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  1. Article ; Online: Masquerader of Lip Angioedema After Lip Injection.

    Hsu, Chih-Hsin / Requena, Luis / LeBoit, Philip E / Gernez, Yael

    The journal of allergy and clinical immunology. In practice

    2021  Volume 9, Issue 6, Page(s) 2472–2473

    MeSH term(s) Angioedema/diagnosis ; Humans ; Injections ; Lip
    Language English
    Publishing date 2021-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2020.12.058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Clinical and biological response to rituximab treatment in 3 patients with acquired C1-inhibitor deficiency.

    Busse, Paula J / Gernez, Yael

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2017  Volume 119, Issue 4, Page(s) 380–382

    Language English
    Publishing date 2017-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2017.07.032
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  3. Article ; Online: Masqueraders of angioedema after a dental procedure.

    Lee, Ivan T / Arioka, Masaki / Kleinman, Sara H / Gernez, Yael

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2020  Volume 124, Issue 6, Page(s) 536–541

    MeSH term(s) Angioedema/diagnosis ; Angioedema/etiology ; Child, Preschool ; Diagnosis, Differential ; Female ; Humans ; Postoperative Complications ; Pulpotomy/adverse effects ; Pulpotomy/methods ; Risk Factors ; Symptom Assessment
    Language English
    Publishing date 2020-03-20
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2020.03.008
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  4. Article ; Online: Dupilumab use in recalcitrant allergic fungal rhinosinusitis.

    Lo, Rachelle M / Liu, Anne Y / Valdez, Tulio A / Gernez, Yael

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2020  Volume 125, Issue 5, Page(s) 617–619

    MeSH term(s) Adolescent ; Antibodies, Monoclonal, Humanized/therapeutic use ; Fungi/isolation & purification ; Humans ; Magnetic Resonance Imaging ; Male ; Mycoses/diagnosis ; Mycoses/drug therapy ; Rhinitis, Allergic, Perennial/diagnosis ; Rhinitis, Allergic, Perennial/drug therapy ; Rhinitis, Allergic, Perennial/microbiology ; Sinusitis/diagnosis ; Sinusitis/drug therapy ; Sinusitis/microbiology ; Tomography, X-Ray Computed
    Chemical Substances Antibodies, Monoclonal, Humanized ; dupilumab (420K487FSG)
    Language English
    Publishing date 2020-07-21
    Publishing country United States
    Document type Case Reports ; Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2020.07.014
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  5. Article ; Online: Immunotherapy for Food Allergy: Are We There Yet?

    Gernez, Yael / Nowak-Węgrzyn, Anna

    The journal of allergy and clinical immunology. In practice

    2017  Volume 5, Issue 2, Page(s) 250–272

    Abstract: Current clinical research focuses on food allergen-specific immunotherapy through oral (OIT), sublingual (SLIT), or epicutaneous (EPIT) routes. Immunotherapy relies on the delivery of gradually increasing doses of specific allergens to induce ... ...

    Abstract Current clinical research focuses on food allergen-specific immunotherapy through oral (OIT), sublingual (SLIT), or epicutaneous (EPIT) routes. Immunotherapy relies on the delivery of gradually increasing doses of specific allergens to induce desensitization (defined as temporary antigen hyporesponsiveness that depends on regular food ingestion) and, ultimately, tolerance (defined as the ability to ingest food without symptoms despite prolonged periods of avoidance or irregular intake). Although the majority of the patients treated with OIT achieve desensitization, only a minority achieves tolerance. OIT involves higher maintenance doses of food protein (300 mg-4g) compared with SLIT (2.5-7.5 mg) and EPIT (250-500 mcg). OIT efficacy is higher compared with SLIT, but OIT is associated with higher rate of systemic adverse events compared with SLIT and EPIT. OIT is also associated with a minor risk of eosinophilic esophagitis. Combined treatment of OIT and anti-IgE monoclonal antibody has improved safety but not efficacy compared with OIT alone. Early initiation of peanut OIT in peanut-allergic infants and young children may afford superior efficacy and safety. In this review, we discuss the allergen-specific strategies currently explored for the treatment of food allergy, including immunotherapy with native and heat-modified food proteins. Additional research employs strategies to improve the safety and efficacy of allergen immunotherapy through modifications of allergen structure and addition of immunomodulatory adjuvants.
    MeSH term(s) Allergens/immunology ; Allergens/therapeutic use ; Animals ; Child ; Desensitization, Immunologic/adverse effects ; Desensitization, Immunologic/methods ; Desensitization, Immunologic/trends ; Food Hypersensitivity/immunology ; Food Hypersensitivity/therapy ; Hot Temperature ; Humans ; Immune Tolerance ; Treatment Outcome
    Chemical Substances Allergens
    Language English
    Publishing date 2017-03-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2016.12.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Immunogenicity of a third COVID-19 messenger RNA vaccine dose in primary immunodeficiency disorder patients with functional B-cell defects.

    Gernez, Yael / Murugesan, Kanagavel / Cortales, Cristina R / Banaei, Niaz / Hoyte, Lisa / Pinsky, Benjamin A / Lewis, David B / Pham, Michele N

    The journal of allergy and clinical immunology. In practice

    2022  Volume 10, Issue 5, Page(s) 1385–1388.e2

    MeSH term(s) COVID-19/prevention & control ; COVID-19 Vaccines ; Humans ; Primary Immunodeficiency Diseases/genetics ; RNA, Messenger ; Vaccines, Synthetic ; mRNA Vaccines
    Chemical Substances COVID-19 Vaccines ; RNA, Messenger ; Vaccines, Synthetic ; mRNA Vaccines
    Language English
    Publishing date 2022-03-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2022.02.030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Case report: Refractory Evans syndrome in two patients with spondyloenchondrodysplasia with immune dysregulation treated successfully with JAK1/JAK2 inhibition.

    Gernez, Yael / Narula, Mansi / Cepika, Alma-Martina / Valdes Camacho, Juanita / Hoyte, Elisabeth G / Mouradian, Kirsten / Glader, Bertil / Singh, Deepika / Sathi, Bindu / Rao, Latha / Tolin, Ana L / Weinberg, Kenneth I / Lewis, David B / Bacchetta, Rosa / Weinacht, Katja G

    Frontiers in immunology

    2024  Volume 14, Page(s) 1328005

    Abstract: Biallelic mutations in ... ...

    Abstract Biallelic mutations in the
    MeSH term(s) Humans ; Tartrate-Resistant Acid Phosphatase/genetics ; Immunoglobulin G ; Janus Kinase 1 ; Janus Kinase 2 ; Autoimmune Diseases ; Anemia, Hemolytic, Autoimmune ; Osteochondrodysplasias ; Immunologic Deficiency Syndromes ; Thrombocytopenia
    Chemical Substances Tartrate-Resistant Acid Phosphatase (EC 3.1.3.2) ; Immunoglobulin G ; JAK1 protein, human (EC 2.7.10.2) ; Janus Kinase 1 (EC 2.7.10.2) ; JAK2 protein, human (EC 2.7.10.2) ; Janus Kinase 2 (EC 2.7.10.2)
    Language English
    Publishing date 2024-01-29
    Publishing country Switzerland
    Document type Review ; Case Reports
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1328005
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  8. Article ; Online: Mimickers of Classical Urticaria: Cryopyrin-Associated Autoinflammatory Syndrome Presenting as Isolated Urticaria in an Infant.

    Solomon, Benjamin D / Skaljic, Meliha / Liu, Lucy Y / Yan, Di / Sheahon, Kathleen M / Broderick, Lori / Hoffman, Hal M / Beres, Shannon J / Brown, Ryanne A / Teng, Joyce M C / Gernez, Yael

    The journal of allergy and clinical immunology. In practice

    2023  Volume 11, Issue 3, Page(s) 941–942

    MeSH term(s) Infant ; Humans ; Urticaria/diagnosis ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; Cryopyrin-Associated Periodic Syndromes/diagnosis ; Mutation/genetics
    Chemical Substances NLR Family, Pyrin Domain-Containing 3 Protein
    Language English
    Publishing date 2023-01-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2022.12.037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Variability in diagnosis and management of acquired cold-induced urticaria.

    Gernez, Yael / Sicherer, Scott H / Wang, Julie

    The journal of allergy and clinical immunology. In practice

    2018  Volume 6, Issue 4, Page(s) 1396–1399

    MeSH term(s) Biological Variation, Population ; Cold Temperature/adverse effects ; Female ; Humans ; Male ; Practice Patterns, Physicians'/statistics & numerical data ; Surveys and Questionnaires ; United States/epidemiology ; Urticaria/diagnosis ; Urticaria/etiology ; Urticaria/therapy
    Language English
    Publishing date 2018-03-09
    Publishing country United States
    Document type Letter
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2017.12.030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 7086: Show issues Location:
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  10. Article ; Online: Immunotherapy for Food Allergy: Are We There Yet?

    Gernez, Yael / Nowak-Węgrzyn, Anna

    American Academy of Allergy, Asthma & Immunology The Journal of Allergy and Clinical Immunology: In Practice. 2017,

    2017  

    Abstract: Current clinical research focuses on food allergen-specific immunotherapy through oral (OIT), sublingual (SLIT), or epicutaneous (EPIT) routes. Immunotherapy relies on the delivery of gradually increasing doses of specific allergens to induce ... ...

    Abstract Current clinical research focuses on food allergen-specific immunotherapy through oral (OIT), sublingual (SLIT), or epicutaneous (EPIT) routes. Immunotherapy relies on the delivery of gradually increasing doses of specific allergens to induce desensitization (defined as temporary antigen hyporesponsiveness that depends on regular food ingestion) and, ultimately, tolerance (defined as the ability to ingest food without symptoms despite prolonged periods of avoidance or irregular intake). Although the majority of the patients treated with OIT achieve desensitization, only a minority achieves tolerance. OIT involves higher maintenance doses of food protein (300 mg-4g) compared with SLIT (2.5-7.5 mg) and EPIT (250-500 mcg). OIT efficacy is higher compared with SLIT, but OIT is associated with higher rate of systemic adverse events compared with SLIT and EPIT. OIT is also associated with a minor risk of eosinophilic esophagitis. Combined treatment of OIT and anti-IgE monoclonal antibody has improved safety but not efficacy compared with OIT alone. Early initiation of peanut OIT in peanut-allergic infants and young children may afford superior efficacy and safety. In this review, we discuss the allergen-specific strategies currently explored for the treatment of food allergy, including immunotherapy with native and heat-modified food proteins. Additional research employs strategies to improve the safety and efficacy of allergen immunotherapy through modifications of allergen structure and addition of immunomodulatory adjuvants.
    Keywords Food allergy ; Immunotherapy ; Food immunotherapy ; OIT ; Oral immunotherapy ; SLIT ; Sublingual immunotherapy ; EPIT ; Epicutaneous immunotherapy ; AE ; AR ; DBPC ; DBPCFC ; EoE ; FA ; GI ; HydE ; OFC ; QoL ; SPT ; SCD ; SU ; Treg ; VP100 ; VP250
    Language English
    Publishing place Elsevier Inc.
    Document type Article ; Online
    Note Pre-press version
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2016.12.004
    Database NAL-Catalogue (AGRICOLA)

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