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  1. Article ; Online: Effect of coadministration of 10 mg/kg calcium chloride and neostigmine on extubation time: A randomized controlled trial.

    Elkenany, S / Alseoudy, M M / Elshehawi, M E / Bakrey, S / Aboelela, M

    Revista espanola de anestesiologia y reanimacion

    2024  

    Abstract: Introduction and objectives: Some studies investigating the effect of calcium on neostigmine-induced recovery of neuromuscular blockade have shown that this combination promotes neuromuscular recovery, but does not significantly affect the incidence of ... ...

    Abstract Introduction and objectives: Some studies investigating the effect of calcium on neostigmine-induced recovery of neuromuscular blockade have shown that this combination promotes neuromuscular recovery, but does not significantly affect the incidence of postoperative residual curarization and time to extubation. This study aimed to evaluate the effects of 10 mg/kg calcium chloride co-administered with neostigmine on early recovery and time to extubation.
    Patients and methods: This prospective, randomized, double-blinded, placebo-controlled study included 88 ASA I-II patients aged between 18 and 65 years who were scheduled for elective surgery lasting at least 1 h under general anaesthesia in which 10 mg/kg of calcium chloride or the same volume of normal saline was co-administered with 5 μg/kg of neostigmine at the end of surgery. Time to extubation (time from neostigmine administration to extubation), time from neostigmine administration to TOF ratio (TOFr) 0.9 (neuromuscular recovery), and the incidence of residual neuromuscular blockade (RNMB) and other adverse effects were recorded.
    Results: Median (Q1, Q3) extubation time was significantly shorter in the calcium group vs. the placebo group (6.5 min [5.52-7.43] vs. 9.78 min [8.35-11]), P < .001. Median neuromuscular recovery time in the calcium group was 5 min vs. 7.1 min in the placebo group, P < .001. Patients in the calcium group had significantly higher TOFr and lower incidence of RNMB at 5 and 10 min vs. the placebo group, and no significant side effects.
    Conclusion: Calcium chloride at a dose of 10 mg/kg co-administered with neostigmine promotes early neuromuscular recovery and reduces time to extubation by about 32%.
    Language English
    Publishing date 2024-04-12
    Publishing country Spain
    Document type Journal Article
    ISSN 2341-1929
    ISSN (online) 2341-1929
    DOI 10.1016/j.redare.2024.04.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The sex-related discrepancy in laboratory parameters of severe COVID-19 patients with diabetes: A retrospective cohort study.

    Hammad, Maha O / Alseoudy, Mahmoud M

    Primary care diabetes

    2021  Volume 15, Issue 4, Page(s) 713–718

    Abstract: Aim: This study aimed at providing evidence to consider sex differences in interpretations of laboratory parameters of severe COVID-19 patients with diabetes.: Methods: For 118 diabetic patients, laboratory measurements and clinical outcomes were ... ...

    Abstract Aim: This study aimed at providing evidence to consider sex differences in interpretations of laboratory parameters of severe COVID-19 patients with diabetes.
    Methods: For 118 diabetic patients, laboratory measurements and clinical outcomes were compared between males and females. This study also compared inflammatory ratios obtained from combinations of six inflammatory markers between the two groups. The risk factors for mortality were identified through logistic regression.
    Results: Males were 54 (45.8%) and females were 64 (54.2%). Males showed a significant increase in ALT (P = 0.003), CRP (P = 0.03), mean platelet volume (MPV)-to-lymphocyte ratio (P = 0.001), and C-reactive protein-to-albumin ratio (P = 0.044), whereas females had a significant increase in lymphocytes (P < 0.005) and MPV (P = 0.01). In all participants, multivariate analysis illustrated that older age, male sex, increased serum total bilirubin, and decreased PO
    Conclusion: In severe COVID-19 patients with diabetes, there were significant sex differences in many laboratory characteristics with a higher risk of mortality among males.
    MeSH term(s) Age Factors ; Aged ; Alanine Transaminase/blood ; Bilirubin/blood ; Biomarkers/blood ; C-Reactive Protein/analysis ; COVID-19/blood ; COVID-19/diagnosis ; COVID-19/mortality ; Diabetes Mellitus/blood ; Diabetes Mellitus/diagnosis ; Diabetes Mellitus/mortality ; Female ; Health Status Disparities ; Humans ; Lymphocyte Count ; Lymphocytes/metabolism ; Male ; Mean Platelet Volume ; Middle Aged ; Predictive Value of Tests ; Prognosis ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Severity of Illness Index ; Sex Factors
    Chemical Substances Biomarkers ; C-Reactive Protein (9007-41-4) ; Alanine Transaminase (EC 2.6.1.2) ; Bilirubin (RFM9X3LJ49)
    Language English
    Publishing date 2021-05-12
    Publishing country England
    Document type Comparative Study ; Journal Article ; Observational Study
    ZDB-ID 2273997-X
    ISSN 1878-0210 ; 1751-9918
    ISSN (online) 1878-0210
    ISSN 1751-9918
    DOI 10.1016/j.pcd.2021.05.002
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  3. Article ; Online: Ultrasound-guided retrolaminar block versus ilioinguinal nerve block for postoperative analgesia in children undergoing inguinal herniotomy: A randomized controlled trial.

    Alseoudy, Mahmoud M / Abdelbaser, Ibrahim

    Journal of clinical anesthesia

    2021  Volume 74, Page(s) 110421

    Abstract: Study objective: Ultrasound-guided retrolaminar block (RLB) is a new, safe and technically easy nerve block. To our knowledge, no studies have evaluated its analgesic efficacy in pediatric patients. This study aimed to compare the postoperative ... ...

    Abstract Study objective: Ultrasound-guided retrolaminar block (RLB) is a new, safe and technically easy nerve block. To our knowledge, no studies have evaluated its analgesic efficacy in pediatric patients. This study aimed to compare the postoperative analgesic efficacy of RLB and ilioinguinal nerve block (INB) in pediatric patients undergoing unilateral inguinal herniotomy.
    Design: Superiority, prospective, randomized, double-blinded, controlled study.
    Setting: Operating rooms and wards of Mansoura University Children's Hospital, Egypt.
    Patients: Sixty-five patients aged 2 to 6 years undergoing unilateral inguinal herniotomy were enrolled.
    Interventions: In the ultrasound-guided RLB group (n = 30), we injected 0.5 mL/kg bupivacaine 0.25% into the retrolaminar space between the lamina of T12 and the paraspinal muscles and in ultrasound-guided INB group (n = 30), 0.5 mL/kg bupivacaine 0.25% was injected for INB.
    Measurements: The primary outcome measure was the number of patients requiring ibuprofen as rescue analgesia and the secondary outcome measures were intraoperative hemodynamic changes and the postoperative FLACC (Face, Legs, Activity, Cry, Consolability) score.
    Main results: The number of patients who needed rescue analgesia in the first postoperative 24 h was significantly lower (P = 0.023) in the RLB group [5 (16%)] than the INB group [13 (43%)]. The mean (SD) arterial blood pressure and heart rate were significantly higher (P < 0.001) during sac traction in the INB group [74.07 (2.99), 97.33 (6.98)] than the RLB group [67.73 (3.55), 90.79 (5.13)]. The postoperative FLACC scores at 4, 6, 12, and 24 h were significantly lower (P < 0.05) in the RLB group than in the INB group.
    Conclusion: Retrolaminar block is superior to ilioinguinal nerve block in providing postoperative analgesia in pediatric patients undergoing unilateral inguinal herniotomy.
    MeSH term(s) Analgesia ; Child ; Egypt ; Humans ; Nerve Block ; Prospective Studies ; Ultrasonography, Interventional
    Language English
    Publishing date 2021-06-26
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1011618-7
    ISSN 1873-4529 ; 0952-8180
    ISSN (online) 1873-4529
    ISSN 0952-8180
    DOI 10.1016/j.jclinane.2021.110421
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: IFNL1 rs30461 polymorphism as a risk factor for COVID-19 severity: A cross-sectional study.

    Hammad, Maha O / Alseoudy, Mahmoud M / Borg, Asmaa M / El-Mesery, Ahmed / Elgamal, Mohamed / Abdelghany, Dalia A / Elzeiny, Dina

    Cytokine

    2024  Volume 176, Page(s) 156500

    Abstract: Introduction: The molecular basis of the progression of some COVID-19 patients to worse outcomes is not entirely known. Interferons-lambda-1/interleukin-29 (IFN-λ1/IL-29) is a member of the type III IFNs with a strong antiviral activity. Given the scant ...

    Abstract Introduction: The molecular basis of the progression of some COVID-19 patients to worse outcomes is not entirely known. Interferons-lambda-1/interleukin-29 (IFN-λ1/IL-29) is a member of the type III IFNs with a strong antiviral activity. Given the scant data on the potential role of IFN-λ1/IL-29 in COVID-19, we investigated the association of IFN-λ1/IL-29 serum level and the IFNL1 single-nucleotide polymorphism (SNP) (rs30461) with severe course of COVID-19.
    Material and methods: This cross-sectional study included 400 COVID-19 patients, in which 262 mild COVID-19 patients and 138 severe COVID-19 patients were recruited and compared. The IFN-λ1/IL-29 serum levels were assessed in both the mild and severe COVID-19 groups. All participants were genotyped for the IFNL1 SNP (rs30461) by allelic discrimination RT-PCR using specific Taqman probes and primers. The associations between IFNL1 variants and risk of severe COVID-19 were examined via the logistic regression analysis.
    Results: The serum IFN-λ1/IL-29 levels showed no statistically significant difference between mild and severe COVID-19 patients (P = 0.993). The genotype and allele frequencies of IFNL1 SNP (rs30461) were significantly different between the mild and severe groups, in which the minor G allele carried a highly significant risk of severe COVID-19 compared with the wild A allele [OR (95 %CI): 2.1 (1.5-2.9), P ≤ 0.001]. In multivariate analysis, the A/G and G/G genotypes of IFNL1 SNP (rs30461) were independent predictors of COVID-19 severity (P < 0.05).
    Conclusion: The study concluded that the IFNL1 SNP (rs30461) may constitute an independent risk factor for COVID-19 severity.
    MeSH term(s) Humans ; COVID-19/genetics ; Cross-Sectional Studies ; Cytokines ; Interferons/genetics ; Interleukins/genetics ; Risk Factors
    Chemical Substances Cytokines ; Interferons (9008-11-1) ; Interleukins ; interferon-lambda, human
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1018055-2
    ISSN 1096-0023 ; 1043-4666
    ISSN (online) 1096-0023
    ISSN 1043-4666
    DOI 10.1016/j.cyto.2024.156500
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  5. Article ; Online: Ultrasound-Guided Suprazygomatic Sphenopalatine Ganglion Block for Postdural Puncture Headache Resistant to Epidural Blood Patch: A Case Report.

    Alseoudy, Mahmoud M / Abd-Elmoaty, Wael A / Ramzy, Eiad A / Abdelbaser, Ibrahim / El-Emam, El-Sayed M

    A&A practice

    2024  Volume 18, Issue 4, Page(s) e01778

    Abstract: Even though epidural blood patch (EBP) is thought to be the definitive treatment for severe cases of postdural puncture headache (PDPH), it may be accompanied by complications like adhesion arachnoiditis, and cauda equina syndrome, especially if the ... ...

    Abstract Even though epidural blood patch (EBP) is thought to be the definitive treatment for severe cases of postdural puncture headache (PDPH), it may be accompanied by complications like adhesion arachnoiditis, and cauda equina syndrome, especially if the injection is repeated. The sphenopalatine ganglion (SPG) block is a new minimally invasive technique for the treatment of PDPH, with variable results according to the clinical situation and deployed approach. We describe a case of PDPH resistant to EBP in which we successfully managed symptoms using ultrasound-guided suprazygomatic SPG block to deliver local anesthetic directly into pterygopalatine fossa, thus avoiding a second EBP.
    MeSH term(s) Humans ; Post-Dural Puncture Headache/therapy ; Post-Dural Puncture Headache/etiology ; Blood Patch, Epidural/methods ; Sphenopalatine Ganglion Block/methods ; Anesthetics, Local ; Ultrasonography, Interventional/adverse effects
    Chemical Substances Anesthetics, Local
    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Case Reports ; Journal Article
    ISSN 2575-3126
    ISSN (online) 2575-3126
    DOI 10.1213/XAA.0000000000001778
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  6. Article ; Online: Comparison of intravenous ibuprofen versus ketorolac for postoperative analgesia in children undergoing lower abdominal surgery: A randomized, controlled, non-inferiority study.

    Abdelbaser, I / Mageed, N A / El-Emam, E-S M / ALseoudy, M M

    Revista espanola de anestesiologia y reanimacion

    2022  Volume 69, Issue 8, Page(s) 463–471

    Abstract: Background: Non-steroidal anti-inflammatory drugs are often used as part of multimodal analgesia to control postoperative pain. This randomized, controlled, double-blinded, non-inferiority study aimed to compare the postoperative analgesic effects of ... ...

    Abstract Background: Non-steroidal anti-inflammatory drugs are often used as part of multimodal analgesia to control postoperative pain. This randomized, controlled, double-blinded, non-inferiority study aimed to compare the postoperative analgesic effects of intravenous ibuprofen versus ketorolac in children undergoing open unilateral lower abdominal surgery. The authors hypothesized that postoperative analgesia produced by intravenous ibuprofen would be non-inferior to that of intravenous ketorolac.
    Methods: Sixty-six children aged 2 to 8 years who were scheduled to undergo unilateral lower abdominal surgery, were recruited. Patients in the ibuprofen group received 10mg/kg/6h intravenous ibuprofen. Patients in the ketorolac group were given 0.5mg/kg/6h intravenous ketorolac. The primary outcome measure was 24-h postoperative morphine consumption. The secondary outcome measures were postoperative pain score, the incidence of early postoperative fever and the incidence of ibuprofen and ketorolac adverse effects including pain during drug infusion, vomiting, epigastric pain and allergic reaction.
    Results: Fifty-nine patients completed the study (30 ibuprofen, 29 ketorolac). There was no significant difference (P=0.305) in the mean (SD) 24-h postoperative morphine consumption (μ/kg) between intravenous ibuprofen, 16.00 (5.31), and ketorolac, 14.65 (4.61). The reported pain scores were similar in both groups. The incidence of postoperative fever was significantly lower (p=0.039) in the ibuprofen group (3%) than the ketorolac group (20%). The incidence of adverse effects was similar in both ibuprofen and ketorolac groups.
    Conclusions: Intravenous ibuprofen can be used as an alternative to ketorolac for postoperative analgesia in children undergoing unilateral lower abdominal surgery because both drugs similarly provide safe and effective postoperative analgesia.
    MeSH term(s) Analgesia ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Child ; Double-Blind Method ; Humans ; Ibuprofen/therapeutic use ; Ketorolac/therapeutic use ; Morphine/therapeutic use ; Pain, Postoperative/drug therapy ; Tolmetin/adverse effects
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Morphine (76I7G6D29C) ; Tolmetin (D8K2JPN18B) ; Ibuprofen (WK2XYI10QM) ; Ketorolac (YZI5105V0L)
    Language English
    Publishing date 2022-09-07
    Publishing country Spain
    Document type Journal Article ; Randomized Controlled Trial
    ISSN 2341-1929
    ISSN (online) 2341-1929
    DOI 10.1016/j.redare.2022.08.008
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  7. Article ; Online: The effect of ultrasound-guided bilateral thoracic retrolaminar block on analgesia after pediatric open cardiac surgery: a randomized controlled double-blind study.

    Abdelbaser, Ibrahim / Mageed, Nabil A / Elfayoumy, Sherif I / Magdy, Mohamed / Elmorsy, Mohamed M / ALseoudy, Mahmoud M

    Korean journal of anesthesiology

    2022  Volume 75, Issue 3, Page(s) 276–282

    Abstract: Background: The thoracic retrolaminar block (TRLB) is a relatively new regional analgesia technique that can be used as an alternative to the thoracic paravertebral block. This study aimed to evaluate the postoperative analgesia effects of ultrasound- ... ...

    Abstract Background: The thoracic retrolaminar block (TRLB) is a relatively new regional analgesia technique that can be used as an alternative to the thoracic paravertebral block. This study aimed to evaluate the postoperative analgesia effects of ultrasound-guided TRLB in children undergoing open cardiac surgery via median sternotomy incision.
    Methods: Sixty-six patients aged 2-8 years were recruited. In the TRLB group, 0.25% bupivacaine 0.4 ml/kg was injected into the retrolaminar space on both sides at the level of the T4 lamina. Patients in the control group were injected with 0.9% saline. The primary outcome measure was fentanyl consumption in the first 24 h post-extubation. The secondary outcome measures were the total intraoperative fentanyl consumption, postoperative modified objective pain score (MOPS), and time to extubation.
    Results: The total intraoperative fentanyl requirements and fentanyl consumption in the first 24 h post-extubation were significantly lower (P < 0.001) in the TRLB group (9.3 ± 1.2; 6.9 ± 2.1 μg/kg, respectively) than in the control group (12.5 ± 1.4; 16.6 ± 2.8, respectively). The median (Q1, Q3) time to extubation was significantly shorter (P < 0.001) in the TRLB group (2 [1, 3] h) than in the control group (6 [4.5, 6] h). The MOPS was significantly lower (P < 0.05) in the TRLB group than in the control group at 0, 2, 4, 8, 12 and 16 h post-extubation.
    Conclusions: Bilateral ultrasound-guided TRLB is effective in providing postoperative analgesia in children undergoing open cardiac surgery via median sternotomy incision.
    MeSH term(s) Analgesia/methods ; Cardiac Surgical Procedures ; Child ; Child, Preschool ; Double-Blind Method ; Fentanyl ; Humans ; Pain, Postoperative/etiology ; Pain, Postoperative/prevention & control ; Prospective Studies ; Ultrasonography, Interventional/methods
    Chemical Substances Fentanyl (UF599785JZ)
    Language English
    Publishing date 2022-01-12
    Publishing country Korea (South)
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2557340-8
    ISSN 2005-7563 ; 2005-7563
    ISSN (online) 2005-7563
    ISSN 2005-7563
    DOI 10.4097/kja.21466
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  8. Article ; Online: Awake proning of a 2-year-old extubated child with severe COVID-19 pneumonitis.

    Alseoudy, M M / Abo Elfetoh, M A / Alrefaey, A K

    Anaesthesia reports

    2020  Volume 8, Issue 2, Page(s) 183–186

    Abstract: With the progress of the coronavirus disease 2019 (COVID-19) pandemic, available data suggest lower complications and disease severity in children and young patients. Despite most paediatric cases being mild in severity, some children require intensive ... ...

    Abstract With the progress of the coronavirus disease 2019 (COVID-19) pandemic, available data suggest lower complications and disease severity in children and young patients. Despite most paediatric cases being mild in severity, some children require intensive care and mechanical ventilation due to the development of paediatric severe acute respiratory distress. The use of adjuvant therapies in severely ill paediatric patients has not been reported widely in the literature. Prone positioning in spontaneously breathing children has, to our knowledge, not yet been described. In our report, the trachea of a 2-year-old child was intubated, and he was mechanically ventilated for severe bilateral pneumonia. The infant and his mother tested positive for severe acute respiratory syndrome coronavirus disease-2 (SARS-CoV-2) infection with reverse transcription-polymerase chain reaction testing from nasopharyngeal swabs. Immediately after tracheal extubation, the child developed severe respiratory distress and refractory hypoxia. Awake prone position was employed as a rescue therapy for the management of post-extubation hypoxia, resulting in a dramatic improvement in oxygenation. Prone positioning in the paediatric patient may improve oxygenation and can be a useful adjuvant for respiratory therapy either before, during or after invasive mechanical ventilation. Awake prone position may be considered as an option for the management of COVID-19 in paediatric patients, but it requires patient cooperation.
    Language English
    Publishing date 2020-11-25
    Publishing country England
    Document type Journal Article
    ISSN 2637-3726
    ISSN (online) 2637-3726
    DOI 10.1002/anr3.12084
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  9. Article ; Online: Prognostic impact of toll-like receptors gene polymorphism on outcome of COVID-19 pneumonia: A case-control study.

    Alseoudy, Mahmoud M / Elgamal, Mohamed / Abdelghany, Dalia A / Borg, Asmaa M / El-Mesery, Ahmed / Elzeiny, Dina / Hammad, Maha O

    Clinical immunology (Orlando, Fla.)

    2022  Volume 235, Page(s) 108929

    Abstract: Toll-like receptor 3 (TLR3) and TLR7 genes are involved in the host immune response against viral infections including SARS-COV-2. This study aimed to investigate the association between the TLR3(rs3775290) and TLR7(rs179008) polymorphisms with the ... ...

    Abstract Toll-like receptor 3 (TLR3) and TLR7 genes are involved in the host immune response against viral infections including SARS-COV-2. This study aimed to investigate the association between the TLR3(rs3775290) and TLR7(rs179008) polymorphisms with the prognosis and susceptibility to COVID-19 pneumonia accompanying SARS-COV-2 infection. This case-control study included 236 individuals: 136 COVID-19 pneumonia patients and 100 age and sex-matched controls. Two polymorphisms (TLR3 rs3775290 and TLR7 rs179008) were genotyped by allelic discrimination through TaqMan real-time PCR. This study also investigated predictors of mortality in COVID-19 pneumonia through logistic regression. The mutant 'T/T' genotypes and the 'T' alleles of TLR3(rs3775290) and TLR7(rs179008) polymorphisms were significantly associated with increased risk of COVID-19 pneumonia. This study did not report association between the mutant 'T/T' genotypes of TLR3(rs3775290) and TLR7(rs179008) and the disease outcome. In multivariate analysis, the independent predictors of mortality in COVID-19 pneumonia were male sex, SPO
    MeSH term(s) Aged ; Alleles ; COVID-19/diagnosis ; COVID-19/genetics ; COVID-19/virology ; Case-Control Studies ; Female ; Gene Frequency ; Genetic Predisposition to Disease/genetics ; Genotype ; Humans ; Male ; Middle Aged ; Pneumonia/diagnosis ; Pneumonia/genetics ; Pneumonia/virology ; Polymorphism, Single Nucleotide ; Prognosis ; ROC Curve ; Risk Factors ; SARS-CoV-2/physiology ; Toll-Like Receptor 3/genetics ; Toll-Like Receptor 7/genetics
    Chemical Substances TLR3 protein, human ; Toll-Like Receptor 3 ; Toll-Like Receptor 7
    Language English
    Publishing date 2022-01-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2022.108929
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  10. Article ; Online: Preemptive analgesic efficacy of ultrasound-guided transversalis fascia plane block in children undergoing inguinal herniorrhaphy: a randomized, double-blind, controlled study.

    Abdelbaser, Ibrahim / Mageed, Nabil A / El-Emam, El-Sayed M / ALseoudy, Mahmoud M / Elmorsy, Mohamed M

    Korean journal of anesthesiology

    2020  Volume 74, Issue 4, Page(s) 325–332

    Abstract: Background: Surgical repair of congenital inguinal hernia results in significant postoperative discomfort and pain. The aim of the current study was to evaluate the pre-emptive analgesic efficacy of a transversalis fascia plane (TFP) block after ... ...

    Abstract Background: Surgical repair of congenital inguinal hernia results in significant postoperative discomfort and pain. The aim of the current study was to evaluate the pre-emptive analgesic efficacy of a transversalis fascia plane (TFP) block after pediatric inguinal herniorrhaphy.
    Methods: Forty-four patients aged 12 to 60 months who underwent unilateral inguinal herniorrhaphy were enrolled. Four patients were excluded, and the remaining were allocated to the control group and the TFP block group. In the TFP block group, 0.4 mL/kg bupivacaine 0.25% was instilled in the plane between the transversus abdominis and transversalis fascia, while in the control group 0.9% saline was used instead of bupivacaine. The collected data were the total dose of paracetamol consumed during the first 12 h postoperatively, the postoperative Face, Leg, Activity, Cry, Consolability (FLACC) pain score, time to first use of rescue analgesia, number of patients required additional postoperative analgesics, and parents' satisfaction.
    Results: The median paracetamol consumption was significantly lower in the TFP block group than in the control group, and FLACC pain scores were significantly lower for all study times in the TFP block group with higher parental satisfaction scores than those for the control group. The number of patients who required additional analgesics was significantly lower in the TFP block group than in the control group.
    Conclusions: The use of a TFP block decreases postoperative analgesic consumption and postoperative pain intensity after pediatric inguinal herniorrhaphy. Future studies with larger sample size are required to evaluate the actual complications rate of TFP block.
    MeSH term(s) Analgesics ; Child ; Fascia/diagnostic imaging ; Hernia, Inguinal/diagnostic imaging ; Hernia, Inguinal/surgery ; Herniorrhaphy/adverse effects ; Humans ; Nerve Block/adverse effects ; Prospective Studies ; Ultrasonography, Interventional
    Chemical Substances Analgesics
    Language English
    Publishing date 2020-12-14
    Publishing country Korea (South)
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2557340-8
    ISSN 2005-7563 ; 2005-6419
    ISSN (online) 2005-7563
    ISSN 2005-6419
    DOI 10.4097/kja.20601
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