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Article ; Online: Editorial Commentary: Understanding Injury Epidemiology Builds Trust in Baseball Players.

Hardy, Richard / Brand, Jefferson C

Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association

2023 Volume 39, Issue 8, Page(s) 1936–1937

Abstract: Although the odds are extremely low, some baseball players are fortunate to make it to the professional ranks (minor or major league), where suffering an injury is common. During the 2011 to 2019 seasons, 112,405 injuries were reported in the Major ... ...

Abstract	Although the odds are extremely low, some baseball players are fortunate to make it to the professional ranks (minor or major league), where suffering an injury is common. During the 2011 to 2019 seasons, 112,405 injuries were reported in the Major League Baseball Health and Injury Tracking System database. Compared with other professional sports, baseball players have lower rates of returning to play, take longer to return to play, and have shorter careers after shoulder arthroscopy. By understanding injury epidemiology, the treating physician will gain player trust and understand the prognosis and how to properly return the player safely back to the field and best prolong their career.
MeSH term(s)	Humans ; Baseball/injuries ; Trust ; Athletes ; Sports ; Athletic Injuries/epidemiology ; Return to Sport
Language	English
Publishing date	2023-07-03
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	632528-2
ISSN	1526-3231 ; 0749-8063
ISSN (online)	1526-3231
ISSN	0749-8063
DOI	10.1016/j.arthro.2023.01.097
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Article ; Online: Associations between life course longitudinal growth and hip shapes at ages 60-64 years: evidence from the MRC National Survey of Health and Development.

Staines, Katherine Ann / Saunders, Fiona R / Ireland, Alex / Aspden, Richard M / Gregory, Jennifer S / Hardy, Rebecca J / Cooper, Rachel

RMD open

2024 Volume 10, Issue 2

Abstract: Objective: We sought to examine associations between height gain across childhood and adolescence with hip shape in individuals aged 60-64 years from the Medical Research Council National Survey of Health and Development, a nationally representative ... ...

Abstract	Objective: We sought to examine associations between height gain across childhood and adolescence with hip shape in individuals aged 60-64 years from the Medical Research Council National Survey of Health and Development, a nationally representative British birth cohort. Methods: Height was measured at ages 2, 4, 6, 7, 11 and 15 years, and self-reported at age 20 years. 10 modes of variation in hip shape (HM1-10), described by statistical shape models, were previously ascertained from DXA images taken at ages 60-64 years. Associations between (1) height at each age; (2) Super-Imposition by Translation And Rotation (SITAR) growth curve variables of height size, tempo and velocity; and (3) height gain during specific periods of childhood and adolescence, and HM1-10 were tested. Results: Faster growth velocity was associated with a wider, flatter femoral head and neck, as described by positive scores for HM6 (regression coefficient 0.014; 95% CI 0.08 to 0.019; p<0.001) and HM7 (regression coefficient 0.07; 95% CI 0.002 to 0.013; p=0.009), and negative scores for HM10 (regression coefficient -0.006; 95% CI -0.011 to 0.00, p=0.04) and HM2 (males only, regression coefficient -0.017; 95% CI -0.026 to -0.09; p<0.001). Similar associations were observed with greater height size and later height tempo. Examination of height gains during specific periods of childhood and adolescence identified those during the adolescence period as being most consistently associated. Conclusion: Our analyses suggest that individual growth patterns, particularly in the adolescent period, are associated with modest variations in hip shape at 60-64 years, which are consistent with features seen in osteoarthritis.
MeSH term(s)	Male ; Adolescent ; Humans ; Young Adult ; Adult ; Life Change Events
Language	English
Publishing date	2024-04-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2812592-7
ISSN	2056-5933 ; 2056-5933
ISSN (online)	2056-5933
ISSN	2056-5933
DOI	10.1136/rmdopen-2023-003816
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Article ; Online: Genicular nerve and fracture site chemical neurolysis for distal femoral fracture: a case report.

Dhingra, Prateek / McHardy, Paul G / Jenkinson, Richard / Meng, Howard

Regional anesthesia and pain medicine

2023 Volume 48, Issue 7, Page(s) 378–382

Abstract: Background: Distal femur fractures account for approximately 3%-6% of all femoral fractures. Non-operative management may be an attractive option for the elderly with significant perioperative mortality risk. Adequate pain control is a major barrier to ... ...

Abstract	Background: Distal femur fractures account for approximately 3%-6% of all femoral fractures. Non-operative management may be an attractive option for the elderly with significant perioperative mortality risk. Adequate pain control is a major barrier to non-operative fracture management. Chemical neurolysis has been described for analgesic management of proximal hip fractures, however no description of interventional management of distal femur fracture exists in literature. We describe a case of phenol chemical neurolysis of genicular nerves in addition to injection at the site of fracture to provide effective analgesia for distal femur fracture. Case presentation: A patient in their 90s with a witnessed mechanical fall sustained an intra-articular displaced fracture of the distal right femur shaft with extension into the distal femoral condyle. The patient elected to undergo non-surgical management given the high perioperative mortality risk. Acute pain service was involved and multimodal oral analgesics including opioids were insufficient in managing the patient's pain. The addition of femoral nerve catheter local anesthetic infusion did not sufficiently improve analgesia. Phenol chemical neurolysis of the superolateral, superomedial, inferomedial genicular nerves and of the fracture site was offered and performed. Resting pain decreased from Numerical Rating Scale 5/10 to 0/10 on postprocedure day 1. This was sustained at the 2-month timepoint. Conclusions: We report the successful use of phenol neurolysis of genicular nerves and the fracture site in an elderly patient with a conservatively managed distal femur fracture. These interventions resulted in improved analgesia and achieved prolonged duration of effect.
MeSH term(s)	Humans ; Aged ; Femoral Fractures, Distal ; Knee Joint/surgery ; Nerve Block/methods ; Femoral Fractures/surgery ; Pain ; Phenols
Chemical Substances	Phenols
Language	English
Publishing date	2023-02-08
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1425299-5
ISSN	1532-8651 ; 1098-7339 ; 0146-521X
ISSN (online)	1532-8651
ISSN	1098-7339 ; 0146-521X
DOI	10.1136/rapm-2022-104159
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Article ; Online: Investigating Specific Associations Between Childhood Victimization Profiles and Positive Psychosis Symptoms: The Mediating Roles of Anxiety, Depression, and Schema.

Barnes, Georgina L / Emsley, Richard / Garety, Philippa / Hardy, Amy

Schizophrenia bulletin open

2023 Volume 4, Issue 1, Page(s) sgad017

Abstract: Background: Childhood trauma is a risk factor for psychosis. It is proposed this is due to traumatic events giving rise to psychological mechanisms that are implicated in the development and maintenance of symptoms. Investigation of the psychological ... ...

Abstract	Background: Childhood trauma is a risk factor for psychosis. It is proposed this is due to traumatic events giving rise to psychological mechanisms that are implicated in the development and maintenance of symptoms. Investigation of the psychological mechanisms accounting for relationships between trauma and psychosis will be assisted by focusing on specific trauma profiles, hallucination modalities, and delusion subtypes. Study design: In 171 adults with schizophrenia-spectrum diagnoses and high-conviction delusions, associations between childhood trauma classes, and hallucination and delusion factors, were tested using structural equation models (SEMs). Anxiety, depression, and negative schema were examined as potential mediators of trauma class-psychosis symptom factor links. Study results: Significant associations were found between the emotional abuse/neglect and poly-victimization classes with persecutory delusions and delusions of influence, that were all mediated through anxiety (β = 1.24-0.23, Conclusions: In a sample of people with strongly held delusions, this study demonstrates that childhood victimization is associated with delusions of influence and grandiose beliefs, as well as with persecutory delusions in psychosis. Consistent with previous findings, the potent, mediating role of anxiety supports affective pathway theories and the utility of targeting threat-related processes when treating trauma effects in psychosis.
Language	English
Publishing date	2023-06-15
Publishing country	United States
Document type	Journal Article
ISSN	2632-7899
ISSN (online)	2632-7899
DOI	10.1093/schizbullopen/sgad017
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Article ; Online: Wolbachia

Lindsey, Amelia R I / Bhattacharya, Tamanash / Hardy, Richard W / Newton, Irene L G

mBio

2021 Volume 12, Issue 1

Abstract: ... ...

Abstract	Wolbachia
MeSH term(s)	Animals ; Drosophila melanogaster/genetics ; Drosophila melanogaster/microbiology ; Drosophila melanogaster/virology ; Female ; Gene Expression Profiling ; Host-Pathogen Interactions/genetics ; Male ; Metabolic Networks and Pathways ; Microbial Interactions ; Mosquito Vectors/microbiology ; Mosquito Vectors/virology ; Nucleotides/genetics ; Nucleotides/metabolism ; Symbiosis ; Transcriptome ; Virus Diseases/virology ; Virus Replication ; Viruses/pathogenicity ; Wolbachia/pathogenicity
Chemical Substances	Nucleotides
Language	English
Publishing date	2021-02-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2557172-2
ISSN	2150-7511 ; 2161-2129
ISSN (online)	2150-7511
ISSN	2161-2129
DOI	10.1128/mBio.03472-20
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Article ; Online: Renal mitochondrial toxicity: effects of thymidine analogues and tenofovir disoproxil fumarate in African people with HIV.

Hunt, Matthew / Phillips, Richard / Hardy, Yasmine / Owusu, Dorcas O / Mitchelmore, Rosa / Durrani, Mehrab / Payne, Brendan A I / Chadwick, David R

AIDS (London, England)

2022 Volume 36, Issue 7, Page(s) 1049–1051

Abstract: We investigated the contributions of thymidine analogue and tenofovir disoproxil fumarate (TDF) antiretroviral therapy on renal mitochondrial toxicity in Ghanaian people with HIV (PWH). Similar levels of renal biochemical and mitochondrial dysfunction ... ...

Abstract	We investigated the contributions of thymidine analogue and tenofovir disoproxil fumarate (TDF) antiretroviral therapy on renal mitochondrial toxicity in Ghanaian people with HIV (PWH). Similar levels of renal biochemical and mitochondrial dysfunction were seen, and there was no increased risk in PWH who had sequenced from thymidine analogue to TDF. However, mild renal impairment was associated with mitochondrial DNA damage in TDF but not thymidine analogue-treated PWH. These data support the continued use of TDF in resource-limited settings.
MeSH term(s)	Anti-HIV Agents/adverse effects ; Ghana ; HIV Infections/complications ; HIV Infections/drug therapy ; Humans ; Mitochondria ; Renal Insufficiency/chemically induced ; Tenofovir/adverse effects ; Thymidine/adverse effects
Chemical Substances	Anti-HIV Agents ; Tenofovir (99YXE507IL) ; Thymidine (VC2W18DGKR)
Language	English
Publishing date	2022-03-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639076-6
ISSN	1473-5571 ; 0269-9370 ; 1350-2840
ISSN (online)	1473-5571
ISSN	0269-9370 ; 1350-2840
DOI	10.1097/QAD.0000000000003209
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Zs.A 2228: Show issues

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Article ; Online: A heme pocket aromatic quadrupole modulates gas binding to cytochrome c'-β: Implications for NO sensors.

Adams, Hannah R / Svistunenko, Dimitri A / Wilson, Michael T / Fujii, Sotaro / Strange, Richard W / Hardy, Zoe A / Vazquez, Priscilla A / Dabritz, Tyler / Streblow, Gabriel J / Andrew, Colin R / Hough, Michael A

The Journal of biological chemistry

2023 Volume 299, Issue 6, Page(s) 104742

Abstract: The structural basis by which gas-binding heme proteins control their interactions with NO, CO, and ... ...

Abstract	The structural basis by which gas-binding heme proteins control their interactions with NO, CO, and O
MeSH term(s)	Humans ; Cytochromes c'/chemistry ; Gases ; Heme/metabolism ; Hemeproteins/genetics ; Hemeproteins/metabolism ; Methylococcus capsulatus/chemistry
Chemical Substances	Cytochromes c' ; Gases ; Heme (42VZT0U6YR) ; Hemeproteins
Language	English
Publishing date	2023-04-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1016/j.jbc.2023.104742
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Article ; Online: Extraoral Taste Buds on the Paired Fins of Damselfishes.

Hardy, Adam R / Hale, Melina E

Integrative organismal biology (Oxford, England)

2022 Volume 4, Issue 1, Page(s) obac035

Abstract: ... of diurnal midwater fishes that inhabit the light-rich waters of coral reefs. Immunohistochemistry ...

Abstract	Some fish species have taste buds on the surface of their bodies and fins, as well as in the oral cavity. The extraoral taste system of fish has traditionally been studied in species that inhabit environments and/or employ feeding strategies where vision is limited. Here we examined taste sensation in a new ecological context by investigating the paired fins of damselfish (Pomacentridae), a group of diurnal midwater fishes that inhabit the light-rich waters of coral reefs. Immunohistochemistry demonstrated the presence of taste buds on the paired fins of
Language	English
Publishing date	2022-08-11
Publishing country	England
Document type	Journal Article
ISSN	2517-4843
ISSN (online)	2517-4843
DOI	10.1093/iob/obac035
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Article ; Online: Development of the Butterfly Agility Test.

Cahanin, Richard / Esleck, Brandon / Hardy, Jonathan / Bass, Brianna / Rogers, Taylor / Looney, Kyle

Physical therapy in sport : official journal of the Association of Chartered Physiotherapists in Sports Medicine

2021 Volume 52, Page(s) 38–44

Abstract: ... 95 % CI = 0.023-0.97), strong correlation with the PAT (r = 0.73-0.77), moderate correlations ... with the BJ and 40 YS (r = 0.50-0.60), and moderate correlations with the mSEBT (r = 0.37-0.62).: Conclusion ...

Abstract	Objectives: To develop a PPT that incorporates multiple components of athletic ability and to assess its reliability. Design: Test-retest experimental design. Setting: Indoor basketball court in southern Alabama, USA. Participants: A convenient sample of 21 asymptomatic subjects (14 male, 7 female). Main outcome measures: Subjects performed the Butterfly Agility Test (BAT), the modified Star Excursion Balance Test (mSEBT), a standing double-legged broad jump (BJ), the Pro Agility Test (PAT), and a forty-yard sprint (40 YS). Results: Overall, the BAT was found to have good reliability (ICC = 0.89, 95 % CI = 0.023-0.97), strong correlation with the PAT (r = 0.73-0.77), moderate correlations with the BJ and 40 YS (r = 0.50-0.60), and moderate correlations with the mSEBT (r = 0.37-0.62). Conclusion: The BAT appears to be a promising composite assessment of athletic ability among young asymptomatic adults, but it is not recommended for clinical use at this time. Level of evidence: 3b.
MeSH term(s)	Adult ; Athletic Performance ; Exercise Test ; Female ; Humans ; Male ; Reproducibility of Results
Language	English
Publishing date	2021-08-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2008604-0
ISSN	1873-1600 ; 1466-853X
ISSN (online)	1873-1600
ISSN	1466-853X
DOI	10.1016/j.ptsp.2021.08.004
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Article ; Online: A high-resolution daily global dataset of statistically downscaled CMIP6 models for climate impact analyses.

Gebrechorkos, Solomon / Leyland, Julian / Slater, Louise / Wortmann, Michel / Ashworth, Philip J / Bennett, Georgina L / Boothroyd, Richard / Cloke, Hannah / Delorme, Pauline / Griffith, Helen / Hardy, Richard / Hawker, Laurence / McLelland, Stuart / Neal, Jeffrey / Nicholas, Andrew / Tatem, Andrew J / Vahidi, Ellie / Parsons, Daniel R / Darby, Stephen E

Scientific data

2023 Volume 10, Issue 1, Page(s) 611

Abstract: A large number of historical simulations and future climate projections are available from Global Climate Models, but these are typically of coarse resolution, which limits their effectiveness for assessing local scale changes in climate and attendant ... ...

Abstract	A large number of historical simulations and future climate projections are available from Global Climate Models, but these are typically of coarse resolution, which limits their effectiveness for assessing local scale changes in climate and attendant impacts. Here, we use a novel statistical downscaling model capable of replicating extreme events, the Bias Correction Constructed Analogues with Quantile mapping reordering (BCCAQ), to downscale daily precipitation, air-temperature, maximum and minimum temperature, wind speed, air pressure, and relative humidity from 18 GCMs from the Coupled Model Intercomparison Project Phase 6 (CMIP6). BCCAQ is calibrated using high-resolution reference datasets and showed a good performance in removing bias from GCMs and reproducing extreme events. The globally downscaled data are available at the Centre for Environmental Data Analysis ( https://doi.org/10.5285/c107618f1db34801bb88a1e927b82317 ) for the historical (1981-2014) and future (2015-2100) periods at 0.25° resolution and at daily time step across three Shared Socioeconomic Pathways (SSP2-4.5, SSP5-3.4-OS and SSP5-8.5). This new climate dataset will be useful for assessing future changes and variability in climate and for driving high-resolution impact assessment models.
Language	English
Publishing date	2023-09-11
Publishing country	England
Document type	Dataset ; Journal Article
ZDB-ID	2775191-0
ISSN	2052-4463 ; 2052-4463
ISSN (online)	2052-4463
ISSN	2052-4463
DOI	10.1038/s41597-023-02528-x
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