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  1. Article ; Online: Remembering Laura Corrigan

    Karis Baker / Fiona Bracken / Rich Corrigan / Simon Creer / Andy Foote / Heather Fotherby / Howard Gray / Martyn Lucas / Stefano Mariani / Colin McKenzie / Boyd McKew

    Environmental DNA, Vol 3, Iss 2, Pp 321-

    2021  Volume 322

    Keywords Environmental sciences ; GE1-350 ; Microbial ecology ; QR100-130
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Systematic pulmonary embolism follow-up: why we should all do it!

    Howard, Luke S / Price, Laura C

    The European respiratory journal

    2024  Volume 63, Issue 3

    MeSH term(s) Humans ; Follow-Up Studies ; Hypertension, Pulmonary ; Pulmonary Embolism/diagnosis ; Registries
    Language English
    Publishing date 2024-03-14
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00253-2024
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2322: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MO 292: Show issues

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  3. Book ; Online: Psychische Gesundheit und Krankheit von Kindern und Jugendlichen in der Schweiz: Versorgung und Epidemiologie

    Wyl, Agnes von / Chew Howard, Erica / Bohleber, Laura / Haemmerle, Patrick

    eine systematische Zusammenstellung empirischer Berichte von 2006 bis 2016

    (Obsan Dossier ; 62)

    2017  

    Author's details Autoren: Agnes von Wyl, Erica Chew Howard, Laura Bohleber, Patrick Haemmerle
    Series title Obsan Dossier ; 62
    Dossier / OBSAN
    Collection Dossier / OBSAN
    Subject code 610
    Language German
    Size 1 Online-Ressource (68 Seiten), Diagramme
    Publisher Schweizerisches Gesundheitsobservatorium (Obsan)
    Publishing place Neuchâtel
    Publishing country Switzerland
    Document type Book ; Online
    Note Zusammenfassung in deutscher und französischer Sprache
    HBZ-ID HT019617624
    ISBN 978-2-940502-70-7 ; 2-940502-70-6
    DOI 10.4126/FRL01-006407064
    Database Repository for Life Sciences

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  4. Article ; Online: Thirty years of slug control using the parasitic nematode Phasmarhabditis hermaphrodita and beyond.

    Rae, Robbie / Sheehy, Laura / McDonald-Howard, Kerry

    Pest management science

    2023  Volume 79, Issue 10, Page(s) 3408–3424

    Abstract: Several slug species are highly pestiferous and threaten global sustainable agriculture. Current control methods rely heavily on metaldehyde pellets, which are often ineffective, harm nontarget organisms and have been banned in some countries. A viable ... ...

    Abstract Several slug species are highly pestiferous and threaten global sustainable agriculture. Current control methods rely heavily on metaldehyde pellets, which are often ineffective, harm nontarget organisms and have been banned in some countries. A viable alternative is the parasitic nematode Phasmarhabditis hermaphrodita (and recently P. californica), which has been formulated into a biological control agent (Nemaslug®) to control slugs across northern Europe. Nematodes are mixed with water and applied to soil where they seek out slugs, penetrate behind the mantle and kill them in 4-21 days. Phasmarhabditis hermaphrodita has been on the market since 1994 and since then there has been ample research on its use. Here we review the research carried out on P. hermaphrodita over the last 30 years since its development and release as a commercial product. We provide information on life cycle, worldwide distribution, history of commercialisation, gastropod immunity, host range, ecological and environmental factors that affect its success in the field, bacterial relationships, and summarise results of field trials. Finally, we suggest future directions for P. hermaphrodita research (and other Phasmarhabditis species) to enhance its use as a biological control agent to control slugs for the next 30 years. © 2023 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
    MeSH term(s) Animals ; Gastropoda/parasitology ; Biological Control Agents ; Pest Control, Biological/methods ; Rhabditoidea ; Nematoda
    Chemical Substances Biological Control Agents
    Language English
    Publishing date 2023-07-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2001705-4
    ISSN 1526-4998 ; 1526-498X
    ISSN (online) 1526-4998
    ISSN 1526-498X
    DOI 10.1002/ps.7636
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    In stock of ZB MED Bonn / Germany

    Z 2731: Show issues

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  5. Article ; Online: Gastrointestinal conditions related to tooth wear.

    Howard, John P / Howard, Laura J / Geraghty, Joe / Leven, A Johanna / Ashley, Martin

    British dental journal

    2023  Volume 234, Issue 6, Page(s) 451–454

    Abstract: Gastro-oesophageal reflux disease (GORD) is a relatively common condition that occurs in adults and less commonly in children. It develops when the reflux of stomach contents into the oesophagus causes troublesome symptoms and/or complications. Signs and ...

    Abstract Gastro-oesophageal reflux disease (GORD) is a relatively common condition that occurs in adults and less commonly in children. It develops when the reflux of stomach contents into the oesophagus causes troublesome symptoms and/or complications. Signs and symptoms include heartburn, retrosternal discomfort, epigastric pain and hoarseness, dental erosion, chronic cough, burning mouth syndrome, halitosis and laryngitis. A proportion of patients will, however, have silent reflux. Strongly associated risk factors include family history, age, hiatus hernia, obesity and neurological conditions, such as cerebral palsy. There are different treatment options which may be considered for GORD, consisting of conservative, medical and surgical therapy. Dentists should be aware of the symptoms of GORD and dental signs of intrinsic erosion indicative of possible GORD so that they can question patients about this and, if appropriate, initiate a referral to a general medical practitioner.
    MeSH term(s) Adult ; Child ; Humans ; Gastroesophageal Reflux/complications ; Gastroesophageal Reflux/diagnosis ; Tooth Wear/diagnosis ; Tooth Wear/etiology ; Tooth Wear/therapy ; Risk Factors ; Tooth Attrition
    Language English
    Publishing date 2023-03-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 218090-x
    ISSN 1476-5373 ; 0007-0610
    ISSN (online) 1476-5373
    ISSN 0007-0610
    DOI 10.1038/s41415-023-5677-0
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    In stock of ZB MED Cologne/Königswinter

    Ul III Zs.143: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 447: Show issues

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  6. Article ; Online: A Modular Albumin-Oligonucleotide Biomolecular Assembly for Delivery of Antisense Therapeutics.

    Elkhashab, Marwa / Dilek, Yeter / Foss, Morten / Creemers, Laura B / Howard, Kenneth A

    Molecular pharmaceutics

    2024  Volume 21, Issue 2, Page(s) 491–500

    Abstract: Antisense nucleic acid drugs are susceptible to nuclease degradation, rapid renal clearance, and short circulatory half-life. In this work, we introduce a modular-based recombinant human albumin-oligonucleotide (rHA-cODN) biomolecular assembly that ... ...

    Abstract Antisense nucleic acid drugs are susceptible to nuclease degradation, rapid renal clearance, and short circulatory half-life. In this work, we introduce a modular-based recombinant human albumin-oligonucleotide (rHA-cODN) biomolecular assembly that allows incorporation of a chemically stabilized therapeutic gapmer antisense oligonucleotide (ASO) and FcRn-driven endothelial cellular recycling. A phosphodiester ODN linker (cODN) was conjugated to recombinant human albumin (rHA) using maleimide chemistry, after which a complementary gapmer ASO, targeting ADAMTS5 involved in osteoarthritis pathogenesis, was annealed. The rHA-cODN/ASO biomolecular assembly production, fluorescence labeling, and purity were confirmed using polyacrylamide gel electrophoresis. ASO release was triggered by DNase-mediated degradation of the linker strand, reaching 40% in serum after 72 h, with complete release observed following 30 min of incubation with DNase. Cellular internalization and trafficking of the biomolecular assembly using confocal microscopy in C28/I2 cells showed higher uptake and endosomal localization by increasing incubation time from 4 to 24 h. FcRn-mediated cellular recycling of the assembly was demonstrated in FcRn-expressing human microvascular endothelial cells. ADAMTS5 in vitro silencing efficiency reached 40%, which was comparable to free gapmer after 72 h incubation with human osteoarthritis patients' chondrocytes. This work introduces a versatile biomolecular modular-based "Plug-and-Play" platform potentially applicable for albumin-mediated half-life extension for a range of different types of ODN therapeutics.
    MeSH term(s) Humans ; Oligonucleotides/chemistry ; Endothelial Cells/metabolism ; Albumins ; Oligonucleotides, Antisense/chemistry ; Serum Albumin, Human/metabolism ; Osteoarthritis ; Deoxyribonucleases
    Chemical Substances Oligonucleotides ; Albumins ; Oligonucleotides, Antisense ; Serum Albumin, Human (ZIF514RVZR) ; Deoxyribonucleases (EC 3.1.-)
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2138405-8
    ISSN 1543-8392 ; 1543-8384
    ISSN (online) 1543-8392
    ISSN 1543-8384
    DOI 10.1021/acs.molpharmaceut.3c00561
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6250: Show issues Location:
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  7. Article: BIOLOGICAL VARIATION OF HEMATOLOGY PARAMETERS AND CLINICAL APPLICATION IN AFRICAN ELEPHANTS (

    Browning, Geoffrey R / Kjelgaard-Hansen, Mads / Howard, Lauren L / Keener, Laura / LaFarga, Mindy / Perrin, Kathryn L

    Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians

    2024  Volume 55, Issue 1, Page(s) 173–181

    Abstract: Detailed knowledge of biological variation can facilitate accurate interpretation of clinical pathology parameters. A recent biological variation study in Asian elephants ( ...

    Abstract Detailed knowledge of biological variation can facilitate accurate interpretation of clinical pathology parameters. A recent biological variation study in Asian elephants (
    MeSH term(s) Animals ; Elephants ; Hematology ; Herpesviridae ; Herpesviridae Infections/veterinary ; Retrospective Studies
    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2174930-9
    ISSN 1937-2825 ; 1042-7260
    ISSN (online) 1937-2825
    ISSN 1042-7260
    DOI 10.1638/2023-0055
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  8. Article: Complete placenta previa and increta after radical trachelectomy: A case report.

    Chen, Jiahua / Gilroy, Laura / Minkoff, Howard / Palileo, Albert

    Gynecologic oncology reports

    2023  Volume 50, Page(s) 101307

    Abstract: Background: Placenta accreta spectrum (PAS) disorders are increasing in incidence and represent a significant contributor to severe maternal morbidity in the US. Prior uterine surgeries other than cesarean section are important, yet less common, risk ... ...

    Abstract Background: Placenta accreta spectrum (PAS) disorders are increasing in incidence and represent a significant contributor to severe maternal morbidity in the US. Prior uterine surgeries other than cesarean section are important, yet less common, risk factors for PAS.
    Case: This is a case of a 43-year-old woman with a prior history of cervical cancer necessitating radical trachelectomy. She was subsequently diagnosed with a complete placenta previa with a high degree of suspicion for PAS. Multidisciplinary teams convened to plan for delivery. A cesarean hysterectomy was performed at 32 weeks. Final surgical pathology confirmed the presence of morbidly adherent placenta invading the vaginal cuff.
    Conclusion: Patients who are diagnosed with early-stage cervical cancers have the option of fertility-preserving surgical management. Serial ultrasound evaluations, specifically looking for PAS, might be warranted in post-trachelectomy pregnancies.
    Language English
    Publishing date 2023-11-22
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2818505-5
    ISSN 2352-5789
    ISSN 2352-5789
    DOI 10.1016/j.gore.2023.101307
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  9. Article ; Online: Clinical and radiographic assessment and restoration of maxillary sinus function in relation to oro-antral fistula closure: a systematic review.

    Bell, Garmon / Howard, Laura / Lamont, Thomas

    Oral surgery, oral medicine, oral pathology and oral radiology

    2022  Volume 134, Issue 4, Page(s) 432–441

    Abstract: Background: The purpose of this study was to determine current practice in assessment of maxillary sinus health during oro-antral fistula closure.: Method: A systematic review using specific MeSH headings between 1990 and September 2021 on Medline, ... ...

    Abstract Background: The purpose of this study was to determine current practice in assessment of maxillary sinus health during oro-antral fistula closure.
    Method: A systematic review using specific MeSH headings between 1990 and September 2021 on Medline, Ovid, and PubMed was performed. The inclusion criterion was closure of oro-antral fistula in adult patients. Exclusion criteria were oro-antral fistula arising in children; or from trauma, malignancy, or developmental abnormality; or any osteonecrotic lesion of bone. Risk of bias for individual papers was not assessed. Oxford Centre for Evidence Based Medicine levels of evidence were recorded.
    Results: 4309 papers were identified, and 119 were eligible for review. Nineteen were from otolaryngology (16%), 25 from combined ear, nose, and throat (ENT) and oral/oral and maxillofacial (OS/OMF) surgery (21%), and 75 from OS/OMF surgery (63%). Preoperative rhinoscopy and cross-sectional imaging were reported in 33 papers (28%), reflecting the role of ENT with or without OS/OMFS. Sixty-eight did not record any formal assessment of maxillary sinus health (57%), of which 60 were from OS/OMF surgery (50%). Use of computed tomography was reported in 58 papers (49%), and use of cone beam computed tomography was reported in 8 papers (7%) but did not correlate with assessment of sinus health.
    Discussion: Most surgery for oro-antral fistual closure was undertaken without objective assessment of maxillary sinus health, pre- or postoperatively. The involvement of ENT was associated with formal assessment of maxillary sinus health.
    MeSH term(s) Adult ; Child ; Cone-Beam Computed Tomography ; Endoscopy/methods ; Humans ; Maxillary Sinus/diagnostic imaging ; Maxillary Sinus/surgery ; Oroantral Fistula/complications ; Oroantral Fistula/diagnostic imaging ; Oroantral Fistula/surgery ; Rhinoplasty
    Language English
    Publishing date 2022-03-03
    Publishing country United States
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 2650843-6
    ISSN 2212-4411 ; 2212-4403
    ISSN (online) 2212-4411
    ISSN 2212-4403
    DOI 10.1016/j.oooo.2022.02.015
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    In stock of ZB MED Cologne/Königswinter

    Ul III Zs.121: Show issues Location:
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  10. Book ; Online: Human evaluation of robotic grippers for berry picking

    Alvarez-Hidalgo, Laura / Howard, Ian S.

    2023  

    Abstract: We describe the construction and evaluation of two robotic grippers for berry picking. Using a pneumatic cylinder drive, one was constructed from hard materials and the other from soft materials. A novel evaluation paradigm using a handle mechanism was ... ...

    Abstract We describe the construction and evaluation of two robotic grippers for berry picking. Using a pneumatic cylinder drive, one was constructed from hard materials and the other from soft materials. A novel evaluation paradigm using a handle mechanism was developed, so the grippers could be directly op-erated by human participants. An artificial bush was also constructed and used for evaluation purposes. Overall, both grippers performed worse than the human hand, indicating that further development is needed.

    Comment: 4 pages, 8 figures, abstract presented at TAROS2023
    Keywords Computer Science - Robotics ; J.2
    Publishing date 2023-09-08
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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