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  1. Article: Editorial: Free Fatty Acids as Signaling Molecules: Role of Free Fatty Acid Receptors and CD36.

    Puebla, Carlos / Morselli, Eugenia / Khan, Naim Akhtar / Retamal, Mauricio A

    Frontiers in physiology

    2022  Volume 13, Page(s) 862458

    Language English
    Publishing date 2022-03-16
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.862458
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Mechanoautophagy: Synergies Between Autophagy and Cell Mechanotransduction at Adhesive Complexes.

    Ravasio, Andrea / Morselli, Eugenia / Bertocchi, Cristina

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 917662

    Abstract: Cells are exposed and respond to various mechanical forces and physical cues stemming from their environment. This interaction has been seen to differentially regulate various cellular processes for maintenance of homeostasis, of which autophagy ... ...

    Abstract Cells are exposed and respond to various mechanical forces and physical cues stemming from their environment. This interaction has been seen to differentially regulate various cellular processes for maintenance of homeostasis, of which autophagy represents one of the major players. In addition, autophagy has been suggested to regulate mechanical functions of the cells including their interaction with the environment. In this minireview, we summarize the state of the art of the fascinating interplay between autophagy and the mechanotransduction machinery associated with cell adhesions, that we name ¨Mechanoautophagy¨.
    Language English
    Publishing date 2022-06-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.917662
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Editorial: New Roles of Autophagy Pathways in Cancer.

    Martins, Waleska K / Fader, Claudio M / Morselli, Eugenia / Grasso, Daniel

    Frontiers in oncology

    2021  Volume 11, Page(s) 726989

    Language English
    Publishing date 2021-07-07
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.726989
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Mechanoautophagy

    Andrea Ravasio / Eugenia Morselli / Cristina Bertocchi

    Frontiers in Cell and Developmental Biology, Vol

    Synergies Between Autophagy and Cell Mechanotransduction at Adhesive Complexes

    2022  Volume 10

    Abstract: Cells are exposed and respond to various mechanical forces and physical cues stemming from their environment. This interaction has been seen to differentially regulate various cellular processes for maintenance of homeostasis, of which autophagy ... ...

    Abstract Cells are exposed and respond to various mechanical forces and physical cues stemming from their environment. This interaction has been seen to differentially regulate various cellular processes for maintenance of homeostasis, of which autophagy represents one of the major players. In addition, autophagy has been suggested to regulate mechanical functions of the cells including their interaction with the environment. In this minireview, we summarize the state of the art of the fascinating interplay between autophagy and the mechanotransduction machinery associated with cell adhesions, that we name ¨Mechanoautophagy¨
    Keywords mechanoautophagy ; Extracellular Matrix ; focal adhesion ; cadherin mediated adhesion ; Autophagy ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Implications of High-Density Cholesterol Metabolism for Oocyte Biology and Female Fertility.

    Arias, Andreina / Quiroz, Alonso / Santander, Nicolás / Morselli, Eugenia / Busso, Dolores

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 941539

    Abstract: Cholesterol is an essential component of animal cells. Different regulatory mechanisms converge to maintain adequate levels of this lipid because both its deficiency and excess are unfavorable. Low cell cholesterol content promotes its synthesis and ... ...

    Abstract Cholesterol is an essential component of animal cells. Different regulatory mechanisms converge to maintain adequate levels of this lipid because both its deficiency and excess are unfavorable. Low cell cholesterol content promotes its synthesis and uptake from circulating lipoproteins. In contrast, its excess induces the efflux to high-density lipoproteins (HDL) and their transport to the liver for excretion, a process known as reverse cholesterol transport. Different studies suggest that an abnormal HDL metabolism hinders female fertility. HDL are the only lipoproteins detected in substantial amounts in follicular fluid (FF), and their size and composition correlate with embryo quality. Oocytes obtain cholesterol from cumulus cells
    Language English
    Publishing date 2022-09-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.941539
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Corrigendum: Impact of short and long exposure to cafeteria diet on food intake and white adipose tissue lipolysis mediated by glucagon-like peptide 1 receptor.

    Mattar, Pamela / Jaque, Cristian / Teske, Jennifer A / Morselli, Eugenia / Kerr, Bredford / Cortés, Víctor / Baudrand, Rene / Perez-Leighton, Claudio E

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1240246

    Abstract: This corrects the article DOI: 10.3389/fendo.2023.1164047.]. ...

    Abstract [This corrects the article DOI: 10.3389/fendo.2023.1164047.].
    Language English
    Publishing date 2023-06-26
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1240246
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Autophagy Process in Trophoblast Cells Invasion and Differentiation: Similitude and Differences With Cancer Cells.

    Carvajal, Lorena / Gutiérrez, Jaime / Morselli, Eugenia / Leiva, Andrea

    Frontiers in oncology

    2021  Volume 11, Page(s) 637594

    Abstract: Early human placental development begins with blastocyst implantation, then the trophoblast differentiates and originates the cells required for a proper fetal nutrition and placental implantation. Among them, extravillous trophoblast corresponds to a ... ...

    Abstract Early human placental development begins with blastocyst implantation, then the trophoblast differentiates and originates the cells required for a proper fetal nutrition and placental implantation. Among them, extravillous trophoblast corresponds to a non-proliferating trophoblast highly invasive that allows the vascular remodeling which is essential for appropriate placental perfusion and to maintain the adequate fetal growth. This process involves different placental cell types as well as molecules that allow cell growth, cellular adhesion, tissular remodeling, and immune tolerance. Remarkably, some of the cellular processes required for proper placentation are common between placental and cancer cells to finally support tumor growth. Indeed, as in placentation trophoblasts invade and migrate, cancer cells invade and migrate to promote tumor metastasis. However, while these processes respond to a controlled program in trophoblasts, in cancer cells this regulation is lost. Interestingly, it has been shown that autophagy, a process responsible for the degradation of damaged proteins and organelles to maintain cellular homeostasis, is required for invasion of trophoblast cells and for vascular remodeling during placentation. In cancer cells, autophagy has a dual role, as it has been shown both as tumor promoter and inhibitor, depending on the stage and tumor considered. In this review, we summarized the similarities and differences between trophoblast cell invasion and cancer cell metastasis specifically evaluating the role of autophagy in both processes.
    Language English
    Publishing date 2021-04-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.637594
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Role of lipids in the control of autophagy and primary cilium signaling in neurons.

    Hernández-Cáceres, María Paz / Pinto-Nuñez, Daniela / Rivera, Patricia / Burgos, Paulina / Díaz-Castro, Francisco / Criollo, Alfredo / Yañez, Maria Jose / Morselli, Eugenia

    Neural regeneration research

    2023  Volume 19, Issue 2, Page(s) 264–271

    Abstract: The brain is, after the adipose tissue, the organ with the greatest amount of lipids and diversity in their composition in the human body. In neurons, lipids are involved in signaling pathways controlling autophagy, a lysosome-dependent catabolic process ...

    Abstract The brain is, after the adipose tissue, the organ with the greatest amount of lipids and diversity in their composition in the human body. In neurons, lipids are involved in signaling pathways controlling autophagy, a lysosome-dependent catabolic process essential for the maintenance of neuronal homeostasis and the function of the primary cilium, a cellular antenna that acts as a communication hub that transfers extracellular signals into intracellular responses required for neurogenesis and brain development. A crosstalk between primary cilia and autophagy has been established; however, its role in the control of neuronal activity and homeostasis is barely known. In this review, we briefly discuss the current knowledge regarding the role of autophagy and the primary cilium in neurons. Then we review the recent literature about specific lipid subclasses in the regulation of autophagy, in the control of primary cilium structure and its dependent cellular signaling in physiological and pathological conditions, specifically focusing on neurons, an area of research that could have major implications in neurodevelopment, energy homeostasis, and neurodegeneration.
    Language English
    Publishing date 2023-07-23
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.377414
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Novel insights into the non-canonical roles of PSMD14/POH1/Rpn11 in proteostasis and in the modulation of cancer progression.

    Bustamante, Hianara A / Albornoz, Nicolás / Morselli, Eugenia / Soza, Andrea / Burgos, Patricia V

    Cellular signalling

    2022  Volume 101, Page(s) 110490

    Abstract: PSMD14/POH1/Rpn11 plays a crucial role in cellular homeostasis. PSMD14 is a structural subunit of the lid subcomplex of the proteasome 19S regulatory particle with constitutive deubiquitinase activity. Canonically, PSMD14 removes the full ubiquitin ... ...

    Abstract PSMD14/POH1/Rpn11 plays a crucial role in cellular homeostasis. PSMD14 is a structural subunit of the lid subcomplex of the proteasome 19S regulatory particle with constitutive deubiquitinase activity. Canonically, PSMD14 removes the full ubiquitin chains with K48-linkages by hydrolyzing the isopeptide bond between the substrate and the C-terminus of the first ubiquitin, a crucial step for the entry of substrates into the catalytic barrel of the 20S proteasome and their subsequent degradation, all in context of the 26S proteasome. However, more recent discoveries indicate PSMD14 DUB activity is not only coupled to the translocation of substrates into the core of 20S proteasome. During the assembly of the lid, activity of PSMD14 has been detected in the context of the heterodimer with PSMD7. Additionally, assembly of the lid subcomplex occurs as an independent event of the base subcomplex and 20S proteasome. This feature opens the possibility that the regulatory particle, free lid subcomplex or the heterodimer PSMD14-PSMD7 might play other physiological roles including a positive function on protein stability through deubiquitination. Here we discuss scenarios that could enhance this PSMD14 non-canonical pathway, the potential impact in preventing degradation of substrates by autophagy highlighting the main findings that support this hypothesis. Finally, we discuss why this information should be investigated in biomedicine specifically with focus on cancer progression to design new therapeutic strategies against the lid subcomplex and the heterodimer PSMD14-PSMD7, highlighting PSMD14 as a druggable target for cancer therapy.
    MeSH term(s) Humans ; Proteasome Endopeptidase Complex/metabolism ; Proteostasis ; Ubiquitin/metabolism ; Neoplasms ; Trans-Activators/metabolism
    Chemical Substances Proteasome Endopeptidase Complex (EC 3.4.25.1) ; Ubiquitin ; PSMD14 protein, human ; Trans-Activators
    Language English
    Publishing date 2022-10-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1002702-6
    ISSN 1873-3913 ; 0898-6568
    ISSN (online) 1873-3913
    ISSN 0898-6568
    DOI 10.1016/j.cellsig.2022.110490
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2579: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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  10. Article: Impact of short and long exposure to cafeteria diet on food intake and white adipose tissue lipolysis mediated by glucagon-like peptide 1 receptor.

    Mattar, Pamela / Jaque, Cristian / Teske, Jennifer A / Morselli, Eugenia / Kerr, Bredford / Cortés, Víctor / Baudrand, Rene / Perez-Leighton, Claudio E

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1164047

    Abstract: Introduction: The modern food environment facilitates excessive calorie intake, a major driver of obesity. Glucagon-like peptide 1 (GLP1) is a neuroendocrine peptide that has been the basis for developing new pharmacotherapies against obesity. The GLP1 ... ...

    Abstract Introduction: The modern food environment facilitates excessive calorie intake, a major driver of obesity. Glucagon-like peptide 1 (GLP1) is a neuroendocrine peptide that has been the basis for developing new pharmacotherapies against obesity. The GLP1 receptor (GLP1R) is expressed in central and peripheral tissues, and activation of GLP1R reduces food intake, increases the expression of thermogenic proteins in brown adipose tissue (BAT), and enhances lipolysis in white adipose tissue (WAT). Obesity decreases the efficiency of GLP1R agonists in reducing food intake and body weight. Still, whether palatable food intake before or during the early development of obesity reduces the effects of GLP1R agonists on food intake and adipose tissue metabolism remains undetermined. Further, whether GLP1R expressed in WAT contributes to these effects is unclear.
    Methods: Food intake, expression of thermogenic BAT proteins, and WAT lipolysis were measured after central or peripheral administration of Exendin-4 (EX4), a GLP1R agonist, to mice under intermittent-short exposure to CAF diet (3 h/d for 8 days) or a longer-continuous exposure to CAF diet (24 h/d for 15 days).
    Results: During intermittent-short exposure to CAF diet (3 h/d for 8 days), third ventricle injection (ICV) and intra-peritoneal administration of EX4 reduced palatable food intake. Yet, during a longer-continuous exposure to CAF diet (24 h/d for 15 days), only ICV EX4 administration reduced food intake and body weight. However, this exposure to CAF diet blocked the increase in uncoupling protein 1 (UCP1) caused by ICV EX4 administration in mice fed control diet. Finally, GLP1R expression in WAT was minimal, and EX4 failed to increase lipolysis
    Discussion: Exposure to a CAF diet during the early stages of obesity reduces the effects of peripheral and central GLP1R agonists, and WAT does not express a functional GLP1 receptor. These data support that exposure to the obesogenic food environment, without the development or manifestation of obesity, can alter the response to GLP1R agonists. .
    MeSH term(s) Mice ; Animals ; Lipolysis ; Glucagon-Like Peptide-1 Receptor/agonists ; Diet ; Obesity/etiology ; Obesity/metabolism ; Exenatide/pharmacology ; Exenatide/metabolism ; Body Weight ; Glucagon-Like Peptide 1/metabolism ; Adipose Tissue, White/metabolism ; Eating
    Chemical Substances Glucagon-Like Peptide-1 Receptor ; Exenatide (9P1872D4OL) ; Glucagon-Like Peptide 1 (89750-14-1)
    Language English
    Publishing date 2023-05-24
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1164047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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