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Article: BCG Vaccine does not Protect Against COVID-19.

Allam, Mohamed F / Amin, Ghada E

2020 Volume 14, Page(s) 78

Language	English
Publishing date	2020-12-31
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2395996-4
ISSN	1874-3064
ISSN	1874-3064
DOI	10.2174/1874306402014010078
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Proportion and Risk Factors of Silent Vertebral Fractures Among Egyptian Females With Fragility Hip Fracture Presenting to the Emergency Room of Ain Shams University Hospitals.

Abdelrahman Ali, Mohamed A / Sweed, Hala S / Allam, Mohamed F / Aly, Walaa W / Mohamed Matter, Abeer H / Abdelalim Elshabrawy, Walid E

Cureus

2023 Volume 15, Issue 9, Page(s) e46214

Abstract: Background Fragility fractures caused by osteoporosis are known to increase the risk of further fragility fractures. Also, several factors have been associated with an increasing risk of fracture in postmenopausal women with osteoporosis, as prior ... ...

Abstract	Background Fragility fractures caused by osteoporosis are known to increase the risk of further fragility fractures. Also, several factors have been associated with an increasing risk of fracture in postmenopausal women with osteoporosis, as prior fracture, advancing age, low bone mineral density (BMD), greater risk or history of falls certain, pharmacologic therapies such as glucocorticoids, and medical conditions increase the risk of secondary osteoporosis and related fractures through their direct impact on bone density or structure. Menstrual history including age at menarche menopause and a history of amenorrhea is documented as a predicting osteoporotic fracture. Objective The aim of the current study is to find the proportion of hidden vertebral fractures among Egyptian females with fragility hip fracture. Patients and methods A cross-sectional study was conducted on patients who presented to the orthopedic emergency room (ER) of Ain Shams University Hospitals in Cairo, Egypt, from September 2020 to September 2021. Our inclusion criteria include females aged 40 years or older, who presented to the ER with fragility hip fractures. A simple random sample of females fulfilling our inclusion criteria for osteoporotic hip fracture was thoroughly investigated. Conventional lateral and anteroposterior radiographs of the dorsolumbar spine were obtained excluding those with high-impact fractures or pathological fractures. Results During the study period, a total of 43,935 persons presented to the orthopedic ER, of whom 30,901 were females, comprising 70.03% of total orthopedic ER visits. A sample of 150 females met our inclusion criteria. Results showed that 16 of our 150 cases had concomitant vertebral fracture, meaning that 10.7% of cases had hidden vertebral fracture at the time of osteoporotic hip fracture, as diagnosed by the screening lumbosacral plain X-rays. Older age at menarche, younger age at menopause, and amenorrhea are shown to be risk factors for hidden vertebral fracture in Egyptian females. Conclusion Osteoporosis is a complex and costly disease. Osteoporotic fractures may be largely preventable, as environmental factors are open to intervention, and effective pharmacological agents are available. Concomitant hidden vertebral fracture is prevalent among females with osteoporotic hip fractures, and those who had later menarche, earlier menopause, and menstrual irregularities have a higher incidence of developing associated vertebral fracture, which warrants identification and management to evade complications and mortality.
Language	English
Publishing date	2023-09-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.46214
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Article ; Online: New pyrazolylindolin-2-one based coumarin derivatives as anti-melanoma agents: design, synthesis, dual BRAF

Sabt, Ahmed / Khedr, Mohammed A / Eldehna, Wagdy M / Elshamy, Abdelsamed I / Abdelhameed, Mohamed F / Allam, Rasha M / Batran, Rasha Z

RSC advances

2024 Volume 14, Issue 9, Page(s) 5907–5925

Abstract: Malignant melanoma is the most invasive skin cancer with the highest risk of death. The inhibition of ... ...

Abstract	Malignant melanoma is the most invasive skin cancer with the highest risk of death. The inhibition of BRAF
Language	English
Publishing date	2024-02-16
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d4ra00157e
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Article ; Online: Design and development of a portable low-cost QCM-based system for liquid biosensing.

Adel, Mohamed / Allam, Ahmed / Sayour, Ashraf E / Ragai, Hani F / Umezu, Shinjiro / Fath El-Bab, Ahmed M R

Biomedical microdevices

2024 Volume 26, Issue 1, Page(s) 11

Abstract: Quartz crystal microbalance (QCM) is a versatile sensing platform that has gained increasing attention for its use in bioapplications due to its high sensitivity, real-time measurement capabilities, and label-free detection. This article presents a ... ...

Abstract	Quartz crystal microbalance (QCM) is a versatile sensing platform that has gained increasing attention for its use in bioapplications due to its high sensitivity, real-time measurement capabilities, and label-free detection. This article presents a portable QCM system for liquid biosensing that uses a modified Hartley oscillator to drive 14 mm-diameter commercial QCM sensors. The system is designed to be low-cost, easy to use, and highly sensitive, making it ideal for various bioapplications. A new flow cell design to deliver samples to the surface of the sensor has been designed, fabricated, and tested. For portability and miniaturization purposes, a micropump-based pumping system is used in the current system. The system has a built-in temperature controller allowing for accurate frequency measurements. In addition, the system can be used in benchtop mode. The capability of the present system to be used in liquid biosensing is demonstrated through an experimental test for sensitivity to changes in the viscosity of glycerol samples. It was found to have a sensitivity of 263.51 Hz/mPa.s using a 10 MHz QCM sensor. Future work regarding potential applications was suggested.
MeSH term(s)	Quartz Crystal Microbalance Techniques ; Glycerol ; Temperature ; Viscosity
Chemical Substances	Glycerol (PDC6A3C0OX)
Language	English
Publishing date	2024-01-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2004019-2
ISSN	1572-8781 ; 1387-2176
ISSN (online)	1572-8781
ISSN	1387-2176
DOI	10.1007/s10544-024-00696-0
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Article ; Online: UCHID consensus for hepatocellular carcinoma.

Mostafa, Ehab F / Alaty, Waleed Hamed Abd / Abdelmalek, Mohamed / Salaheldin, Mohamed / Zaghlol, Amr / Allam, Enas / Cordie, Ahmed / Tharwat, Mina / Abdallah, Mohamed / Esmat, Gamal

Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology

2023 Volume 24, Issue 1, Page(s) 73–75

MeSH term(s)	Humans ; Carcinoma, Hepatocellular/diagnosis ; Carcinoma, Hepatocellular/therapy ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/diagnosis ; Liver Neoplasms/therapy ; Liver Neoplasms/pathology ; Consensus
Language	English
Publishing date	2023-02-04
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2502114-X
ISSN	2090-2387 ; 1687-1979
ISSN (online)	2090-2387
ISSN	1687-1979
DOI	10.1016/j.ajg.2023.01.003
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Article: Proportion of Hidden Vertebral Fractures Among Egyptian Males With Fragility Hip Fractures in the Emergency Room of Ain Shams University Hospitals.

Abbas, Adel A / Allam, Mohamed F / Sweed, Hala S / Abdul-Rahman, Samia A / Ali, Walaa W

Cureus

2023 Volume 15, Issue 12, Page(s) e49960

Abstract: Background Fragility fractures are linked to significant costs for society as well as significant pain and suffering, disability, and even death. It is well-recognized that osteoporosis-related fragility fractures raise the risk of subsequent fragility ... ...

Abstract	Background Fragility fractures are linked to significant costs for society as well as significant pain and suffering, disability, and even death. It is well-recognized that osteoporosis-related fragility fractures raise the risk of subsequent fragility fractures. One of the most frequent osteoporotic fractures brought on by low bone mineral density and other risk factors is vertebral fractures. Considering that most vertebral fractures are asymptomatic and not clinically identified, proactive screening could stop additional impairment. Objective The current study aims to determine the prevalence and risk factors of hidden vertebral fractures in Egyptian males who have fragility hip fractures. Patients and methods A cross-sectional case-control study examining the correlation of risk factors between cases (fragility hip fracture and vertebral fractures) and a control group (fragility hip fracture without vertebral fracture) was carried out from September 2020 to September 2021 on patients visiting the orthopedic emergency department of a university hospital in Cairo, Egypt. Males who presented to the emergency room (ER) with fragility hip fractures and were 40 years of age or older met our inclusion criteria. For every patient who presented with a fragility hip fracture, standard lateral and anteroposterior radiographs of the dorso-lumbar spine were taken. Results A total of 43,935 patients visited the orthopedic emergency room (ER) throughout the study period; 13,034 of those patients were men, accounting for 29.7% of all orthopedic ER visits. Our inclusion criteria for fragility hip fractures were met by 132 male participants. The screening lumbosacral plain X-rays identified 27 (20.5%) of the 132 patients as having concomitant vertebral fractures in addition to the fragility hip fractures. Concomitant hidden vertebral fractures among Egyptian males with other fragility fractures, particularly fragility hip fractures, are predicted by the number of co-morbid diseases, hypertension, and continuous use of steroids and anti-epileptics. Conclusion Most fragility fractures are avoidable. Because one fragility fracture increases the likelihood of others, early detection is crucial. To prevent complications and mortality, it is important to identify and manage individuals who have a fragility hip fracture as they frequently have concurrent hidden vertebral fractures. Predictive risk factors for fragility vertebral fractures include hypertension, the number of concomitant illnesses, and chronic drugs (anti-epileptics and steroids).
Language	English
Publishing date	2023-12-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.49960
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Article ; Online: The "new normal" for medical education during and post-COVID-19.

Andraous, Fady / Amin, Ghada Essam Al-Din / Allam, Mohamed Farouk

Education for health (Abingdon, England)

2023 Volume 35, Issue 2, Page(s) 67–68

Abstract: After outbreaks in more than 110 countries, the World Health Organization declared COVID-19 a global pandemic on the March 11, 2020, heralding unprecedented challenges in medical education. Our aim is to provide a descriptive overview of the impact of ... ...

Abstract	After outbreaks in more than 110 countries, the World Health Organization declared COVID-19 a global pandemic on the March 11, 2020, heralding unprecedented challenges in medical education. Our aim is to provide a descriptive overview of the impact of COVID-19 on medical education worldwide and to assess its future repercussions. Worldwide, medical students were removed from clerkship training. Clinical skills and practical procedure training transitioned to being online, and in some cases, postponed. Medical educators scrambled to convert the curriculum into online formats. Access to Internet, technology, and computer education posed resource allocation challenges in developing countries and further widened the disparities in medical education. Even in countries where the framework and funding were available to support the online transition, debatably, this arrangement can lead to disparities in clinical skills, bedside manner, and field experience among pre- and post-COVID-19 medical graduates. Challenges extend beyond undergraduate medical education to include the medical licensing process of international and national postgraduates. The international community of medical educators needs to collaborate to drive the future of medical education, as the world adapts to the "new normal."
MeSH term(s)	Humans ; COVID-19/epidemiology ; Curriculum ; Education, Distance/methods ; Education, Medical ; Education, Medical, Undergraduate/methods ; Students, Medical
Language	English
Publishing date	2023-01-14
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	1318454-4
ISSN	1469-5804 ; 1357-6283
ISSN (online)	1469-5804
ISSN	1357-6283
DOI	10.4103/efh.efh_412_20
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Article: Fabrication of Spiral Low-Cost Microchannel with Trapezoidal Cross Section for Cell Separation Using a Grayscale Approach.

Adel, Mohamed / Allam, Ahmed / Sayour, Ashraf E / Ragai, Hani F / Umezu, Shinjiro / Fath El-Bab, Ahmed M R

Micromachines

2023 Volume 14, Issue 7

Abstract: Trapezoidal cross-sectional spiral microfluidic channels showed high resolution and throughput in cell separation in bio-applications. The main challenges are the complexity and high cost of the fabrication process of trapezoidal cross-sectional channels ...

Abstract	Trapezoidal cross-sectional spiral microfluidic channels showed high resolution and throughput in cell separation in bio-applications. The main challenges are the complexity and high cost of the fabrication process of trapezoidal cross-sectional channels on the micro-scale. In this work, we present the application of grayscale in microfluidic channel design to overcome the complexity of the fabrication process. We also use direct engraving with a CO
Language	English
Publishing date	2023-06-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2620864-7
ISSN	2072-666X
ISSN	2072-666X
DOI	10.3390/mi14071340
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Article ; Online: Design, synthesis, and molecular docking of novel pyrazole-chalcone analogs of lonazolac as 5-LOX, iNOS and tubulin polymerization inhibitors with potential anticancer and anti-inflammatory activities.

Ahmed, Asmaa H H / Mohamed, Mamdouh F A / Allam, Rasha M / Nafady, Ayman / Mohamed, Shaaban K / Gouda, Ahmed E / Beshr, Eman A M

Bioorganic chemistry

2022 Volume 129, Page(s) 106171

Abstract: Uncontrolled inflammation predisposes to pleiotropic effects leading to cancer development thanks to promoting all stages of tumorigenesis. Therefore, cancer-associated inflammation has been delegated as the seventh hallmark of cancer. Thus, raging the ... ...

Abstract	Uncontrolled inflammation predisposes to pleiotropic effects leading to cancer development thanks to promoting all stages of tumorigenesis. Therefore, cancer-associated inflammation has been delegated as the seventh hallmark of cancer. Thus, raging the war against both inflammation and cancer via the innovation of bioactive agents with dual anti-inflammatory and anticancer activities is a necessity. Herein, a novel series of pyrazole-chalcone analogs of Lonazolac (7a-g and 8a-g) have been synthesized and investigated for their in vitro anticancer activity against four cancer cell lines using the MTT assay method. Among all, hybrid 8g was the most potent against three cancer cell lines, HeLa, HCT-116, and RPMI-822 with IC<sub>50</sub> values of 2.41, 2.41, and 3.34 µM, respectively. In contrast, hybrid 8g showed moderate inhibitory activity against MCF-7 with IC<sub>50</sub> 28.93 μM and with a selectivity profile against MCF-10A (non-cancer cells). Mechanistically, hybrid 8g was the most potent inhibitor against tubulin polymerization (IC<sub>50</sub> = 4.77 µM), suggesting tubulin as a molecular target and explaining the observed cytotoxicity of hybrid 8g. This was mirrored by the detected potent pre-G1 apoptosis induction and G2/M cell cycle arrest. Moreover, hybrid8gexhibited selectivity against COX-2 (IC<sub>50</sub> = 5.13 µM) more than COX-1 (IC<sub>50</sub> = 33.46 µM), indicating that 8g may have lower cardiovascular side effects, but is still not potent as celecoxib (COX-2 IC<sub>50</sub> = 0.204 µM, COX-1 = 35.8 µM). Notably, hybrid 8g showed promising inhibitory activity towards 5-LOX (IC<sub>50</sub> = 5.88 µM). Finally, the anti-inflammatory activity of hybrid8 g was confirmed by high iNOS and PGE2 inhibitory activities in LPS-stimulated RAW cells with IC<sub>50</sub> values of4.93 µM and 10.98 µM, respectively, that accompanied by showingthe most potent inhibition of NO release (70.61 % inhibition rate). Molecular docking studies of hybrid 8g confirmed good correlations with the executed biological results. Furthermore, hybrid 8g had good drug-likeness and suitable physicochemical properties. Taken together, the combined results suggested hybrid8gas a promising orally administered candidate in the journey of repurposing NSAIDs for cancer chemopreventionand treatment.
MeSH term(s)	Humans ; Molecular Docking Simulation ; Tubulin Modulators/pharmacology ; Chalcone/pharmacology ; Chalcones/pharmacology ; Tubulin/metabolism ; Cyclooxygenase 2/metabolism ; Structure-Activity Relationship ; Pyrazoles/pharmacology ; Pyrazoles/chemistry ; Anti-Inflammatory Agents/pharmacology ; Inflammation ; Antineoplastic Agents/chemistry ; Molecular Structure ; Drug Screening Assays, Antitumor ; Cell Proliferation ; Cell Line, Tumor
Chemical Substances	Tubulin Modulators ; lonazolac (13097143QI) ; Chalcone (5S5A2Q39HX) ; Chalcones ; Tubulin ; Cyclooxygenase 2 (EC 1.14.99.1) ; Pyrazoles ; Anti-Inflammatory Agents ; Antineoplastic Agents
Language	English
Publishing date	2022-09-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120080-x
ISSN	1090-2120 ; 0045-2068
ISSN (online)	1090-2120
ISSN	0045-2068
DOI	10.1016/j.bioorg.2022.106171
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Article ; Online: Risk of influenza A(nrH7N9) pandemic in the eastern Mediterranean region.

Allam, Mohamed F

The Libyan journal of medicine

2014 Volume 9, Issue 1, Page(s) 24455

MeSH term(s)	Animals ; Chickens ; Columbidae ; Ducks ; Humans ; Incidence ; Influenza A Virus, H7N9 Subtype/isolation & purification ; Influenza A virus/pathogenicity ; Influenza in Birds/prevention & control ; Influenza in Birds/transmission ; Influenza in Birds/virology ; Influenza, Human/prevention & control ; Influenza, Human/transmission ; Influenza, Human/virology ; Mediterranean Region ; Pandemics/prevention & control ; Phylogeny ; Poultry Diseases/virology ; Risk Factors ; Zoonoses
Language	English
Publishing date	2014-04-23
Publishing country	United States
Document type	Letter
ZDB-ID	2273005-9
ISSN	1819-6357 ; 1819-6357
ISSN (online)	1819-6357
ISSN	1819-6357
DOI	10.3402/ljm.v9.24455
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