LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 1105

Search options

  1. Book ; Online: Conversations with Shotetsu

    Brower, Robert H. / Carter, Steven D.

    2020  

    Abstract: ... of the great poet-critic Fujiwara no Teika (1162-1241). The last project of the late Robert H. Brower ... by Hisamatsu Senichi. Steven D. Carter has annotated the translation and provided an introduction that details ...

    Abstract Shotetsu monogatari was written by a disciple of Shotetsu (1381-1459), whom many scholars regard as the last great poet of the courtly tradition. The work provides information about the practice of poetry during the 14th and 15th centuries, including anecdotes about famous poets, advice on how to treat certain standard topics, and lessons in etiquette when attending or participating in poetry contests and gatherings. But unlike the many other works of that time that stop at that level, Shotetsu's contributions to medieval aesthetics gained prominence, showing him as a worthy heir-both as poet and thinker-to the legacy of the great poet-critic Fujiwara no Teika (1162-1241). The last project of the late Robert H. Brower, Conversations with Shôtetsu provides a translation of the complete Nihon koten bungaku taikei text, as edited by Hisamatsu Senichi. Steven D. Carter has annotated the translation and provided an introduction that details Shôtetsu's life, his place in the poetic circles of his day, and the relationship of his work to the larger poetic tradition of medieval Japan. Conversations with Shotetsu is important reading for anyone interested in medieval Japanese literature and culture, in poetry, and in aesthetics. It provides a unique look at the literary world of late medieval Japan
    Keywords Literature (General)
    Size 1 electronic resource (237 pages)
    Publisher University of Michigan Press
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020678080
    ISBN 9780472901579 ; 0472901575
    DOI 10.3998/mpub.18809
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    More links

    Kategorien

  2. Article ; Online: The Back Pain Consortium (BACPAC) Research Program: Cover.

    Carter, Robert H / Criswell, Lindsey A

    Pain medicine (Malden, Mass.)

    2022  Volume 24, Issue Suppl 1, Page(s) S1–S2

    MeSH term(s) Humans ; Research ; Low Back Pain/therapy
    Language English
    Publishing date 2022-12-27
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2015903-1
    ISSN 1526-4637 ; 1526-2375
    ISSN (online) 1526-4637
    ISSN 1526-2375
    DOI 10.1093/pm/pnac199
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Relationship between longitudinal changes in neuropsychological outcome and disease biomarkers in urea cycle disorders.

    Lichter-Konecki, Uta / Sanz, Jacqueline H / McCarter, Robert

    Pediatric research

    2023  Volume 94, Issue 6, Page(s) 2005–2015

    Abstract: Background: Urea cycle disorders (UCDs) cause impaired conversion of waste nitrogen to urea leading to rise in glutamine and ammonia. Elevated ammonia and glutamine have been implicated in brain injury. This study assessed relationships between ... ...

    Abstract Background: Urea cycle disorders (UCDs) cause impaired conversion of waste nitrogen to urea leading to rise in glutamine and ammonia. Elevated ammonia and glutamine have been implicated in brain injury. This study assessed relationships between biomarkers of metabolic control and long-term changes in neuropsychological test scores in participants of the longitudinal study of UCDs. The hypothesis was that elevated ammonia and glutamine are associated with neuropsychological impairment.
    Methods: Data from 146 participants who completed 2 neuropsychological assessments were analyzed. Neuropsychological tests that showed significant changes in scores over time were identified and associations between score change and interim metabolic biomarker levels were investigated.
    Results: Participants showed a significant decrease in performance on visual motor integration (VMI) and verbal learning immediate-recall. A decrease in scores was associated with experiencing interim hyperammonemic events (HAE) and frequency of HAE. Outside of HAE there was a significant association between median ammonia levels ≥50µmol/L and impaired VMI.
    Conclusion: VMI and memory encoding are specifically affected in UCDs longitudinally, indicating that patients experience difficulties when required to integrate motor and visual functions and learn new information. Only ammonia biomarkers showed a significant association with impairment. Preventing HAE and controlling ammonia levels is key in UCD management.
    Impact: The Beery-Buktenica Developmental Test of Visual-Motor Integration (Beery VMI) and List A Trial 5 of the California Verbal Learning Test (CVLT) may be good longitudinal biomarkers of treatment outcome in urea cycle disorders (UCD). This is the first report of longitudinal biomarkers for treatment outcome in UCD. These two biomarkers of outcome may be useful for clinical trials assessing new treatments for UCD. These results will also inform educators how to design interventions directed at improving learning in individuals with UCDs.
    MeSH term(s) Humans ; Longitudinal Studies ; Ammonia ; Glutamine ; Urea Cycle Disorders, Inborn/diagnosis ; Urea Cycle Disorders, Inborn/drug therapy ; Hyperammonemia ; Neuropsychological Tests ; Biomarkers
    Chemical Substances Ammonia (7664-41-7) ; Glutamine (0RH81L854J) ; Biomarkers
    Language English
    Publishing date 2023-07-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-023-02722-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Educating for capability and preparing for practice: Integrating theory and skills.

    Carter, Harry / Hanks, Sally / Johnson, Robert / Gale, Thomas

    The clinical teacher

    2024  , Page(s) e13725

    Abstract: Capability is the ability to perform clinical skills in ever-changing real world contexts, adapting to challenges and integrating technical and non-technical skills and competencies, for example, cannulating an uncooperative patient at night. Going ... ...

    Abstract Capability is the ability to perform clinical skills in ever-changing real world contexts, adapting to challenges and integrating technical and non-technical skills and competencies, for example, cannulating an uncooperative patient at night. Going beyond teaching competency and ensuring capability is imperative, as recommended by the national outcomes for medical graduates. A course on intravenous cannulation was developed with e-learning modules and high-fidelity complex simulation scenarios, aiming to promote capability in practice. The course delivered an intravenous cannulation e-learning package between two practical simulations to 10 final-year medical students. The hybrid simulation design consisted of an actor with a bespoke cannulation part-task trainer strapped to their arm. Each simulation delivered a challenging scenario, requiring the integration of procedural and behavioural skills to succeed. Simulations were video recorded, and participants reviewed their performances before completing semi-structured interviews. Transcribed interviews were thematically analysed. Interview analysis demonstrated two overarching themes: 'Impact on Capability' and 'Preparedness for Practice'. There was consistent recognition of improved capability from the interviews. Simulation exercises were described as the most valuable tool for developing capability. The e-learning helped with structure, facilitating students' adaptation to scenarios. Participants felt that training in medical school was largely competency-based and did not tackle complex interactions. Following e-learning and simulations, students felt more prepared for clinical practice. The course structure has value for medical professionals in developing capability and preparing for clinical practice, helping to reach standards expected of graduates. Plans to assess capability across multiple undergraduate programmes through Entrustable Professional Activities are in progress.
    Language English
    Publishing date 2024-01-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2151518-9
    ISSN 1743-498X ; 1743-4971
    ISSN (online) 1743-498X
    ISSN 1743-4971
    DOI 10.1111/tct.13725
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Metrics of color-difference formula improvement.

    Carter, Robert Charles / García, Pedro A / Melgosa, Manuel / Brill, Michael H

    Journal of the Optical Society of America. A, Optics, image science, and vision

    2022  Volume 39, Issue 8, Page(s) 1360–1370

    Abstract: Metrics of color-difference formula improvement (i.e., standardized residual sum of squares and Pearson product moment correlation) are shown to convey the same information. Furthermore, each metric has two computational forms that assume different ... ...

    Abstract Metrics of color-difference formula improvement (i.e., standardized residual sum of squares and Pearson product moment correlation) are shown to convey the same information. Furthermore, each metric has two computational forms that assume different linear data models, specifically, with or without an ordinate intercept. It is essential to choose a computational form that matches the data model. We recommend explicitly declaring whether or not the data have been centered, i.e., by subtracting the mean value from each datum, to match the intercept-free data model. Statistical testing of the metrics assumes independent, normally distributed randomness of residuals from the data model, and homogeneous variance. Procedures consistent with these assumptions include robust statistical tests, homogenizing data transformations, and meta-analysis.
    MeSH term(s) Linear Models
    Language English
    Publishing date 2022-10-10
    Publishing country United States
    Document type Journal Article ; Meta-Analysis
    ZDB-ID 283633-6
    ISSN 1520-8532 ; 1084-7529 ; 0740-3232
    ISSN (online) 1520-8532
    ISSN 1084-7529 ; 0740-3232
    DOI 10.1364/JOSAA.461542
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: The Role of Growth Hormone in Chronic Kidney Disease.

    Oliveira, Eduardo A / Carter, Caitlin E / Mak, Robert H

    Seminars in nephrology

    2021  Volume 41, Issue 2, Page(s) 144–155

    Abstract: Growth hormone (GH) has become a critical therapy for treating growth delay and failure in pediatric chronic kidney disease. Recombinant human GH treatment is safe and significantly improves height and height velocity in these growing patients and ... ...

    Abstract Growth hormone (GH) has become a critical therapy for treating growth delay and failure in pediatric chronic kidney disease. Recombinant human GH treatment is safe and significantly improves height and height velocity in these growing patients and improved growth outcomes are associated with decreased morbidity and mortality as well as improved quality of life. However, the utility of recombinant human GH in adults with chronic kidney disease and end-stage renal disease for optimization of body habitus and reducing frailty remains uncertain. Semin Nephrol 41:x-xx © 2021 Elsevier Inc. All rights reserved.
    MeSH term(s) Body Height ; Child ; Growth Hormone/therapeutic use ; Human Growth Hormone/therapeutic use ; Humans ; Quality of Life ; Renal Insufficiency, Chronic/drug therapy
    Chemical Substances Human Growth Hormone (12629-01-5) ; Growth Hormone (9002-72-6)
    Language English
    Publishing date 2021-06-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 604652-6
    ISSN 1558-4488 ; 0270-9295
    ISSN (online) 1558-4488
    ISSN 0270-9295
    DOI 10.1016/j.semnephrol.2021.03.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Nonadiabatic Photodissociation and Dehydrogenation Dynamics of

    Heald, Lauren F / Gosman, Robert S / Rotteger, Chase H / Jarman, Carter K / Sayres, Scott G

    The journal of physical chemistry letters

    2023  Volume 14, Issue 27, Page(s) 6278–6285

    Abstract: ... calculations are employed to reveal the mechanism of C═C and C≡C formation (and related H ...

    Abstract Femtosecond time-resolved mass spectrometry, correlation mapping, and density functional theory calculations are employed to reveal the mechanism of C═C and C≡C formation (and related H
    Language English
    Publishing date 2023-07-03
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.3c01438
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Evaluation of a High Stakes Physician Competency Assessment: Lessons for Assessor Training, Program Accountability, and Continuous Improvement.

    Wenghofer, Elizabeth F / Steele, Robert S / Christiansen, Richard G / Carter, Misti H

    The Journal of continuing education in the health professions

    2021  Volume 41, Issue 2, Page(s) 111–118

    Abstract: Introduction: There is a dearth of evidence evaluating postlicensure high-stakes physician competency assessment programs. Our purpose was to contribute to this evidence by evaluating a high-stakes assessment for assessor inter-rater reliability and the ...

    Abstract Introduction: There is a dearth of evidence evaluating postlicensure high-stakes physician competency assessment programs. Our purpose was to contribute to this evidence by evaluating a high-stakes assessment for assessor inter-rater reliability and the relationship between performance on individual assessment components and overall performance. We did so to determine if the assessment tools identify specific competency needs of the assessed physicians and contribute to our understanding of physician dyscompetence more broadly.
    Method: Four assessors independently reviewed 102 video-recorded assessments and scored physicians on seven assessment components and overall performance. Inter-rater reliability was measured using intraclass correlation coefficients using a multiple rater, consistency, two-way random effect model. Analysis of variance with least-significant difference post-hoc analyses examined if the mean component scores differed significantly by quartile ranges of overall performance. Linear regression analysis determined the extent to which each component score was associated with overall performance.
    Results: Intraclass correlation coefficients ranged between 0.756 and 0.876 for all components scored and was highest for overall performance. Regression indicated that individual component scores were positively associated with overall performance. Levels of variation in component scores were significantly different across quartile ranges with higher variability in poorer performers.
    Discussion: High-stake assessments can be conducted reliably and identify performance gaps of potentially dyscompetent physicians. Physicians who performed well tended to do so in all aspects evaluated, whereas those who performed poorly demonstrated areas of strength and weakness. Understanding that dyscompetence rarely means a complete or catastrophic lapse competence is vital to understanding how educational needs change through a physician's career.
    MeSH term(s) Clinical Competence ; Educational Measurement ; Humans ; Physicians ; Reproducibility of Results ; Social Responsibility
    Language English
    Publishing date 2021-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639445-0
    ISSN 1554-558X ; 0894-1912
    ISSN (online) 1554-558X
    ISSN 0894-1912
    DOI 10.1097/CEH.0000000000000362
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: The Drosophila melanogaster enzyme glycerol-3-phosphate dehydrogenase 1 is required for oogenesis, embryonic development, and amino acid homeostasis.

    Rai, Madhulika / Carter, Sarah M / Shefali, Shefali A / Mahmoudzadeh, Nader H / Pepin, Robert / Tennessen, Jason M

    G3 (Bethesda, Md.)

    2022  Volume 12, Issue 8

    Abstract: As the fruit fly, Drosophila melanogaster, progresses from one life stage to the next, many of the enzymes that compose intermediary metabolism undergo substantial changes in both expression and activity. These predictable shifts in metabolic flux allow ... ...

    Abstract As the fruit fly, Drosophila melanogaster, progresses from one life stage to the next, many of the enzymes that compose intermediary metabolism undergo substantial changes in both expression and activity. These predictable shifts in metabolic flux allow the fly meet stage-specific requirements for energy production and biosynthesis. In this regard, the enzyme glycerol-3-phosphate dehydrogenase 1 (GPDH1) has been the focus of biochemical genetics studies for several decades and, as a result, is one of the most well-characterized Drosophila enzymes. Among the findings of these earlier studies is that GPDH1 acts throughout the fly lifecycle to promote mitochondrial energy production and triglyceride accumulation while also serving a key role in maintaining redox balance. Here, we expand upon the known roles of GPDH1 during fly development by examining how depletion of both the maternal and zygotic pools of this enzyme influences development, metabolism, and viability. Our findings not only confirm previous observations that Gpdh1 mutants exhibit defects in larval development, lifespan, and fat storage but also reveal that GPDH1 serves essential roles in oogenesis and embryogenesis. Moreover, metabolomics analysis reveals that a Gpdh1 mutant stock maintained in a homozygous state exhibits larval metabolic defects that significantly differ from those observed in the F1 mutant generation. Overall, our findings highlight unappreciated roles for GPDH1 in early development and uncover previously undescribed metabolic adaptations that could allow flies to survive the loss of this key enzyme.
    MeSH term(s) Amino Acids/metabolism ; Animals ; Drosophila/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Drosophila melanogaster ; Embryonic Development/genetics ; Glycerolphosphate Dehydrogenase/genetics ; Glycerolphosphate Dehydrogenase/metabolism ; Homeostasis ; Oogenesis/genetics
    Chemical Substances Amino Acids ; Drosophila Proteins ; Glycerolphosphate Dehydrogenase (EC 1.1.-)
    Language English
    Publishing date 2022-05-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2629978-1
    ISSN 2160-1836 ; 2160-1836
    ISSN (online) 2160-1836
    ISSN 2160-1836
    DOI 10.1093/g3journal/jkac115
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Documented Penicillin Allergies on Antibiotic Selection at Pediatric Emergency Department Visits.

    Carter, Eileen J / Zavez, Katherine / Rogers, Steven C / deMayo, Richelle / Harel, Ofer / Gerber, Jeffrey S / Aseltine, Robert H

    Pediatric emergency care

    2023  Volume 40, Issue 4, Page(s) 283–288

    Abstract: Background: Penicillin or amoxicillin are the recommended treatments for the most common pediatric bacterial illnesses. Allergies to penicillin are commonly reported among children but rarely true. We evaluated the impact of reported penicillin ... ...

    Abstract Background: Penicillin or amoxicillin are the recommended treatments for the most common pediatric bacterial illnesses. Allergies to penicillin are commonly reported among children but rarely true. We evaluated the impact of reported penicillin allergies on broad-spectrum antibiotic use overall and for the treatment of common respiratory infections among treat-and-release pediatric emergency department (ED) visits.
    Methods: Retrospective cohort study of pediatric patients receiving antibiotics during a treat-and-release visit at a large, pediatric ED in the northeast from 2014 to 2016. Study exposure was a reported allergy to penicillin in the electronic medical record. Study outcomes were the selection of broad-spectrum antibiotics and alternative (second-line) antibiotic therapy for the treatment of acute otitis media (AOM) and group A streptococcus (GAS) pharyngitis. We used unadjusted and adjusted generalized estimating equation models to analyze the impact of reported penicillin allergies on the selection of broad-spectrum antibiotics. We used unadjusted and adjusted logistic regression models to determine the probability of children with a documented penicillin allergy receiving alternative antibiotic treatments for AOM and GAS.
    Results: Among 12,987 pediatric patients, 810 (6.2%) had a documented penicillin allergy. Penicillin allergies increased the odds of children receiving a broad spectrum versus narrow spectrum antibiotic (adjusted odds ratio, 13.55; 95% confidence interval (CI), 11.34-16.18). In our adjusted logistic regression model, the probability of children with a documented penicillin allergy receiving alternative antibiotic treatment for AOM was 0.97 (95% CI, 0.94-0.99) and for GAS was 0.97 (95% CI, 0.92-0.99).
    Conclusions: Antibiotic stewardship efforts in pediatric EDs may consider the delabeling of penicillin allergies particularly among children receiving antibiotics for an acute respiratory infection as a target for intervention.
    MeSH term(s) Child ; Humans ; Anti-Bacterial Agents/adverse effects ; Retrospective Studies ; Emergency Room Visits ; Penicillins/adverse effects ; Emergency Service, Hospital ; Drug Hypersensitivity/epidemiology ; Drug Hypersensitivity/drug therapy ; Disease Progression ; Otitis Media/drug therapy ; Hypersensitivity
    Chemical Substances Anti-Bacterial Agents ; Penicillins
    Language English
    Publishing date 2023-08-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632588-9
    ISSN 1535-1815 ; 0749-5161
    ISSN (online) 1535-1815
    ISSN 0749-5161
    DOI 10.1097/PEC.0000000000003023
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top