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Article ; Online: Nasogastric tube placement perforating the nasopharynx causing mediastinal passage and feeding into the pleural space.

Zafran, Muhammad / Crook, Rebecca / Tuck, Alexander / Banerjee, Atmadeep

BMJ case reports

2024 Volume 17, Issue 3

Abstract: A mid-60s female with known primary progressive multiple sclerosis was admitted to our hospital with aspiration pneumonia. Due to reduced consciousness, a nasogastric (NG) tube was inserted for feeding. A chest x-ray (CXR) report from a thoracic ... ...

Abstract	A mid-60s female with known primary progressive multiple sclerosis was admitted to our hospital with aspiration pneumonia. Due to reduced consciousness, a nasogastric (NG) tube was inserted for feeding. A chest x-ray (CXR) report from a thoracic radiologist confirmed an atypical tip position due to a hiatus hernia but concluded it was almost certainly within the stomach. However, after deteriorating on feed commencement, a CT scan of the chest confirmed the tube had perforated the nasopharynx and run parallel to the oesophagus through the mediastinum into the right pleural space. The patient subsequently developed an empyema and pneumothorax, requiring multiple therapeutic interventions and a prolonged hospital stay. This case demonstrates how the routine insertion of an NG tube can lead to serious complications. Additionally, position check CXRs can be difficult to interpret, so the decision to use the tube must be made cautiously by the clinical team.
MeSH term(s)	Humans ; Female ; Mediastinum ; Radiography ; Pneumothorax/diagnostic imaging ; Pneumothorax/etiology ; Pneumothorax/therapy ; Intubation, Gastrointestinal/adverse effects ; Nasopharynx
Language	English
Publishing date	2024-03-21
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2023-254771
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Article ; Online: A Visual Diagnosis: Lipodystrophy.

Bhat, Salman Zahoor / Brown, Rebecca J / Banerjee, Ronadip R

JCEM case reports

2023 Volume 1, Issue 3, Page(s) luad066

Abstract: Lipodystrophy syndromes are rare metabolic disorders characterized by local or generalized loss of adipose tissue, resulting in insulin resistance, dyslipidemia, and cosmetic disfiguration. The lipodystrophic phenotype is highly variable, with partial ... ...

Abstract	Lipodystrophy syndromes are rare metabolic disorders characterized by local or generalized loss of adipose tissue, resulting in insulin resistance, dyslipidemia, and cosmetic disfiguration. The lipodystrophic phenotype is highly variable, with partial lipodystrophy often missed or misdiagnosed as other diseases from a lack of a proper physical examination and low physician awareness. Correct diagnosis is important for optimal treatment and follow-up strategies in these patients. The use of GLP-1 analogs has not been systematically evaluated in lipodystrophy and could be a potential precision medicine therapy. We aim to make the reader, particularly generalists or endocrinologists outside of tertiary referral centers, aware of the presentation and clinical features of partial lipodystrophy, emphasize the role of a full physical examination in diagnosis, and discuss therapeutic options, including GLP-1-based glycemic management illustrated by our clinical case.
Language	English
Publishing date	2023-06-12
Publishing country	England
Document type	Case Reports
ISSN	2755-1520
ISSN (online)	2755-1520
DOI	10.1210/jcemcr/luad066
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Article ; Online: Practice Versus Potential: The Impact of the BioFire FilmArray Pneumonia Panel on Antibiotic Use in Children.

Plattner, Alexander S / Lockowitz, Christine R / Dumm, Rebekah / Banerjee, Ritu / Newland, Jason G / Same, Rebecca G

Journal of the Pediatric Infectious Diseases Society

2024 Volume 13, Issue 3, Page(s) 196–202

Abstract: Background: The BioFire FilmArray Pneumonia Panel (BFPP), a multiplex PCR panel for the diagnosis of lower respiratory tract infections, has been proposed as a tool for antimicrobial stewardship. Few studies evaluate real-world implementation of the ... ...

Abstract	Background: The BioFire FilmArray Pneumonia Panel (BFPP), a multiplex PCR panel for the diagnosis of lower respiratory tract infections, has been proposed as a tool for antimicrobial stewardship. Few studies evaluate real-world implementation of the BFPP and no studies focus exclusively on children. Our institution implemented BFPP testing without restrictions. Methods: We conducted a retrospective cohort study in children hospitalized at St. Louis Children's Hospital to (1) characterize the use of the BFPP in pediatric patients and (2) assess how results impacted antibiotic use. We included all BFPP tests obtained during the first year after the introduction of the test, September 2021 through August 2022. The primary outcome was change in antibiotic therapy within 24 hours of results, which was compared to the potential change in antibiotic therapy determined by two infectious diseases clinicians. Results: One hundred sixty-nine tests from 126 patients were included. Nine patients were immunocompromised and 19 had chronic tracheostomy. The majority of tests were sent from tracheal aspirate specimens (92%) and from patients in an intensive care unit (94%). Only 51% of tests were obtained due to respiratory failure or suspected pneumonia. For 80% of test results, there was potential to change antibiotics, but change occurred in only 46% of tests in practice. Antibiotic escalation was more common (26%) than de-escalation (15%) or discontinuation (4.1%). Conclusions: In a cohort of pediatric patients tested with the BFPP, the majority of tests were sent from tracheal aspirates and less than half of tests were associated with a change in antibiotics.
MeSH term(s)	Humans ; Child ; Anti-Bacterial Agents/therapeutic use ; Retrospective Studies ; Pneumonia/diagnosis ; Pneumonia/drug therapy ; Respiratory Tract Infections/diagnosis ; Multiplex Polymerase Chain Reaction
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2024-02-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2668791-4
ISSN	2048-7207 ; 2048-7193
ISSN (online)	2048-7207
ISSN	2048-7193
DOI	10.1093/jpids/piae014
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Article ; Online: Severe electrolyte derangements from lysozymuria in acute myeloid leukemia.

Pérez-Pinzón, Juliana / Olin, Rebecca L / Banerjee, Rahul

EJHaem

2022 Volume 3, Issue 3, Page(s) 1018–1020

Abstract: Renal dysfunction in patients with acute myeloid leukemia (AML) can be multifactorial. We present the case of a 72-year-old male with relapsed myelomonocytic AML who presented with transient acute kidney injury (AKI) and severe persistent electrolyte ... ...

Abstract	Renal dysfunction in patients with acute myeloid leukemia (AML) can be multifactorial. We present the case of a 72-year-old male with relapsed myelomonocytic AML who presented with transient acute kidney injury (AKI) and severe persistent electrolyte derangements. In the setting of nephrotic-range proteinuria and electrolyte wasting without significant albuminuria or glucosuria, a diagnosis of lysozymuria was made. Lysozymuria is a rare paraneoplastic complication of AML and chronic myelomonocytic leukemia characterized by lysozyme. This represents the first case of lysozymuria presenting primarily with refractory electrolyte derangements rather than severe AKI. Lysozymuria portends a poor clinical prognosis even with aggressive management.
Language	English
Publishing date	2022-05-16
Publishing country	United States
Document type	Case Reports
ISSN	2688-6146
ISSN (online)	2688-6146
DOI	10.1002/jha2.464
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Article ; Online: Current Geriatric Emergency Medicine Education and Training in Australasia: How this relates to the global context and opportunities for the future.

Heath, Rebecca / Banerjee, Jay / Tyler, Katren R / Pattiaratchi, Tesni / Burkett, Ellen

Emergency medicine Australasia : EMA

2023 Volume 36, Issue 1, Page(s) 140–148

MeSH term(s)	Humans ; Aged ; Geriatrics ; Australasia ; Educational Status ; Emergency Medicine/education ; Curriculum
Language	English
Publishing date	2023-12-12
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2161824-0
ISSN	1742-6723 ; 1742-6731 ; 1035-6851
ISSN (online)	1742-6723
ISSN	1742-6731 ; 1035-6851
DOI	10.1111/1742-6723.14348
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Zs.A 5940: Show issues

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Article ; Online: Automated, cryogen-free headspace-trap with gas chromatography-mass spectrometry analysis of ethylene oxide and 2-chloroethanol as residual fumigants in foods.

Hearn, Lucy / Szafnauer, Rachael / Cole, Rebecca / Green, Bob / Mayser, Jan Peter / Tomar, Vikas / Banerjee, Kaushik / Amin, Priyesh

Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes

2024 Volume 59, Issue 3, Page(s) 81–87

Abstract: Ethylene oxide (EtO), although banned for use, is still being detected in foodstuffs that have been fumigated to eradicate pests during storage and transport. Residual levels over the European Union's (EU) maximum residue limit (MRL) pose severe health ... ...

Abstract	Ethylene oxide (EtO), although banned for use, is still being detected in foodstuffs that have been fumigated to eradicate pests during storage and transport. Residual levels over the European Union's (EU) maximum residue limit (MRL) pose severe health concerns. Recent detection of EtO and its by-product 2-chloroethanol (2-CE) at alarming levels have led to product recalls throughout the EU. Here, a simple, automated headspace (HS)-trap method for the simultaneous determination of EtO and its derivative 2-CE by gas chromatography-mass spectrometry (GC-MS) at the required MRL of ≤ 0.05 mg/kg has been implemented. Syringe-based HS combined with backflushed trapping technology provided enrichment of multiple extractions from the same sample vial (known as multi-step enrichment or MSE®) to increase sensitivity for EtO and 2-CE analysis by GC-MS using single-ion-monitoring (SIM) mode. Method detection limits (MDLs) of 0.00059 mg/kg and 0.00219 mg/kg for EtO and 2-CE, respectively, were obtained without the need for manual handling, solvent extraction or derivatization methods. Recoveries were shown to average (
MeSH term(s)	Gas Chromatography-Mass Spectrometry/methods ; Ethylene Oxide ; Reproducibility of Results ; Pesticides ; Ethylene Chlorohydrin
Chemical Substances	Ethylene Oxide (JJH7GNN18P) ; Pesticides ; Ethylene Chlorohydrin (753N66IHAN)
Language	English
Publishing date	2024-01-05
Publishing country	England
Document type	Journal Article
ZDB-ID	197072-0
ISSN	1532-4109 ; 0360-1234
ISSN (online)	1532-4109
ISSN	0360-1234
DOI	10.1080/03601234.2023.2298169
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Zs.B 1217: Show issues

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Article ; Online: Association of dopamine receptor D3 polymorphism with Levodopa-induced Dyskinesia: A study on Parkinson's disease patients from India.

Sarkar, Swagata / Biswas, Arindam / Ansari, Sabbir / Choudhury, Supriyo / Banerjee, Rebecca / Chatterjee, Suparna / Dey, Sanjit / Kumar, Hrishikesh

Neuroscience letters

2024 Volume 825, Page(s) 137706

Abstract: Introduction: Levodopa-induced dyskinesia (LID) is a debilitating motor feature in a subset of patients with Parkinson's disease (PD) after prolonged therapeutic administration of levodopa. Preliminary animal and human studies are suggestive of a key ... ...

Abstract	Introduction: Levodopa-induced dyskinesia (LID) is a debilitating motor feature in a subset of patients with Parkinson's disease (PD) after prolonged therapeutic administration of levodopa. Preliminary animal and human studies are suggestive of a key role of dopamine type 3 (D3) receptor polymorphism (Ser9Gly; rs6280) in LID. Its contribution to development of LID among Indian PD patients has remained relatively unexplored and merits further investigation. Methods and materials: 200 well-characterised PD patients (100 without LID and 100 with LID) and 100 age-matched healthy controls were recruited from the outpatient department of Institute of Neurosciences Kolkata. MDS-UPDRS (Unified Parkinson's Disease Rating Scale from International Movement Disorder Society) Part III and AIMS (abnormal involuntary movement scale) were performed for estimation of severity of motor features and LID respectively in the ON state of the disease. Participants were analysed for the presence of Ser9Gly single nucleotide variant (SNV) (rs6280) by polymerase chain reaction followed by restriction fragment length polymorphism techniques. Results: The frequency of AA genotype (serine type) was more frequently present in PD patients with LID compared to PD patients without LID (50 % vs 28 %; P = 0.002; OR = 2.57, 95 % CI: 1.43 - 4.62). The abnormal involuntary movement scale score was significantly higher in PD patients with AA genotype compared to carriers of glycine allele (AG + GG) (4.08 ± 3.35; P = 0.002). Conclusion: We observed a significant association of serine type SNV (rs6280) in D3 receptor gene in a cohort of PD patients with LID from India. More severe motor severity was found in patients with glycine substitution of the same SNV. The current study emphasised the role of D3 receptor in the pathogenesis of LID.
MeSH term(s)	Animals ; Humans ; Antiparkinson Agents/therapeutic use ; Dyskinesia, Drug-Induced/genetics ; Dyskinesia, Drug-Induced/drug therapy ; Glycine ; Levodopa/adverse effects ; Parkinson Disease/drug therapy ; Parkinson Disease/genetics ; Polymorphism, Single Nucleotide ; Receptors, Dopamine D3/genetics ; Serine/genetics
Chemical Substances	Antiparkinson Agents ; Glycine (TE7660XO1C) ; Levodopa (46627O600J) ; Receptors, Dopamine D3 ; Serine (452VLY9402) ; DRD3 protein, human
Language	English
Publishing date	2024-02-29
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	194929-9
ISSN	1872-7972 ; 0304-3940
ISSN (online)	1872-7972
ISSN	0304-3940
DOI	10.1016/j.neulet.2024.137706
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Zs.A 1166: Show issues

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Article ; Online: Small-Group Teaching: Should It Be Recorded?

Crook, Peter / Javadzadeh, Shagayegh / Shone, Rebecca / Joseph, Vikram / Banerjee, Debasish / Annear, Nicholas M P

Medical science educator

2023 Volume 33, Issue 5, Page(s) 1073–1079

Abstract: Background: Recording large-group lectures is commonplace in higher education, allowing students to access content asynchronously and remotely. With the move towards online learning during the COVID-19 pandemic, recording of small-group teaching ... ...

Abstract	Background: Recording large-group lectures is commonplace in higher education, allowing students to access content asynchronously and remotely. With the move towards online learning during the COVID-19 pandemic, recording of small-group teaching sessions has also become increasingly common; however, the educational value of this practice is unknown. Methods: All medical students rotating through the Acute Medicine Department of a large teaching hospital were invited to enrol in the study. Consenting students were recorded for the second half of an online case-based learning (CBL) session. The recording was available for 6 months; viewing patterns were analysed. Students were sent a questionnaire after the session, asking them to reflect on the recorded and unrecorded halves of the session. Findings: Thirty-three students underwent recording in 12 separate groups; 31 students (94%) completed the questionnaire. All 31 respondents (100%) described the session as "useful" or "very useful". Twenty-four respondents (77%) recommended continuing to record small-group sessions and 17 (55%) reported being "likely" or "very likely" to watch the recording. Six respondents (19%) reported a negative impact of being recorded. During 6 months of follow-up, no students returned to view the recording for more than 1 minute. Conclusion: Despite positive feedback for the session and high student demand for ongoing recording, no students viewed the recording for any significant duration. One-fifth of students reported a negative impact of being recorded. The findings from this study do not support routine recording of small-group CBL sessions, even where demand for this may exist. Supplementary information: The online version contains supplementary material available at 10.1007/s40670-023-01837-5.
Language	English
Publishing date	2023-07-25
Publishing country	United States
Document type	Journal Article
ISSN	2156-8650
ISSN (online)	2156-8650
DOI	10.1007/s40670-023-01837-5
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Article: Levodopa-induced Dyskinesia in Parkinson's Disease: Plausible Inflammatory and Oxidative Stress Biomarkers.

Sarkar, Swagata / Roy, Akash / Choudhury, Supriyo / Banerjee, Rebecca / Dey, Sanjit / Kumar, Hrishikesh

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

2023 Volume 51, Issue 1, Page(s) 104–109

Abstract: Background: Pathophysiology of levodopa-induced dyskinesia (LID) remains obscure. Increased dopamine metabolism due to prolonged levodopa treatment can exacerbate oxidative damage and neuroinflammatory pathology in Parkinson's disease (PD). Association ... ...

Abstract	Background: Pathophysiology of levodopa-induced dyskinesia (LID) remains obscure. Increased dopamine metabolism due to prolonged levodopa treatment can exacerbate oxidative damage and neuroinflammatory pathology in Parkinson's disease (PD). Association of novel peripheral markers with LID severity might provide insight into LID pathomechanisms. Objective: We aimed to study specific peripheral blood inflammatory-oxidative markers in LID patients and investigate their association with clinical severity of LID. Method: Motor, non-motor and cognitive changes in PD with and without LID compared to healthy-matched controls were identified. Within the same cohort, inflammatory marker (sLAG3, TOLLIP, NLRP3 and IL-1β) levels and antioxidant enzyme activities were determined by ELISA and spectrophotometric methods. Results: LID patients showed distinctly upregulated TOLLIP, IL-1β levels with significant diminution of antioxidant activity compared to controls. Significant negative association of cognitive markers with oxidative changes was also observed. Conclusion: To our understanding, this is the first study that indicates the involvement of toll-like receptor-mediated distinct and low-grade inflammatory activation in LID pathophysiology.
MeSH term(s)	Humans ; Levodopa/adverse effects ; Parkinson Disease/drug therapy ; Antiparkinson Agents/therapeutic use ; Dyskinesia, Drug-Induced/etiology ; Biomarkers ; Oxidative Stress
Chemical Substances	Levodopa (46627O600J) ; Antiparkinson Agents ; Biomarkers
Language	English
Publishing date	2023-01-20
Publishing country	England
Document type	Journal Article
ZDB-ID	197622-9
ISSN	0317-1671
ISSN	0317-1671
DOI	10.1017/cjn.2023.8
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Zs.A 1203: Show issues

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Article: Under-Treatment of Older Patients with Newly Diagnosed Epithelial Ovarian Cancer Remains an Issue.

Dumas, Lucy / Bowen, Rebecca / Butler, John / Banerjee, Susana

Cancers

2021 Volume 13, Issue 5

Abstract: Older women with ovarian cancer have disproportionately poorer survival outcomes than their younger counterparts and receive less treatment. In order to understand where the gaps lie in the treatment of older patients, studies incorporating more detailed ...

Abstract	Older women with ovarian cancer have disproportionately poorer survival outcomes than their younger counterparts and receive less treatment. In order to understand where the gaps lie in the treatment of older patients, studies incorporating more detailed assessment of baseline characteristics and treatment delivery beyond the scope of most cancer registries are required. We aimed to assess the proportion of women over the age of 65 who are offered and receive standard of care for first-line ovarian cancer at two UK NHS Cancer Centres over a 5-year period (December 2009 to August 2015). Standard of care treatment was defined as a combination of cytoreductive surgery and if indicated platinum-based chemotherapy (combination or single-agent). Sixty-five percent of patients aged 65 and above received standard of care treatment. Increasing age was associated with lower rates of receiving standard of care (35% > 80 years old versus 78% of 65-69-year-olds,
Language	English
Publishing date	2021-02-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers13050952
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