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Article: Ayurvedic treatment of COVID-19: A case report

Girija, P.L.T. / Sivan, Nithya

Journal of Ayurveda and integrative medicine. 2022 Jan., Mar., v. 13, no. 1

2022

Abstract: This is the first known case of a Coronavirus disease (COVID-19) positive patient treated entirely with Ayurveda. So far in Modern Western Medicine (MWM), no cure has been found which is specific to COVID-19. The only literature relevant to the treatment ...

Abstract	This is the first known case of a Coronavirus disease (COVID-19) positive patient treated entirely with Ayurveda. So far in Modern Western Medicine (MWM), no cure has been found which is specific to COVID-19. The only literature relevant to the treatment of Coronavirus disease has surfaced from Traditional Chinese Medicine (TCM). TCM which was extensively used to control the epidemic in China, also consists of herbal medicines similar to Ayurveda. In this case, the patient, who was familiar with the use of Ayurvedic medicines, fully aware that no proven cure exists in MWM, decided to entirely rely on the limited Ayurvedic medicines that he had in his possession at the time of falling ill. Despite the patient presenting with symptoms, namely high fever, severe body pain and severe cough, along with many of the other associated symptoms of COVID-19, the progress of the disease could be arrested within a short period by being exclusively on Ayurvedic medicines. This illustrates that there is a wide scope to explore the variety of pertinent medicines present in Ayurvedic pharmacopoeia which can be used more rationally to suit every stage of the disease. Being the first-of-its-kind it is a valuable contribution to scientific literature from the world of Ayurveda. This should encourage the healthcare policy makers to quickly use Ayurveda to bring the COVID-19 pandemic under control in India, as they seemed to have demonstrated it in China with TCM.
Keywords	Ayurvedic medicine ; COVID-19 infection ; Oriental traditional medicine ; Orthocoronavirinae ; case studies ; cough ; fever ; health services ; issues and policy ; pain ; patients ; India
Language	English
Dates of publication	2022-01
Publishing place	Elsevier B.V.
Document type	Article
ISSN	0975-9476
DOI	10.1016/j.jaim.2020.06.001
Database	NAL-Catalogue (AGRICOLA)

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Article: Ayurvedic treatment of COVID-19: A case report.

Girija, P L T / Sivan, Nithya

Journal of Ayurveda and integrative medicine

2020 Volume 13, Issue 1, Page(s) 100329

Abstract	This is the first known case of a Coronavirus disease (COVID-19) positive patient treated entirely with Ayurveda. So far in Modern Western Medicine (MWM), no cure has been found which is specific to COVID-19. The only literature relevant to the treatment of Coronavirus disease has surfaced from Traditional Chinese Medicine (TCM). TCM which was extensively used to control the epidemic in China, also consists of herbal medicines similar to Ayurveda. In this case, the patient, who was familiar with the use of Ayurvedic medicines, fully aware that no proven cure exists in MWM, decided to entirely rely on the limited Ayurvedic medicines that he had in his possession at the time of falling ill. Despite the patient presenting with symptoms, namely high fever, severe body pain and severe cough, along with many of the other associated symptoms of COVID-19, the progress of the disease could be arrested within a short period by being exclusively on Ayurvedic medicines. This illustrates that there is a wide scope to explore the variety of pertinent medicines present in Ayurvedic pharmacopoeia which can be used more rationally to suit every stage of the disease. Being the first-of-its-kind it is a valuable contribution to scientific literature from the world of Ayurveda. This should encourage the healthcare policy makers to quickly use Ayurveda to bring the COVID-19 pandemic under control in India, as they seemed to have demonstrated it in China with TCM.
Keywords	covid19
Language	English
Publishing date	2020-06-19
Publishing country	United States
Document type	Case Reports
ISSN	0975-9476
ISSN	0975-9476
DOI	10.1016/j.jaim.2020.06.001
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Ayurvedic treatment of COVID-19/SARS-CoV-2

Girija, P.L.T. / Sivan, Nithya

Journal of Ayurveda and Integrative Medicine ; ISSN 0975-9476

A case report

2020

Keywords	Complementary and alternative medicine ; Drug Discovery ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
DOI	10.1016/j.jaim.2020.06.001
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Ayurvedic treatment of COVID-19/SARS-CoV-2: A case report

Girija, P L T / Sivan, Nithya

Abstract	This is the first known case of a Coronavirus disease (COVID-19) positive patient treated entirely with Ayurveda. So far in Modern Western Medicine (MWM), no cure has been found which is specific to COVID-19. The only literature relevant to the treatment of Coronavirus disease has surfaced from Traditional Chinese Medicine (TCM). TCM which was extensively used to control the epidemic in China, also consists of herbal medicines similar to Ayurveda. In this case, the patient, who was familiar with the use of Ayurvedic medicines, fully aware that no proven cure exists in MWM, decided to entirely rely on the limited Ayurvedic medicines that he had in his possession at the time of falling ill. Despite the patient presenting with symptoms, namely high fever, severe body pain and severe cough, along with many of the other associated symptoms of COVID-19, the progress of the disease could be arrested within a short period by being exclusively on Ayurvedic medicines. This illustrates that there is a wide scope to explore the variety of pertinent medicines present in Ayurvedic pharmacopoeia which can be used more rationally to suit every stage of the disease. Being the first-of-its-kind it is a valuable contribution to scientific literature from the world of Ayurveda. This should encourage the healthcare policy makers to quickly use Ayurveda to bring the COVID-19 pandemic under control in India, as they seemed to have demonstrated it in China with TCM.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #611984
Database	COVID19

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Article: Stand-alone Ayurvedic intervention with home quarantine in COVID-19 - Outcomes of clinical practice.

Girija, P L T / Sivan, Nithya / Murugavel, Yamini Agalya / Naik, Pallavi / Mukundan, T M / Duraikannan, Monica

Journal of Ayurveda and integrative medicine

2021 Volume 13, Issue 2, Page(s) 100445

Abstract: This article reports the treatment outcomes of 167 COVID-19 positive patients who were treated with a stand-alone Ayurvedic therapeutic intervention. The main outcomes are quick resolution of symptoms, no deterioration in any of the cases and safe ... ...

Abstract	This article reports the treatment outcomes of 167 COVID-19 positive patients who were treated with a stand-alone Ayurvedic therapeutic intervention. The main outcomes are quick resolution of symptoms, no deterioration in any of the cases and safe treatment for patients with multiple comorbidities. There was no observed mortality. There were no adverse events due to the Ayurvedic medications. The treatment was undertaken in an out-patient setting and at a low cost. The efficacy and safety of the treatment, and the quick resolution of symptoms were demonstrated. This shows that if COVID-19 patients are treated with Ayurvedic medicines early in the course of COVID-SARS-2 infection, Ayurveda has the potential to prevent progression and deterioration of the disease, with decreased morbidity and mortality.
Language	English
Publishing date	2021-05-25
Publishing country	United States
Document type	Case Reports
ISSN	0975-9476
ISSN	0975-9476
DOI	10.1016/j.jaim.2021.04.015
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Standalone Ayurvedic treatment of high-risk COVID-19 patients with multiple co-morbidities: A case series

Girija, P.L.T. / Sivan, Nithya / Naik, Pallavi / Murugavel, Yamini Agalya / M Ravindranath, Thyyar / CV, Krishnaswami

Journal of Ayurveda and integrative medicine. 2022 Jan., Mar., v. 13, no. 1

2022

Abstract: We report a case-series of Ayurvedic treatment in seven COVID-19 positive patients with multiple co-morbidities, categorized as high-risk for poor outcome from SARS-CoV-2 infection. All of them recovered completely from their illness with resolution of ... ...

Abstract	We report a case-series of Ayurvedic treatment in seven COVID-19 positive patients with multiple co-morbidities, categorized as high-risk for poor outcome from SARS-CoV-2 infection. All of them recovered completely from their illness with resolution of symptoms following Ayurvedic treatment. The data was collected from patients treated during the early months of the COVID-19 pandemic (June 2020 to September 2020) at an out-patient Ayurvedic Clinic, Chennai, India. This is a retrospective case series from among the initial 247 COVID-19 patients out of whom 39% were found to be suffering from co-morbidities. We have chosen seven of these patients who fulfilled the criteria for high-risk category, represented by multiple co-morbidities that included cancer, chronic kidney disease (CKD), coronary artery disease (CAD), chronic obstructive pulmonary disease (COPD), diabetes mellitus (DM), hypertension, and an elderly person over the age of 90 years. Classical Ayurvedic formulations for COVID -19 were chosen so as to avoid complicating co-morbid conditions and patients were maintained on a modified diet. All these high-risk patients were treated at an out-patient setting. The patients were under home quarantine and self-monitored their progress with daily follow-up over the phone by the treating Ayurvedic physician. The main outcome measure included resolution of symptoms and complete recovery from COVID-19 disease in all patients. This case series demonstrates the scope of Ayurvedic interventions in the management of high-risk COVID-19 patients with severe co-morbidities with successful outcome in an out-patient setting.
Keywords	Ayurvedic medicine ; COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; coronary artery disease ; diabetes mellitus ; diet ; elderly ; hypertension ; kidney diseases ; quarantine ; respiratory tract diseases ; India
Language	English
Dates of publication	2022-01
Publishing place	Elsevier B.V.
Document type	Article
ISSN	0975-9476
DOI	10.1016/j.jaim.2021.06.006
Database	NAL-Catalogue (AGRICOLA)

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Article: SCPNB is an adjuvant to local anaesthesia for maxillofacial surgical practice.

Kumar, Sachin / Parashar, Pranav / Mallick, Saurabh / Abhishek, Dr / L Mane, Sanjivani / Girija, Adsure

Bioinformation

2023 Volume 19, Issue 5, Page(s) 605–610

Abstract: ... demand, pulse rate, and blood pressure. The unpaired t-test was used to compare groups. Multiple ... diastolic arterial blood pressure at ten minutes, the SCPNB group demonstrated a substantial (P ≤.01 ...

Abstract	The superficial cervical plexus nerve block [SCPNB] procedure is frequently used throughout head and neck surgery because it is simple to learn and has a low rate of complications. The investigation of this method might produce superior outcomes in treating frequent maxillofacial disorders including mandibular fractures and infections of the odontogenic region. The SCPNB is known to play a part in the medical evacuation of head and neck abscesses, the excision of superficial diseases in the perimandibular region, and the therapy of mandibular fracture, despite the dearth of research in this area. Considering this background, it was expected that the SCPNB might be helpful as an adjuvant to regional anaesthesia in maxillofacial surgery. The purpose of this study was to assess the effectiveness of the SCPNB in the treatment of mandibular fractures and infectious diseases in the perimandibular area. 48 patients with either submandibular space infections or mandibular injuries who were anticipated for surgical procedure under regional anaesthesia participated in a prospective randomized clinical study (eg, inferior alveolar nerve block, long buccal nerve block). Administering a combination of a local infiltration and regional anaesthesia was used as the control group. Regional anaesthesia and a SCPNB were administered to the intervention class. The following factors were examined: pain, anaesthesia's duration and onset, waiting period before initial analgesic demand, pulse rate, and blood pressure. The unpaired t-test was used to compare groups. Multiple variables ANOVA (for more than two observations) was used for intragroup analysis, accompanied by a post-hoc analysis of variance. In aspects of intra - operative pain at thirty minutes, time required of anaesthesia, intraoperative anesthetic necessity, duration until first analgesic recommendation, and intra - operative diastolic arterial blood pressure at ten minutes, the SCPNB group demonstrated a substantial (P ≤.01) improved performance. It can be concluded that the use of a regional anaesthetic approach in conjunction with a SCPNB is a good substitute to localized infiltration for patients having surgery for fracture of mandible and perimandibular area infections.
Language	English
Publishing date	2023-05-31
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2203786-X
ISSN	0973-2063
ISSN	0973-2063
DOI	10.6026/97320630019605
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: “Standalone Ayurvedic Intervention with Home Quarantine in COVID-19 - Outcomes of Clinical Practice”

Girija, P.L.T / Sivan, Nithya / Agalya Murugavel, Yamini / Naik, Pallavi / Mukundan, T.M / Duraikannan, Monica

Journal of Ayurveda and integrative medicine. 2021 Apr. 26,

2021

Abstract: This article reports the treatment outcomes of 167 COVID-19 positive patients who were treated with stand-alone Ayurvedic therapeutic intervention. The main outcomes are quick resolution of symptoms, no deterioration in any of the cases and safe ... ...

Abstract	This article reports the treatment outcomes of 167 COVID-19 positive patients who were treated with stand-alone Ayurvedic therapeutic intervention. The main outcomes are quick resolution of symptoms, no deterioration in any of the cases and safe treatment for patients with multiple comorbidities. There was no observed mortality. There were no adverse events due to the Ayurvedic medications. The treatment was undertaken in an out-patient setting and at a low cost.The efficacy and safety of the treatment, and the quick resolution of symptoms are demonstrated. This shows that if COVID-19 patients are treated with Ayurvedic medicines early in the course of COVID-SARS-2 infection, Ayurveda has the potential to prevent progression and deterioration of the disease, with decreased morbidity and mortality.
Keywords	Ayurvedic medicine ; COVID-19 infection ; morbidity ; mortality ; quarantine ; therapeutics
Language	English
Dates of publication	2021-0426
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean ; Pre-press version
ISSN	0975-9476
DOI	10.1016/j.jaim.2021.04.015
Database	NAL-Catalogue (AGRICOLA)

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Article: Standalone Ayurvedic treatment of high-risk COVID-19 patients with multiple co-morbidities: A case series.

Girija, P L T / Sivan, Nithya / Naik, Pallavi / Murugavel, Yamini Agalya / M Ravindranath, Thyyar / Cv, Krishnaswami

Journal of Ayurveda and integrative medicine

2021 Volume 13, Issue 1, Page(s) 100466

Abstract	We report a case-series of Ayurvedic treatment in seven COVID-19 positive patients with multiple co-morbidities, categorized as high-risk for poor outcome from SARS-CoV-2 infection. All of them recovered completely from their illness with resolution of symptoms following Ayurvedic treatment. The data was collected from patients treated during the early months of the COVID-19 pandemic (June 2020 to September 2020) at an out-patient Ayurvedic Clinic, Chennai, India. This is a retrospective case series from among the initial 247 COVID-19 patients out of whom 39% were found to be suffering from co-morbidities. We have chosen seven of these patients who fulfilled the criteria for high-risk category, represented by multiple co-morbidities that included cancer, chronic kidney disease (CKD), coronary artery disease (CAD), chronic obstructive pulmonary disease (COPD), diabetes mellitus (DM), hypertension, and an elderly person over the age of 90 years. Classical Ayurvedic formulations for COVID -19 were chosen so as to avoid complicating co-morbid conditions and patients were maintained on a modified diet. All these high-risk patients were treated at an out-patient setting. The patients were under home quarantine and self-monitored their progress with daily follow-up over the phone by the treating Ayurvedic physician. The main outcome measure included resolution of symptoms and complete recovery from COVID-19 disease in all patients. This case series demonstrates the scope of Ayurvedic interventions in the management of high-risk COVID-19 patients with severe co-morbidities with successful outcome in an out-patient setting.
Language	English
Publishing date	2021-06-17
Publishing country	United States
Document type	Case Reports
ISSN	0975-9476
ISSN	0975-9476
DOI	10.1016/j.jaim.2021.06.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Endothelial Adenosine Monophosphate-Activated Protein Kinase-Alpha1 Deficiency Potentiates Hyperoxia-Induced Experimental Bronchopulmonary Dysplasia and Pulmonary Hypertension

Elsaie, Ahmed / Menon, Renuka T. / Shrestha, Amrit K. / Gowda, Sharada H. / Varghese, Nidhy P. / Barrios, Roberto J. / Blanco, Cynthia L. / Konduri, Girija G. / Shivanna, Binoy

Antioxidants. 2021 Nov. 29, v. 10, no. 12

2021

Abstract: ... We performed lung morphometric and echocardiographic studies on postnatal day (P) 28 on endothelial AMPKα1 ...

Abstract	Bronchopulmonary dysplasia and pulmonary hypertension, or BPD-PH, are serious chronic lung disorders of prematurity, without curative therapies. Hyperoxia, a known causative factor of BPD-PH, activates adenosine monophosphate-activated protein kinase (AMPK) α1 in neonatal murine lungs; however, whether this phenomenon potentiates or mitigates lung injury is unclear. Thus, we hypothesized that (1) endothelial AMPKα1 is necessary to protect neonatal mice against hyperoxia-induced BPD-PH, and (2) AMPKα1 knockdown decreases angiogenesis in hyperoxia-exposed neonatal human pulmonary microvascular endothelial cells (HPMECs). We performed lung morphometric and echocardiographic studies on postnatal day (P) 28 on endothelial AMPKα1-sufficient and -deficient mice exposed to 21% O₂ (normoxia) or 70% O₂ (hyperoxia) from P1–P14. We also performed tubule formation assays on control- or AMPKα1-siRNA transfected HPMECs, exposed to 21% O₂ or 70% O₂ for 48 h. Hyperoxia-mediated alveolar and pulmonary vascular simplification, pulmonary vascular remodeling, and PH were significantly amplified in endothelial AMPKα1-deficient mice. AMPKα1 siRNA knocked down AMPKα1 expression in HPMECs, and decreased their ability to form tubules in normoxia and hyperoxia. Furthermore, AMPKα1 knockdown decreased proliferating cell nuclear antigen expression in hyperoxic conditions. Our results indicate that AMPKα1 is required to reduce hyperoxia-induced BPD-PH burden in neonatal mice, and promotes angiogenesis in HPMECs to limit lung injury.
Keywords	AMP-activated protein kinase ; adenosine ; angiogenesis ; bronchopulmonary dysplasia ; echocardiography ; humans ; hyperoxia ; hypertension ; lungs ; mice ; morphometry ; normoxia ; premature birth
Language	English
Dates of publication	2021-1129
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox10121913
Database	NAL-Catalogue (AGRICOLA)

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