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Article ; Online: ESAs in transplant anemia: one size does not "fit all".

Mehrotra, Anita

Journal of the American Society of Nephrology : JASN

2012 Volume 23, Issue 2, Page(s) 192–193

MeSH term(s)	Anemia/drug therapy ; Erythropoietin/therapeutic use ; Female ; Humans ; Kidney Diseases/prevention & control ; Kidney Transplantation/adverse effects ; Male ; Recombinant Proteins/therapeutic use
Chemical Substances	Recombinant Proteins ; epoetin beta ; Erythropoietin (11096-26-7)
Language	English
Publishing date	2012-01-12
Publishing country	United States
Document type	Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	1085942-1
ISSN	1533-3450 ; 1046-6673
ISSN (online)	1533-3450
ISSN	1046-6673
DOI	10.1681/ASN.2011121220
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Article: Usefulness of Thromboelastography for Perioperative Evaluation of Hemostatic Profile in Patients with Primary Brain Tumors Undergoing Surgery.

Khatri, Vikalp / Hemlata / Mehrotra, Megha Kohli / Kohli, Monica / Malik, Anita / Verma, Anupam

Anesthesia, essays and researches

2022 Volume 15, Issue 3, Page(s) 279–284

Abstract: Context: Hemostatic abnormalities are more common in patients with brain tumors than systemic malignant diseases. Conventional coagulation tests (CCT) are poor assays for dynamic assessment of clot strength in whole blood. Thromboelastography (TEG) ... ...

Abstract	Context: Hemostatic abnormalities are more common in patients with brain tumors than systemic malignant diseases. Conventional coagulation tests (CCT) are poor assays for dynamic assessment of clot strength in whole blood. Thromboelastography (TEG) gives us detailed information on the dynamics of clot development, stabilization, and dissolution reflecting Aims: This study aimed to investigate the temporal trends in hemostatic profile occurring during surgery for primary brain tumors, using a combination of TEG and CCT, and to assess perioperative blood component support. Subjects and methods: A prospective, observational study was done on 40 patients with primary brain tumors larger than 4 cm in maximum diameter on computed tomography or magnetic resonance imaging. The tests (TEG and CCT [PT, INR, activated partial thromboplastin time, and platelet count]) were performed preoperatively (on the day of surgery), intraoperatively (2 h into surgery), and postoperatively (the day after surgery). Statistical analysis: SPSS Version 21.0 statistical analysis software was used. Results: We found a universal trend toward hypercoagulability (persistent decrease in R-time, K-time and increase in MA, α-angle, Coagulation Index) in all the TEG parameters measured intraoperatively and postoperatively even though the values were within normal limits. Results of CCT had poor correlation with TEG parameters. The mean intraoperative blood loss was 737.7 ± 185.6 mL, for which PRBC was transfused in 17 patients, FFP in 13, but no platelet transfusion was done intraoperatively. Conclusions: We found a trend toward hypercoagulability in our study in intraoperative and postoperative period using TEG which was not evident on CCT. TEG was a useful diagnostic tool to identify coagulation abnormalities and to guide perioperative blood transfusion.
Language	English
Publishing date	2022-02-07
Publishing country	India
Document type	Journal Article
ZDB-ID	2626233-2
ISSN	2229-7685 ; 0259-1162
ISSN (online)	2229-7685
ISSN	0259-1162
DOI	10.4103/aer.aer_136_21
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Article ; Online: To Host or Not to Host? A Comparison Study on the Long-Run Impact of the Olympic Games

Anita Mehrotra

Michigan Journal of Business, Vol 5, Iss 2, Pp 61-

2012 Volume 92

Abstract: Macroeconomic research on sporting mega-events, like the Olympic Games, often focuses on the short-run economic impact of individual countries. In this paper, I explore the long-run effect of the Olympics on host countries, in general. I analyze hosts in ...

Abstract	Macroeconomic research on sporting mega-events, like the Olympic Games, often focuses on the short-run economic impact of individual countries. In this paper, I explore the long-run effect of the Olympics on host countries, in general. I analyze hosts in relation to "runner-up" countries, i.e. countries that come in second to the hosts in the bidding process. Upon rectifying anomalies in the data set and including control variables for the initial state of the economy and population, I find that hosts' long-run GDP per capita (GDPpc) is negative in comparison to runner-up countries' at a statistically significant level. This suggests that a one-time spike in government expenditure may lead to long-run detrimental effects: a "reverse multiplier effect" perpetuates the fall in investment demand and consumption levels back to pre-Olympic levels. My results extend the view that individual countries experience a negative economic impact, to the group of host countries in general.
Keywords	Business ; HF5001-6182 ; Commerce ; HF1-6182 ; Social Sciences ; H ; DOAJ:Business and Management ; DOAJ:Business and Economics
Subject code	300
Language	English
Publishing date	2012-09-01T00:00:00Z
Publisher	University of Michigan
Document type	Article ; Online
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Article: Maternal Near Miss: Unraveling Our Experience in the Tertiary Care Hospital of Andaman and Nicobar Islands.

Sharma, Charu / Yadav, Anita / Mehrotra, Manju / Saha, Mrinmoy Kumar / Tambe, Rupali R

Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine

2021 Volume 46, Issue 1, Page(s) 35–39

Abstract: Context: Women who survive life-threatening complications related to pregnancy and delivery have many common aspects with those who die of such complications. This similarity brought forward the near miss concept in maternal health. Analysis of the ... ...

Abstract	Context: Women who survive life-threatening complications related to pregnancy and delivery have many common aspects with those who die of such complications. This similarity brought forward the near miss concept in maternal health. Analysis of the similarities, differences, and the relationship between these two groups of women provide a complete assessment of quality of maternal health care. Aims: The aim of this study is to assess the baseline indices of maternal near miss (MNM) and analyze the quality of care at a tertiary care center in Andaman and Nicobar Islands. Settings and design: Facility-based, cross-sectional study. Subjects and methods: The study was conducted for a period of 18 months from January 1, 2015, to August 31, 2016. Cases, who met the World Health Organization (WHO) criteria of severe obstetric morbidity, were included and followed up during their hospital stay and till their discharge or death. Quality of maternal health care was assessed through the WHO near-miss criteria and criterion-based clinical audit methodology. Statistical analysis used: Descriptive statistics using mean and percentages and Student's Results: Among 4720 women who delivered in our hospital, there were 4677 live births, 52 patients were near miss, and there were 9 maternal deaths. The MNM incidence ratio was 11.11%, the MNM mortality ratio was 5.77, and the mortality index 14.75%. The most common cause of maternal morbidity was hemorrhage followed by hypertensive disorders. Conclusions: Improving referral systems, effective use of critical care, and evidence-based interventions can potentially reduce severe maternal outcomes.
Language	English
Publishing date	2021-03-01
Publishing country	India
Document type	Journal Article
ZDB-ID	2085330-0
ISSN	1998-3581 ; 0970-0218
ISSN (online)	1998-3581
ISSN	0970-0218
DOI	10.4103/ijcm.IJCM_145_20
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Article ; Online: Maternal near miss

Charu Sharma / Anita Yadav / Manju Mehrotra / Mrinmoy Kumar Saha / Rupali R Tambe

Indian Journal of Community Medicine, Vol 46, Iss 1, Pp 35-

Unraveling our experience in the tertiary care hospital of Andaman and Nicobar Islands

2021 Volume 39

Abstract	Context: Women who survive life-threatening complications related to pregnancy and delivery have many common aspects with those who die of such complications. This similarity brought forward the near miss concept in maternal health. Analysis of the similarities, differences, and the relationship between these two groups of women provide a complete assessment of quality of maternal health care. Aims: The aim of this study is to assess the baseline indices of maternal near miss (MNM) and analyze the quality of care at a tertiary care center in Andaman and Nicobar Islands. Settings and Design: Facility-based, cross-sectional study. Subjects and Methods: The study was conducted for a period of 18 months from January 1, 2015, to August 31, 2016. Cases, who met the World Health Organization (WHO) criteria of severe obstetric morbidity, were included and followed up during their hospital stay and till their discharge or death. Quality of maternal health care was assessed through the WHO near-miss criteria and criterion-based clinical audit methodology. Statistical Analysis Used: Descriptive statistics using mean and percentages and Student's t-test were used. Results: Among 4720 women who delivered in our hospital, there were 4677 live births, 52 patients were near miss, and there were 9 maternal deaths. The MNM incidence ratio was 11.11%, the MNM mortality ratio was 5.77, and the mortality index 14.75%. The most common cause of maternal morbidity was hemorrhage followed by hypertensive disorders. Conclusions: Improving referral systems, effective use of critical care, and evidence-based interventions can potentially reduce severe maternal outcomes.
Keywords	intensive care unit ; maternal near miss ; morbidity ; mortality index ; Public aspects of medicine ; RA1-1270
Subject code	360
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: B cells and kidney transplantation: beyond antibodies.

Mehrotra, Anita / Heeger, Peter S

Journal of the American Society of Nephrology : JASN

2014 Volume 25, Issue 7, Page(s) 1373–1374

MeSH term(s)	B-Lymphocytes, Regulatory/immunology ; Female ; Humans ; Interleukin-10/immunology ; Kidney Neoplasms/immunology ; Male ; Tumor Necrosis Factor-alpha/immunology
Chemical Substances	Tumor Necrosis Factor-alpha ; Interleukin-10 (130068-27-8)
Language	English
Publishing date	2014-03-07
Publishing country	United States
Document type	Editorial ; Research Support, N.I.H., Extramural ; Comment
ZDB-ID	1085942-1
ISSN	1533-3450 ; 1046-6673
ISSN (online)	1533-3450
ISSN	1046-6673
DOI	10.1681/ASN.2014020132
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Article ; Online: Erratum to: Nutritional vitamin D supplementation and health-related outcomes in hemodialysis patients: a protocol for a systematic review and meta-analysis.

Mehrotra, Anita / Leung, Wai-Yin / Joson, Tannia

Systematic reviews

2015 Volume 4, Page(s) 106

Language	English
Publishing date	2015-08-11
Publishing country	England
Document type	Published Erratum
ZDB-ID	2662257-9
ISSN	2046-4053 ; 2046-4053
ISSN (online)	2046-4053
ISSN	2046-4053
DOI	10.1186/s13643-015-0086-3
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Article ; Online: Field-Based Evaluation of Rice Genotypes for Enhanced Growth, Yield Attributes, Yield and Grain Yield Efficiency Index in Irrigated Lowlands of the Indo-Gangetic Plains

Sandeep Gawdiya / Dinesh Kumar / Yashbir S. Shivay / Arti Bhatia / Shweta Mehrotra / Mandapelli Sharath Chandra / Anita Kumawat / Rajesh Kumar / Adam H. Price / Nandula Raghuram / Himanshu Pathak / Mark A. Sutton

Sustainability, Vol 15, Iss 8793, p

2023 Volume 8793

Abstract: Nitrogen (N) fertilizers are widely used worldwide to increase agricultural productivity. However, significant N losses contributing to air and water pollution ultimately reduce the nitrogen use efficiency (NUE) of crops. Numerous research studies have ... ...

Abstract	Nitrogen (N) fertilizers are widely used worldwide to increase agricultural productivity. However, significant N losses contributing to air and water pollution ultimately reduce the nitrogen use efficiency (NUE) of crops. Numerous research studies have emphasized the use of a low dose of N fertilizer, but few have focused on screening N-efficient rice genotypes. This study aimed to identify and screen ten rice genotypes that are N-use-efficient under different N fertilization treatments using the surface placement of neem-oil-coated urea: N 0 (control), N 60 (½ of recommended N), and N 120 (recommended N) for two consecutive years (2020 and 2021) under a split plot design. In both growing seasons, the application of N 120 yielded the highest panicles m −2 (PAN = 453), filled grains panicle −1 (FGP = 133), leaf area index (LAI = 5.47), tillers m −2 (TILL = 541), grain yield t ha −1 (GY = 5.5) and harvest index (HI = 45.4%) by the genotype ‘Nidhi’, being closely followed by the genotype ‘Daya’. Four genotypes (‘Nidhi’, ‘Daya’, ‘PB 1728’ and ‘Nagina 22’), out of the ten genotypes evaluated, responded well to different fertilization treatments with N with respect to the grain yield efficiency index (GYEI ≥ 1). Regarding N fertilization, N 60 and N 120 recorded the highest increase in PAN (28.5%; 41.4%), FGP (29.5%; 39.3%), test weight (29.5%; 45.3%), LAI at 30 days after transplanting (DAT) (143.7%; 223.3%), and LAI at 60 DAT (61.6%; 70.1%) when compared with N 0 . Furthermore, the application of N 60 and N 120 improved GY and HI by 47.6% and 59.4%, and 3.4% and 6.2%, respectively, over N 0 . Nitrogen addition (N 60 and N 120 ) also significantly increased the chlorophyll content at 60 DAT (8.8%; 16.3%), TILL at 60 DAT (22.9%; 46.2%), TILL at harvest (28%; 41.4%), respectively, over N 0 . Overall, our research findings clearly indicate that ‘Nidhi’ and ‘Daya’ could be efficient candidates for improved nitrogen use, grain yield and GYEI in the Indo-Gangetic plains of India.
Keywords	grain yield ; rice genotypes ; nitrogen fertilization ; grain yield efficiency index ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	333
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: "Out of Sight, Out of Mind": The Failed Renal Allograft as a Cause of ESA Resistance.

Mehrotra, Anita / Tan, Judy A / Ames, Scott A

Seminars in dialysis

2015 Volume 28, Issue 5, Page(s) 530–532

Abstract: Approximately 10% of patients treated with erythropoiesis-stimulating agents (ESAs) for the anemia of chronic kidney disease are unresponsive or relatively resistant to therapy. The etiology of this is usually linked to iron deficiency or an independent ... ...

Abstract	Approximately 10% of patients treated with erythropoiesis-stimulating agents (ESAs) for the anemia of chronic kidney disease are unresponsive or relatively resistant to therapy. The etiology of this is usually linked to iron deficiency or an independent underlying illness. We describe a hemodialysis patient with a failed renal transplant 1.5 years earlier, who developed progressive erythropoietin resistance and anemia without an apparent cause. He simultaneously developed nonspecific malaise and fatigue. By exclusion, the only possible cause of these signs and symptoms was inflammation from acute and chronic rejection in the retained failed renal allograft. Following pulse steroids and transplant nephrectomy, the patient's symptoms resolved and both his hemoglobin improved and his erythropoietin requirements decreased significantly. The patient never required a blood transfusion and was successfully relisted for a deceased donor renal transplant. Hence, inflammation from a retained transplant allograft may be an under-recognized cause of erythropoietin resistance in dialysis patients. Although transplant nephrectomy remains a controversial practice due to concerns of alloantibody production, it may be considered in patients with failed renal allografts and anemia refractory to treatment with ESAs.
MeSH term(s)	Adult ; Allografts ; Anemia/drug therapy ; Anemia/etiology ; Drug Resistance ; Graft Rejection/surgery ; Hematinics/therapeutic use ; Humans ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/therapy ; Kidney Transplantation/adverse effects ; Male ; Nephrectomy ; Renal Dialysis/methods
Chemical Substances	Hematinics
Language	English
Publishing date	2015-09
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1028193-9
ISSN	1525-139X ; 0894-0959
ISSN (online)	1525-139X
ISSN	0894-0959
DOI	10.1111/sdi.12401
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Article ; Online: Nutritional vitamin D supplementation and health-related outcomes in hemodialysis patients: a protocol for a systematic review and meta-analysis.

Mehrotra, Anita / Leung, Wai-Yin / Joson, Tannia

Systematic reviews

2015 Volume 4, Page(s) 13

Abstract: Background: The prevalence of vitamin D deficiency in hemodialysis patients is high. While most hemodialysis patients are treated with activated vitamin D (1,25[OH]2D) to prevent renal osteodystrophy, clinical practices of the screening and treatment of ...

Abstract	Background: The prevalence of vitamin D deficiency in hemodialysis patients is high. While most hemodialysis patients are treated with activated vitamin D (1,25[OH]2D) to prevent renal osteodystrophy, clinical practices of the screening and treatment of 25(OH)2D deficiency are highly variable. It is unclear if nutritional vitamin D supplementation with D2 or D3 provides an additional clinical benefit beyond that provided by activated vitamin D treatment in this population. Methods/design: We will conduct a systematic review of nutritional vitamin D (D2/D3) supplementation and health-related outcomes in hemodialysis patients according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The primary objective is to assess the impact of nutritional vitamin D supplementation on clinical outcomes relevant in hemodialysis patients, such as mortality, cardiovascular events, infections, and fractures. Secondary outcomes will include anemia, hyperparathyroidism, medication use (erythrocyte-stimulating agents, activated vitamin D), and quality of life. We will search MEDLINE, Scopus, Web of Science, and ClinicalTrials.gov for randomized, controlled trials of nutritional vitamin D supplementation (ergocalciferol/D2 or cholecalciferol/D3) in chronic hemodialysis patients. The Cochrane Risk Assessment Tool will be used to assess the quality of eligible studies. We will perform meta-analyses using standard techniques for the outcomes listed above if pooling is deemed appropriate/sufficient. The results of this systematic review may highlight gaps in our knowledge of the relevance of nutritional vitamin D in end-stage renal disease, allowing for the informed design of clinical trials assessing the impact of nutritional vitamin D therapy in the hemodialysis population in the future. Systematic review registration: PROSPERO CRD42014013931.
MeSH term(s)	Cardiovascular Diseases/etiology ; Cardiovascular Diseases/prevention & control ; Cholecalciferol/therapeutic use ; Chronic Kidney Disease-Mineral and Bone Disorder/etiology ; Chronic Kidney Disease-Mineral and Bone Disorder/prevention & control ; Clinical Protocols ; Dietary Supplements ; Ergocalciferols/therapeutic use ; Fractures, Bone/etiology ; Fractures, Bone/prevention & control ; Humans ; Infection/etiology ; Renal Dialysis/adverse effects ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/mortality ; Research Design ; Vitamin D Deficiency/drug therapy ; Vitamin D Deficiency/etiology ; Vitamins/therapeutic use
Chemical Substances	Ergocalciferols ; Vitamins ; Cholecalciferol (1C6V77QF41)
Language	English
Publishing date	2015-02-21
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	2662257-9
ISSN	2046-4053 ; 2046-4053
ISSN (online)	2046-4053
ISSN	2046-4053
DOI	10.1186/s13643-015-0002-x
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