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Article: SARS-CoV-2, Uncontrolled Diabetes and Corticosteroids-An Unholy Trinity in Invasive Fungal Infections of the Maxillofacial Region? A Retrospective, Multi-centric Analysis.

Moorthy, Aditya / Gaikwad, Rohith / Krishna, Shreya / Hegde, Raghuraj / Tripathi, K K / Kale, Preeti G / Rao, P Subramanya / Haldipur, Deepak / Bonanthaya, Krishnamurthy

Journal of maxillofacial and oral surgery

2021 Volume 20, Issue 3, Page(s) 418–425

Abstract: Objectives: Collate and analyse data of maxillofacial/rhino-cerebro-orbital fungal infections reported during the era of the Covid-19 pandemic, with the aim of investigating the common contributing factors leading to such infections and of highlighting ... ...

Abstract	Objectives: Collate and analyse data of maxillofacial/rhino-cerebro-orbital fungal infections reported during the era of the Covid-19 pandemic, with the aim of investigating the common contributing factors leading to such infections and of highlighting the significance of this surge seen in patients infected with SARS-CoV-2. Method: This retrospective observational multi-centric study analysed patient data collected from clinicians belonging to different specialties in Bangalore, India. The data included the presentation and management of patients presenting with aggressive maxillofacial and rhino-cerebro-orbital fungal infections and explored the relationship between SARS-CoV-2, corticosteroid administration and uncontrolled diabetes mellitus. Results: All 18 patients were Covid positive. Sixteen of the 18 patients received steroids for Covid treatment and 16 patients were diabetic (of whom 15 patients who were diabetics received steroids for Covid-19 treatment). Loss of vision was noted in 12 of the 18 patients and 7 of them underwent orbital exenteration. The fungi noted was mucormycosis in 16 patients, aspergillosis in 1 patient and a mixed fungal infection in 1 patient. Eleven of the patients survived, 6 died and 1 was lost to follow-up. There was a significantly higher incidence of diabetes ( Conclusion: Despite the limited sample size, it is evident that there is a significant increase in the incidence of angioinvasive maxillofacial fungal infections in diabetic patients treated for SARS-CoV-2 with a strong association with corticosteroid administration.
Language	English
Publishing date	2021-03-06
Publishing country	India
Document type	Journal Article
ZDB-ID	2502352-4
ISSN	0974-942X ; 0972-8279
ISSN (online)	0974-942X
ISSN	0972-8279
DOI	10.1007/s12663-021-01532-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Simultaneous determination of vasicine and vasicinone by High-performance liquid chromatography in roots of eight

Subramanya, M D / Pai, Sandeep R / Ankad, Gireesh M / Hegde, Harsha V / Roy, Subarna / Hoti, S L

Ayu

2017 Volume 37, Issue 2, Page(s) 135–139

Abstract: Introduction: Sida: Aim: The present study aims toward simultaneous determination of two bioactive compounds vasicine and vasicinone in root extracts of eight : Materials and methods: Determination of vasicine and vasicinone was undertaken in ... ...

Abstract	Introduction: Sida Aim: The present study aims toward simultaneous determination of two bioactive compounds vasicine and vasicinone in root extracts of eight Materials and methods: Determination of vasicine and vasicinone was undertaken in methanolic root extracts (10% w/v) of Results: Both calibration curves of standard showed good linear regression ( Conclusion: HPLC method provides simple, accurate, and reproducible quantitative analysis for simultaneous determination of vasicine and vasicinone. Among the selected
Language	English
Publishing date	2017-10-30
Publishing country	India
Document type	Journal Article
ISSN	0974-8520
ISSN	0974-8520
DOI	10.4103/ayu.AYU_49_16
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Book ; Thesis: Modulation of dendritic cell function by Interleukin-6

Hegde, Subramanya

2003

Author's details	von Subramanya Hegde
Language	English
Size	105 S, Ill., graph. Darst
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Univ., Diss.--Köln, 2003
Database	Former special subject collection: coastal and deep sea fishing

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Book ; Thesis: Modulation of dendritic cell function by Interleukin-6

Hegde, Subramanya

2003

Author's details	von Subramanya Hegde
Language	English
Size	105 S, Ill., graph. Darst
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Univ., Diss.--Köln, 2003
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article: Identification of 2-Pyridinylindole-Based Dual Antagonists of Toll-like Receptors 7 and 8 (TLR7/8).

Sreekantha, Ratna Kumar / Mussari, Christopher P / Dodd, Dharmpal S / Pasunoori, Laxman / Hegde, Subramanya / Posy, Shana L / Critton, David / Ruepp, Stefan / Subramanian, Murali / Salter-Cid, Luisa M / Tagore, Debarati Mazumder / Sarodaya, Sanket / Dudhgaonkar, Shailesh / Poss, Michael A / Schieven, Gary L / Carter, Percy H / Macor, John E / Dyckman, Alaric J

ACS medicinal chemistry letters

2022 Volume 13, Issue 5, Page(s) 812–818

Abstract: The toll-like receptors (TLRs) play key roles in activation of the innate immune system. Aberrant activation of TLR7 and TLR8 pathways can occur in the context of autoimmune disorders due to the elevated presence and recognition of self-RNA as activating ...

Abstract	The toll-like receptors (TLRs) play key roles in activation of the innate immune system. Aberrant activation of TLR7 and TLR8 pathways can occur in the context of autoimmune disorders due to the elevated presence and recognition of self-RNA as activating ligands. Control of this unintended activation via inhibition of TLR7/8 signaling holds promise for the treatment of diseases such as psoriasis, arthritis, and lupus. Optimization of a 2-pyridinylindole series of compounds led to the identification of potent dual inhibitors of TLR7 and TLR8, which demonstrated good selectivity against TLR9 and other family members. The in vitro characterization and in vivo evaluation in rodent pharmacokinetic/pharmacodynamic and efficacy studies of BMS-905 is detailed, along with structural information obtained through X-ray cocrystallographic studies.
Language	English
Publishing date	2022-04-25
Publishing country	United States
Document type	Journal Article
ISSN	1948-5875
ISSN	1948-5875
DOI	10.1021/acsmedchemlett.2c00049
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Article: Novel Co–Ni–graphene composite electrodes for hydrogen production

Subramanya, B / Bhat, D. K / Hegde, A. C / Shenoy, S. U / Ullal, Y

RSC advances. 2015 May 26, v. 5, no. 59

2015

Abstract: Active, stable and cost-effective electrocatalysts are key to water splitting for hydrogen production through electrolysis. Herein, we report the facile preparation of highly porous Co–Ni–graphene (Co–Ni–G) composite electrodes by electrodeposition for ... ...

Abstract	Active, stable and cost-effective electrocatalysts are key to water splitting for hydrogen production through electrolysis. Herein, we report the facile preparation of highly porous Co–Ni–graphene (Co–Ni–G) composite electrodes by electrodeposition for electrocatalytic applications. The incorporation of graphene into the Co–Ni matrix enhances the catalyst's activity for the hydrogen evolution reaction (HER) in an alkaline solution. The best coating exhibits a maximum current density of −850 mA cm−2 at −1.6 V, which is approximately 4 times better than that of the binary Co–Ni alloy indicating higher activity for hydrogen production. The addition of graphene to an electrolyte bath results in a porous encapsulated bundle of alloy nano-particles within the graphene network which effectively increases the electrochemically active surface area. As indicated by XPS analysis results, on addition of graphene the Co(0) and Ni(0) content in the deposit increases and as a result both cobalt/cobalt oxide and nickel/nickel oxide sites are evenly distributed on the Co–Ni–G electrode surface which is responsible for increased HER activity. The Tafel slope analysis showed that the HER follows a Volmer–Tafel mechanism. The structure–property relationship of the Co–Ni–G composite coating has been discussed by interpreting field emission scanning electron microscopy (FESEM), X-ray photoelectron spectroscopy (XPS) and X-ray diffraction (XRD) analysis results.
Keywords	alloys ; catalysts ; catalytic activity ; coatings ; cobalt ; cobalt oxide ; cost effectiveness ; electrochemistry ; electrodes ; electrolysis ; electrolytes ; encapsulation ; graphene ; hydrogen production ; nanoparticles ; nickel ; nickel oxide ; scanning electron microscopy ; surface area ; X-ray diffraction ; X-ray photoelectron spectroscopy
Language	English
Dates of publication	2015-0526
Size	p. 47398-47407.
Publishing place	The Royal Society of Chemistry
Document type	Article
ISSN	2046-2069
DOI	10.1039/c5ra07627g
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Trans-vivo delayed type hypersensitivity assay for antigen specific regulation.

Jankowska-Gan, Ewa / Hegde, Subramanya / Burlingham, William J

Journal of visualized experiments : JoVE

2013 , Issue 75, Page(s) e4454

Abstract: Delayed-type hypersensitivity response (DTH) is a rapid in vivo manifestation of T cell-dependent immune response to a foreign antigen (Ag) that the host immune system has experienced in the recent past. DTH reactions are often divided into a ... ...

Abstract	Delayed-type hypersensitivity response (DTH) is a rapid in vivo manifestation of T cell-dependent immune response to a foreign antigen (Ag) that the host immune system has experienced in the recent past. DTH reactions are often divided into a sensitization phase, referring to the initial antigen experience, and a challenge phase, which usually follows several days after sensitization. The lack of a delayed-type hypersensitivity response to a recall Ag demonstrated by skin testing is often regarded as an evidence of anergy. The traditional DTH assay has been effectively used in diagnosing many microbial infections. Despite sharing similar immune features such as lymphocyte infiltration, edema, and tissue necrosis, the direct DTH is not a feasible diagnostic technique in transplant patients because of the possibility of direct injection resulting in sensitization to donor antigens and graft loss. To avoid this problem, the human-to-mouse "trans-vivo" DTH assay was developed (1,2). This test is essentially a transfer DTH assay, in which human peripheral blood mononuclear cells (PBMCs) and specific antigens were injected subcutaneously into the pinnae or footpad of a naïve mouse and DTH-like swelling is measured after 18-24 hr (3). The antigen presentation by human antigen presenting cells such as macrophages or DCs to T cells in highly vascular mouse tissue triggers the inflammatory cascade and attracts mouse immune cells resulting in swelling responses. The response is antigen-specific and requires prior antigen sensitization. A positive donor-reactive DTH response in the Tv-DTH assay reflects that the transplant patient has developed a pro-inflammatory immune disposition toward graft alloantigens. The most important feature of this assay is that it can also be used to detect regulatory T cells, which cause bystander suppression. Bystander suppression of a DTH recall response in the presence of donor antigen is characteristic of transplant recipients with accepted allografts (2,4-14). The monitoring of transplant recipients for alloreactivity and regulation by Tv-DTH may identify a subset of patients who could benefit from reduction of immunosuppression without elevated risk of rejection or deteriorating renal function. A promising area is the application of the Tv-DTH assay in monitoring of autoimmunity(15,16) and also in tumor immunology (17).
MeSH term(s)	Animals ; Antigens/administration & dosage ; Antigens/immunology ; Autoimmunity ; Epitopes ; Graft Rejection/immunology ; Graft Rejection/prevention & control ; Humans ; Hypersensitivity, Delayed/immunology ; Immunologic Tests/methods ; Immunosuppression/methods ; Kidney Transplantation/methods ; Leukocytes, Mononuclear/immunology ; Mice ; Models, Animal ; T-Lymphocytes, Regulatory/immunology ; Transplantation Immunology
Chemical Substances	Antigens ; Epitopes
Language	English
Publishing date	2013-05-02
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Video-Audio Media
ZDB-ID	2259946-0
ISSN	1940-087X ; 1940-087X
ISSN (online)	1940-087X
ISSN	1940-087X
DOI	10.3791/4454
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Article ; Online: Cervical Cancer-Instructed Stromal Fibroblasts Enhance IL23 Expression in Dendritic Cells to Support Expansion of Th17 Cells.

Walch-Rückheim, Barbara / Ströder, Russalina / Theobald, Laura / Pahne-Zeppenfeld, Jennifer / Hegde, Subramanya / Kim, Yoo-Jin / Bohle, Rainer Maria / Juhasz-Böss, Ingolf / Solomayer, Erich-Franz / Smola, Sigrun

Cancer research

2019 Volume 79, Issue 7, Page(s) 1573–1586

Abstract: Persistent infection with high-risk human papillomavirus (HPV) is a prerequisite for the development of cervical cancer. HPV-transformed cells actively instruct their microenvironment, promoting chronic inflammation and cancer progression. We previously ... ...

Abstract	Persistent infection with high-risk human papillomavirus (HPV) is a prerequisite for the development of cervical cancer. HPV-transformed cells actively instruct their microenvironment, promoting chronic inflammation and cancer progression. We previously demonstrated that cervical cancer cells contribute to Th17 cell recruitment, a cell type with protumorigenic properties. In this study, we analyzed the expression of the Th17-promoting cytokine IL23 in the cervical cancer micromilieu and found CD83
MeSH term(s)	Coculture Techniques ; Dendritic Cells/metabolism ; Female ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Humans ; Immunologic Memory ; Interleukin-23 Subunit p19/metabolism ; Interleukins/metabolism ; Th17 Cells/cytology ; Th17 Cells/immunology ; Uterine Cervical Neoplasms/metabolism ; Uterine Cervical Neoplasms/pathology
Chemical Substances	IL23A protein, human ; Interleukin-23 Subunit p19 ; Interleukins
Language	English
Publishing date	2019-01-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1432-1
ISSN	1538-7445 ; 0008-5472
ISSN (online)	1538-7445
ISSN	0008-5472
DOI	10.1158/0008-5472.CAN-18-1913
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Article: Total polyphenolic contents and in vitro antioxidant properties of eight Sida species from Western Ghats, India.

Subramanya, M D / Pai, Sandeep R / Upadhya, Vinayak / Ankad, Gireesh M / Bhagwat, Shalini S / Hegde, Harsha V

Journal of Ayurveda and integrative medicine

2015 Volume 6, Issue 1, Page(s) 24–28

Abstract: Background: Sida L., is a medicinally important genus, the species of which are widely used in traditional systems of medicine in India. Pharmacologically, roots are known for anti-tumor, anti-HIV, hepatoprotective, and many other properties. Phenolic ... ...

Abstract	Background: Sida L., is a medicinally important genus, the species of which are widely used in traditional systems of medicine in India. Pharmacologically, roots are known for anti-tumor, anti-HIV, hepatoprotective, and many other properties. Phenolic antioxidants help in reducing oxidative stress occurring during treatment of such diseases. Objective: The study aimed to evaluate and compare polyphenol contents and antioxidant properties of eight selected species of Sida from Western Ghats, India. Materials and methods: Methanolic root extracts (10% w/v) of Sida species, viz., S. acuta, S. cordata, S. cordifolia, S. indica, S. mysorensis, S. retusa, S. rhombifolia, and S. spinosa were analyzed. Results: Sida cordifolia possessed highest total phenolic content (TPC: 1.92 ± 0.10 mg Caffeic Acid Equivalent/g and 2.13 ± 0.11 mg Tannic Acid Equivalant/g), total flavonoid content (TF: 2.60 ± 0.13 mg Quercetin Equivalent/g) and also possessed highest antioxidant activities in 2,2-diphenylpicrylhydrazyl (DPPH) radical scavenging (51.31 ± 2.57% Radical Scavenging Activity, (RSA); Trolox Equivalent Antioxidant Capacity: 566.25 ± 28.31μM; Ascorbic acid Equivalent Antioxidant Capacity: 477.80 ± 23.89 μM) and Ferric Reducing Antioxidant Power assays (TEAC: 590.67 ± 29.53 μM; AEAC: 600.67 ± 30.03 μM). Unlike DPPH and Ferric Reducing Antioxidant Power (FRAP) activity, 2, 2'-Azinobis (3-ethyl Benzo Thiazoline-6-Sulfonic acid) ABTS(+) antioxidant activity was highest in S. indica (TEAC: 878.44 ± 43.92 μM; AEAC 968.44 ± 48.42 μM). It was significant to note that values of AEAC (μM) for all the antioxidant activities analyzed were higher than that of TEAC. Conclusion: The high contents of phenolic compounds in the root extracts of selected Sida species have direct correlation with their antioxidant properties. Conclusively, roots of S. cordifolia can be considered as the potential source of polyphenols and antioxidants.
Language	English
Publishing date	2015-04-16
Publishing country	United States
Document type	Journal Article
ISSN	0975-9476
ISSN	0975-9476
DOI	10.4103/0975-9476.146544
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Article ; Online: Natural killer T cells: innate lymphocytes positioned as a bridge between acute and chronic inflammation?

Fox, Lisa / Hegde, Subramanya / Gumperz, Jenny E

Microbes and infection

2010 Volume 12, Issue 14-15, Page(s) 1125–1133

Abstract: Natural killer T cells are an innate population of T lymphocytes that recognize antigens derived from host lipids and glycolipids. In this review, we focus on how these unique T cells are positioned to influence both acute and chronic inflammatory ... ...

Abstract	Natural killer T cells are an innate population of T lymphocytes that recognize antigens derived from host lipids and glycolipids. In this review, we focus on how these unique T cells are positioned to influence both acute and chronic inflammatory processes through their early recruitment to sites of inflammation, interactions with myeloid antigen presenting cells, and recognition of lipids associated with inflammation.
MeSH term(s)	Antigen-Presenting Cells/immunology ; Glycolipids/metabolism ; Humans ; Inflammation/immunology ; Inflammation/pathology ; Natural Killer T-Cells/immunology
Chemical Substances	Glycolipids
Language	English
Publishing date	2010-09-17
Publishing country	France
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	1465093-9
ISSN	1769-714X ; 1286-4579
ISSN (online)	1769-714X
ISSN	1286-4579
DOI	10.1016/j.micinf.2010.08.011
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