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Article ; Online: Study of the K_{L}→π^{0}νν[over ¯] Decay at the J-PARC KOTO Experiment.

Ahn, J K / Beckford, B / Campbell, M / Chen, S H / Comfort, J / Dona, K / Farrington, M S / Hanai, K / Hara, N / Haraguchi, H / Hsiung, Y B / Hutcheson, M / Inagaki, T / Isoe, M / Kamiji, I / Kato, T / Kim, E J / Kim, J L / Kim, H M /

Komatsubara, T K / Kotera, K / Lee, S K / Lee, J W / Lim, G Y / Lin, Q S / Lin, C / Luo, Y / Mari, T / Masuda, T / Matsumura, T / Mcfarland, D / McNeal, N / Miyazaki, K / Murayama, R / Nakagiri, K / Nanjo, H / Nishimiya, H / Noichi, Y / Nomura, T / Nunes, T / Ohsugi, M / Okuno, H / Redeker, J C / Sanchez, J / Sasaki, M / Sasao, N / Sato, T / Sato, K / Sato, Y / Shimizu, N / Shimogawa, T / Shinkawa, T / Shinohara, S / Shiomi, K / Shiraishi, R / Su, S / Sugiyama, Y / Suzuki, S / Tajima, Y / Taylor, M / Tecchio, M / Togawa, M / Toyoda, T / Tung, Y-C / Vuong, Q H / Wah, Y W / Watanabe, H / Yamanaka, T / Yoshida, H Y / Zaidenberg, L

Physical review letters

2021 Volume 126, Issue 12, Page(s) 121801

Abstract: The rare decay K_{L}→π^{0}νν[over ¯] was studied with the dataset taken at the J-PARC KOTO ...

Abstract	The rare decay K_{L}→π^{0}νν[over ¯] was studied with the dataset taken at the J-PARC KOTO experiment in 2016, 2017, and 2018. With a single event sensitivity of (7.20±0.05_{stat}±0.66_{syst})×10^{-10}, three candidate events were observed in the signal region. After unveiling them, contaminations from K^{±} and scattered K_{L} decays were studied, and the total number of background events was estimated to be 1.22±0.26. We conclude that the number of observed events is statistically consistent with the background expectation. For this dataset, we set an upper limit of 4.9×10^{-9} on the branching fraction of K_{L}→π^{0}νν[over ¯] at the 90% confidence level.
Language	English
Publishing date	2021-03-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.126.121801
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Article ; Online: Search for K_{L}→π^{0}νν[over ¯] and K_{L}→π^{0}X^{0} Decays at the J-PARC KOTO Experiment.

Ahn, J K / Beckford, B / Beechert, J / Bryant, K / Campbell, M / Chen, S H / Comfort, J / Dona, K / Hara, N / Haraguchi, H / Hsiung, Y B / Hutcheson, M / Inagaki, T / Kamiji, I / Kawasaki, N / Kim, E J / Kim, J L / Kim, Y J / Ko, J W /

Komatsubara, T K / Kotera, K / Kurilin, A S / Lee, J W / Lim, G Y / Lin, C / Lin, Q / Luo, Y / Ma, J / Maeda, Y / Mari, T / Masuda, T / Matsumura, T / Mcfarland, D / McNeal, N / Micallef, J / Miyazaki, K / Murayama, R / Naito, D / Nakagiri, K / Nanjo, H / Nishimiya, H / Nomura, T / Ohsugi, M / Okuno, H / Sasaki, M / Sasao, N / Sato, K / Sato, T / Sato, Y / Schamis, H / Seki, S / Shimizu, N / Shimogawa, T / Shinkawa, T / Shinohara, S / Shiomi, K / Su, S / Sugiyama, Y / Suzuki, S / Tajima, Y / Taylor, M / Tecchio, M / Togawa, M / Tung, Y C / Wah, Y W / Watanabe, H / Woo, J K / Yamanaka, T / Yoshida, H Y

Physical review letters

2019 Volume 122, Issue 2, Page(s) 21802

Abstract: A search for the rare decay K_{L}→π^{0}νν[over ¯] was performed. With the data collected in 2015, corresponding to 2.2×10^{19} protons on target, a single event sensitivity of (1.30±0.01_{stat}±0.14_{syst})×10^{-9} was achieved and no candidate events ... ...

Abstract	A search for the rare decay K_{L}→π^{0}νν[over ¯] was performed. With the data collected in 2015, corresponding to 2.2×10^{19} protons on target, a single event sensitivity of (1.30±0.01_{stat}±0.14_{syst})×10^{-9} was achieved and no candidate events were observed. We set an upper limit of 3.0×10^{-9} for the branching fraction of K_{L}→π^{0}νν[over ¯] at the 90% confidence level (C.L.), which improved the previous limit by almost an order of magnitude. An upper limit for K_{L}→π^{0}X^{0} was also set as 2.4×10^{-9} at the 90% C.L., where X^{0} is an invisible boson with a mass of 135 MeV/c^{2}.
Language	English
Publishing date	2019-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.122.021802
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Article ; Online: Corrigendum to "Elevated 20-HETE in metabolic syndrome regulates arterial stiffness and systolic hypertension via MMP12 activation" [J. Mol. Cell. Cardiol. 117 (2018) 88-99].

Soler, Amanda / Hunter, Ian / Joseph, Gregory / Hutcheson, Rebecca / Hutcheson, Brenda / Yang, Jenny / Zhang, Frank Fan / Joshi, Sachindra Raj / Bradford, Chastity / Gotlinger, Katherine H / Maniyar, Rachana / Falck, John R / Proctor, Spencer / Schwartzman, Michal Laniado / Gupte, Sachin A / Rocic, Petra

Journal of molecular and cellular cardiology

2018 Volume 121, Page(s) 308

Language	English
Publishing date	2018-04-04
Publishing country	England
Document type	Journal Article ; Published Erratum
ZDB-ID	80157-4
ISSN	1095-8584 ; 0022-2828
ISSN (online)	1095-8584
ISSN	0022-2828
DOI	10.1016/j.yjmcc.2018.03.015
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Article: Comment on "The properties of free polymer surfaces and their influence on the glass transition temperature of thin polystyrene films" by J.S. Sharp, J.H. Teichroeb and J.A. Forrest.

Hutcheson, S A / McKenna, G B

The European physical journal. E, Soft matter

2007 Volume 22, Issue 4, Page(s) 281–6; discussion 287–91

Abstract: Sharp, Teichroeb and Forrest [J.S. Sharp, J.H. Teichroeb, J.A. Forrest, Eur. Phys. J. E 15, 473 ...

Abstract	Sharp, Teichroeb and Forrest [J.S. Sharp, J.H. Teichroeb, J.A. Forrest, Eur. Phys. J. E 15, 473 (2004)] recently published a viscoelastic contact mechanics analysis of the embedment of gold nanospheres into a polystyrene (PS) surface. In the present comment, we investigate the viscoelastic response of the surface and conclude that the embedment experiments do not support the hypothesis of a liquid surface layer of sufficiently reduced "rheological temperature" to explain reports of very large reductions in the glass temperature of freely standing ultrathin polystyrene films. We also report some errors and discrepancies in the paper under comment that resulted in an inability to reproduce the reported calculations. We present our findings of error in a spirit of clarifying the problem of embedment of spheres into surfaces and in order that others can understand why they may not reproduce the results reported by Sharp, Teichroeb and Forrest. In the comment, we also examine the effects of the magnitude of the forces that result from the polymer surface-nanosphere particle interactions on the viscoelastic properties deduced from the embedment data and we provide a comparison of apparent surface or "rheological" temperature vs. experimental temperature that indicates further work needs to be performed to fully understand the surface embedment experiments. Finally, we comment that the nanosphere embedment measurements have potential as a powerful tool to determine surface viscoelastic properties.
MeSH term(s)	Elasticity ; Glass/chemistry ; Gold/chemistry ; Nanotubes ; Polystyrenes/chemistry ; Rheology ; Surface Properties ; Time Factors ; Transition Temperature ; Viscosity
Chemical Substances	Polystyrenes ; Gold (7440-57-5)
Language	English
Publishing date	2007-03-30
Publishing country	France
Document type	Comment ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2004003-9
ISSN	1292-895X ; 1292-8941
ISSN (online)	1292-895X
ISSN	1292-8941
DOI	10.1140/epje/e2007-00030-1
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Article: George Ben Johnston, M.D., LL.D.

Hutcheson, J Morrison

Annals of medical history

2021 Volume 10, Issue 1, Page(s) 15–22

Language	English
Publishing date	2021-05-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	418598-5
ISSN	0743-3131
ISSN	0743-3131
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Article ; Online: Time to oral anticoagulant reversal in intracranial hemorrhage with an emergency medicine pharmacist presence.

Hutcheson, Brooklyn / Spetz, Samantha / Davenport, Jillian / Shuler, Evan

The American journal of emergency medicine

2024 Volume 80, Page(s) 114–118

Abstract: Purpose: Intracranial hemorrhage (ICH) is associated with high morbidity and mortality, with mortality rates up to 65%. Oral anticoagulants (OAC) are a major risk factor for ICH. Since these patients are usually diagnosed in the emergency department (ED) ...

Abstract	Purpose: Intracranial hemorrhage (ICH) is associated with high morbidity and mortality, with mortality rates up to 65%. Oral anticoagulants (OAC) are a major risk factor for ICH. Since these patients are usually diagnosed in the emergency department (ED), emergency medicine (EM) pharmacists can help ensure appropriate selection and delivery of medications in urgent situations including reversal agents for OAC-associated bleeding. The purpose of this study was to determine the impact EM pharmacist presence has on time to OAC reversal in patients presenting with an ICH. Procedures: This was a retrospective, single-center cohort study evaluating time to reversal of OAC-associated ICH at a level one trauma center between November 2016 and September 2022. Patients 18 years or older who presented to the ED with an OAC-associated ICH and received at least one dose of an emergent reversal agent were included. Patients were excluded if their ICH was diagnosed at an outside facility, if they received emergent reversal agents for other indications, or if they had do not resuscitate orders upon admission. The primary outcome was time to administration of reversal agent with or without an EM pharmacist present, represented as median [interquartile range]. Secondary outcomes included hematoma expansion, hospital length of stay, intensive care unit LOS, and in-hospital mortality. Results: Of the 157 patients evaluated, 83 met criteria for inclusion. Majority of patients presented with warfarin-associated ICH (55%) and the most common indication for OAC was atrial fibrillation (66%). The most common type of ICH was intracerebral hemorrhage (35%). The median time to emergent reversal agent administration was significantly shorter in the EM pharmacist group (50 min [31-65] vs. 85 min [51-121], p < 0.01). No significant differences in secondary outcomes existed. Conclusions: The presence of an EM pharmacist at the bedside of patients who present to the ED with ICH was associated with a decrease in the time to OAC reversal by 36 min. Presence of an EM pharmacist was not associated with improved clinical outcomes for ICH in our study. Larger trials are warranted to determine whether the presence of an EM pharmacist is associated with improved functional and clinical outcomes in patients with OAC-associated ICH and whether time to newer reversal agents, other than 4F-PCC, has an effect on outcomes.
Language	English
Publishing date	2024-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	605890-5
ISSN	1532-8171 ; 0735-6757
ISSN (online)	1532-8171
ISSN	0735-6757
DOI	10.1016/j.ajem.2024.03.014
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Article ; Online: A “Central Bureau of Feminine Algology:” Algae, Mutualism, and Gendered Ecological Perspectives, 1880–1910

Hutcheson, Emily S.

J Hist Biol. 2022 Dec., v. 55, no. 4 p.791-825

2022

Abstract: While women’s participation at research stations has been celebrated as a success story for women in science, their experiences were not quite equal to that of men scientists. This article shows how women interested in practicing marine science at ... ...

Abstract	While women’s participation at research stations has been celebrated as a success story for women in science, their experiences were not quite equal to that of men scientists. This article shows how women interested in practicing marine science at research institutions experienced different living and research environments than their male peers; moreover, it illustrates how those gendered experiences reflected and informed the nature of their scientific practices and ideas. Set in Roscoff, France, this article excavates the work and social worlds of a Russian scientist, Natalie Karsakoff (1863–1941), and a British émigré in France, Anna Vickers (1853–1906), to show how a small group of single women who studied algae created a “central bureau of feminine algology.” The social aspects of this bureau, and the physical space and support funded by Vickers, allowed these women scientists to both participate in male-dominated practices of science and lend evidentiary support to an ecological category that emphasized benign coexistence rather than struggle. This study adds an empirical case of single women scientists managing successful careers in science and contributing to science through publication and research.
Keywords	algology ; males ; marine science ; mutualism ; scientists ; France
Language	English
Dates of publication	2022-12
Size	p. 791-825.
Publishing place	Springer Netherlands
Document type	Article ; Online
ZDB-ID	6925-5
ISSN	1573-0387 ; 0022-5010
ISSN (online)	1573-0387
ISSN	0022-5010
DOI	10.1007/s10739-022-09698-1
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Protecting Proteins from Desiccation Stress Using Molecular Glasses and Gels.

Olgenblum, Gil I / Hutcheson, Brent O / Pielak, Gary J / Harries, Daniel

Chemical reviews

2024

Abstract: Faced with desiccation stress, many organisms deploy strategies to maintain the integrity of their cellular components. Amorphous glassy media composed of small molecular solutes or protein gels present general strategies for protecting against drying. ... ...

Abstract	Faced with desiccation stress, many organisms deploy strategies to maintain the integrity of their cellular components. Amorphous glassy media composed of small molecular solutes or protein gels present general strategies for protecting against drying. We review these strategies and the proposed molecular mechanisms to explain protein protection in a vitreous matrix under conditions of low hydration. We also describe efforts to exploit similar strategies in technological applications for protecting proteins in dry or highly desiccated states. Finally, we outline open questions and possibilities for future explorations.
Language	English
Publishing date	2024-04-18
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	207949-5
ISSN	1520-6890 ; 0009-2665
ISSN (online)	1520-6890
ISSN	0009-2665
DOI	10.1021/acs.chemrev.3c00752
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Article ; Online: Properties of a tardigrade desiccation-tolerance protein aerogel.

Eicher, Jonathan / Hutcheson, Brent O / Pielak, Gary J

Biophysical journal

2023 Volume 122, Issue 12, Page(s) 2500–2505

Abstract: Lyophilization is promising for tackling degradation during the drying and storage of protein-based drugs. Tardigrade cytosolically abundant heat soluble (CAHS) proteins are necessary and sufficient for desiccation-tolerance in vivo and protein ... ...

Abstract	Lyophilization is promising for tackling degradation during the drying and storage of protein-based drugs. Tardigrade cytosolically abundant heat soluble (CAHS) proteins are necessary and sufficient for desiccation-tolerance in vivo and protein protection in vitro. Hydrated CAHS proteins form coiled-coil-based fine-stranded, cold-setting hydrogels, but the dried protein remains largely uncharacterized. Here, we show that dried CAHS D gels (i.e., aerogels) retain the structural units of their hydrogels, but the details depend on prelyophilization CAHS concentrations. Low concentration samples (<10 g/L) form thin (<0.2 μm) tangled fibrils lacking regular structure on the micron scale. Upon increasing the concentration, the fibers thicken and form slabs comprising the walls of the aerogel pores. These changes in morphology are associated with a loss in disorder and an increase in large β sheets and a decrease in α helices and random coils. This disorder-to-order transition is also seen in hydrated gels as a function of concentration. These results suggest a mechanism for pore formation and indicate that using CAHS proteins as excipients will require attention to initial conditions because the starting concentration impacts the lyophilized product.
MeSH term(s)	Animals ; Desiccation/methods ; Proteins/metabolism ; Tardigrada/metabolism ; Freeze Drying ; Hydrogels
Chemical Substances	Proteins ; Hydrogels
Language	English
Publishing date	2023-05-06
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	218078-9
ISSN	1542-0086 ; 0006-3495
ISSN (online)	1542-0086
ISSN	0006-3495
DOI	10.1016/j.bpj.2023.05.002
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Zs.A 235: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Internal oedema and dysphagia characteristics in patients with head and neck cancer.

Starmer, Heather M / Hutcheson, Katherine / Patterson, Joanne

Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery

2023 Volume 48, Issue 4, Page(s) 700–704

MeSH term(s)	Humans ; Deglutition Disorders ; Edema ; Head and Neck Neoplasms
Language	English
Publishing date	2023-03-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2205891-6
ISSN	1749-4486 ; 1749-4478 ; 0307-7772 ; 1365-2273
ISSN (online)	1749-4486
ISSN	1749-4478 ; 0307-7772 ; 1365-2273
DOI	10.1111/coa.14046
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