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Article ; Online: Injury mechanism of COVID-19-induced cardiac complications.

Leng, Ling / Bian, Xiu-Wu

2023 Volume 8, Issue 3, Page(s) 159–166

Abstract: Heart dysfunction is one of the most life-threatening organ dysfunctions caused by coronavirus disease 2019 (COVID-19). Myocardial or cardiovascular damage is the most common extrapulmonary organ complication in critically ill patients. Understanding the ...

Abstract	Heart dysfunction is one of the most life-threatening organ dysfunctions caused by coronavirus disease 2019 (COVID-19). Myocardial or cardiovascular damage is the most common extrapulmonary organ complication in critically ill patients. Understanding the pathogenesis and pathological characteristics of myocardial and vascular injury is important for improving clinical diagnosis and treatment approach. Herein, the mechanism of direct damage caused by severe acute respiratory syndrome coronavirus 2 to the heart and secondary damage caused by virus-driven inflammation was reviewed. The pathological mechanism of ischemia and hypoxia due to microthrombosis and inflammatory injury as well as the injury mechanism of tissue inflammation and single myocardial cell necrosis triggered by the viral infection of pericytes or macrophages, hypoxia, and energy metabolism disorders were described. The latter can provide a novel diagnosis, treatment, and investigation strategy for heart dysfunctions caused by COVID-19 or the Omicron variant.
Language	English
Publishing date	2023-06-23
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2987027-6
ISSN	2470-752X ; 2470-7511
ISSN (online)	2470-752X
ISSN	2470-7511
DOI	10.1097/CP9.0000000000000055
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Autopsy of COVID-19 patients in China.

Bian, Xiu-Wu

National science review

2020 Volume 7, Issue 9, Page(s) 1414–1418

Language	English
Publishing date	2020-06-06
Publishing country	China
Document type	Journal Article
ZDB-ID	2745465-4
ISSN	2053-714X ; 2053-714X
ISSN (online)	2053-714X
ISSN	2053-714X
DOI	10.1093/nsr/nwaa123
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Article: Autopsy of COVID-19 victims in China

Bian, Xiu-Wu

National Science Review

Abstract: Distribution of SARS-CoV-2 virus and pathological features of multiple organs in COVID-19 patients remains unclear, which interferes with the improvement of COVID-19 diagnosis and treatment In this article, we summarize the pathological findings obtained ...

Abstract	Distribution of SARS-CoV-2 virus and pathological features of multiple organs in COVID-19 patients remains unclear, which interferes with the improvement of COVID-19 diagnosis and treatment In this article, we summarize the pathological findings obtained from systematic autopsy (37 cases) and percutaneous multiple organ biopsy (“minimally invasive autopsy”, 54 cases) These findings should shed light on better understanding of the progression of COVID-19 infection and the means of more effective intervention
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #548542
Database	COVID19

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Article ; Online: An Immunocompetent Hafnium Oxide-Based STING Nanoagonist for Cancer Radio-immunotherapy.

Cao, Yuhua / Ding, Shuaishuai / Hu, Yunping / Zeng, Lijuan / Zhou, Jingrong / Lin, Ling / Zhang, Xiao / Ma, Qinghua / Cai, Ruili / Zhang, Yu / Duan, Guangjie / Bian, Xiu-Wu / Tian, Gan

ACS nano

2024 Volume 18, Issue 5, Page(s) 4189–4204

Abstract: cGAS-STING signaling plays a critical role in radiotherapy (RT)-mediated immunomodulation. However, RT alone is insufficient to sustain STING activation in tumors under a safe X-ray dose. Here, we propose a radiosensitization cooperated with cGAS ... ...

Abstract	cGAS-STING signaling plays a critical role in radiotherapy (RT)-mediated immunomodulation. However, RT alone is insufficient to sustain STING activation in tumors under a safe X-ray dose. Here, we propose a radiosensitization cooperated with cGAS stimulation strategy by engineering a core-shell structured nanosized radiosensitizer-based cGAS-STING agonist, which is constituted with the hafnium oxide (HfO
MeSH term(s)	Humans ; Manganese Compounds/pharmacology ; Oxides/pharmacology ; Oxides/therapeutic use ; Immunotherapy ; Neoplasms/drug therapy ; Neoplasms/radiotherapy ; Nucleotidyltransferases ; Hafnium
Chemical Substances	hafnium oxide (3C4Z4KG52T) ; Manganese Compounds ; Oxides ; Nucleotidyltransferases (EC 2.7.7.-) ; Hafnium (X71938L1DO)
Language	English
Publishing date	2024-01-09
Publishing country	United States
Document type	Journal Article
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.3c09293
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Article ; Online: A Lactate-Depleting metal organic framework-based nanocatalyst reinforces intratumoral T cell response to boost anti-PD1 immunotherapy.

Zhou, Jingrong / Hu, Yunping / Cao, Yuhua / Ding, Shuaishuai / Zeng, Lijuan / Zhang, Yu / Cao, Mianfu / Duan, Guangjie / Zhang, Xiao / Bian, Xiu-Wu / Tian, Gan

Journal of colloid and interface science

2024 Volume 660, Page(s) 869–884

Abstract: Infiltration and activation of intratumoral T lymphocytes are critical for immune checkpoint blockade (ICB) therapy. Unfortunately, the low tumor immunogenicity and immunosuppressive tumor microenvironment (TME) induced by tumor metabolic reprogramming ... ...

Abstract	Infiltration and activation of intratumoral T lymphocytes are critical for immune checkpoint blockade (ICB) therapy. Unfortunately, the low tumor immunogenicity and immunosuppressive tumor microenvironment (TME) induced by tumor metabolic reprogramming cooperatively hinder the ICB efficacy. Herein, we engineered a lactate-depleting MOF-based catalytic nanoplatform (LOX@ZIF-8@MPN), encapsulating lactate oxidase (LOX) within zeolitic imidazolate framework-8 (ZIF-8) coupled with a coating of metal polyphenol network (MPN) to reinforce T cell response based on a "two birds with one stone" strategy. LOX could catalyze the degradation of the immunosuppressive lactate to promote vascular normalization, facilitating T cell infiltration. On the other hand, hydrogen peroxide (H
MeSH term(s)	Humans ; Lactic Acid/pharmacology ; Metal-Organic Frameworks/pharmacology ; Hydrogen Peroxide/pharmacology ; T-Lymphocytes ; Immunotherapy ; Cell Line, Tumor ; Neoplasms ; Tumor Microenvironment
Chemical Substances	Lactic Acid (33X04XA5AT) ; Metal-Organic Frameworks ; Hydrogen Peroxide (BBX060AN9V)
Language	English
Publishing date	2024-01-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2024.01.129
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Article ; Online: Disorganized adrenocortical zonational structure in COVID-19 patients: Implications of critical illness duration.

Wen, Tian-Zi / Fu, Wen-Juan / Xiao, Shi-Qi / Wang, Shuai / Li, Tian-Ran / Chen, Xin-Yu / Chen, He-Yuan / Luo, Jie / Bian, Xiu-Wu / Yao, Xiao-Hong

Pathology, research and practice

2024 Volume 256, Page(s) 155251

Abstract: Aberrant adrenal function has been frequently reported in COVID-19 patients, but histopathological evidence remains limited. This retrospective autopsy study aims to scrutinize the impact of COVID-19 duration on adrenocortical zonational architecture and ...

Abstract	Aberrant adrenal function has been frequently reported in COVID-19 patients, but histopathological evidence remains limited. This retrospective autopsy study aims to scrutinize the impact of COVID-19 duration on adrenocortical zonational architecture and peripheral corticosteroid reactivity. The adrenal glands procured from 15 long intensive care unit (ICU)-stay COVID-19 patients, 9 short ICU-stay COVID-19 patients, and 20 matched controls. Subjects who had received glucocorticoid treatment prior to sampling were excluded. Applying hematoxylin and eosin (H&E) and immunohistochemical (IHC) staining, we disclosed that the adrenocortical zonational structure was substantially disorganized in COVID-19 patients, which long ICU-stay patients manifested a higher prevalence of severe disorganization (67%) than short ICU-stay patients (11%; P = 0.0058). The adrenal cortex of COVID-19 patients exhibited a 40% decrease in the zona glomerulosa (ZG) area and a 74% increase in the zona fasciculata (ZF) area (both P < 0.0001) relative to controls. Furthermore, among long ICU-stay COVID-19 patients, the ZG area diminished by 31% (P = 0.0004), and the ZF area expanded by 27% (P = 0.0004) in comparison to short ICU-stay patients. The zona reticularis (ZR) area remained unaltered. Nuclear translocation of corticosteroid receptors in the liver and kidney of long ICU-stay COVID-19 patients was at least 43% lower than in short ICU-stay patients (both P < 0.05). These findings underscore the necessity for clinicians to monitor adrenal function in long-stay COVID-19 patients.
MeSH term(s)	Humans ; Critical Illness ; Retrospective Studies ; COVID-19 ; Adrenal Cortex ; Adrenal Glands ; Adrenal Cortex Hormones
Chemical Substances	Adrenal Cortex Hormones
Language	English
Publishing date	2024-03-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	391889-0
ISSN	1618-0631 ; 0344-0338
ISSN (online)	1618-0631
ISSN	0344-0338
DOI	10.1016/j.prp.2024.155251
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Article: Primary pulmonary hyalinizing clear cell carcinoma with fusions of both EWSR1::CREM and IRF2::NTRK3: report of a case with an aggressive behavior.

Wu, You-Li / Wu, Feng / Cao, Mian-Fu / Lan, Yang / Du, Ming-Shan / Yu, Song-Tao / Wang, Yan / Yan, Xiao-Chu / Bian, Xiu-Wu / Duan, Guang-Jie

Frontiers in oncology

2023 Volume 13, Page(s) 1175279

Abstract: Primary pulmonary hyalinizing clear cell carcinoma (HCCC) is a rare salivary gland-type tumor newly recognized in recent years, with approximately 21 cases reported to date in the English literature, which constitutes a challenge in pathology diagnosis, ... ...

Abstract	Primary pulmonary hyalinizing clear cell carcinoma (HCCC) is a rare salivary gland-type tumor newly recognized in recent years, with approximately 21 cases reported to date in the English literature, which constitutes a challenge in pathology diagnosis, particularly in small biopsy specimens. Here, we present a case of pulmonary HCCC diagnosed by computed tomography-guided percutaneous lung biopsy in a 70-year-old man's right lower lung. Although the morphology and immunophenotype of the tumor suggested the diagnosis of mucoepidermoid carcinoma, fluorescence
Language	English
Publishing date	2023-05-17
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1175279
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Article ; Online: FANCD2 deficiency sensitizes SHH medulloblastoma to radiotherapy via ferroptosis.

Zhou, Hong / Wang, Yan-Xia / Wu, Min / Lan, Xi / Xiang, Dongfang / Cai, Ruili / Ma, Qinghua / Miao, Jingya / Fang, Xuanyu / Wang, Junjie / Luo, Dan / He, Zhicheng / Cui, Youhong / Liang, Ping / Wang, Yan / Bian, Xiu-Wu

The Journal of pathology

2024 Volume 262, Issue 4, Page(s) 427–440

Abstract: Radiotherapy is one of the standard therapeutic regimens for medulloblastoma (MB). Tumor cells utilize DNA damage repair (DDR) mechanisms to survive and develop resistance during radiotherapy. It has been found that targeting DDR sensitizes tumor cells ... ...

Abstract	Radiotherapy is one of the standard therapeutic regimens for medulloblastoma (MB). Tumor cells utilize DNA damage repair (DDR) mechanisms to survive and develop resistance during radiotherapy. It has been found that targeting DDR sensitizes tumor cells to radiotherapy in several types of cancer, but whether and how DDR pathways are involved in the MB radiotherapy response remain to be determined. Single-cell RNA sequencing was carried out on 38 MB tissues, followed by expression enrichment assays. Fanconi anemia group D2 gene (FANCD2) expression was evaluated in MB samples and public MB databases. The function of FANCD2 in MB cells was examined using cell counting assays (CCK-8), clone formation, lactate dehydrogenase activity, and in mouse orthotopic models. The FANCD2-related signaling pathway was investigated using assays of peroxidation, a malondialdehyde assay, a reduced glutathione assay, and using FerroOrange to assess intracellular iron ions (Fe
MeSH term(s)	Mice ; Animals ; Humans ; Medulloblastoma/genetics ; Medulloblastoma/radiotherapy ; Fanconi Anemia ; Ferroptosis/genetics ; Hedgehog Proteins/genetics ; Hedgehog Proteins/metabolism ; Cerebellar Neoplasms/genetics ; Cerebellar Neoplasms/radiotherapy ; Cell Line, Tumor ; Fanconi Anemia Complementation Group D2 Protein/genetics
Chemical Substances	Hedgehog Proteins ; SHH protein, human ; FANCD2 protein, human ; Fanconi Anemia Complementation Group D2 Protein
Language	English
Publishing date	2024-01-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3119-7
ISSN	1096-9896 ; 0022-3417
ISSN (online)	1096-9896
ISSN	0022-3417
DOI	10.1002/path.6245
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Article ; Online: Stabilization of Pin1 by USP34 promotes Ubc9 isomerization and protein sumoylation in glioma stem cells.

Zhu, Qiuhong / Liang, Panpan / Meng, Hao / Li, Fangzhen / Miao, Wei / Chu, Cuiying / Wang, Wei / Li, Dongxue / Chen, Cong / Shi, Yu / Yu, Xingjiang / Ping, Yifang / Niu, Chaoshi / Wu, Hai-Bo / Zhang, Aili / Bian, Xiu-Wu / Zhou, Wenchao

Nature communications

2024 Volume 15, Issue 1, Page(s) 40

Abstract: The peptidyl-prolyl cis-trans isomerase Pin1 is a pivotal therapeutic target in cancers, but the regulation of Pin1 protein stability is largely unknown. High Pin1 expression is associated with SUMO1-modified protein hypersumoylation in glioma stem cells ...

Abstract	The peptidyl-prolyl cis-trans isomerase Pin1 is a pivotal therapeutic target in cancers, but the regulation of Pin1 protein stability is largely unknown. High Pin1 expression is associated with SUMO1-modified protein hypersumoylation in glioma stem cells (GSCs), but the underlying mechanisms remain elusive. Here we demonstrate that Pin1 is deubiquitinated and stabilized by USP34, which promotes isomerization of the sole SUMO E2 enzyme Ubc9, leading to SUMO1-modified hypersumoylation to support GSC maintenance. Pin1 interacts with USP34, a deubiquitinase with preferential expression and oncogenic function in GSCs. Such interaction is facilitated by Plk1-mediated phosphorylation of Pin1. Disruption of USP34 or inhibition of Plk1 promotes poly-ubiquitination and degradation of Pin1. Furthermore, Pin1 isomerizes Ubc9 to upregulate Ubc9 thioester formation with SUMO1, which requires CDK1-mediated phosphorylation of Ubc9. Combined inhibition of Pin1 and CDK1 with sulfopin and RO3306 most effectively suppresses orthotopic tumor growth. Our findings provide multiple molecular targets to induce Pin1 degradation and suppress hypersumoylation for cancer treatment.
MeSH term(s)	Humans ; NIMA-Interacting Peptidylprolyl Isomerase/genetics ; NIMA-Interacting Peptidylprolyl Isomerase/metabolism ; Peptidylprolyl Isomerase/genetics ; Peptidylprolyl Isomerase/metabolism ; Sumoylation ; Isomerism ; Phosphorylation ; Glioma/genetics ; Neoplastic Stem Cells/metabolism ; Ubiquitin-Specific Proteases/metabolism
Chemical Substances	NIMA-Interacting Peptidylprolyl Isomerase ; Peptidylprolyl Isomerase (EC 5.2.1.8) ; USP34 protein, human (EC 3.4.19.12) ; Ubiquitin-Specific Proteases (EC 3.4.19.12)
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-44349-x
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Article ; Online: Stabilization of Pin1 by USP34 promotes Ubc9 isomerization and protein sumoylation in glioma stem cells

Qiuhong Zhu / Panpan Liang / Hao Meng / Fangzhen Li / Wei Miao / Cuiying Chu / Wei Wang / Dongxue Li / Cong Chen / Yu Shi / Xingjiang Yu / Yifang Ping / Chaoshi Niu / Hai-bo Wu / Aili Zhang / Xiu-wu Bian / Wenchao Zhou

Nature Communications, Vol 15, Iss 1, Pp 1-

2024 Volume 19

Abstract: Abstract The peptidyl-prolyl cis-trans isomerase Pin1 is a pivotal therapeutic target in cancers, but the regulation of Pin1 protein stability is largely unknown. High Pin1 expression is associated with SUMO1-modified protein hypersumoylation in glioma ... ...

Abstract	Abstract The peptidyl-prolyl cis-trans isomerase Pin1 is a pivotal therapeutic target in cancers, but the regulation of Pin1 protein stability is largely unknown. High Pin1 expression is associated with SUMO1-modified protein hypersumoylation in glioma stem cells (GSCs), but the underlying mechanisms remain elusive. Here we demonstrate that Pin1 is deubiquitinated and stabilized by USP34, which promotes isomerization of the sole SUMO E2 enzyme Ubc9, leading to SUMO1-modified hypersumoylation to support GSC maintenance. Pin1 interacts with USP34, a deubiquitinase with preferential expression and oncogenic function in GSCs. Such interaction is facilitated by Plk1-mediated phosphorylation of Pin1. Disruption of USP34 or inhibition of Plk1 promotes poly-ubiquitination and degradation of Pin1. Furthermore, Pin1 isomerizes Ubc9 to upregulate Ubc9 thioester formation with SUMO1, which requires CDK1-mediated phosphorylation of Ubc9. Combined inhibition of Pin1 and CDK1 with sulfopin and RO3306 most effectively suppresses orthotopic tumor growth. Our findings provide multiple molecular targets to induce Pin1 degradation and suppress hypersumoylation for cancer treatment.
Keywords	Science ; Q
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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