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  1. Book ; Conference proceedings: Proceedings des 28. Symposiums Experimentelle Strahlentherapie und Klinische Strahlenbiologie "Präklinische und translationale Strahlentherapie"

    Cordes, Nils / Krause, Mechthild / Petersen, Cordula / Rodemann, Hans Peter / Rothkamm, Kai / Zips, Daniel / Baumann, Michael

    Dresden, 14.-16. März 2019

    (Experimentelle Strahlentherapie und klinische Strahlenbiologie ; 28)

    2019  

    Title variant Präklinische und translationale Strahlentherapie und personalisierte Medizin: -omics
    Event/congress Symposium Experimentelle Strahlentherapie und Klinische Strahlenbiologie "Präklinische und translationale Strahlentherapie (28., 2019, Dresden)
    Author's details Herausgegeben von Michael Baumann, Nils Cordes, Mechthild Krause, Cordula Petersen, H. Peter Rodemann, Kai Rothkamm, Daniel Zips
    Series title Experimentelle Strahlentherapie und klinische Strahlenbiologie ; 28
    Collection
    Language German ; English
    Size 95 Seiten, Illustrationen
    Publisher Selbstverlag
    Publishing place Dresden
    Publishing country Germany
    Document type Book ; Conference proceedings
    HBZ-ID HT020023730
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2019 A 417 available for loan (reading room) Lesesaal EG

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  2. Book ; Online ; E-Book: Neuropharmacology of new psychoactive substances (NPS)

    Baumann, Michael H. / Glennon, Richard A. / Wiley, Jenny L.

    the science behind the headlines

    (Current topics in behavioral neurosciences ; 32)

    2017  

    Abstract: Designer drugs, or new psychoactive substances (NPS), are synthetic chemicals that mimic the effects of classic drugs of abuse. There has been an alarming worldwide increase in the abuse of NPS in recent years. NPS are cheap, easy to obtain, and often ... ...

    Author's details Michael H. Baumann, Richard A. Glennon, Jenny L. Wiley editors
    Series title Current topics in behavioral neurosciences ; 32
    Collection
    Abstract Designer drugs, or new psychoactive substances (NPS), are synthetic chemicals that mimic the effects of classic drugs of abuse. There has been an alarming worldwide increase in the abuse of NPS in recent years. NPS are cheap, easy to obtain, and often legally available. In this volume, leading experts summarize the latest studies regarding the molecular mechanisms of action, behavioral effects, and adverse consequences of popular NPS. Specific chapters clarify the differences between various types of NPS, namely: stimulants, cannabinoids and hallucinogens. Thus, this volume broadens our understanding of NPS and provides insight into the rapidly evolving "new drug" phenomenon
    Keywords Psychotropic Drugs / pharmacology ; Psychotropic Drugs / adverse effects ; Substance-Related Disorders ; Designer Drugs ; Street Drugs ; Brain / drug effects
    Language English
    Size 1 Online-Ressource (viii, 380 Seiten), Illustrationen, Diagramme
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019660978
    ISBN 978-3-319-52444-3 ; 9783319524429 ; 3-319-52444-5 ; 3319524429
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  3. Article ; Online: Comparative Pharmacological Effects of Lisuride and Lysergic Acid Diethylamide Revisited.

    Glatfelter, Grant C / Pottie, Eline / Partilla, John S / Stove, Christophe P / Baumann, Michael H

    ACS pharmacology & translational science

    2024  Volume 7, Issue 3, Page(s) 641–653

    Abstract: Lisuride is a non-psychedelic serotonin (5-HT) 2A receptor (5- ... ...

    Abstract Lisuride is a non-psychedelic serotonin (5-HT) 2A receptor (5-HT
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article
    ISSN 2575-9108
    ISSN (online) 2575-9108
    DOI 10.1021/acsptsci.3c00192
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Psychedelic-like Activity of Norpsilocin Analogues.

    Sherwood, Alexander M / Burkhartzmeyer, Elise K / Williamson, Samuel E / Baumann, Michael H / Glatfelter, Grant C

    ACS chemical neuroscience

    2024  Volume 15, Issue 2, Page(s) 315–327

    Abstract: Primary metabolites of mushroom tryptamines, psilocybin and baeocystin (i.e., psilocin and norpsilocin), exhibit potent agonist activity at the serotonin 2A receptor (5- ... ...

    Abstract Primary metabolites of mushroom tryptamines, psilocybin and baeocystin (i.e., psilocin and norpsilocin), exhibit potent agonist activity at the serotonin 2A receptor (5-HT
    MeSH term(s) Mice ; Animals ; Hallucinogens/chemistry ; Serotonin/metabolism ; Receptors, Serotonin/metabolism ; Brain/metabolism ; Receptor, Serotonin, 5-HT2A/metabolism
    Chemical Substances Hallucinogens ; omega-N-methyl-4-hydroxytryptamine ; Serotonin (333DO1RDJY) ; Receptors, Serotonin ; Receptor, Serotonin, 5-HT2A
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7193
    ISSN (online) 1948-7193
    DOI 10.1021/acschemneuro.3c00610
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Novel Benzofuran Derivatives Induce Monoamine Release and Substitute for the Discriminative Stimulus Effects of 3,4-Methylenedioxymethamphetamine.

    Johnson, Candace B / Walther, Donna / Baggott, Matthew J / Baker, Lisa E / Baumann, Michael H

    The Journal of pharmacology and experimental therapeutics

    2024  

    Abstract: 3,4-Methylenedioxymethamphetamine (MDMA) has shown efficacy as a medication adjunct for treating post-traumatic stress disorder (PTSD). However, MDMA is also used in non-medical contexts that pose risk for cardiovascular and neurological complications. ... ...

    Abstract 3,4-Methylenedioxymethamphetamine (MDMA) has shown efficacy as a medication adjunct for treating post-traumatic stress disorder (PTSD). However, MDMA is also used in non-medical contexts that pose risk for cardiovascular and neurological complications. It is well established that MDMA exerts its effects by stimulating transporter-mediated release of the monoamines, 5‑hydroxytryptamine (5-HT), norepinephrine, and dopamine. Current research efforts are aimed at developing MDMA-like monoamine releasers with better efficacy and safety profiles. To this end, we investigated neurochemical and behavioral effects of novel analogs of the designer drug, 5-(2-methylaminopropyl)benzofuran (5-MAPB). We used
    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3106-9
    ISSN 1521-0103 ; 0022-3565
    ISSN (online) 1521-0103
    ISSN 0022-3565
    DOI 10.1124/jpet.123.001837
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uf I Zs.40: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Automated Computer Software Assessment of 5-Hydroxytryptamine 2A Receptor-Mediated Head Twitch Responses from Video Recordings of Mice.

    Glatfelter, Grant C / Chojnacki, Michael R / McGriff, Shelby A / Wang, Tianpeng / Baumann, Michael H

    ACS pharmacology & translational science

    2022  Volume 5, Issue 5, Page(s) 321–330

    Abstract: Psychedelics are a class of drugs that produce unique subjective effects via agonist actions at the 5-hydroxytryptamine 2A receptor (5- ... ...

    Abstract Psychedelics are a class of drugs that produce unique subjective effects via agonist actions at the 5-hydroxytryptamine 2A receptor (5-HT
    Language English
    Publishing date 2022-04-08
    Publishing country United States
    Document type Journal Article
    ISSN 2575-9108
    ISSN (online) 2575-9108
    DOI 10.1021/acsptsci.1c00237
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The Changing Face of Recreational Drug Use.

    Baumann, Michael H

    Cerebrum : the Dana forum on brain science

    2016  Volume 2016

    Abstract: Our author writes that recent data from the United Nations Office of Drugs and Crime indicate that 540 different drugs classified as new psychoactive substances (NPS) have been identified worldwide as of 2014, and this number is expected to rise. His ... ...

    Abstract Our author writes that recent data from the United Nations Office of Drugs and Crime indicate that 540 different drugs classified as new psychoactive substances (NPS) have been identified worldwide as of 2014, and this number is expected to rise. His article describes the complexity of the NPS problem, what is known about the molecular mechanisms of action, and the pharmacological effects of NPS. It also highlights some of the considerable challenges in dealing with this emerging issue.
    Language English
    Publishing date 2016-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2251230-5
    ISSN 1524-6205
    ISSN 1524-6205
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  8. Article ; Online: In Vitro Functional Profiling of Fentanyl and Nitazene Analogs at the μ-Opioid Receptor Reveals High Efficacy for Gi Protein Signaling.

    Tsai, Meng-Hua M / Chen, Li / Baumann, Michael H / Canals, Meritxell / Javitch, Jonathan A / Lane, J Robert / Shi, Lei

    ACS chemical neuroscience

    2024  Volume 15, Issue 4, Page(s) 854–867

    Abstract: Novel synthetic opioids (NSOs), including both fentanyl and non-fentanyl analogs that act as μ-opioid receptor (MOR) agonists, are associated with serious intoxication and fatal overdose. Previous studies proposed that G-protein-biased MOR agonists are ... ...

    Abstract Novel synthetic opioids (NSOs), including both fentanyl and non-fentanyl analogs that act as μ-opioid receptor (MOR) agonists, are associated with serious intoxication and fatal overdose. Previous studies proposed that G-protein-biased MOR agonists are safer pain medications, while other evidence indicates that low intrinsic efficacy at MOR better explains the reduced opioid side effects. Here, we characterized the in vitro functional profiles of various NSOs at the MOR using adenylate cyclase inhibition and β-arrestin2 recruitment assays, in conjunction with the application of the receptor depletion approach. By fitting the concentration-response data to the operational model of agonism, we deduced the intrinsic efficacy and affinity for each opioid in the Gi protein signaling and β-arrestin2 recruitment pathways. Compared to the reference agonist [d-Ala
    MeSH term(s) Fentanyl/pharmacology ; Analgesics, Opioid/pharmacology ; Receptors, Opioid, mu/agonists ; Signal Transduction ; GTP-Binding Proteins/metabolism ; Enkephalins/pharmacology ; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-/pharmacology
    Chemical Substances Fentanyl (UF599785JZ) ; Analgesics, Opioid ; Receptors, Opioid, mu ; GTP-Binding Proteins (EC 3.6.1.-) ; Enkephalins ; Enkephalin, Ala(2)-MePhe(4)-Gly(5)- (100929-53-1)
    Language English
    Publishing date 2024-02-12
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7193
    ISSN (online) 1948-7193
    DOI 10.1021/acschemneuro.3c00750
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Kartograf: A Geometrically Accurate Atom Mapper for Hybrid-Topology Relative Free Energy Calculations.

    Ries, Benjamin / Alibay, Irfan / Swenson, David W H / Baumann, Hannah M / Henry, Michael M / Eastwood, James R B / Gowers, Richard J

    Journal of chemical theory and computation

    2024  Volume 20, Issue 5, Page(s) 1862–1877

    Abstract: Relative binding free energy (RBFE) calculations have emerged as a powerful tool that supports ligand optimization in drug discovery. Despite many successes, the use of RBFEs can often be limited by automation problems, in particular, the setup of such ... ...

    Abstract Relative binding free energy (RBFE) calculations have emerged as a powerful tool that supports ligand optimization in drug discovery. Despite many successes, the use of RBFEs can often be limited by automation problems, in particular, the setup of such calculations. Atom mapping algorithms are an essential component in setting up automatic large-scale hybrid-topology RBFE calculation campaigns. Traditional algorithms typically employ a 2D subgraph isomorphism solver (SIS) in order to estimate the maximum common substructure. SIS-based approaches can be limited by time-intensive operations and issues with capturing geometry-linked chemical properties, potentially leading to suboptimal solutions. To overcome these limitations, we have developed Kartograf, a geometric-graph-based algorithm that uses primarily the 3D coordinates of atoms to find a mapping between two ligands. In free energy approaches, the ligand conformations are usually derived from docking or other previous modeling approaches, giving the coordinates a certain importance. By considering the spatial relationships between atoms related to the molecule coordinates, our algorithm bypasses the computationally complex subgraph matching of SIS-based approaches and reduces the problem to a much simpler bipartite graph matching problem. Moreover, Kartograf effectively circumvents typical mapping issues induced by molecule symmetry and stereoisomerism, making it a more robust approach for atom mapping from a geometric perspective. To validate our method, we calculated mappings with our novel approach using a diverse set of small molecules and used the mappings in relative hydration and binding free energy calculations. The comparison with two SIS-based algorithms showed that Kartograf offers a fast alternative approach. The code for Kartograf is freely available on GitHub (https://github.com/OpenFreeEnergy/kartograf). While developed for the OpenFE ecosystem, Kartograf can also be utilized as a standalone Python package.
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Journal Article
    ISSN 1549-9626
    ISSN (online) 1549-9626
    DOI 10.1021/acs.jctc.3c01206
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Eutylone and Its Structural Isomers Interact with Monoamine Transporters and Induce Locomotor Stimulation.

    Glatfelter, Grant C / Walther, Donna / Evans-Brown, Michael / Baumann, Michael H

    ACS chemical neuroscience

    2021  Volume 12, Issue 7, Page(s) 1170–1177

    Abstract: Synthetic cathinones are a class of new psychoactive substances that induce psychostimulant effects and pose risk for hospitalizations, overdose, and death. At the present time, derivatives of the synthetic cathinone, methylone, are being confiscated in ... ...

    Abstract Synthetic cathinones are a class of new psychoactive substances that induce psychostimulant effects and pose risk for hospitalizations, overdose, and death. At the present time, derivatives of the synthetic cathinone, methylone, are being confiscated in nonmedical (i.e., recreational) drug markets worldwide. In particular, eutylone is a newly emerging methylone analog that possesses ethyl groups at the α-carbon and amine positions. Little information is available about the pharmacological effects of eutylone, but based on its structure, we surmised that the compound interacts with monoamine transporters in the brain. To test this hypothesis, we compared the effects of eutylone and its structural isomers, dibutylone and pentylone, using
    MeSH term(s) Animals ; Central Nervous System Stimulants/pharmacology ; Dopamine Plasma Membrane Transport Proteins ; Mice ; Norepinephrine Plasma Membrane Transport Proteins ; Rats ; Rats, Sprague-Dawley ; Serotonin Plasma Membrane Transport Proteins ; Synaptosomes
    Chemical Substances Central Nervous System Stimulants ; Dopamine Plasma Membrane Transport Proteins ; Norepinephrine Plasma Membrane Transport Proteins ; Serotonin Plasma Membrane Transport Proteins
    Language English
    Publishing date 2021-03-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ISSN 1948-7193
    ISSN (online) 1948-7193
    DOI 10.1021/acschemneuro.0c00797
    Database MEDical Literature Analysis and Retrieval System OnLINE

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