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  1. Article ; Online: Contribuição à herpetologia da Argentina e do Rio Grande do Sul, Brasil por William Wright Milstead (Amphibia, Reptilia) Contribution to the herpetology of Argentina and Rio Grande do Sul, Brazil by William Wright Milstead (Amphibia, Reptilia)

    Thales de Lema / Pedro Canísio Braun

    Revista Brasileira de Zoologia, Vol 10, Iss 2, Pp 261-

    1993  Volume 287

    Abstract: In this paper we are presenting the list of the specimens and the taxa obtained; there are 73 names of species belonging to 40 genera, of which 32 species and 13 genera are amphibians, and 42 species and 27 genera are reptiles. There are several field ... ...

    Abstract In this paper we are presenting the list of the specimens and the taxa obtained; there are 73 names of species belonging to 40 genera, of which 32 species and 13 genera are amphibians, and 42 species and 27 genera are reptiles. There are several field notes of Milstead and many data on the snakes studied by Lema with Milstead. The collection was widespread by Milstead to several institutions, but mainly to Field Museum of Natural History, Chicago, and Museu Nacional do Rio de Janeiro, Brazil.
    Keywords Zoogeography ; Amphibia ; Reptilia ; Argentina ; Brazil ; Science ; Q ; Zoology ; QL1-991
    Language English
    Publishing date 1993-01-01T00:00:00Z
    Publisher Sociedade Brasileira de Zoologia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  2. Book: William Shakespeare

    Bendach, Traute / Braun, Alfred / Kinski, Klaus / Schlegel, August Wilhelm von / Shakespeare, William / Stöckel, Otto

    : das Hörspielarchiv auf 40 CDs

    2006  

    Institution Der Bayerische Rundfunk
    Author's details Bayerischer Rundfunk
    Language German
    Size 2 CDs (83 Min.), 12 cm
    Publisher Random House Audio
    Publishing place Köln
    Document type Book
    Note Die Vorlage enth. insgesamt 2 Werke ; Produktion: Berliner Rundfunk, 1949
    Accompanying material 1 Beibl. ([4] S.)
    Database Former special subject collection: coastal and deep sea fishing

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  3. Book ; Thesis: William Shakespeares "King Lear" in seinen Fassungen

    Braun-Rau, Alexandra / Shakespeare, William

    ein elektronisch-dialogisches Editionsmodell

    (Beihefte zu Editio ; 20)

    2004  

    Author's details Alexandra Braun-Rau
    Series title Beihefte zu Editio ; 20
    Keywords Fassung ; Edition ; Elektronisches Editieren
    Language German
    Size XII, 173 S., Ill.
    Publisher Niemeyer
    Publishing place Tübingen
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--München, 2001
    ISBN 3484295201 ; 9783484295209
    Database Former special subject collection: coastal and deep sea fishing

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  4. Article ; Online: Advances in autosomal dominant polycystic kidney disease-2014 and beyond.

    Braun, William E

    Cleveland Clinic journal of medicine

    2014  Volume 81, Issue 9, Page(s) 545–556

    Abstract: Autosomal dominant polycystic kidney disease (ADPKD), which frequently leads to end-stage renal disease, currently has no specific drug therapies. Better understanding of its pathogenesis and recent clinical trials have led to more accurate diagnosis of ... ...

    Abstract Autosomal dominant polycystic kidney disease (ADPKD), which frequently leads to end-stage renal disease, currently has no specific drug therapies. Better understanding of its pathogenesis and recent clinical trials have led to more accurate diagnosis of the disease and its manifestations, as well as to promising new approaches to treatment.
    MeSH term(s) Drug Discovery ; Humans ; Hypertension/etiology ; Intracranial Aneurysm/etiology ; Pain/etiology ; Polycystic Kidney, Autosomal Dominant/complications ; Polycystic Kidney, Autosomal Dominant/diagnosis ; Polycystic Kidney, Autosomal Dominant/etiology ; Polycystic Kidney, Autosomal Dominant/metabolism ; Polycystic Kidney, Autosomal Dominant/therapy ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism ; Urinary Tract Infections/etiology ; Vasopressins/antagonists & inhibitors ; Vasopressins/metabolism
    Chemical Substances Vasopressins (11000-17-2) ; MTOR protein, human (EC 2.7.1.1) ; TOR Serine-Threonine Kinases (EC 2.7.1.1)
    Language English
    Publishing date 2014-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 639116-3
    ISSN 1939-2869 ; 0891-1150
    ISSN (online) 1939-2869
    ISSN 0891-1150
    DOI 10.3949/ccjm.81gr.14001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Extracellular domain, hinge, and transmembrane determinants affecting surface CD4 expression of a novel anti-HIV chimeric antigen receptor (CAR) construct.

    Zenere, Giorgio / Wu, Chengxiang / Midkiff, Cecily C / Johnson, Nathan M / Grice, Christopher P / Wimley, William C / Kaur, Amitinder / Braun, Stephen E

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Chimeric antigen receptor (CAR)-T cells have demonstrated clinical potential, but current receptors still need improvements to be successful against chronic HIV infection. In this study, we address some requirements of CAR motifs for strong surface ... ...

    Abstract Chimeric antigen receptor (CAR)-T cells have demonstrated clinical potential, but current receptors still need improvements to be successful against chronic HIV infection. In this study, we address some requirements of CAR motifs for strong surface expression of a novel anti-HIV CAR by evaluating important elements in the extracellular, hinge, and transmembrane (TM) domains. When combining a truncated CD4 extracellular domain and CD8α hinge/TM, the novel CAR did not express extracellularly but was detectable intracellularly. By shortening the CD8α hinge, CD4-CAR surface expression was partially recovered and addition of the LYC motif at the end of the CD8α TM fully recovered both intracellular and extracellular CAR expression. Mutation of LYC to TTA or TTC showed severe abrogation of CAR expression by flow cytometry and confocal microscopy. Additionally, we determined that CD4-CAR surface expression could be maximized by the removal of FQKAS motif at the junction of the extracellular domain and the hinge region. CD4-CAR surface expression also resulted in cytotoxic CAR T cell killing of HIV Env
    Language English
    Publishing date 2023-10-26
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.10.25.563930
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: CITEViz: interactively classify cell populations in CITE-Seq via a flow cytometry-like gating workflow using R-Shiny.

    Kong, Garth L / Nguyen, Thai T / Rosales, Wesley K / Panikar, Anjali D / Cheney, John H W / Lusardi, Theresa A / Yashar, William M / Curtiss, Brittany M / Carratt, Sarah A / Braun, Theodore P / Maxson, Julia E

    BMC bioinformatics

    2024  Volume 25, Issue 1, Page(s) 142

    Abstract: Background: The rapid advancement of new genomic sequencing technology has enabled the development of multi-omic single-cell sequencing assays. These assays profile multiple modalities in the same cell and can often yield new insights not revealed with ... ...

    Abstract Background: The rapid advancement of new genomic sequencing technology has enabled the development of multi-omic single-cell sequencing assays. These assays profile multiple modalities in the same cell and can often yield new insights not revealed with a single modality. For example, Cellular Indexing of Transcriptomes and Epitopes by Sequencing (CITE-Seq) simultaneously profiles the RNA transcriptome and the surface protein expression. The surface protein markers in CITE-Seq can be used to identify cell populations similar to the iterative filtration process in flow cytometry, also called "gating", and is an essential step for downstream analyses and data interpretation. While several packages allow users to interactively gate cells, they often do not process multi-omic sequencing datasets and may require writing redundant code to specify gate boundaries. To streamline the gating process, we developed CITEViz which allows users to interactively gate cells in Seurat-processed CITE-Seq data. CITEViz can also visualize basic quality control (QC) metrics allowing for a rapid and holistic evaluation of CITE-Seq data.
    Results: We applied CITEViz to a peripheral blood mononuclear cell CITE-Seq dataset and gated for several major blood cell populations (CD14 monocytes, CD4 T cells, CD8 T cells, NK cells, B cells, and platelets) using canonical surface protein markers. The visualization features of CITEViz were used to investigate cellular heterogeneity in CD14 and CD16-expressing monocytes and to detect differential numbers of detected antibodies per patient donor. These results highlight the utility of CITEViz to enable the robust classification of single cell populations.
    Conclusions: CITEViz is an R-Shiny app that standardizes the gating workflow in CITE-Seq data for efficient classification of cell populations. Its secondary function is to generate basic feature plots and QC figures specific to multi-omic data. The user interface and internal workflow of CITEViz uniquely work together to produce an organized workflow and sensible data structures for easy data retrieval. This package leverages the strengths of biologists and computational scientists to assess and analyze multi-omic single-cell datasets. In conclusion, CITEViz streamlines the flow cytometry gating workflow in CITE-Seq data to help facilitate novel hypothesis generation.
    MeSH term(s) Humans ; Software ; Sequence Analysis, RNA/methods ; Workflow ; Leukocytes, Mononuclear ; Flow Cytometry ; Membrane Proteins ; Single-Cell Analysis/methods ; Gene Expression Profiling/methods
    Chemical Substances Membrane Proteins
    Language English
    Publishing date 2024-04-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041484-5
    ISSN 1471-2105 ; 1471-2105
    ISSN (online) 1471-2105
    ISSN 1471-2105
    DOI 10.1186/s12859-024-05762-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: In Situ Smoothing of Facets on Spalled GaAs(100) Substrates during OMVPE Growth of III-V Epilayers, Solar Cells, and Other Devices: The Impact of Surface Impurities/Dopants.

    McMahon, William E / Braun, Anna K / Perna, Allison N / Coll, Pablo G / Schulte, Kevin L / Boyer, Jacob T / Neumann, Anica N / Geisz, John F / Warren, Emily L / Ptak, Aaron J / Merkle, Arno P / Bertoni, Mariana I / Packard, Corinne E / Steiner, Myles A

    Crystal growth & design

    2024  Volume 24, Issue 8, Page(s) 3218–3227

    Abstract: One possible pathway toward reducing the cost of III-V solar cells is to remove them from their growth substrate by spalling fracture, and then reuse the substrate for the growth of multiple cells. Here we consider the growth of III-V cells on spalled ... ...

    Abstract One possible pathway toward reducing the cost of III-V solar cells is to remove them from their growth substrate by spalling fracture, and then reuse the substrate for the growth of multiple cells. Here we consider the growth of III-V cells on spalled GaAs(100) substrates, which typically have faceted surfaces after spalling. To facilitate the growth of high-quality cells, these faceted surfaces should be smoothed prior to cell growth. In this study, we show that these surfaces can be smoothed during organometallic vapor-phase epitaxy growth, but the choice of epilayer material and modification of the various surfaces by impurities/dopants greatly impacts whether or not the surface becomes smooth, and how rapidly the smoothing occurs. Representative examples are presented along with a discussion of the underlying growth processes. Although this work was motivated by solar cell growth, the methods are generally applicable to the growth of any III-V device on a nonplanar substrate.
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article
    ISSN 1528-7483
    ISSN 1528-7483
    DOI 10.1021/acs.cgd.3c01407
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: mTOR inhibitors and autosomal dominant polycystic kidney disease.

    Braun, William E

    The New England journal of medicine

    2011  Volume 364, Issue 3, Page(s) 287; author reply 287–8

    MeSH term(s) Everolimus ; Female ; Glomerular Filtration Rate ; Humans ; Kidney/drug effects ; Kidney/pathology ; Male ; Organ Size/drug effects ; Polycystic Kidney, Autosomal Dominant/drug therapy ; Polycystic Kidney, Autosomal Dominant/pathology ; Polycystic Kidney, Autosomal Dominant/physiopathology ; Sirolimus/analogs & derivatives ; Sirolimus/therapeutic use ; TOR Serine-Threonine Kinases/antagonists & inhibitors
    Chemical Substances Everolimus (9HW64Q8G6G) ; TOR Serine-Threonine Kinases (EC 2.7.1.1) ; Sirolimus (W36ZG6FT64)
    Language English
    Publishing date 2011-01-20
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1010845#SA3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Backgrounds and Trainings in Cannabis Therapeutics of Dispensary Personnel.

    Braun, Ilana M / Nayak, Manan M / Roberts, Jane E / Chai, Peter R / Tulsky, James A / Abrams, Donald I / Pirl, William

    JCO oncology practice

    2022  Volume 18, Issue 11, Page(s) e1787–e1795

    Abstract: Purpose: A growing body of scientific research indicates that oncology teams tend to offer individuals with cancer little clinical advice regarding medicinal cannabis (MC) and that individuals with cancer instead turn to cannabis dispensaries for MC ... ...

    Abstract Purpose: A growing body of scientific research indicates that oncology teams tend to offer individuals with cancer little clinical advice regarding medicinal cannabis (MC) and that individuals with cancer instead turn to cannabis dispensaries for MC guidance. Our objective was to investigate dispensary personnel's backgrounds and trainings in MC advising.
    Methods: The study design was semistructured interviews across 13 states with cannabis dispensary personnel in managerial or client-facing positions. Of 38 recruited, 26 (68%) completed interview. The primary outcome was training in MC advising. Researchers targeted thematic saturation and adhered to Consolidated Criteria for Reporting Qualitative Research.
    Results: Of 26 participants, 54% were female, with an average age of 40 (range: 22-64) years. Half worked in client-facing roles; half worked in managerial ones. Study participants endorsed passionate commitment to their profession, often motivated by personal experience with MC therapeutics. Cannabis dispensaries often privileged sales skills over cannabis therapeutics knowledge when hiring, resulting in uneven baseline levels of cannabis therapeutics expertise among staff. Most participants reported workplace cannabis therapeutics training to be unstandardized and weak. They described dispensary personnel as resourceful in pursuing cannabis knowledge, self-financing learning in off-hours, sampling dispensary products, and exchanging knowledge. Nearly half the participants called for quality, standardized cannabis therapeutics training for dispensary personnel.
    Conclusion: The many oncology teams who defer to dispensary personnel regarding MC advising rely on a workforce who views themselves as unevenly trained. Further research should include a national survey of cannabis dispensary personnel to learn whether these findings hold true in a larger sample. If so, the oncology community must determine the best approach to clinically advising individuals with cancer about MC.
    MeSH term(s) Humans ; Female ; Adult ; Male ; Cannabis ; Medical Marijuana/pharmacology ; Medical Marijuana/therapeutic use
    Chemical Substances Medical Marijuana
    Language English
    Publishing date 2022-08-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3028198-2
    ISSN 2688-1535 ; 2688-1527
    ISSN (online) 2688-1535
    ISSN 2688-1527
    DOI 10.1200/OP.22.00129
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book: HLA and disease

    BRAUN, WILLIAM E.

    A COMPREHENSIVE REVIEW

    1979  

    Author's details AUTHOR WILLIAM E. BRAUN
    Keywords HLA Antigens
    Size 137 S.
    Publisher CRC PRESS
    Publishing place BOCA RATON, FLA
    Document type Book
    HBZ-ID HT000049683
    ISBN 0-8493-5795-0 ; 978-0-8493-5795-4
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1981 A 1796 order for loan Magazin

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