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Article ; Online: B-cell Lymphoproliferative Disorders Associated with Primary and Acquired Immunodeficiency.

Low, Lawrence K / Song, Joo Y

Surgical pathology clinics

2016 Volume 9, Issue 1, Page(s) 55–77

Abstract: The diagnosis of lymphoproliferative disorders associated with immunodeficiency can be challenging because many of these conditions have overlapping clinical and pathologic features and share similarities with their counterparts in the immunocompetent ... ...

Abstract	The diagnosis of lymphoproliferative disorders associated with immunodeficiency can be challenging because many of these conditions have overlapping clinical and pathologic features and share similarities with their counterparts in the immunocompetent setting. There are subtle but important differences between these conditions that are important to recognize for prognostic and therapeutic purposes. This article provides a clinicopathologic update on how understanding of these B-cell lymphoproliferations in immunodeficiency has evolved over the past decade.
MeSH term(s)	B-Lymphocytes/immunology ; Burkitt Lymphoma/diagnosis ; Burkitt Lymphoma/etiology ; Burkitt Lymphoma/immunology ; Diagnosis, Differential ; Epstein-Barr Virus Infections/complications ; Epstein-Barr Virus Infections/diagnosis ; Epstein-Barr Virus Infections/immunology ; Humans ; Immunologic Deficiency Syndromes/complications ; Immunologic Deficiency Syndromes/immunology ; Immunosuppressive Agents/adverse effects ; Lymphoma, AIDS-Related/diagnosis ; Lymphoma, B-Cell/diagnosis ; Lymphoma, B-Cell/etiology ; Lymphoma, B-Cell/immunology ; Lymphomatoid Granulomatosis/diagnosis ; Lymphomatoid Granulomatosis/etiology ; Lymphomatoid Granulomatosis/immunology ; Lymphoproliferative Disorders/diagnosis ; Lymphoproliferative Disorders/etiology ; Lymphoproliferative Disorders/immunology ; Skin Ulcer/immunology ; Skin Ulcer/virology
Chemical Substances	Immunosuppressive Agents
Language	English
Publishing date	2016-03
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1875-9157
ISSN (online)	1875-9157
DOI	10.1016/j.path.2015.10.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Comprehensive assessment of anaplastic lymphoma kinase in localized and metastatic prostate cancer reveals targetable alterations.

Patel, Radhika A / Coleman, Ilsa / Roudier, Martine P / Konnick, Eric Q / Hanratty, Brian / Dumpit, Ruth / Lucas, Jared M / Ang, Lisa S / Low, Jin-Yih / Tretiakova, Maria S / Ha, Gavin / Lee, John K / True, Lawrence D / De Marzo, Angelo M / Nelson, Peter S / Morrissey, Colm / Pritchard, Colin C / Haffner, Michael C

Cancer research communications

2022 Volume 2, Issue 5, Page(s) 277–285

Abstract: Anaplastic lymphoma kinase (ALK) is a tyrosine kinase with genomic and expression changes in many solid tumors. ALK inhibition is first line therapy for lung cancers ... ...

Abstract	Anaplastic lymphoma kinase (ALK) is a tyrosine kinase with genomic and expression changes in many solid tumors. ALK inhibition is first line therapy for lung cancers with
MeSH term(s)	Male ; Humans ; Anaplastic Lymphoma Kinase/genetics ; Protein Kinase Inhibitors/pharmacology ; Lung Neoplasms/drug therapy ; Protein-Tyrosine Kinases/genetics ; Prostatic Neoplasms/drug therapy
Chemical Substances	Anaplastic Lymphoma Kinase (EC 2.7.10.1) ; Protein Kinase Inhibitors ; Protein-Tyrosine Kinases (EC 2.7.10.1)
Language	English
Publishing date	2022-05-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	2767-9764
ISSN (online)	2767-9764
DOI	10.1158/2767-9764.crc-21-0156
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Article ; Online: Reversible epigenetic alterations mediate PSMA expression heterogeneity in advanced metastatic prostate cancer.

Sayar, Erolcan / Patel, Radhika A / Coleman, Ilsa M / Roudier, Martine P / Zhang, Ailin / Mustafi, Pallabi / Low, Jin-Yih / Hanratty, Brian / Ang, Lisa S / Bhatia, Vipul / Adil, Mohamed / Bakbak, Hasim / Quigley, David A / Schweizer, Michael T / Hawley, Jessica E / Kollath, Lori / True, Lawrence D / Feng, Felix Y / Bander, Neil H /

Corey, Eva / Lee, John K / Morrissey, Colm / Gulati, Roman / Nelson, Peter S / Haffner, Michael C

JCI insight

2023 Volume 8, Issue 7

Abstract: Prostate-specific membrane antigen (PSMA) is an important cell surface target in prostate cancer. There are limited data on the heterogeneity of PSMA tissue expression in metastatic castration-resistant prostate cancer (mCRPC). Furthermore, the ... ...

Abstract	Prostate-specific membrane antigen (PSMA) is an important cell surface target in prostate cancer. There are limited data on the heterogeneity of PSMA tissue expression in metastatic castration-resistant prostate cancer (mCRPC). Furthermore, the mechanisms regulating PSMA expression (encoded by the FOLH1 gene) are not well understood. Here, we demonstrate that PSMA expression is heterogeneous across different metastatic sites and molecular subtypes of mCRPC. In a rapid autopsy cohort in which multiple metastatic sites per patient were sampled, we found that 13 of 52 (25%) cases had no detectable PSMA and 23 of 52 (44%) cases showed heterogeneous PSMA expression across individual metastases, with 33 (63%) cases harboring at least 1 PSMA-negative site. PSMA-negative tumors displayed distinct transcriptional profiles with expression of druggable targets such as MUC1. Loss of PSMA was associated with epigenetic changes of the FOLH1 locus, including gain of CpG methylation and loss of histone 3 lysine 27 (H3K27) acetylation. Treatment with histone deacetylase (HDAC) inhibitors reversed this epigenetic repression and restored PSMA expression in vitro and in vivo. Collectively, these data provide insights into the expression patterns and regulation of PSMA in mCRPC and suggest that epigenetic therapies - in particular, HDAC inhibitors - can be used to augment PSMA levels.
MeSH term(s)	Male ; Humans ; Prostatic Neoplasms, Castration-Resistant/metabolism ; Treatment Outcome ; Prostate-Specific Antigen ; Histone Deacetylase Inhibitors
Chemical Substances	Prostate-Specific Antigen (EC 3.4.21.77) ; Histone Deacetylase Inhibitors
Language	English
Publishing date	2023-04-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	2379-3708
ISSN (online)	2379-3708
DOI	10.1172/jci.insight.162907
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Article ; Online: Reversible epigenetic alterations mediate PSMA expression heterogeneity in advanced metastatic prostate cancer

Erolcan Sayar / Radhika A. Patel / Ilsa M. Coleman / Martine P. Roudier / Ailin Zhang / Pallabi Mustafi / Jin-Yih Low / Brian Hanratty / Lisa S. Ang / Vipul Bhatia / Mohamed Adil / Hasim Bakbak / David A. Quigley / Michael T. Schweizer / Jessica E. Hawley / Lori Kollath / Lawrence D. True / Felix Y. Feng / Neil H. Bander /

Eva Corey / John K. Lee / Colm Morrissey / Roman Gulati / Peter S. Nelson / Michael C. Haffner

JCI Insight, Vol 8, Iss

2023 Volume 7

Abstract	Prostate-specific membrane antigen (PSMA) is an important cell surface target in prostate cancer. There are limited data on the heterogeneity of PSMA tissue expression in metastatic castration-resistant prostate cancer (mCRPC). Furthermore, the mechanisms regulating PSMA expression (encoded by the FOLH1 gene) are not well understood. Here, we demonstrate that PSMA expression is heterogeneous across different metastatic sites and molecular subtypes of mCRPC. In a rapid autopsy cohort in which multiple metastatic sites per patient were sampled, we found that 13 of 52 (25%) cases had no detectable PSMA and 23 of 52 (44%) cases showed heterogeneous PSMA expression across individual metastases, with 33 (63%) cases harboring at least 1 PSMA-negative site. PSMA-negative tumors displayed distinct transcriptional profiles with expression of druggable targets such as MUC1. Loss of PSMA was associated with epigenetic changes of the FOLH1 locus, including gain of CpG methylation and loss of histone 3 lysine 27 (H3K27) acetylation. Treatment with histone deacetylase (HDAC) inhibitors reversed this epigenetic repression and restored PSMA expression in vitro and in vivo. Collectively, these data provide insights into the expression patterns and regulation of PSMA in mCRPC and suggest that epigenetic therapies — in particular, HDAC inhibitors — can be used to augment PSMA levels.
Keywords	Oncology ; Medicine ; R
Subject code	570
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	American Society for Clinical investigation
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Axon pruning: an essential step underlying the developmental plasticity of neuronal connections.

Low, Lawrence K / Cheng, Hwai-Jong

Philosophical transactions of the Royal Society of London. Series B, Biological sciences

2006 Volume 361, Issue 1473, Page(s) 1531–1544

Abstract: Regressive events play a key role in modifying neural connectivity in early development. An important regressive event is the pruning of neuronal processes. Pruning is a strategy often used to selectively remove exuberant neuronal branches and ... ...

Abstract	Regressive events play a key role in modifying neural connectivity in early development. An important regressive event is the pruning of neuronal processes. Pruning is a strategy often used to selectively remove exuberant neuronal branches and connections in the immature nervous system to ensure the proper formation of functional circuitry. In the following review, we discuss our present understanding of the cellular and molecular mechanisms that regulate the pruning of axons during neuronal development as well as in neurological diseases. The evidence suggests that there are several similarities between the mechanisms that are involved in developmental axon pruning and axon elimination in disease. In summary, these findings provide researchers with a unique perspective on how developmental plasticity is achieved and how to develop strategies to treat complex neurological diseases.
MeSH term(s)	Animals ; Axons/physiology ; Nervous System Diseases ; Neural Pathways/physiology ; Neuronal Plasticity/physiology ; Synaptic Transmission/physiology
Language	English
Publishing date	2006-09-29
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	208382-6
ISSN	1471-2970 ; 0962-8436 ; 0080-4622 ; 0264-3839
ISSN (online)	1471-2970
ISSN	0962-8436 ; 0080-4622 ; 0264-3839
DOI	10.1098/rstb.2006.1883
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Article: A little nip and tuck: axon refinement during development and axonal injury.

Low, Lawrence K / Cheng, Hwai-Jong

Current opinion in neurobiology

2005 Volume 15, Issue 5, Page(s) 549–556

Abstract: While building the nervous system, regions of some developing axons are eliminated; this can also happen as a result of axonal injury. During development, many axon branches that are formed in excess of an organism's needs are fated for removal in a ... ...

Abstract	While building the nervous system, regions of some developing axons are eliminated; this can also happen as a result of axonal injury. During development, many axon branches that are formed in excess of an organism's needs are fated for removal in a process called axon pruning. By contrast, when axons are injured the axon segment distal to the injury site is compartmentalized and eliminated. In both cases, the end result is similar -- a region of an axon is selected for removal. Recent evidence suggests that there are some similarities in the cellular and molecular mechanisms that regulate axon elimination in development and during axonal injury.
MeSH term(s)	Animals ; Axons/physiology ; Humans ; Nerve Degeneration/physiopathology ; Nervous System/growth & development
Language	English
Publishing date	2005-10
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review
ZDB-ID	1078046-4
ISSN	1873-6882 ; 0959-4388
ISSN (online)	1873-6882
ISSN	0959-4388
DOI	10.1016/j.conb.2005.08.007
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Zs.A 3260: Show issues

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Article ; Online: Fine focal spot size improves image quality in computed tomography abdomen and pelvis.

Goh, Yin P / Lau, Kenneth K / Low, Keat / Buchan, Kevin / Oh, Lawrence Chia Wei / Kuganesan, Ahilan / Huynh, Minh

European radiology

2016 Volume 26, Issue 12, Page(s) 4545–4550

Abstract: Objectives: To compare the image quality between fine focal spot size (FFSS) and standard focal spot size (SFSS) in computed tomography of the abdomen and pelvis (CTAP) METHODS: This retrospective review included all consecutive adult patients ... ...

Abstract	Objectives: To compare the image quality between fine focal spot size (FFSS) and standard focal spot size (SFSS) in computed tomography of the abdomen and pelvis (CTAP) METHODS: This retrospective review included all consecutive adult patients undergoing contrast-enhanced CTAP between June and September 2014. Two blinded radiologists assessed the margin clarity of the abdominal viscera and the detected lesions using a five-point grading scale. Cohen's kappa test was used to examine the inter-observer reliability between the two reviewers for organ margin clarity. Mann-Whitney U testing was utilised to assess the statistical difference of the organ and lesion margin clarity. Results: 100 consecutive CTAPs were recruited. 52 CTAPs were examined with SFSS of 1.1 × 1.2 mm and 48 CTAPs were examined with FFSS of 0.6 × 0.7 mm. Results showed that there was substantial agreement for organ margin clarity (mean κ = 0.759, p < 0.001) among the reviewers. FFSS produces images with clearer organ margins (U = 76194.0, p < 0.001, r = 0.523) and clearer lesion margins (U = 239, p = 0.052, r = 0.269). Conclusion: FFSS CTAP improves image quality in terms of better organ and lesion margin clarity. Fine focus CT scanning is a novel technique that may be applied in routine CTAP imaging. Key points: • Fine focal spot improves organ margin clarity. • Fine focal spot improves lesion margin clarity. • Fine focal spot can be used in routine CT abdominal imaging.
MeSH term(s)	Abdominal Cavity/diagnostic imaging ; Adult ; Aged ; Aged, 80 and over ; Artifacts ; Cysts/diagnostic imaging ; Female ; Humans ; Male ; Middle Aged ; Multidetector Computed Tomography/methods ; Multidetector Computed Tomography/standards ; Neoplasms/diagnostic imaging ; Observer Variation ; Pelvis/diagnostic imaging ; Radiography, Abdominal/methods ; Reproducibility of Results ; Retrospective Studies ; Vascular Diseases/diagnostic imaging ; Young Adult
Language	English
Publishing date	2016-03-14
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-016-4313-7
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Book: Advances in laser materials processing research and applications

Lawrence, Jonathan / Low, David K. Y

2005

Author's details	eds. Jonathan Lawrence
Language	English
Size	238 S., Ill., graph. Darst.
Publisher	Research Signpost
Publishing place	Trivandrum
Document type	Book
ISBN	8130800780 ; 9788130800783
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article: Axon pruning in the developing vertebrate hippocampus.

Faulkner, Regina L / Low, Lawrence K / Cheng, Hwai-Jong

Developmental neuroscience

2007 Volume 29, Issue 1-2, Page(s) 6–13

Abstract: During early development of the central nervous system (CNS), there is an exuberant outgrowth of projections which later need to be refined to achieve precise connectivity. One widely used strategy for this refinement is axon pruning. Axon pruning has ... ...

Abstract	During early development of the central nervous system (CNS), there is an exuberant outgrowth of projections which later need to be refined to achieve precise connectivity. One widely used strategy for this refinement is axon pruning. Axon pruning has also been suggested to be involved in creating more diverse connection patterns between different species. An understanding of the mechanism of pruning, however, has been elusive in the CNS. Recent studies have focused on a stereotyped pruning event that occurs within the mossy fibers of the developing vertebrate hippocampus. In the following discussion, we will review the cellular and molecular factors that are known to regulate pruning in the hippocampus and highlight some advantages this system presents for future studies on pruning in the developing CNS.
MeSH term(s)	Animals ; Axons/metabolism ; Axons/ultrastructure ; Cell Differentiation/physiology ; Hippocampus/cytology ; Hippocampus/embryology ; Hippocampus/metabolism ; Humans ; Mossy Fibers, Hippocampal/embryology ; Mossy Fibers, Hippocampal/physiology ; Mossy Fibers, Hippocampal/ultrastructure ; Semaphorins/metabolism ; Signal Transduction/physiology ; Vertebrates/embryology ; Vertebrates/metabolism
Chemical Substances	Semaphorins
Language	English
Publishing date	2007
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	556887-0
ISSN	1421-9859 ; 0378-5866
ISSN (online)	1421-9859
ISSN	0378-5866
DOI	10.1159/000096207
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Article: Validation of a Temperature-Feedback Controlled Automated Magnetic Hyperthermia Therapy Device.

Sharma, Anirudh / Jangam, Avesh / Shen, Julian Low Yung / Ahmad, Aiman / Arepally, Nageshwar / Rodriguez, Benjamin / Borrello, Joseph / Bouras, Alexandros / Kleinberg, Lawrence / Ding, Kai / Hadjipanayis, Constantinos / Kraitchman, Dara L / Ivkov, Robert / Attaluri, Anilchandra

Cancers

2023 Volume 15, Issue 2

Abstract: We present in vivo validation of an automated magnetic hyperthermia therapy (MHT) device that uses real-time temperature input measured at the target to control tissue heating. MHT is a thermal therapy that uses heat generated by magnetic materials ... ...

Abstract	We present in vivo validation of an automated magnetic hyperthermia therapy (MHT) device that uses real-time temperature input measured at the target to control tissue heating. MHT is a thermal therapy that uses heat generated by magnetic materials exposed to an alternating magnetic field. For temperature monitoring, we integrated a commercial fiber optic temperature probe containing four gallium arsenide (GaAs) temperature sensors. The controller device used temperature from the sensors as input to manage power to the magnetic field applicator. We developed a robust, multi-objective, proportional-integral-derivative (PID) algorithm to control the target thermal dose by modulating power delivered to the magnetic field applicator. The magnetic field applicator was a 20 cm diameter Maxwell-type induction coil powered by a 120 kW induction heating power supply operating at 160 kHz. Finite element (FE) simulations were performed to determine values of the PID gain factors prior to verification and validation trials. Ex vivo verification and validation were conducted in gel phantoms and sectioned bovine liver, respectively. In vivo validation of the controller was achieved in a canine research subject following infusion of magnetic nanoparticles (MNPs) into the brain. In all cases, performance matched controller design criteria, while also achieving a thermal dose measured as cumulative equivalent minutes at 43 °C (CEM43) 60 ± 5 min within 30 min.
Language	English
Publishing date	2023-01-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15020327
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