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  1. Article ; Online: The Evolving Landscape of Bladder Tertiary Lymphoid Structures.

    Koti, Madhuri / Siemens, D Robert

    The Journal of urology

    2023  Volume 210, Issue 1, Page(s) 3–4

    MeSH term(s) Humans ; Tertiary Lymphoid Structures ; Urinary Bladder/diagnostic imaging ; Urinary Bladder/surgery
    Language English
    Publishing date 2023-05-10
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1097/JU.0000000000003530
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui VI Zs.91: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 331: Show issues

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  2. Article ; Online: A Step Closer to Predicting Progression After Bacillus Calmette-Guérin Immunotherapy in High-risk Non-muscle-invasive Bladder Cancer.

    Koti, Madhuri / Robert Siemens, D

    European urology

    2023  Volume 84, Issue 5, Page(s) 447–448

    Abstract: Treatment-naïve tumors from patients who then experience recurrence or progression after bacillus Calmette-Guérin (BCG) therapy exhibit elevated expression of genes associated with basal differentiation and immune suppression. Three tumor molecular ... ...

    Abstract Treatment-naïve tumors from patients who then experience recurrence or progression after bacillus Calmette-Guérin (BCG) therapy exhibit elevated expression of genes associated with basal differentiation and immune suppression. Three tumor molecular subtypes have been associates with distinct clinical outcomes and will allow early identification of patients unlikely to respond to BCG immunotherapy.
    MeSH term(s) Humans ; BCG Vaccine/therapeutic use ; Adjuvants, Immunologic/therapeutic use ; Non-Muscle Invasive Bladder Neoplasms ; Neoplasm Recurrence, Local/drug therapy ; Immunotherapy/adverse effects ; Urinary Bladder Neoplasms/drug therapy ; Urinary Bladder Neoplasms/genetics ; Administration, Intravesical ; Neoplasm Invasiveness
    Chemical Substances BCG Vaccine ; Adjuvants, Immunologic
    Language English
    Publishing date 2023-07-01
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2023.06.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1247: Show issues Location:
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    Zs.MO 294: Show issues

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  3. Article ; Online: Predicting Response in TIME and Space: Neoadjuvant Chemoimmunotherapy in Muscle-invasive Bladder Cancer.

    Yolmo, Priyanka / Siemens, D Robert / Koti, Madhuri

    European urology

    2023  Volume 85, Issue 3, Page(s) 254–256

    MeSH term(s) Humans ; Neoadjuvant Therapy ; Urinary Bladder Neoplasms/drug therapy ; Cisplatin ; Muscles
    Chemical Substances Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 2023-12-23
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2023.12.003
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    Zs.A 1247: Show issues Location:
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    Zs.MO 294: Show issues

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  4. Article ; Online: Sex and Gender Differences in Cancers of the Genitourinary Tract: The Need to Consider Immune Divergence.

    Koti, Madhuri / Robert Siemens, D

    European urology

    2021  Volume 81, Issue 2, Page(s) 132–133

    Abstract: Delineating the processes of immune response underlying sexual dimorphism in cancers of the genitourinary tract will improve outcomes from immunotherapy treatment. ...

    Abstract Delineating the processes of immune response underlying sexual dimorphism in cancers of the genitourinary tract will improve outcomes from immunotherapy treatment.
    MeSH term(s) Female ; Humans ; Immunotherapy ; Male ; Neoplasms/therapy ; Sex Characteristics ; Sex Factors
    Language English
    Publishing date 2021-11-05
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2021.10.026
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    Zs.A 1247: Show issues Location:
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    Zs.MO 294: Show issues

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  5. Article ; Online: IL-33-ILC2 axis in the female reproductive tract.

    Miller, Jessica E / Koti, Madhuri / Tayade, Chandrakant

    Trends in molecular medicine

    2022  Volume 28, Issue 7, Page(s) 569–582

    Abstract: IL-33 is a member of the IL-1 family and was first identified as an alarmin that acts at mucosal barrier sites. However, IL-33 is now understood to be a pleiotropic cytokine that acts on a variety of immune and non-immune cell types to promote type 2 T ... ...

    Abstract IL-33 is a member of the IL-1 family and was first identified as an alarmin that acts at mucosal barrier sites. However, IL-33 is now understood to be a pleiotropic cytokine that acts on a variety of immune and non-immune cell types to promote type 2 T helper cell (T
    MeSH term(s) Cytokines/metabolism ; Female ; Genitalia, Female/immunology ; Humans ; Immunity, Innate ; Inflammation ; Interleukin-33/metabolism ; Lymphocytes/metabolism
    Chemical Substances Cytokines ; Interleukin-33
    Language English
    Publishing date 2022-05-12
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2036490-8
    ISSN 1471-499X ; 1471-4914
    ISSN (online) 1471-499X
    ISSN 1471-4914
    DOI 10.1016/j.molmed.2022.04.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4345: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: The CXCR3alt-CXCL11 axis in bladder cancer: potential for prediction of neoadjuvant chemotherapy response.

    Chenard, Stephen / Robert Siemens, D / Koti, Madhuri

    Cellular & molecular immunology

    2021  Volume 18, Issue 7, Page(s) 1631–1633

    MeSH term(s) Chemokine CXCL11 ; Humans ; Neoadjuvant Therapy ; Urinary Bladder Neoplasms/drug therapy
    Chemical Substances CXCL11 protein, human ; Chemokine CXCL11
    Language English
    Publishing date 2021-05-14
    Publishing country China
    Document type Journal Article ; Comment
    ZDB-ID 2435097-7
    ISSN 2042-0226 ; 1672-7681
    ISSN (online) 2042-0226
    ISSN 1672-7681
    DOI 10.1038/s41423-021-00692-x
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    Zs.A 6681: Show issues Location:
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  7. Article: Diversifying our research portfolio: A conversation with an early career investigator.

    Siemens, D Robert / Koti, Madhuri

    Canadian Urological Association journal = Journal de l'Association des urologues du Canada

    2018  Volume 12, Issue 8, Page(s) 223–224

    Language English
    Publishing date 2018-08-27
    Publishing country Canada
    Document type Editorial
    ZDB-ID 2431403-1
    ISSN 1911-6470
    ISSN 1911-6470
    DOI 10.5489/cuaj.5524
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  8. Article ; Online: At a time of global BCG shortage, attempts at optimizing BCG dose and schedule is no longer the answer.

    Morales, Alvaro / Siemens, David Robert / Koti, Madhuri

    Urologic oncology

    2020  Volume 39, Issue 2, Page(s) 137–138

    MeSH term(s) Adjuvants, Immunologic/administration & dosage ; Adjuvants, Immunologic/supply & distribution ; BCG Vaccine/administration & dosage ; BCG Vaccine/supply & distribution ; Drug Administration Schedule ; Humans ; Neoplasm Invasiveness ; Urinary Bladder Neoplasms/drug therapy ; Urinary Bladder Neoplasms/pathology
    Chemical Substances Adjuvants, Immunologic ; BCG Vaccine
    Language English
    Publishing date 2020-11-17
    Publishing country United States
    Document type Letter
    ZDB-ID 1336505-8
    ISSN 1873-2496 ; 1078-1439
    ISSN (online) 1873-2496
    ISSN 1078-1439
    DOI 10.1016/j.urolonc.2020.10.009
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    Zs.A 4817: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: The STING pathway: Therapeutic vulnerabilities in ovarian cancer.

    Shakfa, Noor / Li, Deyang / Nersesian, Sarah / Wilson-Sanchez, Juliette / Koti, Madhuri

    British journal of cancer

    2022  Volume 127, Issue 4, Page(s) 603–611

    Abstract: Ovarian cancer is the leading cause of mortality due to gynecologic malignancy. The majority of women diagnosed with the most common subtype, high-grade serous ovarian carcinoma (HGSC), develop resistance to conventional therapies despite initial ... ...

    Abstract Ovarian cancer is the leading cause of mortality due to gynecologic malignancy. The majority of women diagnosed with the most common subtype, high-grade serous ovarian carcinoma (HGSC), develop resistance to conventional therapies despite initial response to treatment. HGSC tumors displaying DNA damage repair (DDR) gene deficiency and high chromosomal instability mainly associate with higher cytotoxic immune cell infiltration and expression of genes associated with these immune pathways. Despite the high level of immune infiltration observed, the majority of patients with HGSC have not benefited from immunomodulatory treatments as the mechanistic basis of this infiltration is unclear. This lack of response can be primarily attributed to heterogeneity at the levels of both cancer cell genetic alterations and the tumour immune microenvironment. Strategies to enhance anti-tumour immunity have been investigated in ovarian cancer, of which interferon activating therapies present as an attractive option. Of the several type I interferon (IFN-1) stimulating therapies, exogenously activating the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway is emerging as a promising avenue. Herein, we highlight our current understanding of how constitutive and induced cGAS-STING pathway activation influences the ovarian tumour microenvironment. We further elaborate on the links between the genomic alterations prevalent in ovarian tumours and how the resultant immune phenotypes can make them more susceptible to exogenous STING pathway activation and potentiate immune-mediated killing of cancer cells. The therapeutic potential of cGAS-STING pathway activation in ovarian cancer and factors implicating treatment outcomes are discussed, providing a rationale for future combinatorial treatment approaches on the backbone of chemotherapy.
    MeSH term(s) Carcinoma, Ovarian Epithelial ; Female ; Humans ; Interferon Type I ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Nucleotidyltransferases/genetics ; Nucleotidyltransferases/metabolism ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/genetics ; Signal Transduction ; Tumor Microenvironment/genetics
    Chemical Substances Interferon Type I ; Membrane Proteins ; STING1 protein, human ; Nucleotidyltransferases (EC 2.7.7.-)
    Language English
    Publishing date 2022-04-05
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 80075-2
    ISSN 1532-1827 ; 0007-0920
    ISSN (online) 1532-1827
    ISSN 0007-0920
    DOI 10.1038/s41416-022-01797-4
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    Uh III Zs.142: Show issues Location:
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  10. Article ; Online: BCG vaccine and COVID-19: implications for infection prophylaxis and cancer immunotherapy.

    Koti, Madhuri / Morales, Alvaro / Graham, Charles H / Siemens, David Robert

    Journal for immunotherapy of cancer

    2020  Volume 8, Issue 2

    Abstract: The COVID-19 pandemic has killed over 400 000 people globally. Ecological evidence indicates that countries with national universal BCG vaccination programs for tuberculosis (TB) prevention have a much lower incidence of severe COVID-19 and mortality ... ...

    Abstract The COVID-19 pandemic has killed over 400 000 people globally. Ecological evidence indicates that countries with national universal BCG vaccination programs for tuberculosis (TB) prevention have a much lower incidence of severe COVID-19 and mortality compared with those that do not have such programs. BCG is a century old vaccine used for TB prevention via infant/childhood vaccination in lowto middle-income countries with high infection prevalence rate and is known to reduce all-cause neonatal mortality. BCG remains the standard immunotherapy treatment for patients with high-risk non-muscle invasive bladder cancer globally for more than 44 years. Several trials are, therefore, investigating BCG as a prophylactic against COVID-19 in healthcare workers and the elderly. In this commentary, we discuss the potential mechanisms that may underlie BCG associated heterologous protection with a focus on tertiary lymphoid structure (TLS) organogenesis. Given the significance of TLSs in mucosal immunity, their association with positive prognosis and response to immune checkpoint blockade with a critical role of Type I interferon (IFN-1) in inducing these, we also discuss potentiating TLS formation as a promising approach to enhance anti-tumor immunity. We propose that lessons learned from BCG immunotherapy success could be applied to not only augment such microbe-based therapeutics but also lead to similar adjunctive IFN-1 activating approaches to improve response to immune checkpoint blockade therapy in cancer.
    MeSH term(s) BCG Vaccine/therapeutic use ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/immunology ; Coronavirus Infections/prevention & control ; Humans ; Immunotherapy ; Interferon Type I/immunology ; Neoplasms/immunology ; Neoplasms/therapy ; Pandemics/prevention & control ; Pneumonia, Viral/immunology ; Pneumonia, Viral/prevention & control ; SARS-CoV-2
    Chemical Substances BCG Vaccine ; Interferon Type I
    Keywords covid19
    Language English
    Publishing date 2020-07-06
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2719863-7
    ISSN 2051-1426 ; 2051-1426
    ISSN (online) 2051-1426
    ISSN 2051-1426
    DOI 10.1136/jitc-2020-001119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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