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Article ; Online: Long-Term Follow-Up Following Stent-in-Stent for Stenosis Caused by Late Endothelialization of Self-Expanding Aortic Valve Struts.

Naganuma, Toru / Onishi, Hirokazu / Ouchi, Toru / Hozawa, Koji

2024 Volume 17, Issue 8, Page(s) 1050–1052

MeSH term(s)	Humans ; Aortic Valve Stenosis/surgery ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/physiopathology ; Treatment Outcome ; Time Factors ; Prosthesis Design ; Heart Valve Prosthesis ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Valve/physiopathology ; Stents ; Male ; Re-Epithelialization ; Heart Valve Prosthesis Implantation/instrumentation ; Heart Valve Prosthesis Implantation/adverse effects ; Aged ; Female ; Aged, 80 and over
Language	English
Publishing date	2024-03-20
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2452157-7
ISSN	1876-7605 ; 1936-8798
ISSN (online)	1876-7605
ISSN	1936-8798
DOI	10.1016/j.jcin.2024.01.289
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Article: Clinical impact of aortic valve replacement in patients with moderate mixed aortic valve disease.

Onishi, Hirokazu / Izumo, Masaki / Ouchi, Toru / Yuki, Haruhito / Naganuma, Toru / Nakao, Tatsuya / Nakamura, Sunao

Frontiers in cardiovascular medicine

2023 Volume 10, Page(s) 1259188

Abstract: Background: Information is scarce regarding the clinical implications of aortic valve replacement (AVR) for patients suffering from moderate mixed aortic valve disease (MAVD), characterized by a combination of moderate aortic stenosis (AS) and ... ...

Abstract	Background: Information is scarce regarding the clinical implications of aortic valve replacement (AVR) for patients suffering from moderate mixed aortic valve disease (MAVD), characterized by a combination of moderate aortic stenosis (AS) and regurgitation (AR). The objective of this retrospective study was to explore the clinical effects of AVR in individuals with moderate MAVD. Methods: We examined the clinical data from patients with moderate MAVD and preserved left ventricular ejection fraction, who had undergone echocardiography in the period spanning from 2010 to 2018. Moderate AS was defined as aortic valve area index of 0.60-0.85 cm Results: Among 88 patients (mean age, 74.4 ± 6.8 years; 48.9%, men), 44 (50.0%) required AVR during a median follow-up period of 3.3 years (interquartile range, 0.5-4.9). Mean values of specific aortic valve variables are as follows: aortic valve area index, 0.64 ± 0.04 cm Conclusions: Approximately half of the patients diagnosed with moderate MAVD eventually necessitated AVR throughout the period of observation, leading to positive clinical results. Vigilant tracking of these patients and watchful monitoring for signs requiring AVR during this time frame are essential.
Language	English
Publishing date	2023-08-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2023.1259188
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Article ; Online: Changes in pulmonary vein size and narrowing depend on the cardiac cycle before and after pulmonary vein isolation.

Ouchi, Kotaro / Sakuma, Toru / Kisaki, Shunsuke / Tokutake, Kenichi / Yamane, Teiichi / Ojiri, Hiroya

Heart and vessels

2024

Abstract: Accurate measurement of the pulmonary vein dimension (PVD) is important for determining stenosis and efficacy following pulmonary vein isolation (PVI). Little is known about the quantitative evaluation of the impact of the cardiac cycle on pulmonary vein ...

Abstract	Accurate measurement of the pulmonary vein dimension (PVD) is important for determining stenosis and efficacy following pulmonary vein isolation (PVI). Little is known about the quantitative evaluation of the impact of the cardiac cycle on pulmonary vein (PV) morphology before and after PVI. This study aims to investigate variations in the ostial size of the PV during the cardiac cycle before and after PVI and the effect of the cardiac cycle on PV stenosis and reduction rate using cardiac computed tomography (CT). Sixty-eight patients with atrial fibrillation who underwent cardiac CT before and after PVI at our institution between 23 January 2021 and 5 February 2022 were retrospectively analyzed. The maximum and minimum PVD were measured at each segment before and after the PV. Each PV was evaluated according to the PVD reduction rate (ΔPVD), calculated as follows: (1 - post-PVD/pre-PVD) × 100 (%). The average dimension of all PVs at the end-diastolic frame was significantly reduced compared to that at the end-systolic frame before PVI. The average dimensions of the right superior and right inferior PV at the end-diastolic frame were significantly reduced compared with those at the end-systolic frame following PVI. The average reduction rate of dimension-classified stenosis of PVs, except for the left inferior PV at the end-diastolic frame, was significantly reduced compared with that at the end-systolic frame. The cardiac cycle affects PVD assessment, including PV stenosis, after PVI. PVD measurement is recommended to be unified to the end-systolic frame of the cardiac cycle to avoid underestimating PV stenosis before and after PVI, ensuring appropriate management and follow-up.
Language	English
Publishing date	2024-03-25
Publishing country	Japan
Document type	Journal Article
ZDB-ID	89678-0
ISSN	1615-2573 ; 0910-8327 ; 0935-736X
ISSN (online)	1615-2573
ISSN	0910-8327 ; 0935-736X
DOI	10.1007/s00380-024-02378-6
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Zs.A 2049: Show issues

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Article ; Online: Prognostic relevance of B-type natriuretic peptide in patients with moderate mixed aortic valve disease.

Onishi, Hirokazu / Naganuma, Toru / Izumo, Masaki / Ouchi, Toru / Yuki, Haruhito / Mitomo, Satoru / Nakamura, Sunao

ESC heart failure

2022 Volume 9, Issue 4, Page(s) 2474–2483

Abstract: Aims: Data on B-type natriuretic peptide (BNP) levels and adverse outcomes in patients with moderate mixed aortic valve disease (MAVD), defined as moderate aortic stenosis (AS) and regurgitation (AR), are scarce. Therefore, this study investigated the ... ...

Abstract	Aims: Data on B-type natriuretic peptide (BNP) levels and adverse outcomes in patients with moderate mixed aortic valve disease (MAVD), defined as moderate aortic stenosis (AS) and regurgitation (AR), are scarce. Therefore, this study investigated the impact of BNP on the clinical outcomes in such patients. Methods and results: Clinical data from 81 patients (mean age, 74.1 ± 6.8 years; 50.6%, men) treated for moderate MAVD and left ventricular ejection fraction (LVEF) ≥ 50% during 2010-2018 were retrospectively analysed. Specific echocardiographic data of the study patients were LVEF of 57.8 ± 5.0%, aortic valve index of 0.64 ± 0.04 cm Conclusions: Patients with moderate MAVD are at higher risk of unfavourable clinical outcomes, and age and BNP are independently related to the occurrence of adverse events. High BNP levels may reflect extravalvular cardiac damage in patients with moderate MAVD.
MeSH term(s)	Aged ; Aged, 80 and over ; Aortic Valve Stenosis/diagnosis ; Aortic Valve Stenosis/surgery ; Female ; Humans ; Male ; Natriuretic Peptide, Brain ; Prognosis ; Retrospective Studies ; Stroke Volume ; Ventricular Function, Left
Chemical Substances	Natriuretic Peptide, Brain (114471-18-0)
Language	English
Publishing date	2022-05-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2814355-3
ISSN	2055-5822 ; 2055-5822
ISSN (online)	2055-5822
ISSN	2055-5822
DOI	10.1002/ehf2.13946
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Article ; Online: Accuracy of aortic valve calcification volume score for identification of significant aortic stenosis on non-electrocardiographic-gated computed tomography compared to the Agatston scoring system.

Ouchi, Kotaro / Sakuma, Toru / Nojiri, Ayumi / Kano, Rui / Higuchi, Takahiro / Hasumi, Jun / Suzuki, Takayuki / Ogihara, Akira / Ojiri, Hiroya / Kawai, Makoto

Journal of cardiovascular computed tomography

2024

Abstract: Background: Considering the absence of reports validating the precision of the volume score and the relationship between the volume and Agatston scores, this study evaluated the accuracy of the volume score compared to the Agatston score for the ... ...

Abstract	Background: Considering the absence of reports validating the precision of the volume score and the relationship between the volume and Agatston scores, this study evaluated the accuracy of the volume score compared to the Agatston score for the quantitative measurement of aortic valve calcification (AVC) on non-electrocardiographic-gated computed tomography (CT). Methods: We retrospectively analysed the AVC scores of 5385 patients who underwent transthoracic echocardiography between March 1, 2013 and December 26, 2019 at our institution, using non-contrast non-electrocardiographic-gated CT. The thresholds for significant aortic stenosis (AS) were computed using receiver operating characteristic curves based on the AVC scores. The area under the curve (AUC) of the Agatston and volume scores for significant AS were compared to evaluate the accuracy of the scoring method. Results: All sex-specific AVC thresholds of the volume score for significant AS (moderate and high AS severity, moderate and high AS severity without discordance, discordant severe AS, and concordant severe AS) showed high sensitivity and specificity (AUC, 0.978-0.996; sensitivity, 94.2-98.4%; specificity, 90.1-100%). No significant differences in the AUC were observed between the Agatston and volume scores for significant AS in male and female patients. Conclusion: All volume score threshold values showed high sensitivity and specificity for identifying significant AS. The accuracy of the test for AVC thresholds of the volume score for significant AS was comparable to that of the Agatston score. Our findings raise questions about the significance of weighting calcium density in the Agatston score for assessing AS severity.
Language	English
Publishing date	2024-03-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2394360-9
ISSN	1876-861X ; 1934-5925
ISSN (online)	1876-861X
ISSN	1934-5925
DOI	10.1016/j.jcct.2024.03.014
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Zs.A 6761: Show issues

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Article: Current Practice and Barriers to the Implementation of Mobilization in ICUs in Japan: A Multicenter Prospective Cohort Study.

Sakuramoto, Hideaki / Nakamura, Kensuke / Ouchi, Akira / Okamoto, Saiko / Watanabe, Shinichi / Liu, Keibun / Morita, Yasunari / Katsukawa, Hajime / Kotani, Toru

Journal of clinical medicine

2023 Volume 12, Issue 12

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2023-06-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12123955
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Article ; Online: Serious Complication of Anticoagulation in Vessel Thrombosis-associated Behçet Disease.

Ouchi, Kotaro / Narui, Ryosuke / Sakuma, Toru / Ojiri, Hiroya

Internal medicine (Tokyo, Japan)

2020 Volume 59, Issue 13, Page(s) 1615–1620

Abstract: Anticoagulation in venous thrombosis associated with Behçet disease (BD) is controversial. We herein report a 47-year-old woman with vessel thrombosis and pulmonary artery aneurysm (PAA) associated with BD who died of massive hemoptysis under oral ... ...

Abstract	Anticoagulation in venous thrombosis associated with Behçet disease (BD) is controversial. We herein report a 47-year-old woman with vessel thrombosis and pulmonary artery aneurysm (PAA) associated with BD who died of massive hemoptysis under oral anticoagulant. Although she was initially diagnosed with oral contraceptive-induced venous thromboembolism, a subsequent investigation led to a diagnosis of BD. Follow-up computed tomography (CT) showed persistent thrombus, so anticoagulant was continued for persistent thrombus. She died of massive hemoptysis after the development of PAA was identified on follow-up CT during the period of anticoagulation. Great care to prevent bleeding events is required when administering anticoagulants for BD with vessel thrombosis.
MeSH term(s)	Aneurysm/complications ; Anticoagulants/adverse effects ; Behcet Syndrome/complications ; Female ; Hemoptysis/etiology ; Humans ; Middle Aged ; Pulmonary Artery/pathology ; Thrombosis/complications ; Tomography, X-Ray Computed/adverse effects ; Venous Thrombosis/complications ; Venous Thrombosis/drug therapy
Chemical Substances	Anticoagulants
Language	English
Publishing date	2020-03-26
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.4109-19
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Zs.A 240: Show issues

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Article ; Online: Risk of Psoas Muscle Atrophy After Endovascular Aneurysm Repair Assessed by Cross-Sectional Psoas Muscle Area.

Ouchi, Kotaro / Oki, Yohei / Sakuma, Toru / Ojiri, Hiroya

Cardiovascular and interventional radiology

2020 Volume 43, Issue 7, Page(s) 981–986

Abstract: Purpose: We evaluated possible association of decreased psoas muscle area (PMA) after endovascular aneurysm repair (EVAR) by measuring the area of muscle in computed tomographic (CT) images.: Materials and methods: We retrospectively reviewed CT ... ...

Abstract	Purpose: We evaluated possible association of decreased psoas muscle area (PMA) after endovascular aneurysm repair (EVAR) by measuring the area of muscle in computed tomographic (CT) images. Materials and methods: We retrospectively reviewed CT images of 201 consecutive patients who underwent EVAR at our institution between April 1, 2015, and November 9, 2018, and compared them with images of 75 consecutive patients with no history of EVAR, who served as controls and underwent thoracic endovascular aortic repair (TEVAR) during the same period. We investigated EVAR and possible associated factors that might be potential predictors of decrease in PMA. Results: Those patients with a history of EVAR demonstrated significantly greater mean decrease in PMA than those with a history of TEVAR after the repair procedure (mean 6.25% (8.5); P < 0.001; odds ratio [OR], 3.63; 95% confidence interval [CI] 1.90-6.90). Conclusion: Although EVAR is a less stressful procedure than other major abdominal surgeries, we identified it as an independent predictor of decreased area of the psoas muscle. Thus, our results might encourage post-procedural evaluation of frailty associated with psoas muscle function and prescription of appropriate rehabilitation interventions after EVAR to help prevent deterioration of patients' abilities.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Aortic Aneurysm, Abdominal/surgery ; Endovascular Procedures/adverse effects ; Endovascular Procedures/methods ; Evaluation Studies as Topic ; Female ; Humans ; Male ; Middle Aged ; Muscular Atrophy/diagnostic imaging ; Muscular Atrophy/etiology ; Muscular Atrophy/pathology ; Postoperative Complications/diagnostic imaging ; Postoperative Complications/etiology ; Postoperative Complications/pathology ; Psoas Muscles/diagnostic imaging ; Psoas Muscles/pathology ; Retrospective Studies ; Risk Assessment/methods ; Tomography, X-Ray Computed/methods ; Treatment Outcome
Language	English
Publishing date	2020-05-15
Publishing country	United States
Document type	Evaluation Study ; Journal Article
ZDB-ID	603082-8
ISSN	1432-086X ; 0342-7196 ; 0174-1551
ISSN (online)	1432-086X
ISSN	0342-7196 ; 0174-1551
DOI	10.1007/s00270-020-02500-x
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Zs.A 1378: Show issues

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Article ; Online: A Predictor for Defects in Filling of the Left Atrial Appendage on Cardiac Computed Tomography in Patients With Atrial Fibrillation.

Ouchi, Kotaro / Sakuma, Toru / Ojiri, Hiroya

Journal of computer assisted tomography

2020 Volume 44, Issue 2, Page(s) 284–288

Abstract: Purpose: The aim of this study was to identify possible predictors for findings of left atrial appendage (LAA) filling defects in patients with atrial fibrillation (AF) on cardiac computed tomography (CT).: Materials and methods: We retrospectively ... ...

Abstract	Purpose: The aim of this study was to identify possible predictors for findings of left atrial appendage (LAA) filling defects in patients with atrial fibrillation (AF) on cardiac computed tomography (CT). Materials and methods: We retrospectively evaluated findings of LAA filling defects on the early phase of cardiac CT of 63 patients with history of AF and compared those images with those of 63 control subjects. We investigated potential predictors for LAA filling defects. Results: Filling defects of the LAA correlated significantly with patient history of persistent AF (P = 0.045; odds ratio [OR], 3.17), chicken wing morphology (P = 0.013; OR, 4.12), and with LAA volume (P = 0.0032; OR, 1.19) of 12.53 cm or greater (sensitivity, 87.3%; specificity, 69.8%). Conclusions: We observed persistent AF, the chicken wing type of LAA morphology, and LAA volume as independent predictors of LAA filling defects on cardiac CT. These findings might improve cardiac CT scanning protocol.
MeSH term(s)	Atrial Appendage/diagnostic imaging ; Atrial Appendage/physiopathology ; Atrial Fibrillation/diagnostic imaging ; Atrial Fibrillation/physiopathology ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors ; Sensitivity and Specificity ; Tomography, X-Ray Computed/methods
Language	English
Publishing date	2020-03-18
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	80392-3
ISSN	1532-3145 ; 0363-8715
ISSN (online)	1532-3145
ISSN	0363-8715
DOI	10.1097/RCT.0000000000000984
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Zs.A 1388: Show issues

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Article: H2AX mRNA expression reflects DNA repair, cell proliferation, metastasis, and worse survival in breast cancer.

Katsuta, Eriko / Sawant Dessai, Abhisha / Ebos, John Ml / Yan, Li / Ouchi, Toru / Takabe, Kazuaki

American journal of cancer research

2022 Volume 12, Issue 2, Page(s) 793–804

Abstract: The phosphorylated histone variant, γ-H2AX, is known to play a key role in DNA damage repair. However, the clinical significance of H2AX mRNA expression in breast cancer remains unclear. Utilizing a bioinformatical approach, a total of 3594 breast cancer ...

Abstract	The phosphorylated histone variant, γ-H2AX, is known to play a key role in DNA damage repair. However, the clinical significance of H2AX mRNA expression in breast cancer remains unclear. Utilizing a bioinformatical approach, a total of 3594 breast cancer patients with clinical and transcriptomic data were investigated. Bioinformatical analysis showed that high expression of H2AX is associated with worse disease-free, disease-specific, and overall survival consistently in two independent cohorts. High H2AX expressing tumors were associated with upregulated DNA repair gene sets. Although H2AX was not predictive of chemotherapy response, it was significantly downregulated after effective chemotherapy or radio-chemotherapy. Notably, tumors with high H2AX expression were enriched for DNA replication and MYC targets gene sets, and associated with increased MKI67 expression, suggesting alterations in cell proliferation machinery. H2AX knockdown cells showed decreased cell proliferation as compared to the control cells. Finally, H2AX mRNA expression was higher in the metastatic clones as compared to the parental cells and in the metastatic tumors as compared to the primary tumors in patients, with higher H2AX mRNA expression found in advanced stage cancer patients. In conclusion, high H2AX mRNA expression is associated with increased DNA repair, cell proliferation, metastasis, and worse survival in breast cancer patients.
Language	English
Publishing date	2022-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2589522-9
ISSN	2156-6976
ISSN	2156-6976
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