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  1. Article: Eugenol ameliorates uveitis in mice with experimental autoimmune encephalomyelitis through the suppression of key inflammatory genes.

    Hong, Sungmoo / Jung, Kyungsook / Ahn, Meejung / Kim, Jeongtae / Moon, Changjong / Shin, Taekyun

    Animal cells and systems

    2024  Volume 28, Issue 1, Page(s) 37–44

    Abstract: Visual impairment associated with uveitis is among the potential complications in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Bioinformatics analyses have shown that some hub genes are closely associated ...

    Abstract Visual impairment associated with uveitis is among the potential complications in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Bioinformatics analyses have shown that some hub genes are closely associated with the molecular mechanisms underlying uveitis in EAE. This study evaluated whether 4-allyl-2-methoxyphenol (eugenol) can mitigate the pathogenesis of uveitis in EAE through the interruption of key uveitogenic gene expression. Myelin oligodendrocyte glycoprotein
    Language English
    Publishing date 2024-01-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2562988-8
    ISSN 2151-2485 ; 1976-8354
    ISSN (online) 2151-2485
    ISSN 1976-8354
    DOI 10.1080/19768354.2024.2304557
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Fermented black radish (Raphanus sativus L. var. niger) attenuates methionine and choline deficient diet‐induced nonalcoholic fatty liver disease in mice

    Ahn, Meejung / Kim, Jeongtae / CHOI, Yuna / Chun, Ji-Yeon / YANG, Dawun / kim, giok / SHIN, Taekyun

    Food Science & Nutrition, 7(10):3327-3337

    2019  

    Abstract: As one of the wide‐ranging form of chronic liver disease, there are only limited therapeutic options for nonalcoholic fatty liver disease (NAFLD). We evaluated whether fermented black radish (Raphanus sativus L. var. niger; FBR) ameliorates lipid ... ...

    Abstract As one of the wide‐ranging form of chronic liver disease, there are only limited therapeutic options for nonalcoholic fatty liver disease (NAFLD). We evaluated whether fermented black radish (Raphanus sativus L. var. niger; FBR) ameliorates lipid accumulation, inflammation, and hepatic fibrosis, which are characteristics of the pathogenesis of NAFLD. Fermented black radish treatment reduced lipid accumulation in 3T3‐L1 adipocytes, which appeared to be associated with the downregulation of adipogenic transcription factors, including sterol regulatory element‐binding protein 1c, CCAAT/enhancer‐binding protein α, peroxisome proliferator‐activated receptor γ, and lipid accumulation‐related genes including adipocyte protein‐2 and fatty acid synthase. Administration of FBR to C57BL/6J mice challenged with methionine and choline deficient (MCD) diet significantly attenuated the increased serum levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and triglyceride. In addition, treatment with FBR interestingly repressed the hepatic inflammation induced with MCD diet, by lowering the expression of inducible nitric oxide synthase and suppressing the inactivation of macrophages and Kupffer cells in the liver. Fermented black radish was also shown to mitigate liver fibrosis through the inhibition of alpha‐smooth muscle actin, transforming growth factor beta‐1, and collagen type I alpha 1 chain. Our results indicate that FBR ameliorates NAFLD and its related metabolic disease by regulating multiple pathways, suggesting that FBR may be an effective dietary supplement for ameliorating NAFLD.
    Keywords MCD diet ; fermented black radish ; fibrosis ; inflammation ; steatosis
    Language English
    Document type Article
    Database Repository for Life Sciences

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  3. Article ; Online: Eugenol ameliorates uveitis in mice with experimental autoimmune encephalomyelitis through the suppression of key inflammatory genes

    Sungmoo Hong / Kyungsook Jung / Meejung Ahn / Jeongtae Kim / Changjong Moon / Taekyun Shin

    Animal Cells and Systems, Vol 28, Iss 1, Pp 37-

    2024  Volume 44

    Abstract: ABSTRACTVisual impairment associated with uveitis is among the potential complications in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Bioinformatics analyses have shown that some hub genes are closely ... ...

    Abstract ABSTRACTVisual impairment associated with uveitis is among the potential complications in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Bioinformatics analyses have shown that some hub genes are closely associated with the molecular mechanisms underlying uveitis in EAE. This study evaluated whether 4-allyl-2-methoxyphenol (eugenol) can mitigate the pathogenesis of uveitis in EAE through the interruption of key uveitogenic gene expression. Myelin oligodendrocyte glycoprotein35–55 (MOG) peptide-immunized C57BL/6 mice were injected intraperitoneally with eugenol. The eyeballs and spinal cords of EAE mice with or without eugenol treatment were collected simultaneously and immunohistochemical and molecular biological analyses were conducted. Eugenol treatment significantly ameliorated hindlimb paralysis. Ionized calcium-binding adapter molecule 1 (Iba-1) immunohistochemistry showed that the inflammatory response was significantly reduced in the uvea of eugenol-treated EAE mice compared with vehicle-treated controls. Eugenol also significantly reduced the expression of key uveitogenic genes including C1qb and Tyrobp. The suppressive effect of eugenol on inflammation was also observed in the spinal cord, as determined by the suppression of Iba-1-positive microglial cells. Together, these results suggest that the ameliorative effect of eugenol against EAE uveitis is associated with the suppression of key proinflammatory genes, which may represent targets for the treatment of uveitis.
    Keywords Anti-inflammation ; eugenol ; experimental autoimmune encephalomyelitis ; neuroinflammation ; uveitis ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
    Subject code 570
    Language English
    Publishing date 2024-12-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Author Correction: Antioxidant effects of phenolic compounds in through the distillation of Lonicera japonica & Chenpi extract and anti-inflammation on skin keratinocyte.

    Kim, Hun Hwan / Jeong, Se Hyo / Park, Min Yeong / Bhosale, Pritam Bhangwan / Abusaliya, Abuyaseer / Kim, Hyun Wook / Seong, Je Kyung / Ahn, Meejung / Park, Kwang Il / Kim, Gon Sup

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 2934

    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-53473-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Eugenol alleviates the symptoms of experimental autoimmune encephalomyelitis in mice by suppressing inflammatory responses.

    Lee, Jihye / Hong, Sungmoo / Ahn, Meejung / Kim, Jeongtae / Moon, Changjong / Matsuda, Hiroshi / Tanaka, Akane / Nomura, Yoshihiro / Jung, Kyungsook / Shin, Taekyun

    International immunopharmacology

    2024  Volume 128, Page(s) 111479

    Abstract: Eugenol is a principal compound in essential clove oil, known for its anti-inflammatory and antioxidant properties. While recent studies have demonstrated its neuroprotective effects on central nervous system (CNS) injuries, such as brain ischemia/ ... ...

    Abstract Eugenol is a principal compound in essential clove oil, known for its anti-inflammatory and antioxidant properties. While recent studies have demonstrated its neuroprotective effects on central nervous system (CNS) injuries, such as brain ischemia/reperfusion injuries, but its potential impact on multiple sclerosis (MS), an autoimmune disease of the CNS, has not yet been explored. We evaluated the therapeutic effects of eugenol on experimental autoimmune encephalomyelitis (EAE), an established animal model of MS. EAE was induced in C57BL/6 mice using the myelin oligodendrocyte glycoprotein (MOG)
    MeSH term(s) Mice ; Animals ; Encephalomyelitis, Autoimmune, Experimental ; Eugenol/therapeutic use ; Cytokines/therapeutic use ; Mice, Inbred C57BL ; Spinal Cord/pathology ; Multiple Sclerosis/drug therapy ; Myelin-Oligodendrocyte Glycoprotein ; Anti-Inflammatory Agents/therapeutic use ; Inflammation Mediators
    Chemical Substances Eugenol (3T8H1794QW) ; Cytokines ; Myelin-Oligodendrocyte Glycoprotein ; Anti-Inflammatory Agents ; Inflammation Mediators
    Language English
    Publishing date 2024-01-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2023.111479
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5408: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Key Genes in Olfactory Disorder in Experimental Autoimmune Encephalomyelitis Identified by Transcriptomic Analysis of the Olfactory Bulbs.

    Hong, Sungmoo / Kim, Jeongtae / Ahn, Meejung / Jung, Kyungsook / Moon, Changjong / Ahn, Changhwan / Sanchez-Quinteiro, Pablo / Shin, Taekyun

    Molecular neurobiology

    2024  

    Abstract: Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis that shows demyelination in the central nervous system and functional deficits, including olfactory impairment. However, the genes related to olfactory impairment in ...

    Abstract Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis that shows demyelination in the central nervous system and functional deficits, including olfactory impairment. However, the genes related to olfactory impairment in EAE are unknown. We evaluated hub genes of the olfactory bulb in EAE mice. Differentially expressed genes (cut-offs, fold change > 2 and adjusted p < 0.05) and their related pathways in olfactory bulbs were subjected to gene ontology (GO) pathway analysis, gene set enrichment analysis (GSEA). Protein-protein interactions with selected genes were evaluated using the Search Tool for the Retrieval of Interacting Genes/Proteins. Gene regulatory networks (GRNs) which were constructed at the post-transcriptional level, including the genes-transcription factors (TFs) and gene-microRNAs (miRNAs) interaction networks. Twelve hub genes were found, three of which (Ctss, Itgb2, and Tlr2) were validated by RT-qPCR to be related to GO pathways such as immune response and regulation of immune response. GSEA showed that neuron-related genes-including Atp6v1g2, Egr1, and Gap43-and their pathways were significantly downregulated. GRNs analysis of six genes (Ctss, Itgb2, Tlr2, Atp6v1g2, Egr1, and Gap43) revealed 37 TFs and 84 miRNAs were identified as potential regulators of six genes, indicating significant interaction among six genes, TFs, and miRNAs. Collectively, these results suggest that transcriptomic analysis of the olfactory bulb of EAE mice can provide insight into olfactory dysfunction and reveal therapeutic targets for olfactory impairment.
    Language English
    Publishing date 2024-01-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645020-9
    ISSN 1559-1182 ; 0893-7648
    ISSN (online) 1559-1182
    ISSN 0893-7648
    DOI 10.1007/s12035-024-03923-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2411: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Inhibitory Effect of Black Radish (

    Jeon, Hyungsik / Yang, Dawun / Lee, Nam Ho / Ahn, Meejung / Kim, Giok

    Preventive nutrition and food science

    2021  Volume 25, Issue 4, Page(s) 408–421

    Abstract: Black radish ( ...

    Abstract Black radish (
    Language English
    Publishing date 2021-01-11
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2668373-8
    ISSN 2287-8602 ; 2287-1098
    ISSN (online) 2287-8602
    ISSN 2287-1098
    DOI 10.3746/pnf.2020.25.4.408
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7808: Show issues

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  8. Article ; Online: Detection of thiocyanate in postmortem blood of a fatal potassium thiocyanate-poisoning patient using gas chromatography-mass spectrometry.

    Kang, Minji / Moon, Sungmin / Kim, Byungjoo / Kim, So-Hyun / Kim, Junghyun / Park, Heejin / Choi, Hyeyoung / Kim, Seongho / Park, Meejung

    Journal of analytical toxicology

    2023  Volume 47, Issue 9, Page(s) 867–870

    Abstract: Thiocyanate is an inorganic compound used in industrial applications. Here, we report a case of suicidal death due to acute thiocyanate overdose. A 44-year-old man who consumed an unknown amount of thiocyanate solution was transferred to the emergency ... ...

    Abstract Thiocyanate is an inorganic compound used in industrial applications. Here, we report a case of suicidal death due to acute thiocyanate overdose. A 44-year-old man who consumed an unknown amount of thiocyanate solution was transferred to the emergency room and died 2 h after admission. An autopsy was performed 2 days after death. General toxicological analysis of blood using gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-tandem mass spectrometry found no drug or alcohol. Quantification using GC-MS post-derivatization with pentafluorobenzyl bromide revealed 2,290 and 1,920 mg/L of thiocyanate in the heart and femoral blood samples, respectively. Thus, the cause of death was attributed to thiocyanate overdose. This study provides useful information for the interpretation of thiocyanate-related fatalities.
    MeSH term(s) Male ; Humans ; Adult ; Gas Chromatography-Mass Spectrometry ; Thiocyanates ; Drug Overdose/diagnosis ; Autopsy
    Chemical Substances potassium thiocyanate (TM7213864A) ; thiocyanate (O748SU14OM) ; Thiocyanates
    Language English
    Publishing date 2023-09-27
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 752391-9
    ISSN 1945-2403 ; 0146-4760
    ISSN (online) 1945-2403
    ISSN 0146-4760
    DOI 10.1093/jat/bkad075
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1333: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Author Correction: Antioxidant effects of phenolic compounds in through the distillation of Lonicera japonica & Chenpi extract and anti-inflammation on skin keratinocyte.

    Kim, Hun Hwan / Jeong, Se Hyo / Park, Min Yeong / Bhosale, Pritam Bhangwan / Abusaliya, Abuyaseer / Kim, Hyun Wook / Seong, Je Kyung / Ahn, Meejung / Park, Kwang Il / Kim, Gon Sup

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 22761

    Language English
    Publishing date 2023-12-20
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-50042-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Blood-retina barrier dysfunction in experimental autoimmune uveitis: the pathogenesis and therapeutic targets.

    Kim, Jeongtae / Chun, Jiyoon / Ahn, Meejung / Jung, Kyungsook / Moon, Changjong / Shin, Taekyun

    Anatomy & cell biology

    2022  Volume 55, Issue 1, Page(s) 20–27

    Abstract: Experimental autoimmune uveitis (EAU), an animal model of human uveitis, is characterized by infiltration of autoimmune T cells in the uvea as well as in the retina of susceptible animals. EAU is induced by the immunization of uveitogenic antigens, ... ...

    Abstract Experimental autoimmune uveitis (EAU), an animal model of human uveitis, is characterized by infiltration of autoimmune T cells in the uvea as well as in the retina of susceptible animals. EAU is induced by the immunization of uveitogenic antigens, including either retinal soluble-antigen or interphotoreceptor retinoid-binding proteins, in Lewis rats. The pathogenesis of EAU in rats involves the proliferation of autoimmune T cells in peripheral lymphoid tissues and breakdown of the blood-retinal barrier, primarily in the uvea and retina, finally inducing visual dysfunction. In this review, we describe recent EAU studies to facilitate the design of a therapeutic strategy through the interruption of uveitogenic factors during the course of EAU, which will be helpful for controlling human uveitis.
    Language English
    Publishing date 2022-03-30
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2590173-4
    ISSN 2093-3673 ; 2093-3665
    ISSN (online) 2093-3673
    ISSN 2093-3665
    DOI 10.5115/acb.21.227
    Database MEDical Literature Analysis and Retrieval System OnLINE

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