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  1. Article: UNC-16 interacts with LRK-1 and WDFY-3 to regulate the termination of axon growth.

    Drozd, Cody J / Chowdhury, Tamjid A / Quinn, Christopher C

    bioRxiv : the preprint server for biology

    2024  

    Abstract: MAPK8IP3 (unc-16/JIP3) ...

    Abstract MAPK8IP3 (unc-16/JIP3)
    Language English
    Publishing date 2024-02-16
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.02.15.580526
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: UNC-116 and UNC-16 function with the NEKL-3 kinase to promote axon targeting.

    Drozd, Cody J / Quinn, Christopher C

    Development (Cambridge, England)

    2023  Volume 150, Issue 18

    Abstract: KIF5C is a kinesin-1 heavy chain that has been associated with neurodevelopmental disorders. Although the roles of kinesin-1 in axon transport are well known, little is known about how it regulates axon targeting. We report that UNC-116/KIF5C functions ... ...

    Abstract KIF5C is a kinesin-1 heavy chain that has been associated with neurodevelopmental disorders. Although the roles of kinesin-1 in axon transport are well known, little is known about how it regulates axon targeting. We report that UNC-116/KIF5C functions with the NEKL-3/NEK6/7 kinase to promote axon targeting in Caenorhabditis elegans. Loss of UNC-116 causes the axon to overshoot its target and UNC-116 gain-of-function causes premature axon termination. We find that loss of the UNC-16/JIP3 kinesin-1 cargo adaptor disrupts axon termination, but loss of kinesin-1 light chain function does not affect axon termination. Genetic analysis indicates that UNC-16 functions with the NEKL-3 kinase to promote axon termination. Consistent with this observation, imaging experiments indicate that loss of UNC-16 and UNC-116 disrupt localization of NEKL-3 in the axon. Moreover, genetic interactions suggest that NEKL-3 promotes axon termination by functioning with RPM-1, a ubiquitin ligase that regulates microtubule stability in the growth cone. These observations support a model where UNC-116 functions with UNC-16 to promote localization of NEKL-3 in the axon. NEKL-3, in turn, functions with the RPM-1 ubiquitin ligase to promote axon termination.
    MeSH term(s) Animals ; Caenorhabditis elegans Proteins/genetics ; Kinesins/genetics ; Axons/physiology ; Caenorhabditis elegans ; Ligases ; Ubiquitins ; Guanine Nucleotide Exchange Factors/genetics
    Chemical Substances Caenorhabditis elegans Proteins ; Kinesins (EC 3.6.4.4) ; Ligases (EC 6.-) ; Ubiquitins ; RPM-1 protein, C elegans ; Guanine Nucleotide Exchange Factors
    Language English
    Publishing date 2023-09-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 90607-4
    ISSN 1477-9129 ; 0950-1991
    ISSN (online) 1477-9129
    ISSN 0950-1991
    DOI 10.1242/dev.201654
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MG 91: Show issues

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  3. Article ; Online: UNC-16 interacts with LRK-1 and WDFY-3 to regulate the termination of axon growth.

    Drozd, Cody J / Chowdhury, Tamjid A / Quinn, Christopher C

    Genetics

    2024  

    Abstract: In humans, MAPK8IP3 (also known as JIP3) is a neurodevelopmental disorder-associated gene. In C ...

    Abstract In humans, MAPK8IP3 (also known as JIP3) is a neurodevelopmental disorder-associated gene. In C. elegans, the UNC-16 ortholog of the MAPK8IP3 protein can regulate the termination of axon growth. However, its role in this process is not well understood. Here, we report that UNC-16 promotes axon termination through a process that includes the LRK-1(LRRK-1/LRRK-2) kinase and the WDFY-3 (WDFY3/Alfy) selective autophagy protein. Genetic analysis suggests that UNC-16 promotes axon termination through an interaction between its RH1 domain and the dynein complex. Loss of unc-16 function causes accumulation of late endosomes specifically in the distal axon. Moreover, we observe synergistic interactions between loss of unc-16 function and disruptors of endolysosomal function, indicating that the endolysosomal system promotes axon termination. We also find that the axon termination defects caused by loss of UNC-16 function require the function of a genetic pathway that includes lrk-1 and wdfy-3, two genes that have been implicated in autophagy. These observations suggest a model where UNC-16 promotes axon termination by interacting with the endolysosomal system to regulate a pathway that includes LRK-1 and WDFY-3.
    Language English
    Publishing date 2024-04-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2167-2
    ISSN 1943-2631 ; 0016-6731
    ISSN (online) 1943-2631
    ISSN 0016-6731
    DOI 10.1093/genetics/iyae053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 767: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: An autism-associated calcium channel variant causes defects in neuronal polarity in the ALM neuron of

    Buddell, Tyler / Quinn, Christopher C

    microPublication biology

    2021  Volume 2021

    Abstract: Variants of ... ...

    Abstract Variants of the
    Language English
    Publishing date 2021-04-01
    Publishing country United States
    Document type Journal Article
    ISSN 2578-9430
    ISSN (online) 2578-9430
    DOI 10.17912/micropub.biology.000378
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  5. Article: Time for a Measurement Check-Up: Testing the Couple's Satisfaction Index and the Global Measure of Sexual Satisfaction Using Structural Equation Modeling and Item Response Theory.

    Quinn-Nilas, Christopher

    Journal of social and personal relationships

    2022  Volume 40, Issue 7, Page(s) 2252–2276

    Abstract: Relationship and sexual satisfaction are two central outcomes in the study of relationships and are commonly used in both academia and applied practice. However, relationship and sexual satisfaction measures infrequently undergo specific psychometric ... ...

    Abstract Relationship and sexual satisfaction are two central outcomes in the study of relationships and are commonly used in both academia and applied practice. However, relationship and sexual satisfaction measures infrequently undergo specific psychometric investigation. Ensuring that measures display strong psychometric performance is an important but under-tested element of replication that has come under more scrutiny lately, and adequate measurement of constructs is an important auxiliary assumption underpinning theory-testing empirical work. A measurement check-up was conducted, including Confirmatory Factor Analysis (CFA) to test factorial validity, measurement invariance to test for group comparability, and Item Response Theory (IRT) to assess the relationship between latent traits and their items/indicators. This format was used to evaluate the psychometric properties of the Couple's Satisfaction Index (CSI) and the Global Measure of Sexual Satisfaction (GMSEX), two commonly used scales of relationship and sexual satisfaction with a sample of 640 midlife (40-59 years old) married Canadians who were recruited by Qualtrics Panels. Results of CFA suggested that both models were satisfactory. Invariance testing provided robust support for intercept invariance across all the groupings tested. IRT analysis supported the CSI and GMSEX, however, there was evidence that the GMSEX provided somewhat less information for those high on sexual satisfaction. This measurement check-up found that the CSI and GMSEX were reasonably healthy with some caveats. Implications are discussed in terms of replicability and meaning for scholars and practitioners.
    Language English
    Publishing date 2022-12-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2023968-3
    ISSN 1460-3608 ; 0265-4075
    ISSN (online) 1460-3608
    ISSN 0265-4075
    DOI 10.1177/02654075221143360
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  6. Article: Management of Shoulder Instability in Patients with Underlying Hyperlaxity.

    Rupp, Marco-Christopher / Rutledge, Joan C / Quinn, Patrick M / Millett, Peter J

    Current reviews in musculoskeletal medicine

    2023  Volume 16, Issue 4, Page(s) 123–144

    Abstract: Purpose of review: Shoulder instability in patients with underlying joint hyperlaxity can be challenging to treat. Poorly defined terminology, heterogeneous treatments, and sparse reports on clinical outcomes impair the development of best practices in ... ...

    Abstract Purpose of review: Shoulder instability in patients with underlying joint hyperlaxity can be challenging to treat. Poorly defined terminology, heterogeneous treatments, and sparse reports on clinical outcomes impair the development of best practices in this patient population. This article provides a review of the current literature regarding optimal management of patients suffering from shoulder instability with concomitant hyperlaxity of the shoulder, from isolated shoulder joint hyperlaxity to congenital hypermobility spectrum disorders (HSD).
    Recent findings: Current research shows specialized physiotherapy protocols focused on strengthening of periscapular muscles and improvement of sensorimotor control are a promising non-surgical therapeutic avenue in certain patients, which can be augmented by device-based intervention in select cases. If surgical treatment is warranted, arthroscopic techniques such as pancapsular shift or plication continue to demonstrate favorable outcomes and are currently considered the benchmark for success. The long-term success of more recent innovations such as coracoid process transfers, conjoint tendon transfers, subscapularis tendon augmentation, and capsular reconstruction remains unproven. For patients affected by connective tissue disorders, treatment success is generally less predictable, and the entire array of non-operative and operative interventions needs to be considered to achieve the best patient-specific treatment results. In the treatment of shoulder instability and concomitant hyperlaxity, specialized physiotherapy protocols augmented by device-based interventions have emerged as powerful, non-operative treatment options for select patients. Successful surgical approaches have been demonstrated to comprehensively address capsular redundancy, labral lesions, and incompetence of additional passive stabilizers in a patient-specific fashion, respective of the underlying connective tissue constitution.
    Language English
    Publishing date 2023-02-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2407827-X
    ISSN 1935-9748 ; 1935-973X
    ISSN (online) 1935-9748
    ISSN 1935-973X
    DOI 10.1007/s12178-023-09822-6
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  7. Article: Autism candidate gene

    Chowdhury, Tamjid A / Luy, David A / Farache, Dorian / Lee, Amy Sy / Quinn, Christopher C

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Mitochondrial dysfunction is thought to be a key component of neurodevelopmental disorders such as autism, intellectual disability, and ADHD. However, little is known about the molecular mechanisms that protect against mitochondrial dysfunction during ... ...

    Abstract Mitochondrial dysfunction is thought to be a key component of neurodevelopmental disorders such as autism, intellectual disability, and ADHD. However, little is known about the molecular mechanisms that protect against mitochondrial dysfunction during neurodevelopment. Here, we address this question through the investigation of
    Language English
    Publishing date 2023-10-14
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.10.12.562060
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  8. Article ; Online: Psychiatric Presentations of Creutzfeldt-Jakob Disease: A Case Report.

    Harrington, Kelly / Abbott, Christopher C / Quinn, Davin

    Journal of the Academy of Consultation-Liaison Psychiatry

    2021  Volume 62, Issue 2, Page(s) 248–252

    MeSH term(s) Creutzfeldt-Jakob Syndrome/diagnosis ; Diagnosis, Differential ; Electroencephalography ; Humans
    Language English
    Publishing date 2021-01-29
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2667-2960
    ISSN (online) 2667-2960
    DOI 10.1016/j.jaclp.2021.01.006
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  9. Article ; Online: All-Polyhydroxyalkanoate Triblock Copolymers via a Stereoselective-Chemocatalytic Route.

    Westlie, Andrea H / Hesse, Sarah A / Tang, Xiaoyan / Quinn, Ethan C / Parker, Celine R / Takacs, Christopher J / Tassone, Christopher J / Chen, Eugene Y-X

    ACS macro letters

    2023  Volume 12, Issue 5, Page(s) 619–625

    Abstract: Biodegradable polyhydroxyalkanoate (PHA) homopolymers and statistical copolymers are ubiquitous in microbially produced PHAs, but the step-growth polycondensation mechanism the biosynthesis operates on presents a challenge to access well-defined block ... ...

    Abstract Biodegradable polyhydroxyalkanoate (PHA) homopolymers and statistical copolymers are ubiquitous in microbially produced PHAs, but the step-growth polycondensation mechanism the biosynthesis operates on presents a challenge to access well-defined block copolymers (BCPs), especially higher-order tri-BCP PHAs. Here we report a stereoselective-chemocatalytic route to produce discrete hard-soft-hard ABA all-PHA tri-BCPs based on the living chain-growth ring-opening polymerization of racemic (
    Language English
    Publishing date 2023-04-24
    Publishing country United States
    Document type Journal Article
    ISSN 2161-1653
    ISSN (online) 2161-1653
    DOI 10.1021/acsmacrolett.3c00162
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Seasonal Captures of

    Quinn, Nicole F / Talamas, Elijah J / Leskey, Tracy C / Bergh, J Christopher

    Insects

    2021  Volume 12, Issue 2

    Abstract: Trissolcus ... ...

    Abstract Trissolcus japonicus
    Language English
    Publishing date 2021-01-29
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2075-4450
    ISSN 2075-4450
    DOI 10.3390/insects12020118
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