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  1. Article ; Online: Reconciling zoogeography and genetics: Origins of deepwater Cisco Coregonus artedi (sensu lato) in the Great Lakes

    Eshenroder, Randy L. / Breckenridge, Andy J. / Jacobson, Peter C.

    Transactions of the American Fisheries Society. 2024 Jan., v. 153, no. 1 p.23-38

    2024  

    Abstract: OBJECTIVE: We propose that deepwater Cisco Coregonus artedi (sensu lato) survived Wisconsin ice advances through introgression with shallow‐water Cisco ~65 ka followed by expression of introgressed genomic fragments after the last retreat of ice from the ...

    Abstract OBJECTIVE: We propose that deepwater Cisco Coregonus artedi (sensu lato) survived Wisconsin ice advances through introgression with shallow‐water Cisco ~65 ka followed by expression of introgressed genomic fragments after the last retreat of ice from the Great Lakes ~15 ka. METHODS: We reviewed Wisconsin Glaciation in relation to putative introgression within Cisco and employed a phylogeographic approach to substantiate locations of Cisco refugia and the implications for dispersal of Cisco ahead of the last advance of Wisconsin ice. RESULT: We showed that deepwater Cisco, in contrast to shallow‐water Cisco, were very unlikely to have survived glacial advances and that a massive introgression event between both types likely occurred as the first of two Wisconsin ice advances reached the Great Lakes ~65 ka. CONCLUSION: The most‐parsimonious explanation for the distribution of deepwater Cisco involves long‐ago introgression as a precursor to its divergence from shallow‐water Cisco following the final retreat of Wisconsin ice.
    Keywords Coregonus artedi ; genomics ; glaciation ; ice ; introgression ; phylogeography ; refuge habitats ; zoogeography ; Wisconsin
    Language English
    Dates of publication 2024-01
    Size p. 23-38.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 416724-7
    ISSN 0002-8487
    ISSN 0002-8487
    DOI 10.1002/tafs.10444
    Database NAL-Catalogue (AGRICOLA)

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  2. Article: Carbon Fiber-Reinforced Polyetheretherketone Spinal Implants for Treatment of Spinal Tumors: Perceived Advantages and Limitations.

    Alvarez-Breckenridge, Christopher / de Almeida, Romulo / Haider, Ali / Muir, Matthew / Bird, Justin / North, Robert / Rhines, Laurence / Tatsui, Claudio

    Neurospine

    2023  Volume 20, Issue 1, Page(s) 317–326

    Abstract: Purpose: Carbon-fiber reinforced polyetheretherketone (CFRP)-based spinal implants are an alternative to titanium, offering less image artifact as their metallic counterparts while maintaining similar biomechanical and biocompatibility properties. Its ... ...

    Abstract Purpose: Carbon-fiber reinforced polyetheretherketone (CFRP)-based spinal implants are an alternative to titanium, offering less image artifact as their metallic counterparts while maintaining similar biomechanical and biocompatibility properties. Its use in the management of spinal tumors has been reported, however the perceived advantages related to improved imaging quality, radiation treatment planning, and detection of tumor recurrence have not been fully assessed.
    Methods: We performed a retrospective review of medical records amongst oncologic patients treated at MD Anderson Cancer Center with CFRP implants. Histology, tumor location, construct features, time of follow-up, adjuvant radiation, recurrences, overall survival, and hardware-related complications were recorded.
    Results: Sixty-nine consecutive patients were assessed (22 primary tumors, 47 metastases) and the median time for follow-up was 5.4 months. Amongst the cohort, a total of 491 CFRP pedicle screws were implanted. Hardware complications were observed in 5 cases (7.04%). Adjuvant radiation was completed in 8 patients with primary tumors and 29 patients with spinal metastases. A total of 28 patients (40.5%) from the combined primary and metastatic cohorts experienced systemic disease progression, with 12 patients (17.3%) demonstrating local recurrences. Amongst primary and metastatic tumors, overall survival (p = 0.363) and rate of local recurrence (p = 0.112) were similar.
    Conclusion: This largest series of CFRP implants demonstrates safe and effective spinal stabilization for patients with both primary and metastatic tumors. Enhanced postoperative imaging led to minimal imaging artifacts which facilitated postoperative radiation planning and the ability to detect local recurrence.
    Language English
    Publishing date 2023-03-31
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 3031654-6
    ISSN 2586-6591 ; 2586-6583
    ISSN (online) 2586-6591
    ISSN 2586-6583
    DOI 10.14245/ns.2244920.460
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Tumor treating fields suppress tumor cell growth and neurologic decline in models of spine metastases.

    Ledbetter, Daniel / de Almeida, Romulo / Wu, Xizi / Naveh, Ariel / Patel, Chirag B / Gonzalez, Queena / Beckham, Thomas H / North, Robert / Rhines, Laurence / Li, Jing / Ghia, Amol / Aten, David / Tatsui, Claudio / Alvarez-Breckenridge, Christopher

    JCI insight

    2024  

    Abstract: Spine metastases can result in severe neurologic compromise and decreased overall survival. Despite treatment advances, local disease progression is frequent, highlighting the need for novel therapies. Tumor treating fields (TTFields) impair tumor cell ... ...

    Abstract Spine metastases can result in severe neurologic compromise and decreased overall survival. Despite treatment advances, local disease progression is frequent, highlighting the need for novel therapies. Tumor treating fields (TTFields) impair tumor cell replication and are influenced by properties of surrounding tissue. We hypothesize bone's dielectric properties will enhance TTFields mediated suppression of tumor growth in spine metastasis models. Computational modeling of TTFields intensity was performed following surgical resection of a spinal metastasis and demonstrated enhanced TTFields intensity within the resected vertebral body. Additionally, luciferase-tagged human KRIB osteosarcoma and A549 lung adenocarcinoma cell lines were cultured in demineralized bone grafts and exposed to TTFields. Following TTFields exposure, BLI signal decreased 10-80% of baseline while control cultures displayed 4.48-9.36 fold increase in signal. Lastly, TTFields were applied in an orthotopic murine model of spinal metastasis. After 21 days of treatment, control mice demonstrated a 5-fold increase in BLI signal compared to TTFields treated mice. TTFields similarly prevented tumor invasion into the spinal canal and development of neurologic symptoms. Our data suggest that TTFields can be leveraged as a local therapy within minimally-conductive bone of spine metastases. This provides the groundwork for future studies investigating TTFields for patients with treatment-refractory spine metastases.
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article
    ISSN 2379-3708
    ISSN (online) 2379-3708
    DOI 10.1172/jci.insight.176962
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Emerging Systemic Treatment Perspectives on Brain Metastases: Moving Toward a Better Outlook for Patients.

    Alvarez-Breckenridge, Christopher / Remon, Jordi / Piña, Yolanda / Nieblas-Bedolla, Edwin / Forsyth, Peter / Hendriks, Lizza / Brastianos, Priscilla K

    American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting

    2022  Volume 42, Page(s) 1–19

    Abstract: The diagnosis of brain metastases has historically been a dreaded, end-stage complication of systemic disease. Additionally, with the increasing effectiveness of systemic therapies that prolong life expectancy and improved imaging tools, the incidence of ...

    Abstract The diagnosis of brain metastases has historically been a dreaded, end-stage complication of systemic disease. Additionally, with the increasing effectiveness of systemic therapies that prolong life expectancy and improved imaging tools, the incidence of intracranial progression is becoming more common. Within this context, there has been increasing attention directed at understanding the molecular underpinnings of intracranial progression. Exploring the unique features of brain metastases compared with their extracranial counterparts to identify aberrant signaling pathways, which can be targeted pharmacologically, may help lead to new treatments for this patient population. Additionally, critical discoveries outside the sphere of the central nervous system are increasingly being applied to brain metastases with the emergence of immune checkpoint inhibition, becoming a prevalent treatment option for patients with brain metastases across multiple histologies. As novel treatment strategies are considered, they require thoughtful incorporation of agents that can cross the blood-brain barrier and can synergize with pre-existing agents through rational combinations. Lastly, as clinicians and scientists continue to understand key molecular features of these tumors, they will continue to influence the treatment algorithms that are developing for the management of these patients. Due to the complexity of treatment decisions for patients with brain metastases, an emerging tool is the utilization of multidisciplinary brain metastasis tumor boards to ensure optimal treatment decisions are made and that patients are provided access to applicable clinical trials. Looking to the future, the collective effort to understand the various tumor-intrinsic and tumor-extrinsic factors that promote central nervous system seeding and propagation will have the potential to change the clinical trajectory for these patients.
    MeSH term(s) Brain Neoplasms/drug therapy ; Brain Neoplasms/secondary ; Humans ; Immune Checkpoint Inhibitors
    Chemical Substances Immune Checkpoint Inhibitors
    Language English
    Publishing date 2022-05-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2431126-1
    ISSN 1548-8756 ; 1548-8748
    ISSN (online) 1548-8756
    ISSN 1548-8748
    DOI 10.1200/EDBK_352320
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Preliminary feasibility of animated video education designed to empower patients' referral to kidney transplantation.

    Kayler, Liise K / Keller, Maria M / Breckenridge, Barbara / Feeley, Thomas H / Suboh, Jamal / Tumiel-Berhalter, Laurene

    Clinical transplantation

    2022  Volume 37, Issue 1, Page(s) e14838

    Abstract: Background: Referral for kidney transplantation is influenced by patient education; digital technologies can enhance broad information accessibility. This single-group study tested the feasibility and acceptability of patient-centered self-directed ... ...

    Abstract Background: Referral for kidney transplantation is influenced by patient education; digital technologies can enhance broad information accessibility. This single-group study tested the feasibility and acceptability of patient-centered self-directed educational animated videos to improve mediators of kidney transplant referral.
    Methods: Community-based adults with chronic kidney disease stage ≥4 invited from a clinical registry or self-responding to flyers viewed eight sequential videos (19:36 min total duration) remotely on their own device. Change in kidney transplant knowledge, concerns, and confidence talking about kidney transplantation to doctors was assessed with self-report surveys before and immediately after viewing. Program feedback was assessed by survey and self-selected exit interview.
    Results: Viewers of the video set (n = 50) demonstrated increases in mean kidney transplantation knowledge by +22%, confidence discussing with their doctor by +6%, and reductions in concerns by -2%. Knowledge results were consistent across age, race, and literacy level. Over 90% indicated positive ratings on understanding, engaging, and helpfulness. In post-study interviews viewers indicated the videos promoted confidence in obtaining a kidney transplant and none reported that the 19-min duration of the home education was too long.
    Conclusion: The animated video education is promising to improve diverse individuals' knowledge, concerns, and communication confidence about kidney transplantation and is highly acceptable.
    MeSH term(s) Adult ; Humans ; Kidney Transplantation ; Feasibility Studies ; Communication ; Kidney ; Referral and Consultation
    Language English
    Publishing date 2022-12-07
    Publishing country Denmark
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 639001-8
    ISSN 1399-0012 ; 0902-0063
    ISSN (online) 1399-0012
    ISSN 0902-0063
    DOI 10.1111/ctr.14838
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Determination of ICH-Q3D Elemental Impurity Leachables in Glass Vials by Inductively Coupled Plasma Mass Spectrometry.

    Breckenridge, Lydia / Oni, Yusuf / Evans, Christina / Franck, Jason / Wood, Sharla / Xu, Meng / Sahin, Erinc / Zacour, Brian

    PDA journal of pharmaceutical science and technology

    2022  Volume 77, Issue 3, Page(s) 197–210

    Abstract: Container closure systems that are used for packaging pharmaceutical products are required to satisfy numerous safety requirements. Maximum permitted limits on the concentrations of numerous toxic elemental impurities that potentially leach from the ... ...

    Abstract Container closure systems that are used for packaging pharmaceutical products are required to satisfy numerous safety requirements. Maximum permitted limits on the concentrations of numerous toxic elemental impurities that potentially leach from the packaging are one such requirement. The implementation of ICH-Q3D Guideline for Elemental Impurities, in conjunction with the 2018 publication of USP <232> Elemental Impurities-Limits and USP <233> Elemental Impurities-Procedures, requires a critical risk assessment of all container closure systems to evaluate their contribution of certain elemental impurities to the enclosed drug product. ICH-Q3D has established limits for each specific elemental impurity that considers relevant toxicological data and administration route (oral, parenteral, or inhalation) and presents them as permitted daily exposures based on the maximum daily dosage of the final drug product. A study was undertaken to assess the degree of elemental impurity leaching from one type of pharmaceutical glass vial under specific, fixed environmental controls. Multiple buffer systems representing a broad spectrum of possible parenteral drug product formulations were used in the study. Resulting buffer solutions that had been in contact with a single type of glass vial under specific conditions were subsequently analyzed using an inductively coupled plasma mass spectrometry (ICP-MS) method developed and validated specifically for the purpose of quantifying elemental impurity leachables in a variety of parenteral formulations. Results indicated that the degree of elemental impurity leachables imparted by the specific type of glass vial evaluated during this study posed no risk to patient safety, regardless of the drug product buffer formulation. Following this evaluation, the ICP-MS method developed for the determination of elemental impurities leachables has been successfully applied to the assessment of elemental impurities in a number of different biological parenteral drug product formulations currently under development. These data can be leveraged for inclusion in elemental impurities component ICH-Q3D risk assessments to satisfy the container closure system contribution.
    MeSH term(s) Humans ; Pharmaceutical Preparations ; Drug Packaging ; Spectrum Analysis ; Risk Assessment/methods ; Mass Spectrometry/methods ; Drug Contamination/prevention & control
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2022-10-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1205009-x
    ISSN 1948-2124 ; 0277-3406 ; 1076-397X ; 0279-7976 ; 1079-7440
    ISSN (online) 1948-2124
    ISSN 0277-3406 ; 1076-397X ; 0279-7976 ; 1079-7440
    DOI 10.5731/pdajpst.2021.012655
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Adverse Childhood Experiences: Concept Mapping in the Bachelor of Science in Nursing Curriculum.

    Gill, Marie E / Zhan, Lin / Rosenberg, Judith / Breckenridge, Leigh Ann

    The Journal of nursing education

    2019  Volume 58, Issue 4, Page(s) 193–200

    Abstract: ... to translate knowledge to practice ACEs awareness and prevention toward health equity for all. [J Nurs Educ. 2019;58(4 ...

    Abstract Background: Adverse childhood experiences (ACEs) have deleterious effects on health across the lifespan. Educating health professionals for ACEs awareness and prevention facilitates quality care. Literature documents concept mapping as an effective teaching strategy used in health professions to stimulate learning and foster students' critical thinking. However, ACEs curricular concept mapping remains unexplored.
    Method: Content analysis with manifest coding was used to identify key concepts based on faculty narratives and discussion notes about ACEs content.
    Results: Major and minor themes emerged to support the ACEs Curricular Concept Map development with direct and indirect paths to culture of health and health equity.
    Conclusions: The ACEs Curricular Concept Map was developed to guide teaching ACEs knowledge in a Bachelor of Science in Nursing program. Future studies are needed to evaluate the impact of ACEs curricular concepts on nursing students' learning and graduates' ability to translate knowledge to practice ACEs awareness and prevention toward health equity for all. [J Nurs Educ. 2019;58(4):193-200.].
    MeSH term(s) Adverse Childhood Experiences ; Concept Formation ; Curriculum ; Education, Nursing, Baccalaureate/organization & administration ; Humans ; Learning ; Nursing Education Research ; Nursing Evaluation Research ; Qualitative Research ; Students, Nursing/psychology ; Thinking
    Language English
    Publishing date 2019-04-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 410686-6
    ISSN 1938-2421 ; 0148-4834
    ISSN (online) 1938-2421
    ISSN 0148-4834
    DOI 10.3928/01484834-20190321-02
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Author Correction: Fructosamine is a valuable marker for glycemic control and predicting adverse outcomes following total hip arthroplasty: a prospective multi‑institutional investigation.

    Shohat, Noam / Goswami, Karan / Breckenridge, Leigham / Held, Michael B / Malkani, Arthur L / Shah, Roshan P / Schwarzkopf, Ran / Parvizi, Javad

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 16026

    Language English
    Publishing date 2021-08-02
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-94867-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Fructosamine is a valuable marker for glycemic control and predicting adverse outcomes following total hip arthroplasty: a prospective multi-institutional investigation.

    Shohat, Noam / Goswami, Karan / Breckenridge, Leigham / Held, Michael B / Malkani, Arthur L / Shah, Roshan P / Schwarzkopf, Ran / Parvizi, Javad

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 2227

    Abstract: ... on the subject, fructosamine levels above 293 µmol/L were used to define inadequate glycemic control. Overall ... from surgery. Of those, 54 patients (4.5%) had elevated fructosamine levels (> 293 µmol/L) and these patients ... L (p = 0.002). Patients with elevated fructosamine were also associated with more readmissions (16.7 ...

    Abstract Recently, fructosamine has shown promising results in predicting adverse outcomes following total knee arthroplasty. The purpose of this study was to assess the utility of fructosamine to predict adverse outcomes following total hip arthroplasty (THA). A prospective multi-center study involving four institutions was conducted. All primary THA were evaluated for glycemic control using fructosamine levels prior to surgery. Adverse outcomes were assessed at a minimum 1 year from surgery. Primary outcome of interest was periprosthetic joint infection (PJI) based on the International Consensus Meeting (ICM) criteria. Secondary outcomes assessed were superficial infections, readmissions and death. Based on previous studies on the subject, fructosamine levels above 293 µmol/L were used to define inadequate glycemic control. Overall 1212 patients were enrolled in the present study and were available for follow up at a minimum 1 year from surgery. Of those, 54 patients (4.5%) had elevated fructosamine levels (> 293 µmol/L) and these patients were 6.7 times more likely to develop PJI compared to patients with fructosamine levels below 293 µmol/L (p = 0.002). Patients with elevated fructosamine were also associated with more readmissions (16.7% vs. 4.4%, p < 0.007) and a higher mortality rate (3.7% vs. 0.6%, p = 0.057). These associations remained statistically significant in a multi-regression analysis after adjusting for age, comorbidities and length of stay; Adjusted odds ratio were 6.37 (95% confidence interval 1.98-20.49, p = 0.002) for PJI and 2.68 (95% confidence interval 1.14-6.29, p = 0.023) for readmissions. Fructosamine is a good predictor of adverse outcomes in patients undergoing THA and should be used routinely to mitigate morbidity and mortality risk.
    MeSH term(s) Aged ; Arthroplasty, Replacement, Hip/adverse effects ; Biomarkers/metabolism ; Blood Glucose ; Female ; Fructosamine/metabolism ; Glycemic Control ; Humans ; Male ; Middle Aged ; Prospective Studies
    Chemical Substances Biomarkers ; Blood Glucose ; Fructosamine (4429-04-3)
    Language English
    Publishing date 2021-01-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-81803-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Direct Anterior Approach to the Hip Does Not Increase the Risk for Subsequent Periprosthetic Joint Infection.

    Shohat, Noam / Goswami, Karan / Clarkson, Samuel / Chisari, Emanuele / Breckenridge, Leigham / Gursay, D'Andrew / Tan, Timothy L / Parvizi, Javad

    The Journal of arthroplasty

    2021  Volume 36, Issue 6, Page(s) 2038–2043

    Abstract: Background: Recent studies suggest an increased risk for periprosthetic joint infection (PJI) utilizing the direct anterior (DA) approach to the hip. The purpose of this study was to investigate whether such an increased risk does indeed exist on a ... ...

    Abstract Background: Recent studies suggest an increased risk for periprosthetic joint infection (PJI) utilizing the direct anterior (DA) approach to the hip. The purpose of this study was to investigate whether such an increased risk does indeed exist on a large cohort of patients, operated by experienced surgeons and taking into account various confounders.
    Methods: This was a single institutional study, including all patients who underwent primary total hip arthroplasty during the last decade, who were operated on by four high-volume arthroplasty surgeons utilizing a single surgical approach. Three of them utilized the direct lateral (DL) approach while one of them used the DA approach throughout the entire study. Patient characteristics, demographics, and comorbidities were assessed as well as operative and perioperative factors and their association with PJI. Association between surgical approach and PJI was evaluated in a univariate followed by a multivariate regression analysis.
    Results: A total of 10,201 patients were included in the study. Of those, 4390 (43.0%) underwent total hip arthroplasty through the DA approach and 5811 (57.0%) through the DL approach. PJI rates were 0.9% (38/4390) in the DA group compared with 1.3% (73/5811) in the DL group (P = .068). Results from a regression analysis showed no significant association between PJI and DA approach (adjusted odds ratio 0.760, 95% confidence interval 0.428-1.348, P = .348). The risk remained nonsignificant in patients with higher body mass index. There were also no significant differences in the infecting organisms between the two groups.
    Conclusion: The DA approach to the hip does not increase the risk for subsequent PJI.
    MeSH term(s) Arthritis, Infectious ; Arthroplasty, Replacement, Hip ; Humans ; Prosthesis-Related Infections/surgery ; Retrospective Studies ; Risk Factors
    Language English
    Publishing date 2021-02-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632770-9
    ISSN 1532-8406 ; 0883-5403
    ISSN (online) 1532-8406
    ISSN 0883-5403
    DOI 10.1016/j.arth.2021.02.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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