LIVIVO - Search results -

Search results

Result 1 - 10 of total 660

Search options

Article ; Online: In-field detection and characterization of B/Victoria lineage deletion variant viruses causing early influenza activity and an outbreak in Louisiana, 2019.

Shu, Bo / Wilson, Malania M / Keller, Matthew W / Tran, Ha / Sokol, Theresa / Lee, Grace / Rambo-Martin, Benjamin L / Kirby, Marie K / Hassell, Norman / Haydel, Danielle / Hand, Julie / Wentworth, David E / Barnes, John R

Influenza and other respiratory viruses

2024 Volume 18, Issue 1, Page(s) e13246

Abstract: Background: In 2019, the Louisiana Department of Health reported an early influenza B/Victoria (B ... to investigate it using genomics and a triplex real-time RT-PCR assay to detect three antigenically distinct B ... VIC lineage variant viruses.: Results: The investigation indicated that B/VIC V1A.3 subclade ...

Abstract	Background: In 2019, the Louisiana Department of Health reported an early influenza B/Victoria (B/VIC) virus outbreak. Method: As it was an atypically large outbreak, we deployed to Louisiana to investigate it using genomics and a triplex real-time RT-PCR assay to detect three antigenically distinct B/VIC lineage variant viruses. Results: The investigation indicated that B/VIC V1A.3 subclade, containing a three amino acid deletion in the hemagglutinin and known to be antigenically distinct to the B/Colorado/06/2017 vaccine virus, was the most prevalent circulating virus within the specimens evaluated (86/88 in real-time RT-PCR). Conclusion: This work underscores the value of portable platforms for rapid, onsite pathogen characterization.
MeSH term(s)	Humans ; Influenza, Human/epidemiology ; Influenza Vaccines ; Disease Outbreaks ; Louisiana/epidemiology
Chemical Substances	Influenza Vaccines ; L 644711 (SC0Y88002K)
Language	English
Publishing date	2024-01-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2274538-5
ISSN	1750-2659 ; 1750-2640
ISSN (online)	1750-2659
ISSN	1750-2640
DOI	10.1111/irv.13246
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6568: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Enhanced fitness of SARS-CoV-2 B.1.617.2 Delta variant in ferrets.

Sun, Xiangjie / Belser, Jessica A / Kieran, Troy J / Brock, Nicole / Pulit-Penaloza, Joanna A / Pappas, Claudia / Basu Thakur, Poulami / Jones, Joyce / Wentworth, David E / Zhou, Bin / Tumpey, Terrence M / Maines, Taronna R

Virology

2023 Volume 582, Page(s) 57–61

Abstract: Competition assays were conducted in vitro and in vivo to examine how the Delta (B.1.617.2) variant ...

Abstract	Competition assays were conducted in vitro and in vivo to examine how the Delta (B.1.617.2) variant displaced the prototype Washington/1/2020 (WA/1) strain. While WA/1 virus exhibited a moderately increased proportion compared to that in the inoculum following co-infection in human respiratory cells, Delta variant possessed a substantial in vivo fitness advantage as this virus becoming predominant in both inoculated and contact animals. This work identifies critical traits of the Delta variant that likely played a role in it becoming a dominant variant and highlights the necessities of employing multiple model systems to assess the fitness of newly emerged SARS-CoV-2 variants.
MeSH term(s)	Animals ; Humans ; Ferrets ; COVID-19 ; SARS-CoV-2/genetics ; Biological Assay
Language	English
Publishing date	2023-04-05
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	200425-2
ISSN	1096-0341 ; 0042-6822
ISSN (online)	1096-0341
ISSN	0042-6822
DOI	10.1016/j.virol.2023.03.014
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ud II Zs.172: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Differential interferon responses to influenza A and B viruses in primary ferret respiratory epithelial cells.

Rowe, Thomas / Davis, William / Wentworth, David E / Ross, Ted

Journal of virology

2024 Volume 98, Issue 2, Page(s) e0149423

Abstract: Influenza B viruses (IBV) cocirculate with influenza A viruses (IAV) and cause periodic ... and H3N2 subtypes) or IBV (B/Victoria and B/Yamagata lineages) and assessed for 72 h. Cells were ...

Abstract	Influenza B viruses (IBV) cocirculate with influenza A viruses (IAV) and cause periodic epidemics of disease, yet antibody and cellular responses following IBV infection are less well understood. Using the ferret model for antisera generation for influenza surveillance purposes, IAV resulted in robust antibody responses following infection, whereas IBV required an additional booster dose, over 85% of the time, to generate equivalent antibody titers. In this study, we utilized primary differentiated ferret nasal epithelial cells (FNECs) which were inoculated with IAV and IBV to study differences in innate immune responses which may result in differences in adaptive immune responses in the host. FNECs were inoculated with IAV (H1N1pdm09 and H3N2 subtypes) or IBV (B/Victoria and B/Yamagata lineages) and assessed for 72 h. Cells were analyzed for gene expression by quantitative real-time PCR, and apical and basolateral supernatants were assessed for virus kinetics and interferon (IFN), respectively. Similar virus kinetics were observed with IAV and IBV in FNECs. A comparison of gene expression and protein secretion profiles demonstrated that IBV-inoculated FNEC expressed delayed type-I/II IFN responses and reduced type-III IFN secretion compared to IAV-inoculated cells. Concurrently, gene expression of Thymic Stromal Lymphopoietin (
MeSH term(s)	Animals ; Child ; Humans ; Adaptive Immunity ; Antibodies, Viral/analysis ; Antibodies, Viral/biosynthesis ; Antibodies, Viral/immunology ; Disease Models, Animal ; Epithelial Cells/cytology ; Epithelial Cells/immunology ; Epithelial Cells/virology ; Ferrets/immunology ; Ferrets/virology ; Immunity, Innate ; Influenza A virus/classification ; Influenza A virus/growth & development ; Influenza A virus/immunology ; Influenza A Virus, H1N1 Subtype/immunology ; Influenza A Virus, H3N2 Subtype/immunology ; Influenza B virus/classification ; Influenza B virus/growth & development ; Influenza B virus/immunology ; Influenza Vaccines ; Influenza, Human/virology ; Interferons/immunology ; Nasal Mucosa/cytology ; Nasal Mucosa/immunology ; Nasal Mucosa/virology ; Thymic Stromal Lymphopoietin/genetics ; Thymic Stromal Lymphopoietin/immunology ; Cells, Cultured
Chemical Substances	Antibodies, Viral ; Influenza Vaccines ; Interferons (9008-11-1) ; Thymic Stromal Lymphopoietin (GT0IL38SP4)
Language	English
Publishing date	2024-01-31
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/jvi.01494-23
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 609: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Genomic Surveillance for SARS-CoV-2 Variants: Predominance of the Delta (B.1.617.2) and Omicron (B.1.1.529) Variants - United States, June 2021-January 2022.

Lambrou, Anastasia S / Shirk, Philip / Steele, Molly K / Paul, Prabasaj / Paden, Clinton R / Cadwell, Betsy / Reese, Heather E / Aoki, Yutaka / Hassell, Norman / Zheng, Xiao-Yu / Talarico, Sarah / Chen, Jessica C / Oberste, M Steven / Batra, Dhwani / McMullan, Laura K / Halpin, Alison Laufer / Galloway, Summer E / MacCannell, Duncan R / Kondor, Rebecca /

Barnes, John / MacNeil, Adam / Silk, Benjamin J / Dugan, Vivien G / Scobie, Heather M / Wentworth, David E / Caravas, Jason / Kovacs, Nicholas A / Gerhart, Jonathan G / Jia Ng, Han / Beck, Andrew / Chau, Reina / Cintron, Roxana / Cook, Peter W / Gulvik, Christopher A / Howard, Dakota / Jang, Yunho / Knipe, Kristen / Lacek, Kristine A / Moser, Kara A / Paskey, Adrian C / Rambo-Martin, Benjamin L / Nagilla, Roopa R / Retchless, Adam C / Schmerer, Matthew W / Seby, Sandra / Shepard, Samuel S / Stanton, Richard A / Stark, Thomas J / Uehara, Anna / Unoarumhi, Yvette / Bentz, Meghan L / Burgin, Alex / Burroughs, Mark / Davis, Morgan L / Keller, Matthew W / Keong, Lisa M / Le, Shoshona S / Lee, Justin S / Madden Jr, Joseph C / Nobles, Sarah / Owuor, D. Collins / Padilla, Jasmine / Sheth, Mili / Wilson, Malania M

MMWR. Morbidity and mortality weekly report

2022 Volume 71, Issue 6, Page(s) 206–211

Abstract: Genomic surveillance is a critical tool for tracking emerging variants of SARS-CoV-2 (the virus that causes COVID-19), which can exhibit characteristics that potentially affect public health and clinical interventions, including increased ... ...

Abstract	Genomic surveillance is a critical tool for tracking emerging variants of SARS-CoV-2 (the virus that causes COVID-19), which can exhibit characteristics that potentially affect public health and clinical interventions, including increased transmissibility, illness severity, and capacity for immune escape. During June 2021-January 2022, CDC expanded genomic surveillance data sources to incorporate sequence data from public repositories to produce weighted estimates of variant proportions at the jurisdiction level and refined analytic methods to enhance the timeliness and accuracy of national and regional variant proportion estimates. These changes also allowed for more comprehensive variant proportion estimation at the jurisdictional level (i.e., U.S. state, district, territory, and freely associated state). The data in this report are a summary of findings of recent proportions of circulating variants that are updated weekly on CDC's COVID Data Tracker website to enable timely public health action.
MeSH term(s)	COVID-19/epidemiology ; COVID-19/virology ; Centers for Disease Control and Prevention, U.S. ; Genomics ; Humans ; Prevalence ; Public Health Surveillance/methods ; SARS-CoV-2/genetics ; United States/epidemiology
Language	English
Publishing date	2022-02-11
Publishing country	United States
Document type	Technical Report
ZDB-ID	412775-4
ISSN	1545-861X ; 0149-2195
ISSN (online)	1545-861X
ISSN	0149-2195
DOI	10.15585/mmwr.mm7106a4
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 1827: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Detection and discrimination of influenza B Victoria lineage deletion variant viruses by real-time RT-PCR.

Shu, Bo / Kirby, Marie K / Warnes, Christine / Sessions, Wendy M / Davis, William G / Liu, Ji / Wilson, Malania M / Lindstrom, Stephen / Wentworth, David E / Barnes, John R

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

2020 Volume 25, Issue 41

Abstract: BackgroundDuring the 2016/17 influenza season, influenza B/VIC lineage variant viruses emerged ...

Abstract	BackgroundDuring the 2016/17 influenza season, influenza B/VIC lineage variant viruses emerged with two (K
MeSH term(s)	Hemagglutinin Glycoproteins, Influenza Virus/genetics ; Humans ; Influenza B virus/classification ; Influenza B virus/genetics ; Influenza B virus/isolation & purification ; Influenza, Human/epidemiology ; Molecular Epidemiology/methods ; Reverse Transcriptase Polymerase Chain Reaction/methods
Chemical Substances	Hemagglutinin Glycoproteins, Influenza Virus
Language	English
Publishing date	2020-10-01
Publishing country	Sweden
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	1338803-4
ISSN	1560-7917 ; 1025-496X
ISSN (online)	1560-7917
ISSN	1025-496X
DOI	10.2807/1560-7917.ES.2020.25.41.1900652
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5066: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Multiplex Real-Time Reverse Transcription PCR for Influenza A Virus, Influenza B Virus, and Severe Acute Respiratory Syndrome Coronavirus 2.

Emerging infectious diseases

2021 Volume 27, Issue 7, Page(s) 1821–1830

Abstract: ... that causes symptoms similar to those caused by influenza A and B viruses. On July 2, 2020 ...

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in late 2019, and the outbreak rapidly evolved into the current coronavirus disease pandemic. SARS-CoV-2 is a respiratory virus that causes symptoms similar to those caused by influenza A and B viruses. On July 2, 2020, the US Food and Drug Administration granted emergency use authorization for in vitro diagnostic use of the Influenza SARS-CoV-2 Multiplex Assay. This assay detects influenza A virus at 10
MeSH term(s)	COVID-19 ; Humans ; Influenza A virus/genetics ; Influenza B virus/genetics ; Multiplex Polymerase Chain Reaction ; Reverse Transcription ; SARS-CoV-2
Language	English
Publishing date	2021-06-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1380686-5
ISSN	1080-6059 ; 1080-6040
ISSN (online)	1080-6059
ISSN	1080-6040
DOI	10.3201/eid2707.210462
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4778: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Multiplex Reverse Transcription-PCR for Simultaneous Surveillance of Influenza A and B Viruses.

Zhou, Bin / Deng, Yi-Mo / Barnes, John R / Sessions, October M / Chou, Tsui-Wen / Wilson, Malania / Stark, Thomas J / Volk, Michelle / Spirason, Natalie / Halpin, Rebecca A / Kamaraj, Uma Sangumathi / Ding, Tao / Stockwell, Timothy B / Salvatore, Mirella / Ghedin, Elodie / Barr, Ian G / Wentworth, David E

Journal of clinical microbiology

2017 Volume 55, Issue 12, Page(s) 3492–3501

Abstract: Influenza A and B viruses are the causative agents of annual influenza epidemics that can be severe ... throughput sequencing of influenza viruses remains a challenge. We developed a single-reaction influenza A/B ... virus (FluA/B) multiplex reverse transcription-PCR (RT-PCR) method that amplifies the most critical ...

Abstract	Influenza A and B viruses are the causative agents of annual influenza epidemics that can be severe, and influenza A viruses intermittently cause pandemics. Sequence information from influenza virus genomes is instrumental in determining mechanisms underpinning antigenic evolution and antiviral resistance. However, due to sequence diversity and the dynamics of influenza virus evolution, rapid and high-throughput sequencing of influenza viruses remains a challenge. We developed a single-reaction influenza A/B virus (FluA/B) multiplex reverse transcription-PCR (RT-PCR) method that amplifies the most critical genomic segments (hemagglutinin [HA], neuraminidase [NA], and matrix [M]) of seasonal influenza A and B viruses for next-generation sequencing, regardless of viral type, subtype, or lineage. Herein, we demonstrate that the strategy is highly sensitive and robust. The strategy was validated on thousands of seasonal influenza A and B virus-positive specimens using multiple next-generation sequencing platforms.
MeSH term(s)	Epidemiological Monitoring ; High-Throughput Nucleotide Sequencing/methods ; Humans ; Influenza A virus/classification ; Influenza A virus/genetics ; Influenza A virus/isolation & purification ; Influenza B virus/classification ; Influenza B virus/genetics ; Influenza B virus/isolation & purification ; Influenza, Human/virology ; Molecular Epidemiology/methods ; Multiplex Polymerase Chain Reaction/methods ; Reverse Transcriptase Polymerase Chain Reaction/methods
Language	English
Publishing date	2017-10-04
Publishing country	United States
Document type	Journal Article ; Validation Studies ; Research Support, Non-U.S. Gov't
ZDB-ID	390499-4
ISSN	1098-660X ; 0095-1137
ISSN (online)	1098-660X
ISSN	0095-1137
DOI	10.1128/JCM.00957-17
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1188: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: (with research data) The contrasting phylodynamics of human influenza B viruses.

Vijaykrishna, Dhanasekaran / Holmes, Edward C / Joseph, Udayan / Fourment, Mathieu / Su, Yvonne C F / Halpin, Rebecca / Lee, Raphael T C / Deng, Yi-Mo / Gunalan, Vithiagaran / Lin, Xudong / Stockwell, Timothy B / Fedorova, Nadia B / Zhou, Bin / Spirason, Natalie / Kühnert, Denise / Bošková, Veronika / Stadler, Tanja / Costa, Anna-Maria / Dwyer, Dominic E /

Huang, Q Sue / Jennings, Lance C / Rawlinson, William / Sullivan, Sheena G / Hurt, Aeron C / Maurer-Stroh, Sebastian / Wentworth, David E / Smith, Gavin J D / Barr, Ian G

eLife

2015 Volume 4, Page(s) e05055

Abstract: ... until now not been available for influenza B viruses, despite their significant disease burden ... lineages of influenza B virus (Victoria and Yamagata), showing that their individual dynamics are ... preference. In sum, this work identifies new factors that are important determinants of influenza B evolution ...

Abstract	A complex interplay of viral, host, and ecological factors shapes the spatio-temporal incidence and evolution of human influenza viruses. Although considerable attention has been paid to influenza A viruses, a lack of equivalent data means that an integrated evolutionary and epidemiological framework has until now not been available for influenza B viruses, despite their significant disease burden. Through the analysis of over 900 full genomes from an epidemiological collection of more than 26,000 strains from Australia and New Zealand, we reveal fundamental differences in the phylodynamics of the two co-circulating lineages of influenza B virus (Victoria and Yamagata), showing that their individual dynamics are determined by a complex relationship between virus transmission, age of infection, and receptor binding preference. In sum, this work identifies new factors that are important determinants of influenza B evolution and epidemiology.
MeSH term(s)	Age Distribution ; Animals ; Antigens, Viral/immunology ; Asparagine/metabolism ; Dogs ; Evolution, Molecular ; Genetic Variation ; Genome, Viral/genetics ; Glycosylation ; Hemagglutinin Glycoproteins, Influenza Virus/genetics ; Humans ; Influenza A virus/genetics ; Influenza A virus/immunology ; Influenza B virus/genetics ; Influenza B virus/immunology ; Influenza, Human/epidemiology ; Influenza, Human/transmission ; Influenza, Human/virology ; Madin Darby Canine Kidney Cells ; Models, Molecular ; New Zealand ; Phylogeny ; Reassortant Viruses/genetics ; Selection, Genetic ; Time Factors ; Victoria
Chemical Substances	Antigens, Viral ; Hemagglutinin Glycoproteins, Influenza Virus ; Asparagine (7006-34-0)
Language	English
Publishing date	2015-01-16
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.05055
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Enhanced fitness of SARS-CoV-2 B.1.617.2 Delta variant in ferrets

Sun, Xiangjie / Belser, Jessica A. / Kieran, Troy J. / Brock, Nicole / Pulit-Penaloza, Joanna A. / Pappas, Claudia / Basu Thakur, Poulami / Jones, Joyce / Wentworth, David E. / Zhou, Bin / Tumpey, Terrence M. / Maines, Taronna R.

Virology. 2023 May, v. 582 p.57-61

2023

Abstract: Competition assays were conducted in vitro and in vivo to examine how the Delta (B.1.617.2) variant ...

Abstract	Competition assays were conducted in vitro and in vivo to examine how the Delta (B.1.617.2) variant displaced the prototype Washington/1/2020 (WA/1) strain. While WA/1 virus exhibited a moderately increased proportion compared to that in the inoculum following co-infection in human respiratory cells, Delta variant possessed a substantial in vivo fitness advantage as this virus becoming predominant in both inoculated and contact animals. This work identifies critical traits of the Delta variant that likely played a role in it becoming a dominant variant and highlights the necessities of employing multiple model systems to assess the fitness of newly emerged SARS-CoV-2 variants.
Keywords	Severe acute respiratory syndrome coronavirus 2 ; humans ; inoculum ; mixed infection ; prototypes ; virology ; viruses ; SARS-CoV-2 ; Delta variant ; Ferrets ; Viral fitness
Language	English
Dates of publication	2023-05
Size	p. 57-61.
Publishing place	Elsevier Inc.
Document type	Article ; Online
ZDB-ID	200425-2
ISSN	1096-0341 ; 0042-6822
ISSN (online)	1096-0341
ISSN	0042-6822
DOI	10.1016/j.virol.2023.03.014
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 3686: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: HOMA2-B enhances assessment of type 1 diabetes risk among TrialNet Pathway to Prevention participants.

Felton, Jamie L / Cuthbertson, David / Warnock, Megan / Lohano, Kuldeep / Meah, Farah / Wentworth, John M / Sosenko, Jay / Evans-Molina, Carmella

Diabetologia

2021 Volume 65, Issue 1, Page(s) 88–100

Abstract: ... stratify autoantibody-positive (Aab+) individuals who are at risk of developing type 1 diabetes. HOMA2-B is ... glucose and insulin. The utility of HOMA2-B in association with type 1 diabetes progression has not been ... tested.: Methods: Baseline HOMA2-B values from single-Aab+ (n = 2652; mean age, 21.1 ± 14.0 years) and ...

Abstract	Aims/hypothesis: Methods to identify individuals at highest risk for type 1 diabetes are essential for the successful implementation of disease-modifying interventions. Simple metabolic measures are needed to help stratify autoantibody-positive (Aab+) individuals who are at risk of developing type 1 diabetes. HOMA2-B is a validated mathematical tool commonly used to estimate beta cell function in type 2 diabetes using fasting glucose and insulin. The utility of HOMA2-B in association with type 1 diabetes progression has not been tested. Methods: Baseline HOMA2-B values from single-Aab+ (n = 2652; mean age, 21.1 ± 14.0 years) and multiple-Aab+ (n = 3794; mean age, 14.5 ± 11.2 years) individuals enrolled in the TrialNet Pathway to Prevention study were compared. Cox proportional hazard models were used to determine associations between HOMA2-B tertiles and time to progression to type 1 diabetes, with adjustments for age, sex, HLA status and BMI z score. Receiver operating characteristic (ROC) analysis was used to test the association of HOMA2-B with type 1 diabetes development in 1, 2, 5 and 10 years. Results: At study entry, HOMA2-B values were higher in single- compared with multiple-Aab+ Pathway to Prevention participants (91.1 ± 44.5 vs 83.9 ± 38.9; p < 0.001). Single- and multiple-Aab+ individuals in the lowest HOMA2-B tertile had a higher risk and faster rate of progression to type 1 diabetes. For progression to type 1 diabetes within 1 year, area under the ROC curve (AUC-ROC) was 0.685, 0.666 and 0.680 for all Aab+, single-Aab+ and multiple-Aab+ individuals, respectively. When correlation between HOMA2-B and type 1 diabetes risk was assessed in combination with additional factors known to influence type 1 diabetes progression (insulin sensitivity, age and HLA status), AUC-ROC was highest for the single-Aab+ group's risk of progression at 2 years (AUC-ROC 0.723 [95% CI 0.652, 0.794]). Conclusions/interpretation: These data suggest that HOMA2-B may have utility as a single-time-point measurement to stratify risk of type 1 diabetes development in Aab+ individuals.
MeSH term(s)	Adolescent ; Adult ; Autoantibodies ; Blood Glucose/metabolism ; Child ; Child, Preschool ; Diabetes Mellitus, Type 1 ; Diabetes Mellitus, Type 2 ; Humans ; Insulin ; Insulin Resistance/physiology ; Young Adult
Chemical Substances	Autoantibodies ; Blood Glucose ; Insulin
Language	English
Publishing date	2021-10-12
Publishing country	Germany
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1694-9
ISSN	1432-0428 ; 0012-186X
ISSN (online)	1432-0428
ISSN	0012-186X
DOI	10.1007/s00125-021-05573-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 279: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito