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Article ; Online: A multi-omics dataset for the analysis of frontotemporal dementia genetic subtypes.

2023 Volume 10, Issue 1, Page(s) 849

Abstract: Understanding the molecular mechanisms underlying frontotemporal dementia (FTD) is essential for the development of successful therapies. Systematic studies on human post-mortem brain tissue of patients with genetic subtypes of FTD are currently lacking. ...

Abstract	Understanding the molecular mechanisms underlying frontotemporal dementia (FTD) is essential for the development of successful therapies. Systematic studies on human post-mortem brain tissue of patients with genetic subtypes of FTD are currently lacking. The Risk and Modyfing Factors of Frontotemporal Dementia (RiMod-FTD) consortium therefore has generated a multi-omics dataset for genetic subtypes of FTD to identify common and distinct molecular mechanisms disturbed in disease. Here, we present multi-omics datasets generated from the frontal lobe of post-mortem human brain tissue from patients with mutations in MAPT, GRN and C9orf72 and healthy controls. This data resource consists of four datasets generated with different technologies to capture the transcriptome by RNA-seq, small RNA-seq, CAGE-seq, and methylation profiling. We show concrete examples on how to use the resulting data and confirm current knowledge about FTD and identify new processes for further investigation. This extensive multi-omics dataset holds great value to reveal new research avenues for this devastating disease.
MeSH term(s)	Humans ; Frontal Lobe ; Frontotemporal Dementia/genetics ; Multiomics ; Mutation
Language	English
Publishing date	2023-12-01
Publishing country	England
Document type	Dataset ; Journal Article
ZDB-ID	2775191-0
ISSN	2052-4463 ; 2052-4463
ISSN (online)	2052-4463
ISSN	2052-4463
DOI	10.1038/s41597-023-02598-x
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Article ; Online: Automated Production of Human Induced Pluripotent Stem Cell-Derived Cortical and Dopaminergic Neurons with Integrated Live-Cell Monitoring.

Dhingra, Ashutosh / Täger, Joachim / Bressan, Elisangela / Rodriguez-Nieto, Salvador / Bedi, Manmeet-Sakshi / Bröer, Stefanie / Sadikoglou, Eldem / Fernandes, Noémia / Castillo-Lizardo, Melissa / Rizzu, Patrizia / Heutink, Peter

Journal of visualized experiments : JoVE

2020 , Issue 162

Abstract: Manual culture and differentiation protocols for human induced pluripotent stem cells (hiPSC) are difficult to standardize, show high variability and are prone to spontaneous differentiation into unwanted cell types. The methods are labor-intensive and ... ...

Abstract	Manual culture and differentiation protocols for human induced pluripotent stem cells (hiPSC) are difficult to standardize, show high variability and are prone to spontaneous differentiation into unwanted cell types. The methods are labor-intensive and are not easily amenable to large-scale experiments. To overcome these limitations, we developed an automated cell culture system coupled to a high-throughput imaging system and implemented protocols for maintaining multiple hiPSC lines in parallel and neuronal differentiation. We describe the automation of a short-term differentiation protocol using Neurogenin-2 (NGN2) over-expression to produce hiPSC-derived cortical neurons within 6‒8 days, and the implementation of a long-term differentiation protocol to generate hiPSC-derived midbrain dopaminergic (mDA) neurons within 65 days. Also, we applied the NGN2 approach to a small molecule-derived neural precursor cells (smNPC) transduced with GFP lentivirus and established a live-cell automated neurite outgrowth assay. We present an automated system with protocols suitable for routine hiPSC culture and differentiation into cortical and dopaminergic neurons. Our platform is suitable for long term hands-free culture and high-content/high-throughput hiPSC-based compound, RNAi and CRISPR/Cas9 screenings to identify novel disease mechanisms and drug targets.
MeSH term(s)	Automation ; Carbon Dioxide ; Cell Count ; Cell Culture Techniques/methods ; Cell Differentiation ; Cell Survival ; Cells, Cultured ; Cerebral Cortex/cytology ; Dopaminergic Neurons/cytology ; Humans ; Image Processing, Computer-Assisted ; Induced Pluripotent Stem Cells/cytology ; Mesencephalon/cytology ; Neural Stem Cells/cytology ; Neuronal Outgrowth ; User-Computer Interface
Chemical Substances	Carbon Dioxide (142M471B3J)
Language	English
Publishing date	2020-08-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Video-Audio Media
ZDB-ID	2259946-0
ISSN	1940-087X ; 1940-087X
ISSN (online)	1940-087X
ISSN	1940-087X
DOI	10.3791/61525
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Article ; Online: A multi-omics dataset for the analysis of frontotemporal dementia genetic subtypes

Scientific Data, Vol 10, Iss 1, Pp 1-

2023 Volume 8

Abstract: Abstract Understanding the molecular mechanisms underlying frontotemporal dementia (FTD) is essential for the development of successful therapies. Systematic studies on human post-mortem brain tissue of patients with genetic subtypes of FTD are currently ...

Abstract	Abstract Understanding the molecular mechanisms underlying frontotemporal dementia (FTD) is essential for the development of successful therapies. Systematic studies on human post-mortem brain tissue of patients with genetic subtypes of FTD are currently lacking. The Risk and Modyfing Factors of Frontotemporal Dementia (RiMod-FTD) consortium therefore has generated a multi-omics dataset for genetic subtypes of FTD to identify common and distinct molecular mechanisms disturbed in disease. Here, we present multi-omics datasets generated from the frontal lobe of post-mortem human brain tissue from patients with mutations in MAPT, GRN and C9orf72 and healthy controls. This data resource consists of four datasets generated with different technologies to capture the transcriptome by RNA-seq, small RNA-seq, CAGE-seq, and methylation profiling. We show concrete examples on how to use the resulting data and confirm current knowledge about FTD and identify new processes for further investigation. This extensive multi-omics dataset holds great value to reveal new research avenues for this devastating disease.
Keywords	Science ; Q
Subject code	616
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The antiangiogenic compound aeroplysinin-1 induces apoptosis in endothelial cells by activating the mitochondrial pathway.

Martínez-Poveda, Beatriz / Rodríguez-Nieto, Salvador / García-Caballero, Melissa / Medina, Miguel-Ángel / Quesada, Ana R

Marine drugs

2012 Volume 10, Issue 9, Page(s) 2033–2046

Abstract: Aeroplysinin-1 is a brominated metabolite extracted from the marine sponge Aplysina aerophoba that has been previously characterized by our group as a potent antiangiogenic compound in vitro and in vivo. In this work, we provide evidence of a selective ... ...

Abstract	Aeroplysinin-1 is a brominated metabolite extracted from the marine sponge Aplysina aerophoba that has been previously characterized by our group as a potent antiangiogenic compound in vitro and in vivo. In this work, we provide evidence of a selective induction of apoptosis by aeroplysinin-1 in endothelial cells. Studies on the nuclear morphology of treated cells revealed that aeroplysinin-1 induces chromatin condensation and nuclear fragmentation, and it increases the percentage of cells with sub-diploid DNA content in endothelial, but not in HCT-116, human colon carcinoma and HT-1080 human fibrosarcoma cells. Treatment of endothelial cells with aeroplysinin-1 induces activation of caspases-2, -3, -8 and -9, as well as the cleavage of apoptotic substrates, such as poly (ADP-ribose) polymerase and lamin-A in a caspase-dependent mechanism. Our data indicate a relevant role of the mitochondria in the apoptogenic activity of this compound. The observation that aeroplysinin-1 prevents the phosphorylation of Bad relates to the mitochondria-mediated induction of apoptosis by this compound.
MeSH term(s)	Acetonitriles/pharmacology ; Angiogenesis Inhibitors/pharmacology ; Animals ; Apoptosis/drug effects ; Caspases/metabolism ; Cattle ; Cell Line ; Cell Line, Tumor ; Cell Nucleus/drug effects ; Cell Nucleus/metabolism ; Chromatin/metabolism ; Cyclohexenes/pharmacology ; Cytochromes c/drug effects ; DNA Fragmentation/drug effects ; Endothelial Cells/drug effects ; Endothelial Cells/metabolism ; HCT116 Cells ; Human Umbilical Vein Endothelial Cells ; Humans ; Lamin Type A/metabolism ; Mitochondria/drug effects ; Mitochondria/metabolism ; Phosphorylation/drug effects ; Poly(ADP-ribose) Polymerases/metabolism ; bcl-Associated Death Protein/metabolism
Chemical Substances	Acetonitriles ; Angiogenesis Inhibitors ; BAD protein, human ; Chromatin ; Cyclohexenes ; Lamin Type A ; bcl-Associated Death Protein ; aeroplysinin I (28656-91-9) ; Cytochromes c (9007-43-6) ; Poly(ADP-ribose) Polymerases (EC 2.4.2.30) ; Caspases (EC 3.4.22.-)
Language	English
Publishing date	2012-09-18
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175190-0
ISSN	1660-3397 ; 1660-3397
ISSN (online)	1660-3397
ISSN	1660-3397
DOI	10.3390/md10092033
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Article ; Online: Role of alterations in the apoptotic machinery in sensitivity of cancer cells to treatment.

Rodriguez-Nieto, Salvador / Zhivotovsky, Boris

Current pharmaceutical design

2006 Volume 12, Issue 34, Page(s) 4411–4425

Abstract: Apoptosis is a genetically controlled and evolutionarily conserved form of cell death of critical importance for normal embryonic development and for the maintenance of tissue homeostasis in the adult organism. The malfunction of the death machinery may ... ...

Abstract	Apoptosis is a genetically controlled and evolutionarily conserved form of cell death of critical importance for normal embryonic development and for the maintenance of tissue homeostasis in the adult organism. The malfunction of the death machinery may play a primary or secondary role in various diseases, with essentially too little or too much apoptosis leading to proliferative or degenerative diseases, respectively. The machinery responsible for killing and degradation of the cell via apoptosis is expressed constitutively and become activated through various stimuli. Apoptotic mechanisms are operating during spontaneous regression of tumors as well as in response to treatment with anti-neoplastic drugs. The therapeutic goal in cancer treatment is to trigger tumor-selective cell death. However, resistance to treatment is a concern for many types of cancer. Since many anti-neoplastic agents induce an apoptotic type of death in susceptible cells, it is likely that defects or dysregulation of different steps of the apoptotic pathways might be an important determinant of resistance to anticancer drugs. These defects might appear at the initiation and/or execution stages of apoptosis and result in the insufficient elimination of tumor cells, which might lead either to acquired resistance to treatment, or to uncontrolled migration of cancer cells and metastasis. Hence, identification and targeting of the disabled pathway, which is most efficiently inactivated in a particular type of tumor might be the most successful approach in the future. Here we review current knowledge concerning function of apoptotic machinery in cancer cells, and how this information can be used to increase the efficiency of tumor treatment.
MeSH term(s)	Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Apoptosis/drug effects ; Apoptosis/genetics ; Cell Transformation, Neoplastic/genetics ; Clinical Trials as Topic ; Drug Resistance, Neoplasm ; Gene Expression Regulation, Neoplastic ; Genomic Instability ; Humans ; Mutation ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/pathology ; Oncogenes/genetics ; Signal Transduction/drug effects
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2006-01-23
Publishing country	United Arab Emirates
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/138161206779010495
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Article: Automated production of human induced pluripotent stem cell-derived cortical and dopaminergic neurons with integrated live-cell monitoring

Journal of visualized experiments. 2020 Aug. 06, , no. 162

2020

Abstract	Manual culture and differentiation protocols for human induced pluripotent stem cells (hiPSC) are difficult to standardize, show high variability and are prone to spontaneous differentiation into unwanted cell types. The methods are labor-intensive and are not easily amenable to large-scale experiments. To overcome these limitations, we developed an automated cell culture system coupled to a high-throughput imaging system and implemented protocols for maintaining multiple hiPSC lines in parallel and neuronal differentiation. We describe the automation of a short-term differentiation protocol using Neurogenin-2 (NGN2) over-expression to produce hiPSC-derived cortical neurons within 6‒8 days, and the implementation of a long-term differentiation protocol to generate hiPSC-derived midbrain dopaminergic (mDA) neurons within 65 days. Also, we applied the NGN2 approach to a small molecule-derived neural precursor cells (smNPC) transduced with GFP lentivirus and established a live-cell automated neurite outgrowth assay. We present an automated system with protocols suitable for routine hiPSC culture and differentiation into cortical and dopaminergic neurons. Our platform is suitable for long term hands-free culture and high-content/high-throughput hiPSC-based compound, RNAi and CRISPR/Cas9 screenings to identify novel disease mechanisms and drug targets.
Keywords	CRISPR-Cas systems ; Lentivirus ; automation ; brain ; cell culture ; drugs ; humans ; neurites
Language	English
Dates of publication	2020-0806
Size	p. e61525.
Publishing place	Journal of Visualized Experiments
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2259946-0
ISSN	1940-087X
ISSN	1940-087X
DOI	10.3791/61525
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Article ; Online: BRG1 and LKB1: tales of two tumor suppressor genes on chromosome 19p and lung cancer.

Rodriguez-Nieto, Salvador / Sanchez-Cespedes, Montse

Carcinogenesis

2009 Volume 30, Issue 4, Page(s) 547–554

Abstract: Losses of heterozygosity (LOH) of the short arm of chromosome 19 are frequent in lung cancer, suggesting that one or more tumor suppressor genes are present in this region. The LKB1 gene, also called STK11, is somatically inactivated through point ... ...

Abstract	Losses of heterozygosity (LOH) of the short arm of chromosome 19 are frequent in lung cancer, suggesting that one or more tumor suppressor genes are present in this region. The LKB1 gene, also called STK11, is somatically inactivated through point mutations and large deletions in lung tumors, demonstrating that LKB1 is a target of the LOH of this chromosomal arm. Data from several independent groups have provided information about the profiles of lung tumors with LKB1 inactivation and it is generally agreed that this alteration strongly predominates in non-small cell lung cancer, in particular adenocarcinomas, in smokers. The LKB1 protein has serine-threonine kinase activity and is involved in the regulation of the cell energetic checkpoint through the phosphorylation and activation of adenosine monophosphate-dependent kinase (AMPK). LKB1 is also involved in other processes such as cell polarization, probably through substrates other than AMPK. Interestingly, another gene on chromosome 19p, BRG1, encoding a component of the SWI/SNF chromatin-remodeling complex, has emerged as a tumor suppressor gene that is altered in lung tumors. Similar to LKB1, BRG1 is somatically inactivated by point mutations or large deletions in lung tumors featuring LOH of chromosome 19p. These observations suggest an important role for BRG1 in lung cancer and highlight the need to further our understanding of the function of Brahma/SWI2-related gene 1 (BRG1) in cancer. Finally, simultaneous mutations at LKB1 and BRG1 are common in lung cancer cells, which exemplifies how a single event, LOH of chromosome 19p in this instance, targets two different tumor suppressors.
MeSH term(s)	Chromosomes, Human, Pair 19/genetics ; DNA Helicases/physiology ; Genes, Tumor Suppressor/physiology ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Nuclear Proteins/physiology ; Protein-Serine-Threonine Kinases/physiology ; Transcription Factors/physiology
Chemical Substances	Nuclear Proteins ; Transcription Factors ; STK11 protein, human (EC 2.7.1.-) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; SMARCA4 protein, human (EC 3.6.1.-) ; DNA Helicases (EC 3.6.4.-)
Language	English
Publishing date	2009-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	603134-1
ISSN	1460-2180 ; 0143-3334
ISSN (online)	1460-2180
ISSN	0143-3334
DOI	10.1093/carcin/bgp035
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Article ; Online: Sensitization to textile dyes in Spain: Epidemiological situation (2019-2022).

Hernández Fernández, Carlos Pelayo / Borrego, Leopoldo / Giménez Arnau, Ana María / Zaragoza Ninet, Violeta / Sanz Sánchez, Tatiana / Miquel Miquel, Francisco Javier / González Pérez, Ricardo / Silvestre Salvador, Juan Francisco / Córdoba Guijarro, Susana / Carrascosa Carrillo, José Manuel / Gatica Ortega, María Elena / Ruiz González, Inmaculada / Mercader García, Pedro / Tous Romero, Fátima / Serra Baldrich, Esther / Pastor-Nieto, María Antonia / Rodríguez Serna, Mercedes / Sánchez Pérez, Javier / Sánchez Gilo, Araceli /

Melé Ninot, Gemma / Sánchez-Pedreño Guillén, Paloma / de Vega Martínez, Marina / Descalzo, Miguel Ángel Gallego / Doval, Ignacio García

Contact dermatitis

2024 Volume 90, Issue 5, Page(s) 486–494

Abstract: Background: Current frequency and features for positivity to textile dye mix (TDM) in Spain are unknown.: Objectives: To study the frequency, clinical features and simultaneous positivity between TDM, para-phenylenediamine (PPD) and specific disperse ...

Abstract	Background: Current frequency and features for positivity to textile dye mix (TDM) in Spain are unknown. Objectives: To study the frequency, clinical features and simultaneous positivity between TDM, para-phenylenediamine (PPD) and specific disperse dyes. Materials and methods: We analysed all consecutive patients patch-tested with TDM from the Spanish Contact Dermatitis Registry (REIDAC), from 1 January 2019 to 31 December 2022. Within this group, we studied all selected patients patch-tested with a textile dye series. Results: Out of 6128 patients analysed, 3.3% were positive to the TDM and in 34% of them, the sensitization was considered currently relevant. TDM positivity was associated with working as a hairdresser/beautician and scalp, neck/trunk and arm/forearm dermatitis. From TDM-positive patients, 57% were positive to PPD. One hundred and sixty-four patients were patch-tested with the textile dye series. Disperse Orange 3 was the most frequent positive dye (16%). One of every six cases positive to any dye from the textile dye series would have been missed if patch-tested with the TDM alone. Conclusions: Positivity to TDM is common in Spain and often associated with PPD sensitization. TDM is a valuable marker of disperse dyes allergy that should be part of the Spanish and European standard series.
MeSH term(s)	Humans ; Dermatitis, Allergic Contact/epidemiology ; Dermatitis, Allergic Contact/etiology ; Spain/epidemiology ; Textiles/adverse effects ; Patch Tests ; Coloring Agents/adverse effects
Chemical Substances	Coloring Agents
Language	English
Publishing date	2024-02-13
Publishing country	England
Document type	Journal Article
ZDB-ID	193121-0
ISSN	1600-0536 ; 0105-1873
ISSN (online)	1600-0536
ISSN	0105-1873
DOI	10.1111/cod.14513
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Article ; Online: [Translated article] Four-year Epidemiological Surveillance of the Spanish Registry of Research in Contact Dermatitis and Cutaneous Allergy: Current Situation and Trends.

Tous-Romero, F / Borrego-Hernando, L / García-Doval, I / Mercader-García, P / Silvester-Salvador, J F / Sánchez-Gilo, A / Sanz-Sánchez, T / Giménez-Arnau, A M / Zaragoza-Ninet, V / Miquel-Miquel, J / González Pérez, R / Córdoba-Guijarro, S / Carrascosa-Carrillo, J M / Gática-Ortega, M E / Ruíz-González, I / Serra-Baldrich, E / Pastor-Nieto, A / Rodríguez-Serna, M / Sánchez-Pérez, J /

Melé I Ninot, G / Sánchez-Pedreño Guillén, P / Ortiz-de Frutos, J

Actas dermo-sifiliograficas

2024 Volume 115, Issue 4, Page(s) T331–T340

Abstract: Background: The epidemiological surveillance of contact dermatitis is one of the objectives of the Spanish Registry of Research in Contact Dermatitis and Cutaneous Allergy. Knowing whether the prevalence of positive tests to the different allergens ... ...

Abstract	Background: The epidemiological surveillance of contact dermatitis is one of the objectives of the Spanish Registry of Research in Contact Dermatitis and Cutaneous Allergy. Knowing whether the prevalence of positive tests to the different allergens changes over time is important for this monitoring process. Objectives: To describe the various temporary trends in allergen positivity in the GEIDAC standard series from 2018 through December 31, 2022. Methods: This was a multicenter, observational trial of consecutive patients analyzed via patch tests as part of the study of possible allergic contact dermatitises collected prospectively within the Spanish Registry of Research in Contact Dermatitis and Cutaneous Allergy. The data was analyzed using 2 statistical tests: one homogeneity test (to describe the changes seen over time) and one trend test (to see whether the changes described followed a linear trend). Results: A total of 11327 patients were included in the study. Overall, the allergens associated with a highest sensitization were nickel sulfate, methylisothiazolinone, cobalt chloride, methylchloroisothiazolinone/methylisothiazolinone, and fragrance mix i. A statistically significant decrease was found in the percentage of methylisothiazolinone positive tests across the study years with an orderly trend. Conclusions: Although various changes were seen in the sensitizations trends to several allergens of the standard testing, it became obvious that a high sensitization to nickel, methylchloroisothiazolinone/methylisothiazolinone and fragrances mix i remained. Only a significant downward trend was seen for methylisothiazolinone.
MeSH term(s)	Humans ; Allergens ; Dermatitis, Allergic Contact/diagnosis ; Dermatitis, Allergic Contact/epidemiology ; Dermatitis, Allergic Contact/etiology ; Dermatitis, Atopic ; Patch Tests ; Retrospective Studies ; Thiazoles
Chemical Substances	2-methyl-4-isothiazolin-3-one (229D0E1QFA) ; 5-chloro-2-methyl-4-isothiazolin-3-one (DEL7T5QRPN) ; Allergens ; Thiazoles
Language	Spanish
Publishing date	2024-02-07
Publishing country	Spain
Document type	Observational Study ; Multicenter Study ; Journal Article
ZDB-ID	390255-9
ISSN	1578-2190 ; 0001-7310 ; 1138-8196
ISSN (online)	1578-2190
ISSN	0001-7310 ; 1138-8196
DOI	10.1016/j.ad.2024.02.006
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Article: Shared Decision-Making in Allergen Immunotherapy (AIT) Options Using a Questionnaire for Respiratory Allergic Patients: A Delphi Consensus Study.

Antón, Mónica / Cabañes, Nieves / Fernández-Meléndez, Salvador / Fernández-Nieto, Mar / Jiménez-Ferrera, Gloria / Letrán, Antonio / Méndez-Brea, Paula / Montoro, Javier / Moreno, Francisco / Mur-Gimeno, Pilar / Rodríguez-Vázquez, Virginia / Rosado, Ana / Sánchez-Guerrero, Inmaculada / Vega-Chicote, Jose Mª / Vidal, Carmen

Patient preference and adherence

2023 Volume 17, Page(s) 1771–1782

Abstract: Purpose: The objective of this study was to develop and validate a questionnaire, through a Delphi consensus, to be used by allergists in their routine clinical practice to assess the preferences of patients starting allergen immunotherapy (AIT) ... ...

Abstract	Purpose: The objective of this study was to develop and validate a questionnaire, through a Delphi consensus, to be used by allergists in their routine clinical practice to assess the preferences of patients starting allergen immunotherapy (AIT) treatment using an objective approach. Patients and methods: A Delphi consensus-driven process was used. The scientific committee, composed of 15 allergists, led the study and participated in the preparation of the questionnaire. Two-hundred panelists from different Spanish regions were invited to complete a 16-item questionnaire on a nine-point Likert scale covering six topic blocks. Consensus was achieved if ≥66.6% of panelists reached agreement or disagreement. Results: Of the 200 experts invited to participate in the Delphi process, a total of 195 (97.5%) answered the questionnaire. The panel experts reached a consensus on "agreement" on a total of 12 of the 16 (75.0%) items, covering a total of six categories: (a) patient knowledge (2 questions), (b) barriers to patient adherence (3 questions), (c) patient behavior (4 questions), (d) future actions (3 questions), (e) treatment costs (2 questions), and (f) final patient preferences (2 questions). Conclusion: This Delphi consensus study validated a set of twelve recommended questions for patients objectively assessing their preferences and suitability for the most common AIT options available. The questionnaire intends to assist allergists in making an objective, unconditioned decision regarding the best AIT option for each patient, after informing them about the different routes.
Language	English
Publishing date	2023-07-24
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2455848-5
ISSN	1177-889X
ISSN	1177-889X
DOI	10.2147/PPA.S409466
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