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  1. Article: Corrigendum: Detecting key functional components group and speculating the potential mechanism of Xiao-Xu-Ming decoction in treating stroke.

    Chen, Yu-Peng / Wang, Ke-Xin / Cai, Jie-Qi / Li, Yi / Yu, Hai-Lang / Wu, Qi / Meng, Wei / Wang, Han-Duo / Yin, Chuan-Hui / Wu, Jie / Huang, Mian-Bo / Li, Rong / Guan, Dao-Gang

    Frontiers in cell and developmental biology

    2023  Volume 10, Page(s) 1107236

    Abstract: This corrects the article DOI: 10.3389/fcell.2022.753425.]. ...

    Abstract [This corrects the article DOI: 10.3389/fcell.2022.753425.].
    Language English
    Publishing date 2023-01-20
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.1107236
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Detecting Key Functional Components Group and Speculating the Potential Mechanism of Xiao-Xu-Ming Decoction in Treating Stroke.

    Chen, Yu-Peng / Wang, Ke-Xin / Cai, Jie-Qi / Li, Yi / Yu, Hai-Lang / Wu, Qi / Meng, Wei / Wang, Han-Duo / Yin, Chuan-Hui / Wu, Jie / Huang, Mian-Bo / Li, Rong / Guan, Dao-Gang

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 753425

    Abstract: ... traditional Chinese medicine (TCM) has widely been used at clinical level in China and some countries in Asia. Xiao-Xu-Ming ...

    Abstract Stroke is a cerebrovascular event with cerebral blood flow interruption which is caused by occlusion or bursting of cerebral vessels. At present, the main methods in treating stroke are surgical treatment, statins, and recombinant tissue-type plasminogen activator (rt-PA). Relatively, traditional Chinese medicine (TCM) has widely been used at clinical level in China and some countries in Asia. Xiao-Xu-Ming decoction (XXMD) is a classical and widely used prescription in treating stroke in China. However, the material basis of effect and the action principle of XXMD are still not clear. To solve this issue, we designed a new system pharmacology strategy that combined targets of XXMD and the pathogenetic genes of stroke to construct a functional response space (FRS). The effective proteins from this space were determined by using a novel node importance calculation method, and then the key functional components group (KFCG) that could mediate the effective proteins was selected based on the dynamic programming strategy. The results showed that enriched pathways of effective proteins selected from FRS could cover 99.10% of enriched pathways of reference targets, which were defined by overlapping of component targets and pathogenetic genes. Targets of optimized KFCG with 56 components can be enriched into 166 pathways that covered 80.43% of 138 pathways of 1,012 pathogenetic genes. A component potential effect score (PES) calculation model was constructed to calculate the comprehensive effective score of components in the components-targets-pathways (C-T-P) network of KFCGs, and showed that ferulic acid, zingerone, and vanillic acid had the highest PESs. Prediction and docking simulations show that these components can affect stroke synergistically through genes such as MEK, NFκB, and PI3K in PI3K-Akt, cAMP, and MAPK cascade signals. Finally, ferulic acid, zingerone, and vanillic acid were tested to be protective for PC12 cells and HT22 cells in increasing cell viabilities after oxygen and glucose deprivation (OGD). Our proposed strategy could improve the accuracy on decoding KFCGs of XXMD and provide a methodologic reference for the optimization, mechanism analysis, and secondary development of the formula in TCM.
    Language English
    Publishing date 2022-05-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.753425
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Detecting Key Functional Components Group and Speculating the Potential Mechanism of Xiao-Xu-Ming Decoction in Treating Stroke

    Yu-peng Chen / Ke-xin Wang / Jie-qi Cai / Yi Li / Hai-lang Yu / Qi Wu / Wei Meng / Han-duo Wang / Chuan-hui Yin / Jie Wu / Mian-bo Huang / Rong Li / Dao-gang Guan

    Frontiers in Cell and Developmental Biology, Vol

    2022  Volume 10

    Abstract: ... traditional Chinese medicine (TCM) has widely been used at clinical level in China and some countries in Asia. Xiao-Xu-Ming ...

    Abstract Stroke is a cerebrovascular event with cerebral blood flow interruption which is caused by occlusion or bursting of cerebral vessels. At present, the main methods in treating stroke are surgical treatment, statins, and recombinant tissue-type plasminogen activator (rt-PA). Relatively, traditional Chinese medicine (TCM) has widely been used at clinical level in China and some countries in Asia. Xiao-Xu-Ming decoction (XXMD) is a classical and widely used prescription in treating stroke in China. However, the material basis of effect and the action principle of XXMD are still not clear. To solve this issue, we designed a new system pharmacology strategy that combined targets of XXMD and the pathogenetic genes of stroke to construct a functional response space (FRS). The effective proteins from this space were determined by using a novel node importance calculation method, and then the key functional components group (KFCG) that could mediate the effective proteins was selected based on the dynamic programming strategy. The results showed that enriched pathways of effective proteins selected from FRS could cover 99.10% of enriched pathways of reference targets, which were defined by overlapping of component targets and pathogenetic genes. Targets of optimized KFCG with 56 components can be enriched into 166 pathways that covered 80.43% of 138 pathways of 1,012 pathogenetic genes. A component potential effect score (PES) calculation model was constructed to calculate the comprehensive effective score of components in the components-targets-pathways (C-T-P) network of KFCGs, and showed that ferulic acid, zingerone, and vanillic acid had the highest PESs. Prediction and docking simulations show that these components can affect stroke synergistically through genes such as MEK, NFκB, and PI3K in PI3K-Akt, cAMP, and MAPK cascade signals. Finally, ferulic acid, zingerone, and vanillic acid were tested to be protective for PC12 cells and HT22 cells in increasing cell viabilities after oxygen and glucose deprivation (OGD). ...
    Keywords XXMD ; KFCG ; network pharmacology ; functional response space ; effective proteins ; PC12 cells ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Book ; Online ; E-Book: Cellular injury in liver diseases

    Ding, Wen Xing / Yin, Xiao-Ming

    (Cell death in biology and diseases)

    2017  

    Author's details Wen-Xing Ding, Xiao-Ming Yin editors
    Series title Cell death in biology and diseases
    Language English
    Size 1 Online-Ressource (xiii, 263 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019410243
    ISBN 978-3-319-53774-0 ; 9783319537733 ; 3-319-53774-1 ; 3319537733
    DOI 10.1007/978-3-319-53774-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Book: Essentials of apoptosis

    Yin, Xiao-Ming

    a guide for basic and clinical research

    2009  

    Author's details Xiao-Ming Yin ... eds
    Keywords Apoptosis / physiology ; Apoptosis
    Subject Apoptose ; Programmierter Zelltod
    Language English
    Size XXVI, 728 S., [7] Bl. : Ill., graph. Darst., 25 cm
    Edition 2. ed.
    Publisher Humana Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    Note Previous ed.: 2003. - Formerly CIP Uk. - Includes bibliographical references and index
    HBZ-ID HT016009566
    ISBN 978-1-60327-380-0 ; 1-60327-380-8 ; 9781603273817 ; 1603273816
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2010 A 1588 order for loan Magazin

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  6. Book: Essentials of apoptosis

    Yin, Xiao-Ming

    a guide for basic and clinical research

    2003  

    Author's details ed. by Xiao-Ming Yin
    Keywords Apoptosis
    Subject Apoptose ; Programmierter Zelltod
    Language English
    Size X, 259 S. : Ill., graph. Darst.
    Publisher Humana Press
    Publishing place Totowa, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT013943753
    ISBN 1-58829-146-4 ; 978-1-58829-146-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2004 A 3008 order for loan Magazin

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  7. Article ; Online: Separation and purification of polyprenols from Ginkgo biloba leaves by silver ion anchored on imidazole-based ionic liquid functionalized mesoporous MCM-41 sorbent.

    Boateng, Isaac Duah / Yang, Xiao-Ming / Yin, Hengbo / Liu, Weimin

    Food chemistry

    2024  Volume 450, Page(s) 139284

    Abstract: Polyprenols (PPs) are compounds with excellent biological activities and are applied in food, pharmaceutical, and cosmetic industries. However, its strong non-polar nature makes it difficult to separate with many saturated impurities (such as saturated ... ...

    Abstract Polyprenols (PPs) are compounds with excellent biological activities and are applied in food, pharmaceutical, and cosmetic industries. However, its strong non-polar nature makes it difficult to separate with many saturated impurities (such as saturated fatty acids) extracted together. Complexation extraction is an effective method for separating saturated and polyunsaturated compounds. In this study, mesoporous silica MCM-41 was modified by imidazole-based ionic liquids (IL) followed by coating these MCM-41-supported IL compounds with silver salt to construct π-complexing adsorbent (AgBF
    Language English
    Publishing date 2024-04-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2024.139284
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 3634: Show issues

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  8. Article ; Online: The Role of Extracellular Vesicles in Liver Pathogenesis.

    Liu, Gang / Yin, Xiao-Ming

    The American journal of pathology

    2022  Volume 192, Issue 10, Page(s) 1358–1367

    Abstract: Extracellular vesicles (EVs) are generated by cells in the form of exosomes, microvesicles, and apoptotic bodies. They can be taken up by neighboring cells, and their contents can have functional impact on the cells that engulf them. As the mediators of ... ...

    Abstract Extracellular vesicles (EVs) are generated by cells in the form of exosomes, microvesicles, and apoptotic bodies. They can be taken up by neighboring cells, and their contents can have functional impact on the cells that engulf them. As the mediators of intercellular communication, EVs can play important roles in both physiological and pathologic contexts. In addition, early detection of EVs in different body fluids may offer a sensitive diagnostic tool for certain diseases, such as cancer. Furthermore, targeting specific EVs may also become a promising therapeutic approach. This review summarizes the latest findings of EVs in the field of liver research, with a focus on the different contents of the EVs and their impact on liver function and on the development of inflammation, fibrosis, and tumor in the liver. The goal of this review is to provide a succinct account of the various molecules that can mediate the function of EVs so the readers may apply this knowledge to their own research.
    MeSH term(s) Cell Communication ; Cell-Derived Microparticles/pathology ; Exosomes ; Extracellular Vesicles/pathology ; Humans ; Liver/pathology ; Neoplasms/pathology
    Language English
    Publishing date 2022-06-22
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2943-9
    ISSN 1525-2191 ; 0002-9440
    ISSN (online) 1525-2191
    ISSN 0002-9440
    DOI 10.1016/j.ajpath.2022.06.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.76: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Autophagy in liver diseases: A matter of what to remove and whether to keep.

    Yin, Xiao-Ming

    Liver research

    2018  Volume 2, Issue 3, Page(s) 109–111

    Language English
    Publishing date 2018-09-06
    Publishing country China
    Document type Journal Article
    ZDB-ID 2899927-7
    ISSN 2542-5684 ; 2096-2878
    ISSN (online) 2542-5684
    ISSN 2096-2878
    DOI 10.1016/j.livres.2018.09.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Acute abdomen after vertebroplasty-A rare complication.

    Zhao, Xiao-Ming / Lou, Xiao-Xiao / Chen, An-Fa / Zhang, Yin-Gang

    Frontiers in surgery

    2023  Volume 9, Page(s) 1048107

    Abstract: Introduction: In recent years, as the concept of minimally invasive treatment has been accepted by the majority of patients, the application of percutaneous vertebroplasty in osteoporotic vertebral compression fractures has gradually increased, and ... ...

    Abstract Introduction: In recent years, as the concept of minimally invasive treatment has been accepted by the majority of patients, the application of percutaneous vertebroplasty in osteoporotic vertebral compression fractures has gradually increased, and research on the adverse complications of bone cement leakage has gradually deepened.
    Case: Here, we report a rare case of acute pancreatitis after vertebroplasty. The patient had no previous history of pancreatitis and presented with obvious abdominal pain after vertebroplasty. Abdominal CT examination revealed that the leaking bone cement penetrated the anterior wall of the L1 vertebral body into the diaphragm, and the heat released by the polymerization reaction caused inflammation and damage to the adjacent pancreas, resulting in poor blood flow to the pancreatic tissue and leading to acute pancreatitis. Early postoperative symptomatic treatment was given to the patient, and the corresponding symptoms were gradually relieved. During postoperative follow-up, the leaking cement did not degrade, but the patient had no symptoms.
    Conclusion: Lesions of adjacent organs caused by bone cement leakage are rare, and clinicians often ignore the association between such complications and vertebroplasty. This case report will provide guidance and a reference for clinicians.
    Language English
    Publishing date 2023-01-06
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2022.1048107
    Database MEDical Literature Analysis and Retrieval System OnLINE

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