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  1. Article: Editorial: The role of iron in cancer progression.

    Hamaï, Ahmed / Gong, Chang / Mehrpour, Maryam

    Frontiers in oncology

    2022  Volume 12, Page(s) 1026420

    Language English
    Publishing date 2022-09-21
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.1026420
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  2. Article: Epidemiological Insights into Diabetic Foot Amputation and its Correlates: A Provincial Study.

    Aalaa, Maryam / Vahdani, Amir Mohammad / Mohajeri Tehrani, Mohammadreza / Mehrdad, Neda / Zohdirad, Mehri / Sadati, Marzieh / Amini, Maryam / Mehrpour, Saeid / Ebrahimi, Mehdi / Larijani, Bagher / Amini, Mohammad Reza / Sanjari, Mahnaz

    Clinical medicine insights. Endocrinology and diabetes

    2024  Volume 17, Page(s) 11795514241227618

    Abstract: Background: Diabetic foot ulcer and potential subsequent lower extremity amputation are major complications of diabetes mellitus and are also prominent morbidity factors that could affect patients' quality of life.: Objectives: This study aimed to ... ...

    Abstract Background: Diabetic foot ulcer and potential subsequent lower extremity amputation are major complications of diabetes mellitus and are also prominent morbidity factors that could affect patients' quality of life.
    Objectives: This study aimed to assess the prevalence of diabetic foot amputation and explore correlates of amputation cause and type among subjects with diabetes mellitus in Tehran, Iran.
    Methods: A descriptive cross-sectional study was conducted to assess the demographic, sociological, and clinical characteristics of subjects who had undergone lower extremity amputation due to diabetic foot ulcers, from 2011 to 2020, in two educational medical centers in Tehran, Iran. We examined the medical records of 4676 individuals who were admitted to Shariati and Sina hospitals due to diabetic foot issues. Information related to patient demographics (age, gender, marital status), social factors (education level, insurance), and clinical data (medical history, laboratory results, and characteristics of diabetic foot ulcers) was collected for subjects who had undergone lower extremity amputation due to diabetic foot ulcer. The collected data was reported using average values, standard deviations and proportions and analyzed using statistical tests.
    Results: During one decade, 882 out of 4676 (18.8%) patients with diabetic foot ulcers underwent lower extremity amputations of various types in Sina and Shariati hospitals in Tehran, Iran. Of these, 692 (14.5%) were included for further analysis in the study and the rest were excluded due to lack of sufficient recorded data. About 75.9% of the study population was male, and the average age including both sexes was 60 years. About 92.7% were married, and on average, subjects had been afflicted with diabetes mellitus for 15.1 years. Statistical analysis using Pearson's chi-square test showed there was a significant association between the treatment regimen for diabetes mellitus and the type of amputation (
    Conclusion: diabetes mellitus related treatment regimen and duration of disease are significantly associated with amputation cause and type.
    Language English
    Publishing date 2024-01-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2628990-8
    ISSN 1179-5514
    ISSN 1179-5514
    DOI 10.1177/11795514241227618
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  3. Article ; Online: If Gharib Hall Could Talk

    Maryam Alizadeh / Dean Parmelee / Saeedreza Mehrpour

    Acta Medica Iranica, Vol 59, Iss

    2021  Volume 2

    Abstract: No Absract No Absract No ... ...

    Abstract No Absract No Absract No Absract
    Keywords No Kewoeds ; No Kewoeds No Kewoeds ; Medicine (General) ; R5-920
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher Tehran University of Medical Sciences
    Document type Article ; Online
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  4. Article ; Online: Autophagy-Associated Immunogenic Modulation and Its Applications in Cancer Therapy.

    Duan, Zhuxi / Shi, Yu / Lin, Qun / Hamaï, Ahmed / Mehrpour, Maryam / Gong, Chang

    Cells

    2022  Volume 11, Issue 15

    Abstract: Autophagy, a lysosome-mediated cellular degradation pathway, recycles intracellular components to maintain metabolic balance and survival. Autophagy plays an important role in tumor immunotherapy as a "double-edged sword" that can both promote and ... ...

    Abstract Autophagy, a lysosome-mediated cellular degradation pathway, recycles intracellular components to maintain metabolic balance and survival. Autophagy plays an important role in tumor immunotherapy as a "double-edged sword" that can both promote and inhibit tumor progression. Autophagy acts on innate and adaptive immunity and interacts with immune cells to modulate tumor immunotherapy. The discovery of autophagy inducers and autophagy inhibitors also provides new insights for clinical anti-tumor therapy. However, there are also difficulties in the application of autophagy-related regulators, such as low bioavailability and the lack of efficient selectivity. This review focuses on autophagy-related immunogenic regulation and its application in cancer therapy.
    MeSH term(s) Adaptive Immunity ; Autophagy/physiology ; Homeostasis ; Humans ; Immunotherapy ; Neoplasms/metabolism
    Language English
    Publishing date 2022-07-28
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11152324
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  5. Article ; Online: Homéostasie du fer et autophagie.

    Hamaï, Ahmed / Mehrpour, Maryam

    Medecine sciences : M/S

    2017  Volume 33, Issue 3, Page(s) 260–267

    Abstract: Iron is an essential nutrient to life. However, the ability of iron to cycle between the oxidized and reduced forms contributes to the formation of reactive oxygen species. The generation of free radicals leads to oxidative stress and the initiation of ... ...

    Title translation Autophagy and iron homeostasis.
    Abstract Iron is an essential nutrient to life. However, the ability of iron to cycle between the oxidized and reduced forms contributes to the formation of reactive oxygen species. The generation of free radicals leads to oxidative stress and the initiation of signaling pathways involved in cell survival or cell death. The iron homeostasis is very carefully regulated and dysregulation of iron metabolism contributes to various human pathologies. The work carried out in recent years has revealed new cellular processes and mechanisms like ferritinophagy, that deepen our understanding of iron homeostasis. Ferritinophagy is a form of selective macroautophagy whereby ferritin, an iron storage protein, is degraded in the lysosome. Here, we describe iron homeostasis and review recent discoveries regarding the mechanism of ferritinophagy and its relationship to a new form of cell-death iron-dependent, the ferroptosis.
    MeSH term(s) Animals ; Autophagy/physiology ; Ferritins/metabolism ; Homeostasis/physiology ; Humans ; Iron/metabolism ; Lysosomes/metabolism ; Metabolic Networks and Pathways
    Chemical Substances Ferritins (9007-73-2) ; Iron (E1UOL152H7)
    Language French
    Publishing date 2017-03
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/20173303012
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  6. Article: Antioxidant Properties of Saffron Stigma and Petals: A Potential Therapeutic Approach for Insulin Resistance through an Insulin-Sensitizing Adipocytokine in High-Calorie Diet Rats.

    Mohaqiq, Zabihullah / Moossavi, Maryam / Hemmati, Mina / Kazemi, Tooba / Mehrpour, Omid

    International journal of preventive medicine

    2020  Volume 11, Page(s) 184

    Abstract: Background: Oxidative stress and alteration of lipid profile due to obesity and overweight is a major risk factor for atherosclerotic plaque or coronary artery disease. Because of antioxidant and lipid lowering potential of saffron, this study ... ...

    Abstract Background: Oxidative stress and alteration of lipid profile due to obesity and overweight is a major risk factor for atherosclerotic plaque or coronary artery disease. Because of antioxidant and lipid lowering potential of saffron, this study investigated weight alteration, lipid profiles, and insulin resistance index in high-calorie diet rats treated with aqueous extract of saffron stigma and petal.
    Methods: Forty Sprague-Dawley male rats were randomly divided into 8 groups including healthy control, high-fat diet control, nicotinic acid treated,
    Results: There was a significant decrease in the mean weight of the groups receiving saffron stigma and petal compared to control group (
    Conclusions: In this study, a remarkable antioxidant and lipid lowering potential was detected for saffron stigma, which could improve insulin resistance in obese rats. Therapeutic and protective effect of saffron is mainly related to its richness in phenolic compounds. Saffron stigma compared with petal had more notable effect, which could and should be mentioned in pharmaceutical studies.
    Language English
    Publishing date 2020-11-26
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2574680-7
    ISSN 2008-8213 ; 2008-7802
    ISSN (online) 2008-8213
    ISSN 2008-7802
    DOI 10.4103/ijpvm.IJPVM_275_19
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  7. Article ; Online: Crosstalk between autophagy and metabolic regulation of cancer stem cells.

    El Hout, Mouradi / Cosialls, Emma / Mehrpour, Maryam / Hamaï, Ahmed

    Molecular cancer

    2020  Volume 19, Issue 1, Page(s) 27

    Abstract: Cancer is now considered as a heterogeneous ecosystem in which tumor cells collaborate with each other and with host cells in their microenvironment. As circumstances change, the ecosystem evolves to ensure the survival and growth of the cancer cells. In ...

    Abstract Cancer is now considered as a heterogeneous ecosystem in which tumor cells collaborate with each other and with host cells in their microenvironment. As circumstances change, the ecosystem evolves to ensure the survival and growth of the cancer cells. In this ecosystem, metabolism is not only a key player but also drives stemness. In this review, we first summarize our current understanding of how autophagy influences cancer stem cell phenotype. We emphasize metabolic pathways in cancer stem cells and discuss how autophagy-mediated regulation metabolism is involved in their maintenance and proliferation. We then provide an update on the role of metabolic reprogramming and plasticity in cancer stem cells. Finally, we discuss how metabolic pathways in cancer stem cells could be therapeutically targeted.
    MeSH term(s) Animals ; Autophagy ; Humans ; Metabolic Networks and Pathways ; Neoplasms/metabolism ; Neoplasms/pathology ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Tumor Microenvironment
    Language English
    Publishing date 2020-02-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2091373-4
    ISSN 1476-4598 ; 1476-4598
    ISSN (online) 1476-4598
    ISSN 1476-4598
    DOI 10.1186/s12943-019-1126-8
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  8. Article ; Online: Autophagy-Associated Immunogenic Modulation and Its Applications in Cancer Therapy

    Zhuxi Duan / Yu Shi / Qun Lin / Ahmed Hamaï / Maryam Mehrpour / Chang Gong

    Cells, Vol 11, Iss 2324, p

    2022  Volume 2324

    Abstract: Autophagy, a lysosome-mediated cellular degradation pathway, recycles intracellular components to maintain metabolic balance and survival. Autophagy plays an important role in tumor immunotherapy as a “double-edged sword” that can both promote and ... ...

    Abstract Autophagy, a lysosome-mediated cellular degradation pathway, recycles intracellular components to maintain metabolic balance and survival. Autophagy plays an important role in tumor immunotherapy as a “double-edged sword” that can both promote and inhibit tumor progression. Autophagy acts on innate and adaptive immunity and interacts with immune cells to modulate tumor immunotherapy. The discovery of autophagy inducers and autophagy inhibitors also provides new insights for clinical anti-tumor therapy. However, there are also difficulties in the application of autophagy-related regulators, such as low bioavailability and the lack of efficient selectivity. This review focuses on autophagy-related immunogenic regulation and its application in cancer therapy.
    Keywords autophagy ; immunity ; cancer therapy ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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  9. Article: A case of aberrant bilateral vertebral arteries orgin presenting with right VA dissection.

    Bahadori, Maryam / Shojaei, Seyedeh Fahimeh / Ashayeri, Rezan / Esmaeili, Sara / Mehrpour, Masoud

    Caspian journal of internal medicine

    2020  Volume 11, Issue 1, Page(s) 116–119

    Language English
    Publishing date 2020-01-17
    Publishing country Iran
    Document type Case Reports
    ZDB-ID 2971933-1
    ISSN 2008-6172 ; 2008-6164
    ISSN (online) 2008-6172
    ISSN 2008-6164
    DOI 10.22088/cjim.11.1.116
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  10. Article ; Online: Non-coding RNAs as new autophagy regulators in cancer progression.

    Lin, Qun / Shi, Yu / Liu, Zihao / Mehrpour, Maryam / Hamaï, Ahmed / Gong, Chang

    Biochimica et biophysica acta. Molecular basis of disease

    2021  Volume 1868, Issue 1, Page(s) 166293

    Abstract: Recent advances highlight that non-coding RNAs (ncRNAs) are emerging as fundamental regulators in various physiological as well as pathological processes by regulating macro-autophagy. Studies have disclosed that macro-autophagy, which is a highly ... ...

    Abstract Recent advances highlight that non-coding RNAs (ncRNAs) are emerging as fundamental regulators in various physiological as well as pathological processes by regulating macro-autophagy. Studies have disclosed that macro-autophagy, which is a highly conserved process involving cellular nutrients, components, and recycling of organelles, can be either selective or non-selective and ncRNAs show their regulation on selective autophagy as well as non-selective autophagy. The abnormal expression of ncRNAs will result in the impairment of autophagy and contribute to carcinogenesis and cancer progression by regulating both selective autophagy as well as non-selective autophagy. This review focuses on the regulatory roles of ncRNAs in autophagy and their involvement in cancer which may provide valuable therapeutic targets for cancer management.
    MeSH term(s) Autophagy/genetics ; Carcinogenesis/genetics ; Disease Progression ; Humans ; Neoplasms/genetics ; Neoplasms/pathology ; RNA, Untranslated/genetics
    Chemical Substances RNA, Untranslated
    Language English
    Publishing date 2021-10-21
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 60-7
    ISSN 1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbadis.2021.166293
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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.247: Show issues Location:
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