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  1. Article: BNT162b2 Vaccine Encoding the SARS-CoV-2 P2 S Protects Transgenic hACE2 Mice against COVID-19.

    Ji, Rui-Ru / Qu, Yajin / Zhu, Hua / Yang, Yumei / Vogel, Annette B / Sahin, Ugur / Qin, Chuan / Hui, Aimin

    Vaccines

    2021  Volume 9, Issue 4

    Abstract: BNT162b2 is a highly efficacious mRNA vaccine approved to prevent COVID-19. This brief report describes the immunogenicity and anti-viral protective effect of BNT162b2 in hACE2 transgenic mice. Prime-boost immunization with BNT162b2 elicited high titers ... ...

    Abstract BNT162b2 is a highly efficacious mRNA vaccine approved to prevent COVID-19. This brief report describes the immunogenicity and anti-viral protective effect of BNT162b2 in hACE2 transgenic mice. Prime-boost immunization with BNT162b2 elicited high titers in neutralizing antibodies against SARS-CoV-2, which correlated with viral clearance and alleviated lung lesions in these mice after viral challenge.
    Language English
    Publishing date 2021-04-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines9040324
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Toxicological Assessments of a Pandemic COVID-19 Vaccine-Demonstrating the Suitability of a Platform Approach for mRNA Vaccines.

    Rohde, Cynthia M / Lindemann, Claudia / Giovanelli, Michael / Sellers, Rani S / Diekmann, Jan / Choudhary, Shambhunath / Ramaiah, Lila / Vogel, Annette B / Chervona, Yana / Muik, Alexander / Sahin, Ugur

    Vaccines

    2023  Volume 11, Issue 2

    Abstract: The emergence of SARS-CoV-2 at the end of 2019 required the swift development of a vaccine to address the pandemic. Nonclinical GLP-compliant studies in Wistar Han rats were initiated to assess the local tolerance, systemic toxicity, and immune response ... ...

    Abstract The emergence of SARS-CoV-2 at the end of 2019 required the swift development of a vaccine to address the pandemic. Nonclinical GLP-compliant studies in Wistar Han rats were initiated to assess the local tolerance, systemic toxicity, and immune response to four mRNA vaccine candidates encoding immunogens derived from the spike (S) glycoprotein of SARS-CoV-2, encapsulated in lipid nanoparticles (LNPs). Vaccine candidates were administered intramuscularly once weekly for three doses at 30 and/or 100 µg followed by a 3-week recovery period. Clinical pathology findings included higher white blood cell counts and acute phase reactant concentrations, lower platelet and reticulocyte counts, and lower RBC parameters. Microscopically, there was increased cellularity (lymphocytes) in the lymph nodes and spleen, increased hematopoiesis in the bone marrow and spleen, acute inflammation and edema at the injection site, and minimal hepatocellular vacuolation. These findings were generally attributed to the anticipated immune and inflammatory responses to the vaccines, except for hepatocyte vacuolation, which was interpreted to reflect hepatocyte LNP lipid uptake, was similar between candidates and resolved or partially recovered at the end of the recovery phase. These studies demonstrated safety and tolerability in rats, supporting SARS-CoV-2 mRNA-LNP vaccine clinical development.
    Language English
    Publishing date 2023-02-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11020417
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: mRNA vaccines expressing homo-prototype/Omicron and hetero-chimeric RBD-dimers against SARS-CoV-2.

    Han, Yuxuan / An, Yaling / Chen, Qian / Xu, Kun / Liu, Xueyuan / Xu, Senyu / Duan, Huixin / Vogel, Annette B / Şahin, Uğur / Wang, Qihui / Dai, Lianpan / Gao, George F

    Cell research

    2022  Volume 32, Issue 11, Page(s) 1022–1025

    MeSH term(s) Humans ; SARS-CoV-2 ; mRNA Vaccines ; COVID-19/prevention & control ; Vaccines, Synthetic ; Antibodies, Viral ; Antibodies, Neutralizing ; Spike Glycoprotein, Coronavirus/genetics
    Chemical Substances mRNA Vaccines ; Vaccines, Synthetic ; Antibodies, Viral ; Antibodies, Neutralizing ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2022-09-14
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1319303-x
    ISSN 1748-7838 ; 1001-0602
    ISSN (online) 1748-7838
    ISSN 1001-0602
    DOI 10.1038/s41422-022-00720-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5283: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Reducing cell intrinsic immunity to mRNA vaccine alters adaptive immune responses in mice.

    Wang, Ziyin / Jacobus, Egon J / Stirling, David C / Krumm, Stefanie / Flight, Katie E / Cunliffe, Robert F / Mottl, Jonathan / Singh, Charanjit / Mosscrop, Lucy G / Santiago, Leticia Aragão / Vogel, Annette B / Kariko, Katalin / Sahin, Ugur / Erbar, Stephanie / Tregoning, John S

    Molecular therapy. Nucleic acids

    2023  Volume 34, Page(s) 102045

    Abstract: The response to mRNA vaccines needs to be sufficient for immune cell activation and recruitment, but moderate enough to ensure efficacious antigen expression. The choice of the cap structure and use of N1-methylpseudouridine (m1Ψ) instead of uridine, ... ...

    Abstract The response to mRNA vaccines needs to be sufficient for immune cell activation and recruitment, but moderate enough to ensure efficacious antigen expression. The choice of the cap structure and use of N1-methylpseudouridine (m1Ψ) instead of uridine, which have been shown to reduce RNA sensing by the cellular innate immune system, has led to improved efficacy of mRNA vaccine platforms. Understanding how RNA modifications influence the cell intrinsic immune response may help in the development of more effective mRNA vaccines. In the current study, we compared mRNA vaccines in mice against influenza virus using three different mRNA formats: uridine-containing mRNA (D1-uRNA), m1Ψ-modified mRNA (D1-modRNA), and D1-modRNA with a cap1 structure (cC1-modRNA). D1-uRNA vaccine induced a significantly different gene expression profile to the modified mRNA vaccines, with an up-regulation of
    Language English
    Publishing date 2023-10-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2662631-7
    ISSN 2162-2531
    ISSN 2162-2531
    DOI 10.1016/j.omtn.2023.102045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: BNT162b2 Vaccine Encoding the SARS-CoV-2 P2 S Protects Transgenic hACE2 Mice against COVID-19

    Rui-Ru Ji / Yajin Qu / Hua Zhu / Yumei Yang / Annette B. Vogel / Ugur Sahin / Chuan Qin / Aimin Hui

    Vaccines, Vol 9, Iss 324, p

    2021  Volume 324

    Abstract: BNT162b2 is a highly efficacious mRNA vaccine approved to prevent COVID-19. This brief report describes the immunogenicity and anti-viral protective effect of BNT162b2 in hACE2 transgenic mice. Prime-boost immunization with BNT162b2 elicited high titers ... ...

    Abstract BNT162b2 is a highly efficacious mRNA vaccine approved to prevent COVID-19. This brief report describes the immunogenicity and anti-viral protective effect of BNT162b2 in hACE2 transgenic mice. Prime-boost immunization with BNT162b2 elicited high titers in neutralizing antibodies against SARS-CoV-2, which correlated with viral clearance and alleviated lung lesions in these mice after viral challenge.
    Keywords SARS-CoV-2 ; COVID-19 ; mRNA vaccine ; efficacy ; immunogenicity ; challenge study ; Medicine ; R
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: A multivalent mRNA monkeypox virus vaccine (BNT166) protects mice and macaques from orthopoxvirus disease.

    Zuiani, Adam / Dulberger, Charles L / De Silva, Nilushi S / Marquette, Meghan / Lu, Yu-Jung / Palowitch, Gavin M / Dokic, Anja / Sanchez-Velazquez, Ricardo / Schlatterer, Katja / Sarkar, Sanjay / Kar, Swagata / Chawla, Bhavna / Galeev, Alibek / Lindemann, Claudia / Rothenberg, Daniel A / Diao, Huitian / Walls, Alexandra C / Addona, Theresa A / Mensa, Federico /
    Vogel, Annette B / Stuart, Lynda M / van der Most, Robbert / Srouji, John R / Türeci, Özlem / Gaynor, Richard B / Şahin, Uğur / Poran, Asaf

    Cell

    2024  Volume 187, Issue 6, Page(s) 1363–1373.e12

    Abstract: In response to the 2022 outbreak of mpox driven by unprecedented human-to-human monkeypox virus (MPXV) transmission, we designed BNT166, aiming to create a highly immunogenic, safe, accessible, and scalable next-generation vaccine against MPXV and ... ...

    Abstract In response to the 2022 outbreak of mpox driven by unprecedented human-to-human monkeypox virus (MPXV) transmission, we designed BNT166, aiming to create a highly immunogenic, safe, accessible, and scalable next-generation vaccine against MPXV and related orthopoxviruses. To address the multiple viral forms and increase the breadth of immune response, two candidate multivalent mRNA vaccines were evaluated pre-clinically: a quadrivalent vaccine (BNT166a; encoding the MPXV antigens A35, B6, M1, H3) and a trivalent vaccine (BNT166c; without H3). Both candidates induced robust T cell responses and IgG antibodies in mice, including neutralizing antibodies to both MPXV and vaccinia virus. In challenge studies, BNT166a and BNT166c provided complete protection from vaccinia, clade I, and clade IIb MPXV. Furthermore, immunization with BNT166a was 100% effective at preventing death and at suppressing lesions in a lethal clade I MPXV challenge in cynomolgus macaques. These findings support the clinical evaluation of BNT166, now underway (NCT05988203).
    MeSH term(s) Animals ; Humans ; Mice ; Macaca fascicularis ; Monkeypox virus/genetics ; Mpox (monkeypox)/immunology ; Mpox (monkeypox)/prevention & control ; Smallpox Vaccine ; Vaccines, Combined ; Vaccinia virus/genetics
    Chemical Substances Smallpox Vaccine ; Vaccines, Combined
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2024.01.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1167: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 58: Show issues

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  7. Book ; Audio / Video ; Online: Influenza virus infection of dendritic cells interferes with the immune response

    Vogel, Annette B.* / Vogel, Annette / Stitz, Lothar

    2012  

    Keywords dendritic cell
    Language English
    Publishing country de
    Document type Book ; Audio / Video ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  8. Book ; Audio / Video ; Online: Influenza virus infection of dendritic cells interferes with the immune response

    Vogel, Annette B.* / Vogel, Annette / Stitz, Lothar

    2012  

    Keywords Text ; dendritic cell
    Language English
    Publishing country de
    Document type Book ; Audio / Video ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article: Immunogenicity of stabilized HIV-1 Env trimers delivered by self-amplifying mRNA.

    Aldon, Yoann / McKay, Paul F / Moreno Herrero, Jorge / Vogel, Annette B / Lévai, Réka / Maisonnasse, Pauline / Dereuddre-Bosquet, Nathalie / Haas, Heinrich / Fábián, Katalin / Le Grand, Roger / Sahin, Ugur / Shattock, Robin J

    Molecular therapy. Nucleic acids

    2021  Volume 25, Page(s) 483–493

    Abstract: Self-amplifying mRNA (saRNA) represents a promising platform for nucleic acid delivery of vaccine immunogens. Unlike plasmid DNA, saRNA does not require entry into the nucleus of target cells for expression, having the capacity to drive higher protein ... ...

    Abstract Self-amplifying mRNA (saRNA) represents a promising platform for nucleic acid delivery of vaccine immunogens. Unlike plasmid DNA, saRNA does not require entry into the nucleus of target cells for expression, having the capacity to drive higher protein expression compared to mRNA as it replicates within the cytoplasm. In this study, we examined the potential of stabilized native-like HIV-1 Envelope glycoprotein (Env) trimers to elicit immune responses when delivered by saRNA polyplexes (PLXs), assembled with linear polyethylenimine. We showed that Venezuelan equine encephalitis virus (VEEV) saRNA induces a stronger humoral immune response to the encoded transgene compared to Semliki Forest virus saRNA. Moreover, we characterized the immunogenicity of the soluble and membrane-bound ConSOSL.UFO Env design in mice and showed a faster humoral kinetic and an immunoglobulin G (IgG)2a skew using a membrane-bound design. The immune response generated by PLX VEEV saRNA encoding the membrane-bound Env was then evaluated in larger animal models including macaques, in which low doses induced high IgG responses. Our data demonstrated that the VEEV saRNA PLX nanoparticle formulation represents a suitable platform for the delivery of stabilized HIV-1 Env and has the potential to be used in a variety of vaccine regimens.
    Language English
    Publishing date 2021-06-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2662631-7
    ISSN 2162-2531
    ISSN 2162-2531
    DOI 10.1016/j.omtn.2021.06.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The T-cell-directed vaccine BNT162b4 encoding conserved non-spike antigens protects animals from severe SARS-CoV-2 infection.

    Arieta, Christina M / Xie, Yushu Joy / Rothenberg, Daniel A / Diao, Huitian / Harjanto, Dewi / Meda, Shirisha / Marquart, Krisann / Koenitzer, Byron / Sciuto, Tracey E / Lobo, Alexander / Zuiani, Adam / Krumm, Stefanie A / Cadima Couto, Carla Iris / Hein, Stephanie / Heinen, André P / Ziegenhals, Thomas / Liu-Lupo, Yunpeng / Vogel, Annette B / Srouji, John R /
    Fesser, Stephanie / Thanki, Kaushik / Walzer, Kerstin / Addona, Theresa A / Türeci, Özlem / Şahin, Uğur / Gaynor, Richard B / Poran, Asaf

    Cell

    2023  Volume 186, Issue 11, Page(s) 2392–2409.e21

    Abstract: T cell responses play an important role in protection against beta-coronavirus infections, including SARS-CoV-2, where they associate with decreased COVID-19 disease severity and duration. To enhance T cell immunity across epitopes infrequently altered ... ...

    Abstract T cell responses play an important role in protection against beta-coronavirus infections, including SARS-CoV-2, where they associate with decreased COVID-19 disease severity and duration. To enhance T cell immunity across epitopes infrequently altered in SARS-CoV-2 variants, we designed BNT162b4, an mRNA vaccine component that is intended to be combined with BNT162b2, the spike-protein-encoding vaccine. BNT162b4 encodes variant-conserved, immunogenic segments of the SARS-CoV-2 nucleocapsid, membrane, and ORF1ab proteins, targeting diverse HLA alleles. BNT162b4 elicits polyfunctional CD4
    MeSH term(s) Animals ; Cricetinae ; Humans ; Antibodies, Neutralizing ; Antibodies, Viral ; BNT162 Vaccine ; COVID-19/prevention & control ; Epitopes ; SARS-CoV-2/genetics
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; BNT162 Vaccine ; Epitopes
    Language English
    Publishing date 2023-04-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2023.04.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1167: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 58: Show issues

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