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  1. Article: Editorial: Genetic and molecular determinants in bone health and diseases.

    Rossi, Michela / Lowery, Jonathan W / Del Fattore, Andrea

    Frontiers in endocrinology

    2024  Volume 15, Page(s) 1347765

    MeSH term(s) Bone Density ; Bone and Bones ; Osteoclasts
    Language English
    Publishing date 2024-01-17
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2024.1347765
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Reducing Frost during Cryoimaging Using a Hygroscopic Ice Frame.

    Lowery, Adam W / Ambi, Ashwin / Miller, Lisa M / Boreyko, Jonathan B

    ACS omega

    2022  Volume 7, Issue 48, Page(s) 43421–43431

    Abstract: Cryomicroscopy is commonly hampered by frost accumulation, reducing the visual clarity of the specimen. Pulling a vacuum or purging with nitrogen gas can greatly reduce the sample chamber's humidity, but at cryogenic temperatures, even minute ... ...

    Abstract Cryomicroscopy is commonly hampered by frost accumulation, reducing the visual clarity of the specimen. Pulling a vacuum or purging with nitrogen gas can greatly reduce the sample chamber's humidity, but at cryogenic temperatures, even minute concentrations of water vapor can still result in frost deposition. Here, a hygroscopic ice frame was created around the specimen to suppress frost growth during cryomicroscopy. Specifically, fluorescently tagged rat brain vessels were frozen on a silicon nitride window with an ice frame, and the luminescence of the fluorescent tag was improved by a factor of 6 compared to a similar specimen in only a nitrogen purge environment. These findings suggest that the simple implementation of a hygroscopic ice frame surrounding the specimen can substantially improve the visual clarity for cryomicroscopy, beyond that of a vacuum or nitrogen purge system.
    Language English
    Publishing date 2022-11-22
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.2c03083
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The BMP Pathway and Its Inhibitors in the Skeleton.

    Lowery, Jonathan W / Rosen, Vicki

    Physiological reviews

    2018  Volume 98, Issue 4, Page(s) 2431–2452

    Abstract: Bone morphogenetic proteins (BMPs) constitute the largest subdivision of the transforming growth factor-β family of ligands. BMPs exhibit widespread utility and pleiotropic, context-dependent effects, and the strength and duration of BMP pathway ... ...

    Abstract Bone morphogenetic proteins (BMPs) constitute the largest subdivision of the transforming growth factor-β family of ligands. BMPs exhibit widespread utility and pleiotropic, context-dependent effects, and the strength and duration of BMP pathway signaling is tightly regulated at numerous levels via mechanisms operating both inside and outside the cell. Defects in the BMP pathway or its regulation underlie multiple human diseases of different organ systems. Yet much remains to be discovered about the BMP pathway in its original context, i.e., the skeleton. In this review, we provide a comprehensive overview of the intricacies of the BMP pathway and its inhibitors in bone development, homeostasis, and disease. We frame the content of the review around major unanswered questions for which incomplete evidence is available. First, we consider the gene regulatory network downstream of BMP signaling in osteoblastogenesis. Next, we examine why some BMP ligands are more osteogenic than others and what factors limit BMP signaling during osteoblastogenesis. Then we consider whether specific BMP pathway components are required for normal skeletal development, and if the pathway exerts endogenous effects in the aging skeleton. Finally, we propose two major areas of need of future study by the field: greater resolution of the gene regulatory network downstream of BMP signaling in the skeleton, and an expanded repertoire of reagents to reliably and specifically inhibit individual BMP pathway components.
    MeSH term(s) Animals ; Bone Morphogenetic Proteins/metabolism ; Gene Expression Regulation/physiology ; Humans ; Osteogenesis/physiology ; Signal Transduction/physiology ; Skeleton/metabolism ; Skeleton/physiology
    Chemical Substances Bone Morphogenetic Proteins
    Language English
    Publishing date 2018-08-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 209902-0
    ISSN 1522-1210 ; 0031-9333
    ISSN (online) 1522-1210
    ISSN 0031-9333
    DOI 10.1152/physrev.00028.2017
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    Uc I Zs.166: Show issues Location:
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  4. Article ; Online: Bone Morphogenetic Protein-Based Therapeutic Approaches.

    Lowery, Jonathan W / Rosen, Vicki

    Cold Spring Harbor perspectives in biology

    2018  Volume 10, Issue 4

    Abstract: Bone morphogenetic proteins (BMPs) constitute the largest subdivision of the transforming growth factor (TGF)-β family of ligands and exert most of their effects through the canonical effectors Smad1, 5, and 8. Appropriate regulation of BMP signaling is ... ...

    Abstract Bone morphogenetic proteins (BMPs) constitute the largest subdivision of the transforming growth factor (TGF)-β family of ligands and exert most of their effects through the canonical effectors Smad1, 5, and 8. Appropriate regulation of BMP signaling is critical for the development and homeostasis of numerous human organ systems. Aberrations in BMP pathways or their regulation are increasingly associated with diverse human pathologies, and there is an urgent and growing need to develop effective approaches to modulate BMP signaling in the clinic. In this review, we provide a wide perspective on diseases and/or conditions associated with dysregulated BMP signal transduction, outline the current strategies available to modulate BMP pathways, highlight emerging second-generation technologies, and postulate prospective avenues for future investigation.
    MeSH term(s) Anemia, Iron-Deficiency/drug therapy ; Bone Morphogenetic Proteins/genetics ; Bone Morphogenetic Proteins/physiology ; Bone Morphogenetic Proteins/therapeutic use ; Central Nervous System Diseases/drug therapy ; Fibrosis/drug therapy ; Hemochromatosis/drug therapy ; Humans ; Models, Biological ; Myocardial Infarction/drug therapy ; Ossification, Heterotopic/drug therapy ; Recombinant Proteins/therapeutic use ; Reperfusion Injury/drug therapy ; Signal Transduction ; Spinal Cord Injuries/drug therapy ; Vascular Diseases/drug therapy
    Chemical Substances Bone Morphogenetic Proteins ; Recombinant Proteins
    Language English
    Publishing date 2018-04-02
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1943-0264
    ISSN (online) 1943-0264
    DOI 10.1101/cshperspect.a022327
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Examining the Role of Hypothalamus-Derived Neuromedin-U (NMU) in Bone Remodeling of Rats.

    Born-Evers, Gabriella / Orr, Ashley L / Hulsey, Elizabeth Q / Squire, Maria E / Hum, Julia M / Plotkin, Lilian / Sampson, Catherine / Hommel, Jonathan / Lowery, Jonathan W

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 4

    Abstract: Global loss of the neuropeptide Neuromedin-U (NMU) is associated with increased bone formation and high bone mass in male and female mice by twelve weeks of age, suggesting that NMU suppresses osteoblast differentiation and/or activity in vivo. NMU is ... ...

    Abstract Global loss of the neuropeptide Neuromedin-U (NMU) is associated with increased bone formation and high bone mass in male and female mice by twelve weeks of age, suggesting that NMU suppresses osteoblast differentiation and/or activity in vivo. NMU is highly expressed in numerous anatomical locations including the skeleton and the hypothalamus. This raises the possibility that NMU exerts indirect effects on bone remodeling from an extra-skeletal location such as the brain. Thus, in the present study we used microinjection to deliver viruses carrying short-hairpin RNA designed to knockdown
    Language English
    Publishing date 2023-03-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13040918
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  6. Article ; Online: PTHrP intracrine actions divergently influence breast cancer growth through p27 and LIFR.

    Edwards, Courtney M / Kane, Jeremy F / Smith, Jailyn A / Grant, Déja M / Johnson, Jasmine A / Diaz, Maria A Hernandez / Vecchi, Lawrence A / Bracey, Kai M / Omokehinde, Tolu N / Fontana, Joseph R / Karno, Breelyn A / Scott, Halee T / Vogel, Carolina J / Lowery, Jonathan W / Martin, T John / Johnson, Rachelle W

    Breast cancer research : BCR

    2024  Volume 26, Issue 1, Page(s) 34

    Abstract: The role of parathyroid hormone (PTH)-related protein (PTHrP) in breast cancer remains controversial, with reports of PTHrP inhibiting or promoting primary tumor growth in preclinical studies. Here, we provide insight into these conflicting findings by ... ...

    Abstract The role of parathyroid hormone (PTH)-related protein (PTHrP) in breast cancer remains controversial, with reports of PTHrP inhibiting or promoting primary tumor growth in preclinical studies. Here, we provide insight into these conflicting findings by assessing the role of specific biological domains of PTHrP in tumor progression through stable expression of PTHrP (-36-139aa) or truncated forms with deletion of the nuclear localization sequence (NLS) alone or in combination with the C-terminus. Although the full-length PTHrP molecule (-36-139aa) did not alter tumorigenesis, PTHrP lacking the NLS alone accelerated primary tumor growth by downregulating p27, while PTHrP lacking the NLS and C-terminus repressed tumor growth through p27 induction driven by the tumor suppressor leukemia inhibitory factor receptor (LIFR). Induction of p27 by PTHrP lacking the NLS and C-terminus persisted in bone disseminated cells, but did not prevent metastatic outgrowth, in contrast to the primary tumor site. These data suggest that the PTHrP NLS functions as a tumor suppressor, while the PTHrP C-terminus may act as an oncogenic switch to promote tumor progression through differential regulation of p27 signaling.
    MeSH term(s) Humans ; Female ; Parathyroid Hormone-Related Protein/genetics ; Parathyroid Hormone-Related Protein/metabolism ; Breast Neoplasms/pathology ; Receptors, OSM-LIF ; Nuclear Localization Signals ; Cell Proliferation/genetics ; Leukemia Inhibitory Factor Receptor alpha Subunit
    Chemical Substances Parathyroid Hormone-Related Protein ; Receptors, OSM-LIF ; Nuclear Localization Signals ; LIFR protein, human ; Leukemia Inhibitory Factor Receptor alpha Subunit
    Language English
    Publishing date 2024-02-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2015059-3
    ISSN 1465-542X ; 1465-5411
    ISSN (online) 1465-542X
    ISSN 1465-5411
    DOI 10.1186/s13058-024-01791-z
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5494: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article: The Metabolic Bone Disease X-linked Hypophosphatemia: Case Presentation, Pathophysiology and Pharmacology.

    Vincze, Jon / Skinner, Brian W / Tucker, Katherine A / Conaway, Kory A / Lowery, Jonathan W / Hum, Julia M

    Life (Basel, Switzerland)

    2021  Volume 11, Issue 6

    Abstract: The authors present a stereotypical case presentation of X-linked hypophosphatemia (XLH) and provide a review of the pathophysiology and related pharmacology of this condition, primarily focusing on the FDA-approved medication burosumab. XLH is a renal ... ...

    Abstract The authors present a stereotypical case presentation of X-linked hypophosphatemia (XLH) and provide a review of the pathophysiology and related pharmacology of this condition, primarily focusing on the FDA-approved medication burosumab. XLH is a renal phosphate wasting disorder caused by loss of function mutations in the
    Language English
    Publishing date 2021-06-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life11060563
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  8. Article ; Online: Soft Tissue Manipulation Alters RANTES/CCL5 and IL-4 Cytokine Levels in a Rat Model of Chronic Low Back Pain.

    Marciano, Carmela L / Hiland, Taylor A / Jackson, Krista L / Street, Sierra / Maris, Carson / Ehrsam, Andrew / Hum, Julia M / Loghmani, Mary Terry / Chu, Tien-Min G / Kang, Kyung S / Lowery, Jonathan W

    International journal of molecular sciences

    2023  Volume 24, Issue 18

    Abstract: Low back pain (LBP) is a common musculoskeletal complaint that can impede physical function and mobility. Current management often involves pain medication, but there is a need for non-pharmacological and non-invasive interventions. Soft tissue ... ...

    Abstract Low back pain (LBP) is a common musculoskeletal complaint that can impede physical function and mobility. Current management often involves pain medication, but there is a need for non-pharmacological and non-invasive interventions. Soft tissue manipulation (STM), such as massage, has been shown to be effective in human subjects, but the molecular mechanisms underlying these findings are not well understood. In this paper, we evaluated potential changes in the soft tissue levels of more than thirty pro- or anti-inflammatory cytokines following instrument-assisted STM (IASTM) in rats with chronic, induced LBP using Complete Freund's Adjuvant. Our results indicate that IASTM is associated with reduced soft tissue levels of Regulated on Activation, Normal T cell Expressed and Secreted (RANTES)/Chemokine (C-C motif) ligand 5 (CCL5) and increased soft tissue levels of Interleukin (IL)-4, which are pro-inflammatory and anti-inflammatory factors, respectively, by 120 min post-treatment. IASTM was not associated with tissue-level changes in C-X-C Motif Chemokine Ligand (CXCL)-5/Lipopolysaccharide-Induced CXC Chemokine (LIX)-which is the murine homologue of IL-8, CXCL-7, Granulocyte-Macrophage-Colony Simulating Factor (GM-CSF), Intercellular Adhesion Molecule (ICAM)-1, IL1-Receptor Antagonist (IL-1ra), IL-6, Interferon-Inducible Protein (IP)-10/CXCL-10, L-selectin, Tumor Necrosis Factor (TNF)-α, or Vascular Endothelial Growth Factor (VEGF) at either 30 or 120 min post-treatment. Combined, our findings raise the possibility that IASTM may exert tissue-level effects associated with improved clinical outcomes and potentially beneficial changes in pro-/anti-inflammatory cytokines in circulation and at the tissue level.
    Language English
    Publishing date 2023-09-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241814392
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  9. Article: Reply to "Bone morphogenetic protein's contribution to pulmonary artery hypertension".

    King, Tyler / de Caestecker, Mark / Lowery, Jonathan W

    Surgical neurology international

    2016  Volume 7, Page(s) 91

    Language English
    Publishing date 2016-10-19
    Publishing country United States
    Document type Journal Article
    ISSN 2229-5097
    ISSN 2229-5097
    DOI 10.4103/2152-7806.192635
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Muscle-derived factors influencing bone metabolism.

    Gries, Kevin J / Zysik, Victoria S / Jobe, Tyler K / Griffin, Nicole / Leeds, Benjamin P / Lowery, Jonathan W

    Seminars in cell & developmental biology

    2021  Volume 123, Page(s) 57–63

    Abstract: A significant amount of attention has been brought to the endocrine-like function of skeletal muscle on various tissues, particularly with bone. Several lines of investigation indicate that the physiology of both bone and muscle systems may be regulated ... ...

    Abstract A significant amount of attention has been brought to the endocrine-like function of skeletal muscle on various tissues, particularly with bone. Several lines of investigation indicate that the physiology of both bone and muscle systems may be regulated by a given stimulus, such as exercise, aging, and inactivity. Moreover, emerging evidence indicates that bone is heavily influenced by soluble factors derived from skeletal muscle (i.e., muscle-to-bone communication). The purpose of this review is to discuss the regulation of bone remodeling (formation and/or resorption) through skeletal muscle-derived cytokines (hereafter myokines) including the anti-inflammatory cytokine METRNL and pro-inflammatory cytokines (e.g., TNF-α, IL-6, FGF-2 and others). Our goal is to highlight possible therapeutic opportunities to improve muscle and bone health in aging.
    MeSH term(s) Bone and Bones ; Cytokines/metabolism ; Exercise/physiology ; Muscle, Skeletal/metabolism
    Chemical Substances Cytokines
    Language English
    Publishing date 2021-10-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1312473-0
    ISSN 1096-3634 ; 1084-9521
    ISSN (online) 1096-3634
    ISSN 1084-9521
    DOI 10.1016/j.semcdb.2021.10.009
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2918: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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