide to membrane atg8ylation and autophagy with reflections on immunity.

    Deretic, Vojo / Lazarou, Michael

    The Journal of cell biology

    2022  Volume 221, Issue 7

    Abstract: The process of membrane atg8ylation, defined herein as the conjugation of the ATG8 family of ubiquitin-like proteins to membrane lipids, is beginning to be appreciated in its broader manifestations, mechanisms, and functions. Classically, membrane ... ...

    Abstract The process of membrane atg8ylation, defined herein as the conjugation of the ATG8 family of ubiquitin-like proteins to membrane lipids, is beginning to be appreciated in its broader manifestations, mechanisms, and functions. Classically, membrane atg8ylation with LC3B, one of six mammalian ATG8 family proteins, has been viewed as the hallmark of canonical autophagy, entailing the formation of characteristic double membranes in the cytoplasm. However, ATG8s are now well described as being conjugated to single membranes and, most recently, proteins. Here we propose that the atg8ylation is coopted by multiple downstream processes, one of which is canonical autophagy. We elaborate on these biological outputs, which impact metabolism, quality control, and immunity, emphasizing the context of inflammation and immunological effects. In conclusion, we propose that atg8ylation is a modification akin to ubiquitylation, and that it is utilized by different systems participating in membrane stress responses and membrane remodeling activities encompassing autophagy and beyond.
    MeSH term(s) Animals ; Autophagy/physiology ; Autophagy-Related Protein 8 Family/genetics ; Autophagy-Related Protein 8 Family/metabolism ; Autophagy-Related Proteins/genetics ; Autophagy-Related Proteins/metabolism ; Mammals/metabolism ; Microtubule-Associated Proteins/metabolism ; Ubiquitination ; Ubiquitins/genetics
    Chemical Substances Autophagy-Related Protein 8 Family ; Autophagy-Related Proteins ; Microtubule-Associated Proteins ; Ubiquitins
    Language English
    Publishing date 2022-06-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 218154-x
    ISSN 1540-8140 ; 0021-9525
    ISSN (online) 1540-8140
    ISSN 0021-9525
    DOI 10.1083/jcb.202203083
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  9. Article ; Online: Not lowering the bar, just providing a step stool.

    Deretic, Vojo / Klionsky, Daniel J

    Autophagy

    2021  Volume 17, Issue 7, Page(s) 1569–1570

    Abstract: There have been a couple of times when we have reviewed papers that are essentially publishable as initially submitted; the "criticisms" were more along the lines of constructive suggestions that the authors might want to consider when they submitted a ... ...

    Abstract There have been a couple of times when we have reviewed papers that are essentially publishable as initially submitted; the "criticisms" were more along the lines of constructive suggestions that the authors might want to consider when they submitted a revised version of the paper, but those changes were not required. However, a much more common experience is for the authors to receive a series of comments from multiple reviewers. Most of those comments are critical for the authors to address, to ensure that the data in the paper are of sufficient quality and rigor, with adequate controls, to support the stated conclusions. That said, reviewers sometimes make requests, with the best of intentions, which might be reasonably considered as "beyond the scope of the present study". Thus, there needs to be a balance between addressing each and every comment of a review and completing a story even though there are additional avenues and questions that remain unexplored. Sometimes, even after a repeated round(s) of review, such questions linger and may impede acceptance of a worthy study.
    MeSH term(s) Editorial Policies ; Humans ; Peer Review ; Periodicals as Topic/standards
    Language English
    Publishing date 2021-06-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2021.1936360
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  10. Article ; Online: Membrane atg8ylation in Canonical and Noncanonical Autophagy.

    Deretic, Vojo / Duque, Thabata / Trosdal, Einar / Paddar, Masroor / Javed, Ruheena / Akepati, Prithvi

    Journal of molecular biology

    2024  , Page(s) 168532

    Abstract: Membrane atg8ylation is a homeostatic process responding to membrane remodeling and stress signals. Membranes are atg8ylated by mammalian ATG8 ubiquitin-like proteins through a ubiquitylation-like cascade. A model has recently been put forward which ... ...

    Abstract Membrane atg8ylation is a homeostatic process responding to membrane remodeling and stress signals. Membranes are atg8ylated by mammalian ATG8 ubiquitin-like proteins through a ubiquitylation-like cascade. A model has recently been put forward which posits that atg8ylation of membranes is conceptually equivalent to ubiquitylation of proteins. Like ubiquitylation, membrane atg8ylation involves E1, E2 and E3 enzymes. The E3 ligases catalyze the final step of atg8ylation of aminophospholipids in membranes. Until recently, the only known E3 ligase for membrane atg8ylation was ATG16L1 in a noncovalent complex with the ATG12-ATG5 conjugate. ATG16L1 was first identified as a factor in canonical autophagy. During canonical autophagy, the ATG16L1-based E3 ligase complex includes WIPI2, which in turn recognizes phosphatidylinositiol 3-phosphate and directs atg8ylation of autophagic phagophores. As an alternative to WIPIs, binding of ATG16L1 to the proton pump V-ATPase guides atg8ylation of endolysosomal and phagosomal membranes in response to lumenal pH changes. Recently, a new E3 complex containing TECPR1 instead of ATG16L1, has been identified that responds to sphingomyelin's presence on the cytofacial side of perturbed endolysosomal membranes. In present review, we cover the principles of membrane atg8ylation, catalog its various presentations, and provide a perspective on the growing repertoire of E3 ligase complexes directing membrane atg8ylation at diverse locations.
    Language English
    Publishing date 2024-03-12
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 80229-3
    ISSN 1089-8638 ; 0022-2836
    ISSN (online) 1089-8638
    ISSN 0022-2836
    DOI 10.1016/j.jmb.2024.168532
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