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Article ; Online: Native myocardial T

Kida, Katsuhiro / Kurosaki, Takamasa / Fukui, Ryohei / Matsuura, Ryutaro / Goto, Sachiko

2024

Abstract: This study proposes the use of the inversion recovery T ...

Abstract	This study proposes the use of the inversion recovery T
Language	English
Publishing date	2024-03-26
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2433581-2
ISSN	1865-0341 ; 1865-0333
ISSN (online)	1865-0341
ISSN	1865-0333
DOI	10.1007/s12194-024-00795-w
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Article ; Online: Identification of a T-bet

Raju, Saravanan / Xia, Yu / Daniel, Bence / Yost, Kathryn E / Bradshaw, Elliot / Tonc, Elena / Verbaro, Daniel J / Kometani, Kohei / Yokoyama, Wayne M / Kurosaki, Tomohiro / Satpathy, Ansuman T / Egawa, Takeshi

Journal of immunology (Baltimore, Md. : 1950)

2021 Volume 206, Issue 12, Page(s) 2924–2936

Abstract: Persistent Ag induces a dysfunctional CD8 T cell state known as "exhaustion" characterized by PD-1 ... expression. Nevertheless, exhausted CD8 T cells retain functionality through continued differentiation ... of progenitor into effector cells. However, it remains ill-defined how CD8 T cell effector responses are ...

Abstract	Persistent Ag induces a dysfunctional CD8 T cell state known as "exhaustion" characterized by PD-1 expression. Nevertheless, exhausted CD8 T cells retain functionality through continued differentiation of progenitor into effector cells. However, it remains ill-defined how CD8 T cell effector responses are sustained in situ. In this study, we show using the mouse chronic lymphocytic choriomeningitis virus infection model that CX3CR1
MeSH term(s)	Animals ; CD8-Positive T-Lymphocytes ; CX3C Chemokine Receptor 1/genetics ; Cell Differentiation ; Hepatitis A Virus Cellular Receptor 2 ; Lymphocytic Choriomeningitis ; Lymphocytic choriomeningitis virus ; Mice
Chemical Substances	CX3C Chemokine Receptor 1 ; Cx3cr1 protein, mouse ; Hepatitis A Virus Cellular Receptor 2
Language	English
Publishing date	2021-06-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.2001348
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Ud II Zs.37: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 28: Show issues

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Article ; Online: Lenvatinib recruits cytotoxic GZMK+CD8 T cells in hepatocellular carcinoma.

Yamada, Tomoharu / Fujiwara, Naoto / Kubota, Naoto / Matsushita, Yuki / Nakatsuka, Takuma / Kurosaki, Shigeyuki / Minami, Tatsuya / Tateishi, Ryosuke / Ichida, Akihiko / Arita, Junichi / Hasegawa, Kiyoshi / Koike, Kazuhiko / Fujishiro, Mitsuhiro / Nakagawa, Hayato

Hepatology communications

2023 Volume 7, Issue 8

Abstract: ... lenvatinib recruited cytotoxic GZMK+CD8 T cells in intratumor stroma by CXCL9 from tumor-associated ...

Abstract	Background: Lenvatinib was expected to enhance the effect of immune checkpoint inhibitors (ICIs) for unresectable HCC; however, their combination therapy failed to show the synergy in the phase III clinical trial. Methods: To elucidate lenvatinib-induced molecular modulation, we performed bulk RNA-sequencing and digital spatial profiling of 5 surgically resected human HCC specimens after lenvatinib treatment and 10 matched controls without any preceding therapy. Findings: Besides its direct antitumor effects, lenvatinib recruited cytotoxic GZMK+CD8 T cells in intratumor stroma by CXCL9 from tumor-associated macrophages, suggesting that lenvatinib-treated HCC is in the so-called excluded condition that can diminish ICI efficacy.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/genetics ; Liver Neoplasms/drug therapy ; Liver Neoplasms/genetics ; Immune Checkpoint Inhibitors ; CD8-Positive T-Lymphocytes
Chemical Substances	lenvatinib (EE083865G2) ; Immune Checkpoint Inhibitors
Language	English
Publishing date	2023-07-17
Publishing country	United States
Document type	Research Support, Non-U.S. Gov't ; Letter
ISSN	2471-254X
ISSN (online)	2471-254X
DOI	10.1097/HC9.0000000000000209
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Article ; Online: Plasma cell generation during T-cell-dependent immune responses.

Ise, Wataru / Kurosaki, Tomohiro

International immunology

2021 Volume 33, Issue 12, Page(s) 797–801

Abstract: ... Upon challenge with T-cell-dependent antigens, plasma cells can be generated during the primary extrafollicular ... with affinity for antigens and is determined by the strength of contact with T follicular helper cells. ...

Abstract	Plasma cells are terminally differentiated from activated B cells and are specialized for secreting antibodies, which are essential effector molecules in humoral immunity to neutralize invading pathogens. Upon challenge with T-cell-dependent antigens, plasma cells can be generated during the primary extrafollicular response, the germinal center (GC) response or the secondary memory response. Recent studies have revealed that plasma cell generation is regulated not only by several key transcription factors but also by epigenetic modifications. In addition, the differentiation of GC B cells toward a plasma cell fate is associated with affinity for antigens and is determined by the strength of contact with T follicular helper cells.
MeSH term(s)	Animals ; Germinal Center/immunology ; Humans ; Plasma Cells/immunology ; T-Lymphocytes/immunology
Language	English
Publishing date	2021-09-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1013745-2
ISSN	1460-2377 ; 0953-8178
ISSN (online)	1460-2377
ISSN	0953-8178
DOI	10.1093/intimm/dxab071
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Zs.A 2619: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 70: Show issues

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Article ; Online: Conversion of antigen-specific effector/memory T cells into Foxp3-expressing T

Akamatsu, Masahiko / Mikami, Norihisa / Ohkura, Naganari / Kawakami, Ryoji / Kitagawa, Yohko / Sugimoto, Atsushi / Hirota, Keiji / Nakamura, Naoto / Ujihara, Satoru / Kurosaki, Toshio / Hamaguchi, Hisao / Harada, Hironori / Xia, Guliang / Morita, Yoshiaki / Aramori, Ichiro / Narumiya, Shuh / Sakaguchi, Shimon

Science immunology

2019 Volume 4, Issue 40

Abstract: ... to convert disease-mediating T cells into immunosuppressive regulatory T (T ...

Abstract	A promising way to restrain hazardous immune responses, such as autoimmune disease and allergy, is to convert disease-mediating T cells into immunosuppressive regulatory T (T
MeSH term(s)	Animals ; Antigens/immunology ; CD4-Positive T-Lymphocytes/immunology ; Cells, Cultured ; Cyclin-Dependent Kinase 8/antagonists & inhibitors ; Cyclin-Dependent Kinase 8/deficiency ; Cyclin-Dependent Kinase 8/immunology ; Cyclin-Dependent Kinases/antagonists & inhibitors ; Cyclin-Dependent Kinases/deficiency ; Cyclin-Dependent Kinases/immunology ; Forkhead Transcription Factors/genetics ; Forkhead Transcription Factors/immunology ; Immunologic Memory/immunology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Inbred NOD ; Mice, Knockout ; Mice, Transgenic ; Protein Kinase Inhibitors/pharmacology ; Pyridines/pharmacology ; Pyrimidines/pharmacology ; T-Lymphocytes, Regulatory/immunology
Chemical Substances	Antigens ; Chir 99021 ; Forkhead Transcription Factors ; Foxp3 protein, mouse ; Protein Kinase Inhibitors ; Pyridines ; Pyrimidines ; CDK19 protein, mouse (EC 2.7.11.22) ; Cdk8 protein, mouse (EC 2.7.11.22) ; Cyclin-Dependent Kinase 8 (EC 2.7.11.22) ; Cyclin-Dependent Kinases (EC 2.7.11.22)
Language	English
Publishing date	2019-10-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2470-9468
ISSN (online)	2470-9468
DOI	10.1126/sciimmunol.aaw2707
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Article ; Online: Primary germinal center-resident T follicular helper cells are a physiologically distinct subset of CXCR5

Yeh, Chen-Hao / Finney, Joel / Okada, Takaharu / Kurosaki, Tomohiro / Kelsoe, Garnett

Immunity

2022 Volume 55, Issue 2, Page(s) 272–289.e7

Abstract: T follicular helper (Tfh) cells are defined by a Bcl6 ...

Abstract	T follicular helper (Tfh) cells are defined by a Bcl6
MeSH term(s)	Animals ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; Cell Communication/immunology ; Cell Differentiation ; Cell Proliferation ; Dendritic Cells/immunology ; Gene Expression Profiling ; Germinal Center/immunology ; Histocompatibility Antigens Class II/metabolism ; Mice ; Programmed Cell Death 1 Receptor/metabolism ; Receptors, Antigen, T-Cell/metabolism ; Receptors, CXCR5/metabolism ; Sphingosine-1-Phosphate Receptors/metabolism ; T Follicular Helper Cells/immunology ; T Follicular Helper Cells/metabolism ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; Thy-1 Antigens/metabolism
Chemical Substances	CXCR5 protein, mouse ; Histocompatibility Antigens Class II ; Pdcd1 protein, mouse ; Programmed Cell Death 1 Receptor ; Receptors, Antigen, T-Cell ; Receptors, CXCR5 ; Sphingosine-1-Phosphate Receptors ; Thy-1 Antigens ; sphingosine-1-phosphate receptor-2, mouse
Language	English
Publishing date	2022-01-25
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/j.immuni.2021.12.015
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Zs.A 4227: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 69: Show issues

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Article ; Online: Administration of the antiviral agent T-1105 fully protects pigs from foot-and-mouth disease infection.

Nishi, Tatsuya / Fukai, Katsuhiko / Masujin, Kentaro / Kawaguchi, Rie / Ikezawa, Mitsutaka / Yamada, Manabu / Nakajima, Nozomi / Komeno, Takashi / Furuta, Yousuke / Sugihara, Hiromi / Kurosaki, Chie / Sakamoto, Kenichi / Morioka, Kazuki

Antiviral research

2022 Volume 208, Page(s) 105425

Abstract: ... In this study, we investigated the antiviral activity of a pyrazinecarboxamide derivative, T-1105, against FMDV ... Cytopathic effect inhibition assays revealed that T-1105 strongly inhibited the replication of 28 reference ... strains of all seven FMDV serotypes at non-cytotoxic concentrations. The antiviral effect of T-1105 ...

Abstract	Foot-and-mouth disease (FMD) is a contagious disease affecting cloven-hoofed animals. Its transmissibility and antigenic variety make this disease difficult to control. Antiviral agents are expected to have an immediate effect that is independent of viral antigenicity; thus, they can serve as effective tools for inhibiting the spread of the causative agent, the FMD virus (FMDV), from infected animals. In this study, we investigated the antiviral activity of a pyrazinecarboxamide derivative, T-1105, against FMDV. Cytopathic effect inhibition assays revealed that T-1105 strongly inhibited the replication of 28 reference strains of all seven FMDV serotypes at non-cytotoxic concentrations. The antiviral effect of T-1105 against FMDV was also evaluated by experimental infection of domestic pigs. T-1105 was administered orally to pigs starting 1 h before or 6 h after the inoculation of a porcinophilic FMDV serotype O, topotype CATHAY. None of the pigs administered with T-1105 showed clinical signs of FMD. Moreover, no infectious FMDVs or FMDV-specific genes were detected in their sera, oral and nasal discharges, or tissues collected 48 h after virus inoculation. These findings strongly suggest that administration of T-1105 is effective in controlling the spread of FMDV in pigs.
MeSH term(s)	Swine ; Animals ; Foot-and-Mouth Disease/drug therapy ; Foot-and-Mouth Disease/prevention & control ; Antiviral Agents/therapeutic use ; Foot-and-Mouth Disease Virus ; Pyrazines/pharmacology
Chemical Substances	T 1105 ; Antiviral Agents ; Pyrazines
Language	English
Publishing date	2022-09-28
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	306628-9
ISSN	1872-9096 ; 0166-3542
ISSN (online)	1872-9096
ISSN	0166-3542
DOI	10.1016/j.antiviral.2022.105425
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Zs.A 1627: Show issues

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Article ; Online: BATF epigenetically and transcriptionally controls the activation program of regulatory T cells in human tumors.

Itahashi, Kota / Irie, Takuma / Yuda, Junichiro / Kumagai, Shogo / Tanegashima, Tokiyoshi / Lin, Yi-Tzu / Watanabe, Sho / Goto, Yasushi / Suzuki, Jun / Aokage, Keiju / Tsuboi, Masahiro / Minami, Yosuke / Ishii, Genichiro / Ohe, Yuichiro / Ise, Wataru / Kurosaki, Tomohiro / Suzuki, Yutaka / Koyama, Shohei / Nishikawa, Hiroyoshi

Science immunology

2022 Volume 7, Issue 76, Page(s) eabk0957

Abstract: Regulatory T (T ...

Abstract	Regulatory T (T
MeSH term(s)	Basic-Leucine Zipper Transcription Factors/genetics ; Basic-Leucine Zipper Transcription Factors/metabolism ; CD8-Positive T-Lymphocytes ; Chromatin/metabolism ; Humans ; Melanoma ; NF-kappa B/genetics ; NF-kappa B/metabolism ; RNA ; T-Lymphocytes, Regulatory ; Tumor Microenvironment
Chemical Substances	BATF protein, human ; Basic-Leucine Zipper Transcription Factors ; Chromatin ; NF-kappa B ; RNA (63231-63-0)
Language	English
Publishing date	2022-10-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2470-9468
ISSN (online)	2470-9468
DOI	10.1126/sciimmunol.abk0957
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Article ; Online: The adaptor molecule CD2AP in CD4 T cells modulates differentiation of follicular helper T cells during chronic LCMV infection.

Raju, Saravanan / Kometani, Kohei / Kurosaki, Tomohiro / Shaw, Andrey S / Egawa, Takeshi

PLoS pathogens

2018 Volume 14, Issue 5, Page(s) e1007053

Abstract: CD4 T cell-mediated help to CD8 T cells and B cells is a critical arm of the adaptive immune system ... required for control of pathogen infection. CD4 T cells express cytokines and co-stimulatory molecules ... that support a sustained CD8 T cell response and also enhance generation of protective antibody ...

Abstract	CD4 T cell-mediated help to CD8 T cells and B cells is a critical arm of the adaptive immune system required for control of pathogen infection. CD4 T cells express cytokines and co-stimulatory molecules that support a sustained CD8 T cell response and also enhance generation of protective antibody by germinal center B cells. However, the molecular components that modulate CD4 T cell functions in response to viral infection or vaccine are incompletely understood. Here we demonstrate that inactivation of the signaling adaptor CD2-associated protein (CD2AP) promotes CD4 T cell differentiation towards the follicular helper lineage, leading to enhanced control of viral infection by augmented germinal center response in chronic lymphocytic choriomeningitis virus (LCMV) infection. The enhanced follicular helper differentiation is associated with extended duration of TCR signaling and enhanced cytokine production of CD2AP-deficient CD4 T cells specifically under TH1 conditions, while neither prolonged TCR signaling nor enhanced follicular helper differentiation was observed under conditions that induce other helper effector subsets. Despite the structural similarity between CD2AP and the closely related adaptor protein CIN85, we observed defective antibody-mediated control of chronic LCMV infection in mice lacking CIN85 in T cells, suggesting non-overlapping and potentially antagonistic roles for CD2AP and CIN85. These results suggest that tuning of TCR signaling by targeting CD2AP improves protective antibody responses in viral infection.
MeSH term(s)	Adaptor Proteins, Signal Transducing/immunology ; Adaptor Proteins, Signal Transducing/metabolism ; Adaptor Proteins, Signal Transducing/physiology ; Animals ; Antibody Formation ; B-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; CD4-Positive T-Lymphocytes/physiology ; CD8-Positive T-Lymphocytes/immunology ; Cell Differentiation/immunology ; Cytoskeletal Proteins/immunology ; Cytoskeletal Proteins/metabolism ; Cytoskeletal Proteins/physiology ; Germinal Center/immunology ; Lymphocytic Choriomeningitis/virology ; Lymphocytic choriomeningitis virus/immunology ; Lymphocytic choriomeningitis virus/pathogenicity ; Mice ; Mice, Inbred C57BL ; Signal Transduction ; T-Lymphocytes, Helper-Inducer/immunology ; T-Lymphocytes, Helper-Inducer/metabolism ; T-Lymphocytes, Helper-Inducer/physiology
Chemical Substances	Adaptor Proteins, Signal Transducing ; CD2-associated protein ; Cytoskeletal Proteins
Language	English
Publishing date	2018-05-07
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2205412-1
ISSN	1553-7374 ; 1553-7374
ISSN (online)	1553-7374
ISSN	1553-7374
DOI	10.1371/journal.ppat.1007053
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Article ; Online: The Role of BACH2 in T Cells in Experimental Malaria Caused by

Edwards, Chelsea L / de Oca, Marcela Montes / de Labastida Rivera, Fabian / Kumar, Rajiv / Ng, Susanna S / Wang, Yulin / Amante, Fiona H / Kometani, Kohei / Kurosaki, Tomohiro / Sidwell, Tom / Kallies, Axel / Engwerda, Christian R

Frontiers in immunology

2018 Volume 9, Page(s) 2578

Abstract: ... a transcription factor best known for its role in B cell development. More recently, it has been associated with T cell ... functions in inflammatory diseases, and has been proposed as a master transcriptional regulator within the T ... cell compartment. In this study, we employed T cell-specific ...

Abstract	BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 2 (BACH2) is a transcription factor best known for its role in B cell development. More recently, it has been associated with T cell functions in inflammatory diseases, and has been proposed as a master transcriptional regulator within the T cell compartment. In this study, we employed T cell-specific
MeSH term(s)	Animals ; Basic-Leucine Zipper Transcription Factors/genetics ; Basic-Leucine Zipper Transcription Factors/metabolism ; Cell Differentiation ; Cell Proliferation ; Cells, Cultured ; Chimera ; Female ; Humans ; Lymphocyte Activation ; Malaria/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Models, Animal ; Plasmodium chabaudi/physiology ; Th17 Cells/immunology ; Th2 Cells/immunology
Chemical Substances	Bach2 protein, mouse ; Basic-Leucine Zipper Transcription Factors
Language	English
Publishing date	2018-11-06
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2018.02578
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