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  1. Book ; Thesis: Immunalteration nach Schlaganfall

    Vogelgesang, Antje / Bröker, Barbara / Watzl, Carsten / Sparwasser, Tim Dominik

    Mechanismen und Therapie

    2019  

    Institution Universität Greifswald
    Author's details vorgelegt von Dr. rer. nat. Antje Vogelgesang ; 1. Gutachter: Prof. Dr. Barbara Bröker, 2. Gutachter: Prof. Dr. Carsten Watzl, 3. Gutachter: Prof. Dr. Tim Sparwasser
    Keywords Schlaganfall ; Immunologie ; Immunsystem ; Immunsuppression ; Neuroimmunologie
    Subject Immunoneurologie ; Immundepression ; Immunsystem ; Körpereigene Abwehr ; Körpereigene Abwehrkräfte ; Körpereigenes Abwehrsystem ; Abwehrkräfte ; Klinische Immunologie ; Apoplektischer Insult ; Apoplexia cerebri ; Apoplexie ; Gehirnschlag ; Hirnschlag ; Zerebrovaskulärer Insult ; ZVI ; Ischämischer Insult ; Stroke
    Language German ; English
    Size 75, iv Seiten, Diagramme
    Publishing place Greifswald
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Habilitationsschrift, Universitätsmedizin der Universität Greifswald, 2021
    Note Text teilweise in deutscher, teilweise in englischer Sprache ; Literaturverzeichnis: Seite 21-26. - Literaturangaben
    HBZ-ID HT021017401
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: The evolutionary tug-of-war of macrophage metabolism during bacterial infection.

    Almeida, Luís / Dhillon-LaBrooy, Ayesha / Sparwasser, Tim

    Trends in endocrinology and metabolism: TEM

    2023  Volume 35, Issue 3, Page(s) 235–248

    Abstract: The function and phenotype of macrophages are intimately linked with pathogen detection. On sensing pathogen-derived signals and molecules, macrophages undergo a carefully orchestrated process of polarization to acquire pathogen-clearing properties. This ...

    Abstract The function and phenotype of macrophages are intimately linked with pathogen detection. On sensing pathogen-derived signals and molecules, macrophages undergo a carefully orchestrated process of polarization to acquire pathogen-clearing properties. This phenotypic change must be adequately supported by metabolic reprogramming that is now known to support the acquisition of effector function, but also generates secondary metabolites with direct microbicidal activity. At the same time, bacteria themselves have adapted to both manipulate and take advantage of macrophage-specific metabolic adaptations. Here, we summarize the current knowledge on macrophage metabolism during infection, with a particular focus on understanding the 'arms race' between host immune cells and bacteria during immune responses.
    MeSH term(s) Humans ; Macrophages/metabolism ; Bacterial Infections/metabolism ; Phenotype
    Language English
    Publishing date 2023-11-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1042384-9
    ISSN 1879-3061 ; 1043-2760
    ISSN (online) 1879-3061
    ISSN 1043-2760
    DOI 10.1016/j.tem.2023.11.002
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  3. Article ; Online: Tregs protect against invariant NKT cell-mediated autoimmune colitis and hepatitis.

    Venken, Koen / Decruy, Tine / Sparwasser, Tim / Elewaut, Dirk

    Immunology

    2023  Volume 171, Issue 2, Page(s) 277–285

    Abstract: Immunomodulatory T cells play a pivotal role in protection against (auto)immune-mediated diseases that open perspectives for therapeutic modulation. However, how immune regulatory networks operate in vivo is less understood. To this end, we focused on ... ...

    Abstract Immunomodulatory T cells play a pivotal role in protection against (auto)immune-mediated diseases that open perspectives for therapeutic modulation. However, how immune regulatory networks operate in vivo is less understood. To this end, we focused on FOXP3+CD4+CD25+ regulatory T cells (Tregs) and invariant natural killer T (iNKT) cells, two lymphocyte populations that independently regulate adaptive and innate immune responses. In vitro, a functional interplay between Tregs and iNKT cells has been described, but whether Tregs modulate the function and phenotype of iNKT cell subsets in vivo and whether this controls iNKT-mediated autoimmunity is unclear. Taking advantage of the conditional depletion of Tregs, we examined the in vivo interplay between iNKT and Treg cells in steady state and in preclinical models of liver and gut autoimmunity. Under non-inflamed conditions, Treg depletion enhanced glycolipid-mediated iNKT cell responses, with a general impact on Type 1, 2 and 17 iNKT subsets. Moreover, in vivo iNKT activation in the absence of Tregs suppressed the induction of iNKT anergy, consistent with a reduction in programmed cell death receptor 1 (PD-1) expression. Importantly, we unveiled a clear role for an in vivo Treg-iNKT crosstalk both in concanavalin A-induced acute hepatitis and oxazolone-induced colitis. Here, the absence of Tregs led to a markedly enhanced liver and gut pathology, which was not observed in iNKT-deficient mice. Taken together, these results provide evidence for a functional interplay between regulatory T cell subsets critical in controlling the onset of autoimmune disease.
    MeSH term(s) Mice ; Animals ; Natural Killer T-Cells ; T-Lymphocytes, Regulatory ; T-Lymphocyte Subsets ; Colitis/metabolism ; Hepatitis/metabolism
    Language English
    Publishing date 2023-11-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 80124-0
    ISSN 1365-2567 ; 0019-2805 ; 0953-4954
    ISSN (online) 1365-2567
    ISSN 0019-2805 ; 0953-4954
    DOI 10.1111/imm.13718
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  4. Article ; Online: A clinically-relevant STING agonist restrains human T

    Damasceno, Luis Eduardo Alves / Cunha, Thiago Mattar / Cunha, Fernando Queiroz / Sparwasser, Tim / Alves-Filho, José Carlos

    International immunopharmacology

    2023  Volume 124, Issue Pt B, Page(s) 111007

    Abstract: The STING signaling pathway has gained attention over the last few years due to its ability to incite antimicrobial and antitumoral immunity. Conversely, in mouse models of autoimmunity such as colitis and multiple sclerosis, where ... ...

    Abstract The STING signaling pathway has gained attention over the last few years due to its ability to incite antimicrobial and antitumoral immunity. Conversely, in mouse models of autoimmunity such as colitis and multiple sclerosis, where T
    MeSH term(s) Humans ; Mice ; Animals ; Inflammation/metabolism ; Signal Transduction ; Colitis/pathology ; Disease Models, Animal ; Th17 Cells
    Language English
    Publishing date 2023-09-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2023.111007
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  5. Book ; Thesis: Enzymatische Modifikation von Low-density-Lipoprotein (LDL) zu einem Komplementaktivator

    Sparwasser, Tim Dominik

    Untersuchungen zum Zusammenhang zwischen Komplement und Atherosklerose

    1996  

    Author's details vorgelegt von Tim Dominik Sparwasser
    Language German
    Size 100 Bl. : Ill., graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Mainz, Univ., Diss., 1996
    Note Mikrofiche-Ausg.: 2 Mikrofiches : 24x
    HBZ-ID HT007343203
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1996 MB 2872 order for loan Magazin

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  6. Article ; Online: Regulation of DC metabolism by nitric oxide in murine GM-CSF cultures.

    Minarrieta, Lucía / Godoy, Gloria J / Velazquez, Lis N / Ghorbani, Peyman / Sparwasser, Tim / Berod, Luciana

    European journal of immunology

    2022  Volume 53, Issue 2, Page(s) e2149691

    Abstract: ... The ... ...

    Abstract The CD11c
    MeSH term(s) Mice ; Animals ; Granulocyte-Macrophage Colony-Stimulating Factor/metabolism ; Nitric Oxide/metabolism ; Dendritic Cells/metabolism ; Cell Differentiation ; Mice, Inbred C57BL
    Chemical Substances Granulocyte-Macrophage Colony-Stimulating Factor (83869-56-1) ; Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2022-12-28
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.202149691
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  7. Article ; Online: Dendritic cell metabolism: moving beyond in vitro-culture-generated paradigms.

    Minarrieta, Lucía / Velasquez, Lis Noelia / Sparwasser, Tim / Berod, Luciana

    Current opinion in biotechnology

    2021  Volume 68, Page(s) 202–212

    Abstract: Dendritic cells (DCs) are key orchestrators of immunity and tolerance. It has become evident that DC function can be influenced by cellular metabolic programs. However, conclusions from early metabolic studies using in vitro GM-CSF DC cultures fail to ... ...

    Abstract Dendritic cells (DCs) are key orchestrators of immunity and tolerance. It has become evident that DC function can be influenced by cellular metabolic programs. However, conclusions from early metabolic studies using in vitro GM-CSF DC cultures fail to correlate with bona fide DC populations. Here, we discuss the existing paradigms in the DC metabolism field, focusing on the limitations of the models utilized. Furthermore, we introduce alternative models to generate DCs in vitro that better emulate DCs found in vivo. Finally, we highlight new techniques to evaluate DC metabolism at the single-cell level. The combination of these two strategies could help advance the DC metabolism field towards a more physiological understanding, which is crucial for the development of effective DC-based therapies.
    MeSH term(s) Cell Differentiation ; Dendritic Cells
    Language English
    Publishing date 2021-01-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1052045-4
    ISSN 1879-0429 ; 0958-1669
    ISSN (online) 1879-0429
    ISSN 0958-1669
    DOI 10.1016/j.copbio.2020.12.010
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  8. Article ; Online: pDCs Take a Deep Breath to Fight Viruses.

    Berod, Luciana / Sparwasser, Tim

    Immunity

    2016  Volume 44, Issue 6, Page(s) 1246–1248

    Abstract: Conventional dendritic cells (cDCs) and plasmacytoid dendritic cells (pDCs) serve non-overlapping functions in immune responses. In this issue of Immunity, Pearce and colleagues (2016) report that pDCs use different metabolic pathways from cDCs to ... ...

    Abstract Conventional dendritic cells (cDCs) and plasmacytoid dendritic cells (pDCs) serve non-overlapping functions in immune responses. In this issue of Immunity, Pearce and colleagues (2016) report that pDCs use different metabolic pathways from cDCs to support their specialized function.
    MeSH term(s) Dendritic Cells/immunology ; Humans ; Immunity ; Viruses
    Language English
    Publishing date 2016--21
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2016.06.005
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  9. Article ; Online: CD4

    Almeida, Luís / Dhillon-LaBrooy, Ayesha / Carriche, Guilhermina / Berod, Luciana / Sparwasser, Tim

    The Journal of allergy and clinical immunology

    2021  Volume 148, Issue 1, Page(s) 16–32

    Abstract: The progression through different steps of T-cell development, activation, and effector function is tightly bound to specific cellular metabolic processes. Previous studies established that T-effector cells have a metabolic bias toward aerobic glycolysis, ...

    Abstract The progression through different steps of T-cell development, activation, and effector function is tightly bound to specific cellular metabolic processes. Previous studies established that T-effector cells have a metabolic bias toward aerobic glycolysis, whereas naive and regulatory T cells mainly rely on oxidative phosphorylation. More recently, the field of immunometabolism has drifted away from the notion that mitochondrial metabolism holds little importance in T-cell activation and function. Of note, T cells possess metabolic promiscuity, which allows them to adapt their nutritional requirements according to the tissue environment. Altogether, the integration of these metabolic pathways culminates in the generation of not only energy but also intermediates, which can regulate epigenetic programs, leading to changes in T-cell fate. In this review, we discuss the recent literature on how glycolysis, amino acid catabolism, and fatty acid oxidation work together with the tricarboxylic acid cycle in the mitochondrion. We also emphasize the importance of the electron transport chain for T-cell immunity. We also discuss novel findings highlighting the role of key enzymes, accessory pathways, and posttranslational protein modifications that distinctively regulate T-cell function and might represent prominent candidates for therapeutic purposes.
    MeSH term(s) Animals ; CD4-Positive T-Lymphocytes/immunology ; Cell Differentiation/immunology ; Fatty Acids/immunology ; Glycolysis/immunology ; Humans ; Mitochondria/immunology ; NAD/immunology ; Polyamines/immunology
    Chemical Substances Fatty Acids ; Polyamines ; NAD (0U46U6E8UK)
    Language English
    Publishing date 2021-05-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2021.03.033
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  10. Book ; Online ; Thesis: The role of mitochondrial translation in T cell function and autoimmunity

    Almeida, Luís [Verfasser] / Sparwasser, Tim Dominik [Akademischer Betreuer] / Hühn, Jochen [Akademischer Betreuer] / Jänsch, Lothar [Akademischer Betreuer]

    2022  

    Author's details Luís Almeida ; Akademische Betreuer: Tim Dominik Sparwasser, Jochen Hühn, Lothar Jänsch ; Twincore, Zentrum für Experimentelle und Klinische Infektionsforschung
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Bibliothek der Medizinischen Hochschule Hannover
    Publishing place Hannover
    Document type Book ; Online ; Thesis
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