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Article: Bu-Yin-Qian-Zheng Formula Ameliorates MPP

Ma, Hao-Jie / Gai, Cong / Chai, Yuan / Feng, Wan-Di / Cheng, Cui-Cui / Zhang, Jin-Kun / Zhang, Yu-Xin / Yang, Lu-Ping / Guo, Zhen-Yu / Gao, Yu-Shan / Sun, Hong-Mei

Frontiers in pharmacology

2020 Volume 11, Page(s) 577017

Abstract: As a typical traditional Chinese medicine, Bu-Yin-Qian-Zheng Formula (BYQZF) has been shown to have ...

Abstract	As a typical traditional Chinese medicine, Bu-Yin-Qian-Zheng Formula (BYQZF) has been shown to have neuroprotective effects in patients with Parkinson's disease (PD), particularly by ameliorating mitochondrial dysfunction and regulating expression of the parkin protein. However, the underlying mechanisms by which BYQZF affects mitochondrial function through parkin are unclear. Accordingly, in this study, we evaluated the mechanisms by which BYQZF ameliorates mitochondrial dysfunction through parkin in PD. We constructed a parkin-knockdown cell model and performed fluorescence microscopy to observe transfected SH-SY5Y cells. Quantitative real-time reverse transcription polymerase chain reaction and western blotting were conducted to detect the mRNA and protein expression levels of parkin. Additionally, we evaluated the cell survival rates, ATP levels, mitochondrial membrane potential (ΔΨm), mitochondrial morphology, parkin protein expression, PINK1 protein expression, and mitochondrial fusion and fission protein expression after treatment with MPP
Language	English
Publishing date	2020-12-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2020.577017
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Qian Yang Yu Yin granule improves hypertensive renal damage: A potential role for TRPC6-CaMKKβ-AMPK-mTOR-mediated autophagy.

Ma, Siqi / Xu, Junyao / Zheng, Yawei / Li, Yin / Wang, Yixuan / Li, Haitao / Fang, Zhuyuan / Li, Jie

Journal of ethnopharmacology

2022 Volume 302, Issue Pt A, Page(s) 115878

Abstract: Ethnopharmacological relevance: Qian Yang Yu Yin granules (QYYYG) have a long history ...

Abstract	Ethnopharmacological relevance: Qian Yang Yu Yin granules (QYYYG) have a long history in the treatment of hypertensive renal damage (HRD) in China. Clinical studies have found that QYYYG stabilizes blood pressure and prevents early renal damage. However, the exact mechanism is not entirely clear. Aim of the study: To evaluate the therapeutic effect and further explore the therapeutic mechanism of QYYYG against HRD. Materials and methods: The efficacy of QYYYG in treating HRD was assessed in spontaneous hypertension rats (SHR). Renal autophagy and the TRPC6-CaMKKβ-AMPK pathway in rats were evaluated. The regulatory role of QYYYG in angiotensin II (Ang II) induced abnormal autophagy in rat podocytes was determined by detecting autophagy-related proteins, intracellular Ca Results: QYYYG alleviated HRD and reversed the abnormal expression of autophagy-related genes in the SHR. In vitro, QYYYG protected against Ang II-induced podocyte damage. Furthermore, treatment of podocytes with QYYYG reversed Ang II-induced autophagy and inhibited Ang II-stimulated TRPC6 activation, Ca Conclusions: The present study suggested that QYYYG may exert its HRD protective effects in part by regulating the abnormal autophagy of podocytes through the TRPC6-CaMKKβ-AMPK-mTOR pathway.
MeSH term(s)	Animals ; Rats ; Calcium-Calmodulin-Dependent Protein Kinase Kinase/metabolism ; TRPC6 Cation Channel/metabolism ; AMP-Activated Protein Kinases/metabolism ; Calcium/metabolism ; Autophagy ; TOR Serine-Threonine Kinases/metabolism ; Podocytes ; Angiotensin II/metabolism ; Hypertension/drug therapy ; Hypertension/metabolism ; TRPC Cation Channels/genetics ; TRPC Cation Channels/metabolism ; TRPC Cation Channels/pharmacology
Chemical Substances	Calcium-Calmodulin-Dependent Protein Kinase Kinase (EC 2.7.11.17) ; TRPC6 Cation Channel ; AMP-Activated Protein Kinases (EC 2.7.11.31) ; qian yang yu yin granule ; Calcium (SY7Q814VUP) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Angiotensin II (11128-99-7) ; mTOR protein, rat (EC 2.7.1.1) ; Trpc6 protein, rat ; TRPC Cation Channels
Language	English
Publishing date	2022-10-29
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.115878
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Zs.A 1494: Show issues

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Article ; Online: Metabolomic analysis reveals a protective effect of Fu-Fang-Jin-Qian-Chao herbal granules on oxalate-induced kidney injury.

Chen, Wei / Liu, Wen-Rui / Hou, Jie-Bin / Ding, Jia-Rong / Peng, Zhong-Jiang / Gao, Song-Yan / Dong, Xin / Ma, Jun-Hua / Lin, Qi-Shan / Lu, Jian-Rao / Guo, Zhi-Yong

Bioscience reports

2019 Volume 39, Issue 2

Abstract: ... of persistent renal dysfunction. Fu-Fang-Jin-Qian-Chao granules (FFJQC), a traditional Chinese herb formula, is ...

Abstract	Nephrolithiasis is one of the world's major public health burdens with a high incidence and a risk of persistent renal dysfunction. Fu-Fang-Jin-Qian-Chao granules (FFJQC), a traditional Chinese herb formula, is commonly used in treatment of nephrolithiasis. However, the therapeutic mechanism of FFJQC on kidney stone has still been a mystery. The objective of the present study is to explore the therapeutic mechanism of FFJQC on kidney injury and identify unique metabolomics patterns using a mouse model of kidney stone induced by a calcium oxalate (CaOx) deposition. Von Kossa staining and immuno-histopathological staining of osteopontin (OPN), cluster of differentiation 44 (CD44) and calbindin-D28k were conducted on renal sections. Biochemical analysis was performed on serum, urine, and kidney tissues. A metabolomics approach based on ultra-HPLC coupled with quadrupole-TOF-MS (UHPLC-Q-TOF/MS) was used for serum metabolic profiling. The immunohistopathological and biochemical analysis showed the therapeutic benefits of FFJQC. The expression levels of OPN and CD44 were decreased while calbindin-D28k increased after the CaOx injured mice were treated with FFJQC. In addition, total of 81 serum metabolites were identified to be associated with protective effects of FFJQC on CaOx crystal injured mice. Most of these metabolites were involved in purine, amino acid, membrane lipid and energy metabolism. Potential metabolite biomarkers were found for CaOx crystal-induced renal damage. Potential metabolite biomarkers of CaOx crystal-induced renal damage were found. FFJQC shows therapeutic benefits on CaOx crystal injured mice via regulation of multiple metabolic pathways including amino acids, purine, pyrimidine, glycerolipid, arachidonic acid (AA), sphingolipid, glycerophospholipid, and fatty acid.
MeSH term(s)	Animals ; Calcium Oxalate/adverse effects ; Disease Models, Animal ; Drugs, Chinese Herbal/therapeutic use ; Kidney/drug effects ; Kidney/metabolism ; Kidney/pathology ; Kidney Calculi/drug therapy ; Kidney Calculi/etiology ; Kidney Calculi/metabolism ; Kidney Calculi/pathology ; Male ; Metabolome/drug effects ; Metabolomics ; Mice, Inbred C57BL ; Protective Agents/therapeutic use
Chemical Substances	Drugs, Chinese Herbal ; Protective Agents ; Calcium Oxalate (2612HC57YE)
Language	English
Publishing date	2019-02-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	764946-0
ISSN	1573-4935 ; 0144-8463
ISSN (online)	1573-4935
ISSN	0144-8463
DOI	10.1042/BSR20181833
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Zs.A 1676: Show issues

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Article: First Report of Fusarium solani Causing Root Rot on Peucedanum praeruptorum (Qian Hu) in Anhui Province, China

Ma, Ji / Guo, Min / Wang, Xingyu / Xiao, Xiong

Plant disease. 2020 Feb., v. 104, no. 2

2020

Abstract: Ningqianhu (Peucedanum praeruptorum Dunn) is an herb commonly cultivated in Ningguo city, Anhui province, China (Guo et al. 2013). The dried roots of P. praeruptorum are a well-known traditional Chinese medicine used to treat coughs and headaches. ... ...

Abstract	Ningqianhu (Peucedanum praeruptorum Dunn) is an herb commonly cultivated in Ningguo city, Anhui province, China (Guo et al. 2013). The dried roots of P. praeruptorum are a well-known traditional Chinese medicine used to treat coughs and headaches. Recently, a root rot disease was observed on ningqianhu in fields in Ningguo, in which up to 150 ha was affected. This disease resulted in approximately 30 to 50% yield loss annually. Initial symptoms were pale to dark brown lesions on the cuticle of the taproot. Over time, the lesions expanded to the root tuber, resulting in extensive rot. Ultimately, the plants wilted and died. To identify the pathogen, 15 diseased plants were collected from three survey fields, and symptomatic roots were surface disinfested in 2% NaClO solution for 2 min followed by 70% ethanol for 30 s and then rinsed three times in sterilized water. Dried tissues were placed on potato dextrose agar (PDA) supplemented with 150 μg/ml of cefotaxime sodium salt at 28°C in the dark. Nineteen fungal colonies with identical morphology emerged from diseased tissues after 2 to 3 days, and seven single-spore isolates were selected for morphological and molecular analysis. On PDA, all isolates produced white fluffy mycelia and small greenish-blue masses at the center of 7-day-old cultures. Microconidia were hyaline, oval or reniform, with zero to one septa and dimensions of 7.1 to 14.9 × 3.3 to 5.6 μm (n = 50). Macroconidia were sickle-shaped, two to four cells, and 27.5 to 38.4 × 3.8 to 6.9 μm (n = 50). Chlamydospores were spherical, single, in pairs or chains, and 5.6 to 8.9 μm in diameter (n = 50). Based on the above characteristics, the pathogens were identified as Fusarium spp. (Leslie and Summerell 2006). To identify the species, the nuclear ribosomal internal transcribed spacer (ITS) region and portion of the translation elongation factor 1-alpha (TEF-1α) gene were amplified with primers ITS4/ITS5 (Guo et al. 2012) and EF1/EF2 (O’Donnell et al. 1998). ITS and TEF-1α sequences of seven strains were 100% identical, and representative sequences from strain NQH-6 were submitted to GenBank. BLAST search of GenBank using the ITS (accession no. MN249607) as the query revealed 100% homology with Fusarium solani strain GJS09-1466 (accession no. NR_163531) (Schroers et al. 2016), and TEF-1α (accession no. MN244531) showed 100% similarity with F. solani isolate AS306 (accession no. KU507193) (Scruggs and Quesada-Ocampo 2016). To complete Koch’s postulates, 5 μl of a conidial suspension (2 × 105 spores/ml) from each of the seven isolates was injected into heathy roots of ten 4-month-old ningqianhu seedlings. As a negative control, ten plants were injected with sterilized water. All plants were potted in sterilized soil and were grown in a chamber with 90 ± 5% relative humidity and an 8-h photoperiod of fluorescent light at 28 ± 0.5°C. The taproots displayed dark brown lesions around the injection sites after 10 days, and they exhibited rot symptoms 3 weeks later. The controls remained asymptomatic. The same fungi were reisolated from the experimental plants and confirmed as F. solani by DNA sequence analysis. The pathogenicity test was repeated three times with similar results. F. solani is known to cause root rot on a broad range of economically important crops, including castor bean (Ricinus communis) and tree peony (Paeonia suffruticosa), in China (Guo et al. 2012; Zhou et al. 2019). To our knowledge, this is the first report of F. solani causing root rot of P. praeruptorum in Anhui province, China.
Keywords	castor beans ; cefotaxime ; chlamydospores ; conidia ; crops ; culture media ; DNA ; DNA primers ; ethanol ; fluorescent lighting ; fungi ; Fusarium solani ; genes ; internal transcribed spacers ; mycelium ; Oriental traditional medicine ; Paeonia suffruticosa ; pathogenicity ; pathogens ; peptide elongation factors ; Peucedanum praeruptorum ; polymerase chain reaction ; relative humidity ; Ricinus communis ; root rot ; roots ; seedlings ; sequence analysis ; sodium hypochlorite ; soil sterilization ; surveys ; tap roots ; tubers ; China
Language	English
Dates of publication	2020-02
Publishing place	Plant Disease
Document type	Article
ZDB-ID	754182-x
ISSN	0191-2917
ISSN	0191-2917
DOI	10.1094/PDIS-09-19-1849-PDN
Database	NAL-Catalogue (AGRICOLA)

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Article: Da-Bu-Yin-Wan and Qian-Zheng-San Ameliorate Mitochondrial Dynamics in the Parkinson's Disease Cell Model Induced by MPP

Gai, Cong / Feng, Wan-Di / Qiang, Tian-Yao / Ma, Hao-Jie / Chai, Yuan / Zhang, Shu-Jing / Guo, Zhen-Yu / Hu, Jing-Hong / Sun, Hong-Mei

Frontiers in pharmacology

2019 Volume 10, Page(s) 372

Abstract: To investigate the effect of Da-Bu-Yin-Wan and Qian-Zheng-San (DBYW and QZS) on mitochondrial mass ...

Abstract	To investigate the effect of Da-Bu-Yin-Wan and Qian-Zheng-San (DBYW and QZS) on mitochondrial mass in Parkinson's disease (PD) cell model induced by 1-Methyl-4-phenylpyridinium Ion (MPP
Language	English
Publishing date	2019-04-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2019.00372
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Article: [The classification method of syndromes in the Bei ji qian jin yao fang (Essential Recipes for Emergent Use Worth A Thousand Gold)].

Shen, Xiaowei / Zheng, Wenjie / Ma, Mingyue / Zhang, Zhibin

Zhonghua yi shi za zhi (Beijing, China : 1980)

2014 Volume 44, Issue 2, Page(s) 77–80

Abstract: Bei ji qian jin yao fang (Essential Recipes for Emergent Use Worth A Thousand Gold) epitomizes ...

Abstract	Bei ji qian jin yao fang (Essential Recipes for Emergent Use Worth A Thousand Gold) epitomizes the medical achievements of the Tang Dynasty with an extensive coverage. The classification method of syndromes in this book is derived from Nei jing (Inner Canon), Nan jing (Classic of Questioning), Shang han za bing lun (Treatise on Cold Pathogenic and Miscellaneous Diseases), Zhu bing yuan hou lun (General Treatise on Causes and Manifestations of All Diseases), and enlightens the later generation with many unique characteristics, reflecting the mature recognition of the diseases in the contemporary clinical medicine from one side. It is still of great significance for understanding the diseases and exploring its pathogenesis even today.
MeSH term(s)	Books/history ; China ; History, Medieval ; Humans ; Medicine, Chinese Traditional/history ; Syndrome
Language	Chinese
Publishing date	2014-03
Publishing country	China
Document type	English Abstract ; Historical Article ; Journal Article
ZDB-ID	1052411-3
ISSN	0255-7053
ISSN	0255-7053
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Zs.A 4688: Show issues

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Article: Da-bu-yin-wan and qian-zheng-san to neuroprotect the mouse model of Parkinson's disease.

Gong, Xiao-Gang / Sun, Hong-Mei / Zhang, Yi / Zhang, Shu-Jing / Gao, Yu-Shan / Feng, Jing / Hu, Jing-Hong / Gai, Cong / Guo, Zhen-Yu / Xu, Hong / Ma, Ling

Evidence-based complementary and alternative medicine : eCAM

2014 Volume 2014, Page(s) 729195

Abstract: Da-Bu-Yin-Wan (DBYW) and Qian-Zheng-San (QZS), two classic traditional Chinese medicinal formulas ...

Abstract	Da-Bu-Yin-Wan (DBYW) and Qian-Zheng-San (QZS), two classic traditional Chinese medicinal formulas, were clinically employed to treat Parkinson's disease (PD). Our previous studies demonstrated neuroprotective effects of them on mitochondrial function in PD mice induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The purpose of this research was to investigate their possible mechanisms in the light of mitochondrial ATP-sensitive potassium (mitoKATP) channels. The neuroprotective effect of DBYW and QZS on dopamine (DA) neurons in substantia nigra (SN) in the MPTP-induced PD mice was investigated by behavioral test (pole test) and immunohistochemistry. Adenosine triphosphate (ATP) level in the midbrain tissue was detected by firefly luciferase method. MitoKATP channel subunits SUR1 and Kir6.2 mRNA and protein expressions were tested by real-time PCR (RT-PCR) and Western blot. It was observed that DBYW and/or QZS served to ameliorate MPTP-induced behavioral impairment and prevent the loss of substantia nigra dopamine neurons, as well as increase ATP level in the midbrain tissue and downregulate SUR1 expression at mRNA and protein levels with no marked influence on Kir6.2. We concluded that DBYW and QZS exhibit neuroprotective effects probably through the regulation of ATP level and mitoKATP channel subunit expressions.
Language	English
Publishing date	2014-12-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2014/729195
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Zs.A 5995: Show issues

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Book: Qing qian bi

Ma, Feihai / Wang, Yuxun / Zou, Zhiliang

(Zhong guo li dai huo bi da quan : 清錢幣 ; / Ma fei hai zong zhu bian ; 6)

2004

Author's details	Ma fei hai, wang yu xun, zou zhi liang fen ze zhu bian
Series title	Zhong guo li dai huo bi da quan : 清錢幣 / Ma fei hai zong zhu bian ; 6
Language	English
Size	811 p, col. ill.
Edition	Di 1 ban, xiu ding ban
Publisher	Shang hai jiao yu chu ban she
Publishing place	Shang hai
Document type	Book
ISBN	753209040X ; 9787532090402
Database	Former special subject collection: coastal and deep sea fishing

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Article: The identity of Callicarpaminutiflora Y. Y. Qian (Lamiaceae) and taxonomic synonym of C.longifolia Lamarck

Ma, Zhonghui / Su, Zhiwei

PhytoKeys. 2016 Nov. 29, v. 75

2016

Abstract: Although the specific epithet of Callicarpaminutiflora Y. Y. Qian has been revised for many times ... during the study of the genus Callicarpa, we find that Callicarpaminutiflora Y. Y. Qian is identical ... Callicarpaminutiflora Y. Y. Qian is reduced as a synonym of Callicarpalongifolia Lamarck. ...

Abstract	Although the specific epithet of Callicarpaminutiflora Y. Y. Qian has been revised for many times, during the study of the genus Callicarpa, we find that Callicarpaminutiflora Y. Y. Qian is identical to Callicarpalongifolia Lamarck by a series of morphologic characters. In order to avoid more confusion, here Callicarpaminutiflora Y. Y. Qian is reduced as a synonym of Callicarpalongifolia Lamarck.
Keywords	Callicarpa ; plant taxonomy ; taxonomic revisions
Language	English
Dates of publication	2016-1129
Size	p. 13-18.
Publishing place	Pensoft Publishers
Document type	Article
ZDB-ID	2579891-1
ISSN	1314-2003 ; 1314-2011
ISSN (online)	1314-2003
ISSN	1314-2011
DOI	10.3897/phytokeys.75.10704
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Da-Bu-Yin-Wan and Qian-Zheng-San to Neuroprotect the Mouse Model of Parkinson’s Disease

Xiao-Gang Gong / Hong-Mei Sun / Yi Zhang / Shu-Jing Zhang / Yu-Shan Gao / Jing Feng / Jing-Hong Hu / Cong Gai / Zhen-Yu Guo / Hong Xu / Ling Ma

Evidence-Based Complementary and Alternative Medicine, Vol

2014 Volume 2014

Keywords	Medicine ; R ; Medicine (General) ; R5-920
Publishing date	2014-01-01T00:00:00Z
Publisher	Hindawi Publishing Corporation
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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