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  1. Book ; Thesis: Detektion beziehungsweise Ausschluss von Lebermetastasen mit SonoVue-verstärktem Ultraschall im Vergleich zu konventionellem Ultraschall, Computertomographie und Magnetresonanztomographie bei Patienten mit extrahepatischem Primärtumor

    Hirschbühl, Klaus Hubert

    Ergebnisse des Ulmer Kollektivs einer Multicenter-Studie

    2005  

    Author's details vorgelegt von Klaus Hubert Hirschbühl
    Language German
    Size II, 57 Bl. : Ill.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Ulm, Univ., Diss., 2005
    HBZ-ID HT014503311
    Database Catalogue ZB MED Medicine, Health

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    2005 E 1369 order for loan Magazin

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  2. Article: Pure White Cell Aplasia Associated With Long-Term Unprotected Exposure to High Concentrations of Benzalkonium Chloride and 2-Phenoxyethanol.

    Lutz, Mathias / Neumann, Daniel T / Farfán López, Francisco / Pfeiffer, Tim / Hirschbühl, Klaus

    Cureus

    2023  Volume 15, Issue 11, Page(s) e49473

    Abstract: Pure white cell aplasia (PWCA) is a very rare hematological disorder with a nearly total absence of granulocytes and their precursor cells. While the disease is rarely diagnosed incidentally in otherwise asymptomatic individuals, most patients suffer ... ...

    Abstract Pure white cell aplasia (PWCA) is a very rare hematological disorder with a nearly total absence of granulocytes and their precursor cells. While the disease is rarely diagnosed incidentally in otherwise asymptomatic individuals, most patients suffer from sometimes life-threatening infections. Due to its very low incidence, the precise pathomechanism of PWCA still needs to be elucidated. While most cases reported in the literature have been associated with an underlying thymic or autoimmune disease, some other factors including the intake of certain drugs such as antimicrobial agents or immune checkpoint inhibitors have been identified as potential triggers. Since PWCA is commonly refractory to treatment with granulocyte colony-stimulating factors (G-CSF), the main focus lies in identifying and eliminating the underlying trigger. Here, we report a unique case where the development of PWCA in a 56-year-old man with an upper respiratory tract infection has to be attributed to the long-term unprotected exposure to an industrial detergent containing high concentrations of the preservatives benzalkonium chloride (BAC) and 2-phenoxyethanol (2-PE). As a matter of fact, certain hematotoxic potential has been described in the literature for both BAC and 2-PE.
    Language English
    Publishing date 2023-11-27
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.49473
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: BCR-ABL1-negative myeloproliferative Neoplasien (MPN)

    Hirschbühl, Klaus / Claus, Rainer

    TumorDiagnostik & Therapie

    2020  Volume 41, Issue 04, Page(s) 235–239

    Language German
    Publishing date 2020-05-01
    Publisher © Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2072365-9
    ISSN 1439-1279 ; 0722-219X
    ISSN (online) 1439-1279
    ISSN 0722-219X
    DOI 10.1055/a-1103-8760
    Database Thieme publisher's database

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  4. Article ; Online: NGS-basierte Molekulargenetik der Leukämie – ein leistungsfähiger und dezentraler Lösungsansatz.

    Dintner, Sebastian / Schmutz, Maximilian / Sommer, Sebastian / Langer, Angela / Hirschbühl, Klaus / Claus, Rainer / Schmid, Christoph / Trepel, Martin / Märkl, Bruno

    Pathologie (Heidelberg, Germany)

    2023  Volume 44, Issue Suppl 3, Page(s) 155–159

    Abstract: The diagnosis of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), originally based on morphological assessment alone, has to bring together more and more disciplines. Today, modern AML/MDS diagnostics rely on cytomorphology, cytochemistry, ...

    Title translation NGS-based molecular genetics of leukemia-a powerful and decentralized approach.
    Abstract The diagnosis of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), originally based on morphological assessment alone, has to bring together more and more disciplines. Today, modern AML/MDS diagnostics rely on cytomorphology, cytochemistry, immunophenotyping, cytogenetics, and molecular genetics. Only the integration of all these methods allows a comprehensive and complementary characterization of each case, which is a prerequisite for optimal AML/MDS diagnosis and treatment. In the following, we present why multidisciplinary and local diagnosis is essential today and will become even more important in the future, especially in the context of precision medicine. We present our idea and strategy implemented at Augsburg University Hospital, which has realized multidisciplinary diagnostics in AML/MDS in an interdisciplinary and decentralized approach. In particular, this includes the recent technical advances that molecular genetics provides with modern methods. The enormous amount of data generated by these techniques represents a major challenge, but also a unique opportunity. We will reflect on how this increase in knowledge can be integrated into routine practice to lead the way for personalized medicine in AML/MDS to improve patient care.
    MeSH term(s) Humans ; Leukemia, Myeloid, Acute/diagnosis ; Myelodysplastic Syndromes/diagnosis ; Forecasting ; Precision Medicine ; Molecular Biology
    Language German
    Publishing date 2023-11-17
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ISSN 2731-7196
    ISSN (online) 2731-7196
    DOI 10.1007/s00292-023-01268-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Autopsy of patients with COVID-19: A balance of fear and curiosity.

    Hirschbühl, Klaus / Schaller, Tina / Kling, Elisabeth / Märkl, Bruno / Claus, Rainer

    Pathology, research and practice

    2020  Volume 216, Issue 8, Page(s) 153039

    MeSH term(s) Autopsy ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Exploratory Behavior ; Fear ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-31
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 391889-0
    ISSN 1618-0631 ; 0344-0338
    ISSN (online) 1618-0631
    ISSN 0344-0338
    DOI 10.1016/j.prp.2020.153039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: NTRK-Fusions - A new kid on the block.

    Märkl, Bruno / Hirschbühl, Klaus / Dhillon, Christine

    Pathology, research and practice

    2019  Volume 215, Issue 10, Page(s) 152572

    Abstract: The neurotrophic tyrosine receptor kinases (NTRK) play an important role in the development and function of the nervous system. Fusions involving NTRK and a wide range of genes that act as fusion partners are oncogenic and activate well-known signal ... ...

    Abstract The neurotrophic tyrosine receptor kinases (NTRK) play an important role in the development and function of the nervous system. Fusions involving NTRK and a wide range of genes that act as fusion partners are oncogenic and activate well-known signal transduction pathways like the MAPK-ERK pathway. NTRK fusions occur in many very different tumor entities in children and youth as well as in adults. There are a few tumors like secretory breast cancer and congenital fibrosarcoma for which NTRK fusions are pathognomonic. At the same time there a large number of tumors in which NTRK fusions occur in very rare frequency (e.g., lung cancer). TRK inhibitors offer now the possibility to use NTRK fusion as antitumorigenic targets in a tumor agnostic fashion regardless of the basic histology. It is the task of modern pathology to identify such targetable fusions in a highly effective and efficient manner.
    MeSH term(s) Humans ; Neoplasms/genetics ; Neoplasms/pathology ; Oncogene Fusion ; Receptor Protein-Tyrosine Kinases/genetics
    Chemical Substances Receptor Protein-Tyrosine Kinases (EC 2.7.10.1)
    Language English
    Publishing date 2019-08-01
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 391889-0
    ISSN 1618-0631 ; 0344-0338
    ISSN (online) 1618-0631
    ISSN 0344-0338
    DOI 10.1016/j.prp.2019.152572
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Granulomatous dermatitis: a rare pitfall in lymphoma staging with [

    Enke, Johanna S / Gäble, Alexander / Reitsam, Nic G / Schaller, Tina / Trepel, Martin / Hirschbühl, Klaus / Welzel, Julia / Dierks, Alexander / Kircher, Malte / Lapa, Constantin

    European journal of nuclear medicine and molecular imaging

    2023  Volume 50, Issue 11, Page(s) 3479–3480

    MeSH term(s) Humans ; Positron Emission Tomography Computed Tomography ; Fluorodeoxyglucose F18 ; Positron-Emission Tomography ; Radiopharmaceuticals ; Lymphoma/diagnostic imaging ; Lymphoma/pathology ; Dermatitis/diagnostic imaging ; Dermatitis/pathology ; Neoplasm Staging
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Radiopharmaceuticals
    Language English
    Publishing date 2023-05-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-023-06284-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: All-Body-Cavity (ABC)-scopy-An approach for a feasible method of minimally invasive autopsy to allow for postmortem tissue sampling in cases where a conventional autopsy is denied.

    Rentschler, Lukas / Märkl, Bruno / Schaller, Tina / Hirschbühl, Klaus / Kleinlein, Irene / Dintner, Sebastian / Waidhauser, Johanna / Wolf, Sebastian / Golling, Christian / Vlasenko, Dmytro

    Pathology, research and practice

    2022  Volume 241, Page(s) 154263

    Abstract: Objectives: The decreasing autopsy numbers in many western countries have been partially attributed to the invasiveness of the autopsy, which causes relatives to decline postmortem examination. This issue has been addressed by developing methods of ... ...

    Abstract Objectives: The decreasing autopsy numbers in many western countries have been partially attributed to the invasiveness of the autopsy, which causes relatives to decline postmortem examination. This issue has been addressed by developing methods of minimally or non-invasive autopsy, which could be shown to increase acceptance for autopsies. The aim of this study is to compare the All-Body-Cavity-scopy (ABC-scopy) to conventional autopsies for diagnostic accuracy.
    Methods: The ABC-scopy is an endoscopic approach for minimally invasive autopsy involving laparoscopic and thoracoscopic evaluation of the accessible organs, followed by excision biopsies of relevant organs and conspicuous findings. The method was performed in 10 cases on deceased patients scheduled for autopsy, each followed by a conventional autopsy.
    Results: The results gathered from ABC-scopy through observation and histopathological evaluation provided an acceptable diagnostic accuracy in 9 out of 10 autopsies when compared to those of the conventional autopsy for diagnostic findings.
    Conclusions: The ABC-scopy is a feasible approach for minimally invasive autopsy that provides acceptable diagnostic value. Despite its minimally invasive nature, the procedure enables representative histology through providing large size excision biopsies from intraabdominal and thoracic organs, which is especially useful for examining disseminated diseases such as metastasized tumors.
    MeSH term(s) Humans ; Autopsy/methods ; Laparoscopy/methods ; Biopsy/methods
    Language English
    Publishing date 2022-12-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 391889-0
    ISSN 1618-0631 ; 0344-0338
    ISSN (online) 1618-0631
    ISSN 0344-0338
    DOI 10.1016/j.prp.2022.154263
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  9. Article ; Online: Postmortem Examination of Patients With COVID-19.

    Schaller, Tina / Hirschbühl, Klaus / Burkhardt, Katrin / Braun, Georg / Trepel, Martin / Märkl, Bruno / Claus, Rainer

    JAMA

    2020  Volume 323, Issue 24, Page(s) 2518–2520

    MeSH term(s) Aged ; Aged, 80 and over ; Autopsy ; Betacoronavirus/isolation & purification ; COVID-19 ; Coronavirus Infections/pathology ; Female ; Humans ; Liver/pathology ; Lung/pathology ; Male ; Middle Aged ; Myocardium/pathology ; Pandemics ; Pneumonia, Viral/pathology ; Respiratory System/virology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2020.8907
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Quantitative multiorgan proteomics of fatal COVID-19 uncovers tissue-specific effects beyond inflammation.

    Schweizer, Lisa / Schaller, Tina / Zwiebel, Maximilian / Karayel, Özge / Müller-Reif, Johannes Bruno / Zeng, Wen-Feng / Dintner, Sebastian / Nordmann, Thierry M / Hirschbühl, Klaus / Märkl, Bruno / Claus, Rainer / Mann, Matthias

    EMBO molecular medicine

    2023  Volume 15, Issue 9, Page(s) e17459

    Abstract: SARS-CoV-2 may directly and indirectly damage lung tissue and other host organs, but there are few system-wide, untargeted studies of these effects on the human body. Here, we developed a parallelized mass spectrometry (MS) proteomics workflow enabling ... ...

    Abstract SARS-CoV-2 may directly and indirectly damage lung tissue and other host organs, but there are few system-wide, untargeted studies of these effects on the human body. Here, we developed a parallelized mass spectrometry (MS) proteomics workflow enabling the rapid, quantitative analysis of hundreds of virus-infected FFPE tissues. The first layer of response to SARS-CoV-2 in all tissues was dominated by circulating inflammatory molecules. Beyond systemic inflammation, we differentiated between systemic and true tissue-specific effects to reflect distinct COVID-19-associated damage patterns. Proteomic changes in the lungs resembled those of diffuse alveolar damage (DAD) in non-COVID-19 patients. Extensive organ-specific changes were also evident in the kidneys, liver, and lymphatic and vascular systems. Secondary inflammatory effects in the brain were related to rearrangements in neurotransmitter receptors and myelin degradation. These MS-proteomics-derived results contribute substantially to our understanding of COVID-19 pathomechanisms and suggest strategies for organ-specific therapeutic interventions.
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Proteomics ; Inflammation ; Lung
    Language English
    Publishing date 2023-07-31
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2467145-9
    ISSN 1757-4684 ; 1757-4676
    ISSN (online) 1757-4684
    ISSN 1757-4676
    DOI 10.15252/emmm.202317459
    Database MEDical Literature Analysis and Retrieval System OnLINE

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