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  1. Book ; Online ; E-Book: Forensic and clinical forensic autopsy

    Pomara, Cristoforo / Fineschi, Vittorio

    an atlas and handbook

    2021  

    Author's details edited by Cristoforo Pomara, MD, PhD and Vittorio Fineschi, MD, PhD
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (xvi, 210 Seiten), Illustrationen
    Edition Second edition
    Publisher CRC Press
    Publishing place Boca Raton
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020700259
    ISBN 978-1-003-04811-4 ; 9780367330712 ; 1-003-04811-0 ; 0367330717
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Autopsies in COVID-related deaths: The need for following the model of German COVID-19 autopsy registry.

    Pomara, Cristoforo / Salerno, Monica / Miani, Alessandro / Piscitelli, Prisco

    The Lancet regional health. Europe

    2022  Volume 17, Page(s) 100392

    Language English
    Publishing date 2022-05-02
    Publishing country England
    Document type Journal Article
    ISSN 2666-7762
    ISSN (online) 2666-7762
    DOI 10.1016/j.lanepe.2022.100392
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Autopsies in COVID-related deaths

    Cristoforo Pomara / Monica Salerno / Alessandro Miani / Prisco Piscitelli

    The Lancet Regional Health. Europe, Vol 17, Iss , Pp 100392- (2022)

    The need for following the model of German COVID-19 autopsy registry

    2022  

    Keywords Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: miRNA Dysregulation in Cardiovascular Diseases: Current Opinion and Future Perspectives.

    Sessa, Francesco / Salerno, Monica / Esposito, Massimiliano / Cocimano, Giuseppe / Pomara, Cristoforo

    International journal of molecular sciences

    2023  Volume 24, Issue 6

    Abstract: MicroRNAs (miRNAs), small noncoding RNAs, are post-transcriptional gene regulators that can promote the degradation or decay of coding mRNAs, regulating protein synthesis. Many experimental studies have contributed to clarifying the functions of several ... ...

    Abstract MicroRNAs (miRNAs), small noncoding RNAs, are post-transcriptional gene regulators that can promote the degradation or decay of coding mRNAs, regulating protein synthesis. Many experimental studies have contributed to clarifying the functions of several miRNAs involved in regulatory processes at the cardiac level, playing a pivotal role in cardiovascular disease (CVD). This review aims to provide an up-to-date overview, with a focus on the past 5 years, of experimental studies on human samples to present a clear background of the latest advances to summarize the current knowledge and future perspectives. SCOPUS and Web of Science were searched using the following keywords: (miRNA or microRNA) AND (cardiovascular diseases); AND (myocardial infarction); AND (heart damage); AND (heart failure), including studies published from 1 January 2018 to 31 December 2022. After an accurate evaluation, 59 articles were included in the present systematic review. While it is clear that miRNAs are powerful gene regulators, all the underlying mechanisms remain unclear. The need for up-to-date data always justifies the enormous amount of scientific work to increasingly highlight their pathways. Given the importance of CVDs, miRNAs could be important both as diagnostic and therapeutic (theranostic) tools. In this context, the discovery of "TheranoMIRNAs" could be decisive in the near future. The definition of well-setout studies is necessary to provide further evidence in this challenging field.
    MeSH term(s) Humans ; Cardiovascular Diseases/genetics ; Cardiovascular Diseases/drug therapy ; Heart Failure/drug therapy ; MicroRNAs/metabolism ; Myocardial Infarction/genetics ; Myocardial Infarction/drug therapy ; RNA, Messenger/genetics
    Chemical Substances MicroRNAs ; RNA, Messenger
    Language English
    Publishing date 2023-03-08
    Publishing country Switzerland
    Document type Journal Article ; Systematic Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24065192
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: miRNA Dysregulation in Cardiovascular Diseases

    Francesco Sessa / Monica Salerno / Massimiliano Esposito / Giuseppe Cocimano / Cristoforo Pomara

    International Journal of Molecular Sciences, Vol 24, Iss 5192, p

    Current Opinion and Future Perspectives

    2023  Volume 5192

    Abstract: MicroRNAs (miRNAs), small noncoding RNAs, are post-transcriptional gene regulators that can promote the degradation or decay of coding mRNAs, regulating protein synthesis. Many experimental studies have contributed to clarifying the functions of several ... ...

    Abstract MicroRNAs (miRNAs), small noncoding RNAs, are post-transcriptional gene regulators that can promote the degradation or decay of coding mRNAs, regulating protein synthesis. Many experimental studies have contributed to clarifying the functions of several miRNAs involved in regulatory processes at the cardiac level, playing a pivotal role in cardiovascular disease (CVD). This review aims to provide an up-to-date overview, with a focus on the past 5 years, of experimental studies on human samples to present a clear background of the latest advances to summarize the current knowledge and future perspectives. SCOPUS and Web of Science were searched using the following keywords: (miRNA or microRNA) AND (cardiovascular diseases); AND (myocardial infarction); AND (heart damage); AND (heart failure), including studies published from 1 January 2018 to 31 December 2022. After an accurate evaluation, 59 articles were included in the present systematic review. While it is clear that miRNAs are powerful gene regulators, all the underlying mechanisms remain unclear. The need for up-to-date data always justifies the enormous amount of scientific work to increasingly highlight their pathways. Given the importance of CVDs, miRNAs could be important both as diagnostic and therapeutic (theranostic) tools. In this context, the discovery of “TheranoMIRNAs” could be decisive in the near future. The definition of well-setout studies is necessary to provide further evidence in this challenging field.
    Keywords MicroRNAs (miRNAs) ; cardiovascular diseases (CVD) ; myocardial infarction ; heart damage ; heart failure ; TheranoMIRNAs ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: The Post-Lockdown Era: What Is Next in Italy?

    Pomara, Cristoforo / Li Volti, Giovanni / Cappello, Francesco

    Frontiers in pharmacology

    2020  Volume 11, Page(s) 1074

    Keywords covid19
    Language English
    Publishing date 2020-07-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2020.01074
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book: Forensic autopsy

    Pomara, Cristoforo / Karch, Steven B. / Fineschi, Vittorio

    a handbook and atlas

    2010  

    Author's details ed. by Cristoforo Pomara ; Steven B. Karch ; Vittorio Fineschi
    Keywords Autopsy / methods ; Forensic Medicine / methods
    Language English
    Size XIII, 147 S. : überw. Ill., 29 cm
    Publisher CRC Press
    Publishing place Boca Raton u.a.
    Publishing country United States
    Document type Book
    Note Formerly CIP Uk
    HBZ-ID HT016386197
    ISBN 978-1-4398-0064-5 ; 1-4398-0064-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2010 A 3437 order for loan Magazin

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  8. Article ; Online: Indirect DNA Transfer and Forensic Implications: A Literature Review.

    Sessa, Francesco / Pomara, Cristoforo / Esposito, Massimiliano / Grassi, Patrizia / Cocimano, Giuseppe / Salerno, Monica

    Genes

    2023  Volume 14, Issue 12

    Abstract: Progress in DNA profiling techniques has made it possible to detect even the minimum amount of DNA at a crime scene (i.e., a complete DNA profile can be produced using as little as 100 pg of DNA, equivalent to only 15-20 human cells), leading to new ... ...

    Abstract Progress in DNA profiling techniques has made it possible to detect even the minimum amount of DNA at a crime scene (i.e., a complete DNA profile can be produced using as little as 100 pg of DNA, equivalent to only 15-20 human cells), leading to new defense strategies. While the evidence of a DNA trace is seldom challenged in court by a defendant's legal team, concerns are often raised about how the DNA was transferred to the location of the crime. This review aims to provide an up-to-date overview of the experimental work carried out focusing on indirect DNA transfer, analyzing each selected paper, the experimental method, the sampling technique, the extraction protocol, and the main results. Scopus and Web of Science databases were used as the search engines, including 49 papers. Based on the results of this review, one of the factors that influence secondary transfer is the amount of DNA shed by different individuals. Another factor is the type and duration of contact between individuals or objects (generally, more intimate or prolonged contact results in more DNA transfer). A third factor is the nature and quality of the DNA source. However, there are exceptions and variations depending on individual characteristics and environmental conditions. Considering that secondary transfer depends on multiple factors that interact with each other in unpredictable ways, it should be considered a complex and dynamic phenomenon that can affect forensic investigation in various ways, for example, placing a subject at a crime scene who has never been there. Correct methods and protocols are required to detect and prevent secondary transfer from compromising forensic evidence, as well as the correct interpretation through Bayesian networks. In this context, the definition of well-designed experimental studies combined with the use of new forensic techniques could improve our knowledge in this challenging field, reinforcing the value of DNA evidence in criminal trials.
    MeSH term(s) Humans ; Bayes Theorem ; DNA/genetics ; DNA Fingerprinting ; Crime ; Research Design
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2023-11-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes14122153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Autopsy Tool in Unknown Diseases: The Experience with Coronaviruses (SARS-CoV, MERS-CoV, SARS-CoV-2).

    Sessa, Francesco / Salerno, Monica / Pomara, Cristoforo

    Medicina (Kaunas, Lithuania)

    2021  Volume 57, Issue 4

    Abstract: In the last two decades, three unknown pathogens have caused outbreaks, generating severe global health concerns. In 2003, after nucleic acid genotyping, a new virus was named severe acute respiratory syndrome coronavirus (SARS-CoV). After nine years, ... ...

    Abstract In the last two decades, three unknown pathogens have caused outbreaks, generating severe global health concerns. In 2003, after nucleic acid genotyping, a new virus was named severe acute respiratory syndrome coronavirus (SARS-CoV). After nine years, another coronavirus emerged in the middle east and was named MERS-CoV (Middle East Respiratory Syndrome-Coronavirus). Finally, in December 2019, a new unknown coronavirus was isolated from a cluster of patients and was named SARS-CoV-2 (COVID-19, coronavirus disease 2019). This review aims to propose a complete overview of autopsy in the three coronaviruses over the past two decades, showing its pivotal role in the management of unknown diseases. A total of 116 studies fulfilled the inclusion criteria: 14 studies were collected concerning SARS-CoV (87 autopsy reports, from Asian and American countries), 2 studies for MERS-CoV (2 autopsy reports, from Middle-East Asian countries), and 100 studies on SARS-CoV-2 (930 autopsy reports). Analyzing the data obtained on COVID-19, based on the country criterion, a large number of post-mortem investigation were performed in European countries (580 reports), followed by American countries (251 reports). It is interesting to note that no data were found from the Oceanic countries, maybe because of the minor involvement of the outbreak. In all cases, autopsy provided much information about each unknown coronavirus. Despite advanced technologies in the diagnostic fields, to date, autopsy remains the gold standard method to understand the biological features and the pathogenesis of unknown infections, especially when awareness of a pathogen is restricted and the impact on the healthcare system is substantial. The knowledge gained through this technique may positively influence therapeutic strategies, ultimately reducing mortality.
    MeSH term(s) Autopsy ; COVID-19/pathology ; Coronavirus Infections/pathology ; Humans ; Middle East Respiratory Syndrome Coronavirus ; Severe acute respiratory syndrome-related coronavirus ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome/pathology
    Language English
    Publishing date 2021-03-25
    Publishing country Switzerland
    Document type Journal Article ; Systematic Review
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina57040309
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Autopsy Tool in Unknown Diseases

    Francesco Sessa / Monica Salerno / Cristoforo Pomara

    Medicina, Vol 57, Iss 309, p

    The Experience with Coronaviruses (SARS-CoV, MERS-CoV, SARS-CoV-2)

    2021  Volume 309

    Abstract: In the last two decades, three unknown pathogens have caused outbreaks, generating severe global health concerns. In 2003, after nucleic acid genotyping, a new virus was named severe acute respiratory syndrome coronavirus (SARS-CoV). After nine years, ... ...

    Abstract In the last two decades, three unknown pathogens have caused outbreaks, generating severe global health concerns. In 2003, after nucleic acid genotyping, a new virus was named severe acute respiratory syndrome coronavirus (SARS-CoV). After nine years, another coronavirus emerged in the middle east and was named MERS-CoV (Middle East Respiratory Syndrome—Coronavirus). Finally, in December 2019, a new unknown coronavirus was isolated from a cluster of patients and was named SARS-CoV-2 (COVID-19, coronavirus disease 2019). This review aims to propose a complete overview of autopsy in the three coronaviruses over the past two decades, showing its pivotal role in the management of unknown diseases. A total of 116 studies fulfilled the inclusion criteria: 14 studies were collected concerning SARS-CoV (87 autopsy reports, from Asian and American countries), 2 studies for MERS-CoV (2 autopsy reports, from Middle-East Asian countries), and 100 studies on SARS-CoV-2 (930 autopsy reports). Analyzing the data obtained on COVID-19, based on the country criterion, a large number of post-mortem investigation were performed in European countries (580 reports), followed by American countries (251 reports). It is interesting to note that no data were found from the Oceanic countries, maybe because of the minor involvement of the outbreak. In all cases, autopsy provided much information about each unknown coronavirus. Despite advanced technologies in the diagnostic fields, to date, autopsy remains the gold standard method to understand the biological features and the pathogenesis of unknown infections, especially when awareness of a pathogen is restricted and the impact on the healthcare system is substantial. The knowledge gained through this technique may positively influence therapeutic strategies, ultimately reducing mortality.
    Keywords autopsy ; unknown diseases ; SARS-CoV ; MERS-CoV ; SARS-CoV-2 ; COVID-19 ; Medicine (General) ; R5-920
    Subject code 306
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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