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  1. Article ; Online: Cardiac Arrest and Sudden Death: Establishing the Need for Focusing on Prehospital and In-Hospital Care.

    Benditt, David G / Cannom, David S

    Journal of the American College of Cardiology

    2022  Volume 79, Issue 18, Page(s) 1828–1831

    MeSH term(s) Cardiopulmonary Resuscitation ; Death, Sudden ; Death, Sudden, Cardiac/prevention & control ; Emergency Medical Services ; Hospitals ; Humans ; Out-of-Hospital Cardiac Arrest/therapy
    Language English
    Publishing date 2022-05-05
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2022.03.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Management of coexistent neurogenic orthostatic hypotension and supine hypertension.

    Cannom, David S

    Journal of clinical hypertension (Greenwich, Conn.)

    2019  Volume 21, Issue 11, Page(s) 1732–1734

    MeSH term(s) Accidental Falls/prevention & control ; Central Nervous System Agents/administration & dosage ; Droxidopa/administration & dosage ; Drug Substitution/methods ; Female ; Humans ; Hypertension/complications ; Hypertension/etiology ; Hypertension/physiopathology ; Hypertension/therapy ; Hypotension, Orthostatic/complications ; Hypotension, Orthostatic/etiology ; Hypotension, Orthostatic/physiopathology ; Hypotension, Orthostatic/therapy ; Middle Aged ; Midodrine/administration & dosage ; Midodrine/adverse effects ; Patient Care Management/methods ; Risk Adjustment/methods ; Supine Position/physiology ; Syncope, Vasovagal/diagnosis ; Syncope, Vasovagal/therapy ; Treatment Outcome ; Vasoconstrictor Agents/administration & dosage ; Vasoconstrictor Agents/adverse effects
    Chemical Substances Central Nervous System Agents ; Vasoconstrictor Agents ; Midodrine (6YE7PBM15H) ; Droxidopa (J7A92W69L7)
    Language English
    Publishing date 2019-10-10
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2077222-1
    ISSN 1751-7176 ; 1524-6175
    ISSN (online) 1751-7176
    ISSN 1524-6175
    DOI 10.1111/jch.13699
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: History of syncope in the cardiac literature.

    Cannom, David S

    Progress in cardiovascular diseases

    2013  Volume 55, Issue 4, Page(s) 334–338

    Abstract: ... with these entities written by clinicians such as Soma Weiss, Sir Thomas Lewis, Laurence Ellis, David Sherf, Milton ...

    Abstract The rich cardiology literature of the past 100 years in which the most important forms of syncope are described - including vasodepressor syncope, postural orthostatic hypotension, and Morgagni-Stokes-Adams syncope - is fascinating. These conditions were of interest to some of our most astute clinicians who were also excellent writers. We thus have available for review the remarkable description of patients with these entities written by clinicians such as Soma Weiss, Sir Thomas Lewis, Laurence Ellis, David Sherf, Milton Shy, and Glenn Drager. In their detailed clinical descriptions we identify the pertinent symptoms and signs we see in our patients today years later. A group of brilliant basic physiologists and cardiologists was able to explain the altered physiology responsible for the clinical presentations of syncope patients. Basic investigations were done by investigators such as Arnold Weissler, James Warren, J. Erlanger and clinical cardiologists including John Parkinson, Cornelio Papp, and William Evans to name just a few. Between the early precise clinical descriptions and the subsequent thorough definition of the altered physiology, a surprisingly complete understanding of these clinical entities was established 50 years ago. It took another generation before clinicians developed methods of caring for patients with these clinical entities. The development of implantable devices, e.g., pacemakers and defibrillators, for use in Morgagni-Adams-Stokes attacks is the best example of curative therapies catching up with clinical diagnoses. Other more simple relevant therapies were developed for patients with vasodepressor syncope and postural orthostatic hypotension. Finally, the development and acceptance of clinical guidelines for the treatment of these conditions brought the original clinical observations and description of altered physiology into focus and ushered in a new generation of improved care for these patients.
    MeSH term(s) Animals ; Autonomic Nervous System/physiopathology ; Cardiology/history ; Cardiovascular System/innervation ; Hemodynamics ; History, 20th Century ; History, 21st Century ; Humans ; Hypotension, Orthostatic/history ; Prognosis ; Syncope/diagnosis ; Syncope/history ; Syncope/physiopathology ; Syncope, Vasovagal/history
    Language English
    Publishing date 2013-01
    Publishing country United States
    Document type Historical Article ; Journal Article ; Review
    ZDB-ID 209312-1
    ISSN 1873-1740 ; 1532-8643 ; 0033-0620
    ISSN (online) 1873-1740 ; 1532-8643
    ISSN 0033-0620
    DOI 10.1016/j.pcad.2012.11.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Is it bradycardia or something else causing symptoms?

    Olshansky, Brian / Feigofsky, Suzy / Cannom, David S

    HeartRhythm case reports

    2018  Volume 4, Issue 12, Page(s) 601–603

    Language English
    Publishing date 2018-10-06
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834871-0
    ISSN 2214-0271
    ISSN 2214-0271
    DOI 10.1016/j.hrcr.2018.09.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: ARTHUR J. MOSS MD.

    Nisam, Seah / Cannom, David S / Zareba, Wojciech

    Journal of cardiovascular electrophysiology

    2018  Volume 29, Issue 4, Page(s) 511–513

    MeSH term(s) Biomedical Research/history ; Cardiology/history ; Death, Sudden, Cardiac/prevention & control ; Defibrillators, Implantable/history ; Electric Countershock/history ; Electric Countershock/instrumentation ; History, 20th Century ; History, 21st Century ; Humans ; Long QT Syndrome/genetics ; Long QT Syndrome/history ; Long QT Syndrome/physiopathology ; Long QT Syndrome/therapy
    Language English
    Publishing date 2018-04-10
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article ; Portrait
    ZDB-ID 1025989-2
    ISSN 1540-8167 ; 1045-3873
    ISSN (online) 1540-8167
    ISSN 1045-3873
    DOI 10.1111/jce.13489
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Neither too fast nor too hot: keeping marathoners' hearts alive during the race.

    Olshansky, Brian / Cannom, David S

    Journal of the American College of Cardiology

    2014  Volume 64, Issue 5, Page(s) 470–471

    MeSH term(s) Arrhythmias, Cardiac/epidemiology ; Death, Sudden, Cardiac/epidemiology ; Female ; Heat Stroke/epidemiology ; Humans ; Male ; Physical Endurance ; Running/physiology
    Language English
    Publishing date 2014-08-05
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2014.04.059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The evolution of the implantable cardioverter defibrillator.

    Cannom, David S / Prystowsky, Eric N

    Heart rhythm

    2013  Volume 1, Issue 5 Suppl, Page(s) 102C–114C

    MeSH term(s) Animals ; Arrhythmias, Cardiac/diagnosis ; Arrhythmias, Cardiac/history ; Arrhythmias, Cardiac/therapy ; Defibrillators, Implantable/history ; Electrophysiologic Techniques, Cardiac/history ; History, 20th Century ; History, 21st Century ; Humans
    Language English
    Publishing date 2013-04-09
    Publishing country United States
    Document type Historical Article ; Journal Article
    ZDB-ID 2229357-7
    ISSN 1556-3871 ; 1547-5271
    ISSN (online) 1556-3871
    ISSN 1547-5271
    DOI 10.1016/j.hrthm.2004.10.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Prevention of sudden cardiac death.

    Cannom, David S

    Journal of cardiovascular electrophysiology

    2005  Volume 16 Suppl 1, Page(s) S21–4

    Abstract: Although the annual incidence of sudden cardiac death (SCD) is dropping in the United States, therapies for the patient who has survived a SCD episode or is at high risk of developing SCD in the future are now well established. The implantable ... ...

    Abstract Although the annual incidence of sudden cardiac death (SCD) is dropping in the United States, therapies for the patient who has survived a SCD episode or is at high risk of developing SCD in the future are now well established. The implantable cardioverter defibrillator (ICD) has emerged from a series of well done randomized clinical trials of the 1990s as providing a survival benefit in carefully defined patient groups with low ejection fraction of any cause. Patients with either an ischemic or idiopathic dilated cardiomyopathy and an EF <or=35% show a significant survival benefit with the ICD and maximal medical therapy. Many challenging patients (e.g., those with long QT syndrome or Brugada syndrome) who have a reasonably high incidence of sudden death have not been the subject of clinical trials involving the ICD and therapy depends on risk stratification that is currently not completely agreed upon. An exciting research frontier of the future will be those that attempt to integrate the appropriate role of the ICD with the ability of chronic resynchronization therapy to enhance left ventricular function in the damaged ventricle.<br />
    MeSH term(s) Cardiomyopathy, Dilated/mortality ; Cardiomyopathy, Dilated/therapy ; Comorbidity ; Coronary Artery Disease/mortality ; Coronary Artery Disease/therapy ; Death, Sudden, Cardiac/epidemiology ; Death, Sudden, Cardiac/prevention & control ; Electric Countershock/methods ; Electric Countershock/statistics & numerical data ; Humans ; Incidence ; Practice Patterns, Physicians' ; Prevalence ; Risk Assessment/methods ; Risk Factors ; Treatment Outcome
    Language English
    Publishing date 2005-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1025989-2
    ISSN 1540-8167 ; 1045-3873
    ISSN (online) 1540-8167
    ISSN 1045-3873
    DOI 10.1111/j.1540-8167.2005.50127.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Mast Cell Activation Disorder and Postural Orthostatic Tachycardia Syndrome: A Clinical Association.

    Kohno, Ritsuko / Cannom, David S / Olshansky, Brian / Xi, Shijun Cindy / Krishnappa, Darshan / Adkisson, Wayne O / Norby, Faye L / Fedorowski, Artur / Benditt, David G

    Journal of the American Heart Association

    2021  Volume 10, Issue 17, Page(s) e021002

    Abstract: Background Recently there has been increased interest in a possible association between mast cell activation (MCA) disorder and postural orthostatic tachycardia syndrome (POTS). This study examined the frequency with which symptoms and laboratory ... ...

    Abstract Background Recently there has been increased interest in a possible association between mast cell activation (MCA) disorder and postural orthostatic tachycardia syndrome (POTS). This study examined the frequency with which symptoms and laboratory findings suggesting MCA disorder occurred in patients diagnosed with POTS. Methods and Results Data were obtained from patients in whom symptoms and orthostatic testing were consistent with a POTS diagnosis. Individuals with <4 months symptom duration, evident ongoing inflammatory disease, suspected volume depletion, or declined consent were excluded. All patients had typical POTS symptoms; some, however, had additional nonorthostatic complaints not usually associated with POTS. The latter patients underwent additional testing for known MCA biochemical mediators including prostaglandins, histamine, methylhistamine, and plasma tryptase. The study comprised 69 patients who met POTS diagnostic criteria. In 44 patients (44/69, 64%) additional nonorthostatic symptoms included migraine, allergic complaints, skin rash, or gastrointestinal symptoms. Of these 44 patients, 29 (66%) exhibited at least 1 laboratory abnormality suggesting MCA disorder, and 11/29 patients had 2 or more such abnormalities. Elevated prostaglandins (n=16) or plasma histamine markers (n=23) were the most frequent findings. Thus, 42% (29/69) of patients initially diagnosed with POTS exhibited both additional symptoms and at least 1 elevated biochemical marker suggesting MCA disorder. Conclusions Laboratory findings suggesting MCA disorder were relatively common in patients diagnosed with POTS and who present with additional nonorthostatic gastrointestinal, cutaneous, and allergic symptoms. While solitary abnormal laboratory findings are not definitive, they favor MCA disorder being considered in such cases.
    MeSH term(s) Gastrointestinal Diseases ; Histamine/blood ; Humans ; Mast Cell Activation Disorders/epidemiology ; Postural Orthostatic Tachycardia Syndrome/epidemiology ; Prostaglandins/blood
    Chemical Substances Prostaglandins ; Histamine (820484N8I3)
    Language English
    Publishing date 2021-08-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.121.021002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Implantable cardioverter defibrillator trials: what's new?

    Cannom, David S

    Current opinion in cardiology

    2003  Volume 17, Issue 1, Page(s) 29–35

    Abstract: The implantable cardioverter defibrillator (ICD) has been in clinical use for 20 years and its clinical role is becoming increasingly clear. A number of well-designed trials demonstrated its effectiveness in high-risk patients who have already ... ...

    Abstract The implantable cardioverter defibrillator (ICD) has been in clinical use for 20 years and its clinical role is becoming increasingly clear. A number of well-designed trials demonstrated its effectiveness in high-risk patients who have already experienced a malignant arrhythmia. A more controversial role for the ICD is in patients who are at high risk but have not yet had an arrhythmic event. Randomized clinical trials published in the late 1990s demonstrated survival benefit with the ICD in narrowly defined high-risk populations. These populations are presently defined by a low ejection fraction and inducible ventricular tachyarrhythmia. Clinical trials still in progress will determine whether broader populations will benefit from prophylactic ICD implantation. These trials will have broad clinical importance.
    MeSH term(s) Defibrillators, Implantable/trends ; Forecasting ; Humans ; Tachycardia, Ventricular/complications ; Tachycardia, Ventricular/therapy ; Treatment Outcome ; United States/epidemiology ; Ventricular Fibrillation/complications ; Ventricular Fibrillation/therapy
    Language English
    Publishing date 2003-02-21
    Publishing country United States
    Document type Clinical Trial ; Journal Article ; Review
    ZDB-ID 645186-x
    ISSN 1531-7080 ; 0268-4705
    ISSN (online) 1531-7080
    ISSN 0268-4705
    DOI 10.1097/00001573-200201000-00005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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