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Article ; Online: Impact of a new conceptualized anti-reflux Trumpet stent on the quality of life of patients with advanced carcinoma of the cardio-oesophageal junction.

Tata, Mahadevan D / Mahazir, Nur Q A / Keat, Ooi W / Burud, Ismail A S

2023 Volume 56, Issue 2, Page(s) 95–99

Abstract: Objectives: To evaluate a newly developed, self-expandable anti-reflux Trumpet (ART) stent customized for cardio oesophageal junctional (COJ) cancer on the feasibility of deployment, stent migration, quality of life, and symptom relief.: Design: ... ...

Abstract	Objectives: To evaluate a newly developed, self-expandable anti-reflux Trumpet (ART) stent customized for cardio oesophageal junctional (COJ) cancer on the feasibility of deployment, stent migration, quality of life, and symptom relief. Design: Prospective case series, Proof of concept pilot study. Setting: Tertiary Health Care Center, Hospital Tuanku Jaafar, Seremban, Malaysia. Department of Surgery. Participants: A total of 17 patients diagnosed with advanced COJ tumour and who had never undergone any surgical, endoscopic, or chemoradiotherapy and indicated for stenting were recruited. Interventions: The study period was over nine months, and follow-up was one-month post-stenting. Main outcome measures: Endpoint measures were feasibility of deployment of the new design, symptoms relief, early stent migration, early complication, GERD Q score, and (QOL)assessment. Results: The ART stent was inserted successfully in all cases (17/17, 100%). There were two stent migrations due to the flexibility of the stent at the neck. There were no early or post-stenting one-month complications associated with the procedure. A good flow of contrast was seen in all the stents deployed. GERD Q score was low in all patients pre and post-stenting. Post-stenting there was a relief of dysphagia, weight gain, and a 60% improvement in QOL score. Conclusions: ART stent is feasible and technically successful in COJ tumours. It provides good symptom relief, improves the QOL, and has minimal early complications. Funding: None declared.
MeSH term(s)	Humans ; Quality of Life ; Pilot Projects ; Esophageal Neoplasms/therapy ; Esophageal Neoplasms/complications ; Palliative Care/methods ; Gastroesophageal Reflux/therapy ; Gastroesophageal Reflux/complications ; Carcinoma ; Stents ; Treatment Outcome
Language	English
Publishing date	2023-07-11
Publishing country	Ghana
Document type	Journal Article
ZDB-ID	2259233-7
ISSN	2616-163X ; 2616-163X
ISSN (online)	2616-163X
ISSN	2616-163X
DOI	10.4314/gmj.v56i2.6
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Article ; Online: Multiplex electrochemical sensing platforms for the detection of breast cancer biomarkers.

O'Brien, Connor / Khor, Chun Keat / Ardalan, Sina / Ignaszak, Anna

Frontiers in medical technology

2024 Volume 6, Page(s) 1360510

Abstract: Herein, advancements in electroanalytical devices for the simultaneous detection of diverse breast cancer (BC) markers are demonstrated. This article identifies several important areas of exploration for electrochemical diagnostics and highlights ... ...

Abstract	Herein, advancements in electroanalytical devices for the simultaneous detection of diverse breast cancer (BC) markers are demonstrated. This article identifies several important areas of exploration for electrochemical diagnostics and highlights important factors that are pivotal for the successful deployment of novel bioanalytical devices. We have highlighted that the limits of detection (LOD) reported for the multiplex electrochemical biosensor can surpass the sensitivity displayed by current clinical standards such as ELISA, FISH, and PCR. HER-2; a breast cancer marker characterised by increased metastatic potential, more aggressive development, and poor clinical outcomes; can be sensed with a LOD of 0.5 ng/ml using electrochemical multiplex platforms, which falls within the range of that measured by ELISA (from picogram/ml to nanogram/ml). Electrochemical multiplex biosensors are reported with detection limits of 0.53 ng/ml and 0.21 U/ml for MUC-1 and CA 15-3, respectively, or 5.8 × 10
Language	English
Publishing date	2024-02-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ISSN	2673-3129
ISSN (online)	2673-3129
DOI	10.3389/fmedt.2024.1360510
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Article ; Online: In vitro

Gebreyesus, Eyerusalem A / Park, Alice / Guldberg, Robert E / Ong, Keat Ghee

Biomedical physics & engineering express

2023 Volume 9, Issue 2

Abstract: Fluid shear stress (FSS) is an important parameter that regulates various cell functions such as proliferation and migration. While there are a number of techniques to generate ... ...

Abstract	Fluid shear stress (FSS) is an important parameter that regulates various cell functions such as proliferation and migration. While there are a number of techniques to generate FSS
MeSH term(s)	Cell Movement ; Stress, Mechanical
Language	English
Publishing date	2023-02-08
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	2057-1976
ISSN (online)	2057-1976
DOI	10.1088/2057-1976/acb711
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Article: Modelling a Consultant Workforce for the United Kingdom: needs-based planning for Dental Public Health.

Gallagher, J E / Donaldson, M / Karki, A / Keat, R / Yeung, C A / Roberts, W / Birch, S / Listl, S / Witton, R

Community dental health

2023 Volume 40, Issue 4, Page(s) 233–241

Abstract: Objective: To develop a needs-based workforce planning model to explore specialist workforce capacity and capability for the effective, efficient, and safe provision of services in the United Kingdom (UK); and test the model using Dental Public Health ( ... ...

Abstract	Objective: To develop a needs-based workforce planning model to explore specialist workforce capacity and capability for the effective, efficient, and safe provision of services in the United Kingdom (UK); and test the model using Dental Public Health (DPH). Basic research design: Data from a national workforce survey, national audit, and specialty workshops in 2020 and 2021 set the parameters for a safe effective DPH workforce. A working group drawing on external expertise, developed a conceptual workforce model which informed the mathematical modelling, taking a Markovian approach. The latter enabled the consideration of possible scenarios relating to workforce development. It involved exploration of capacity within each career stage in DPH across a time horizon of 15 years. Workforce capacity requirements were calculated, informed by past principles. Results: Currently an estimated 100 whole time equivalent (WTE) specialists are required to provide a realistic basic capacity nationally for DPH across the UK given the range of organisations, population growth, complexity and diversity of specialty roles. In February 2022 the specialty had 53.55 WTE academic/service consultants, thus a significant gap. The modelling evidence suggests a reduction in DPH specialist capacity towards a steady state in line with the current rate of training, recruitment and retention. The scenario involving increasing training numbers and drawing on other sources of public health trained dentists whilst retaining expertise within DPH has the potential to build workforce capacity. Conclusions: Current capacity is below basic requirements and approaching 'steady state'. Retention and innovative capacity building are required to secure and safeguard the provision of specialist DPH services to meet the needs of the UK health and care systems.
MeSH term(s)	Humans ; Public Health ; Consultants ; United Kingdom ; Workforce ; Dentists
Language	English
Publishing date	2023-11-30
Publishing country	England
Document type	Journal Article
ZDB-ID	631156-8
ISSN	0265-539X
ISSN	0265-539X
DOI	10.1922/CDH_00045Gallagher09
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Article: The Singapore Experience With Uncontrolled Gout: Unmet Needs in the Management of Patients.

Lee, Zheng Cong / Santosa, Anindita / Khor, Andrew Yu Keat / Sriranganathan, Melonie K

Cureus

2023 Volume 15, Issue 3, Page(s) e36682

Abstract: Gout is the most common type of inflammatory arthritis, and its impact on cardiovascular health and quality of life is often underestimated. The prevalence and incidence of gout are increasing globally. Further, ischemic heart disease (IHD) and chronic ... ...

Abstract	Gout is the most common type of inflammatory arthritis, and its impact on cardiovascular health and quality of life is often underestimated. The prevalence and incidence of gout are increasing globally. Further, ischemic heart disease (IHD) and chronic kidney disease (CKD) are prevalent in gout patients. Some unmet needs for gout management include physicians' low initiation rate of urate-lowering therapy (ULT) and poor treatment adherence in patients with gout. There is also a lack of randomized controlled trials that establish safe doses of acute and long-term treatment for gout, particularly in patients with IHD and stage 4 CKD and above (including end-stage renal failure). Furthermore, there is also a lack of studies showing optimal serum uric acid (SUA) target and validated clinical outcome measures, including disease activity and remission criteria for gout tailored to treat-to-target approaches and the high cost of newer gout medications. The causal relationship between asymptomatic hyperuricemia or gout with comorbidities such as IHD and CKD has yet to be fully elucidated. There is a pressing need for collaborative international efforts to address the overall suboptimal management of gout.
Language	English
Publishing date	2023-03-25
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.36682
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Article ; Online: Complement dysregulation is a prevalent and therapeutically amenable feature of long COVID.

Baillie, Kirsten / Davies, Helen E / Keat, Samuel B K / Ladell, Kristin / Miners, Kelly L / Jones, Samantha A / Mellou, Ermioni / Toonen, Erik J M / Price, David A / Morgan, B Paul / Zelek, Wioleta M

Med (New York, N.Y.)

2024 Volume 5, Issue 3, Page(s) 239–253.e5

Abstract: Background: Long COVID encompasses a heterogeneous set of ongoing symptoms that affect many individuals after recovery from infection with SARS-CoV-2. The underlying biological mechanisms nonetheless remain obscure, precluding accurate diagnosis and ... ...

Abstract	Background: Long COVID encompasses a heterogeneous set of ongoing symptoms that affect many individuals after recovery from infection with SARS-CoV-2. The underlying biological mechanisms nonetheless remain obscure, precluding accurate diagnosis and effective intervention. Complement dysregulation is a hallmark of acute COVID-19 but has not been investigated as a potential determinant of long COVID. Methods: We quantified a series of complement proteins, including markers of activation and regulation, in plasma samples from healthy convalescent individuals with a confirmed history of infection with SARS-CoV-2 and age/ethnicity/sex/infection/vaccine-matched patients with long COVID. Findings: Markers of classical (C1s-C1INH complex), alternative (Ba, iC3b), and terminal pathway (C5a, TCC) activation were significantly elevated in patients with long COVID. These markers in combination had a receiver operating characteristic predictive power of 0.794. Other complement proteins and regulators were also quantitatively different between healthy convalescent individuals and patients with long COVID. Generalized linear modeling further revealed that a clinically tractable combination of just four of these markers, namely the activation fragments iC3b, TCC, Ba, and C5a, had a predictive power of 0.785. Conclusions: These findings suggest that complement biomarkers could facilitate the diagnosis of long COVID and further suggest that currently available inhibitors of complement activation could be used to treat long COVID. Funding: This work was funded by the National Institute for Health Research (COV-LT2-0041), the PolyBio Research Foundation, and the UK Dementia Research Institute.
MeSH term(s)	Humans ; Post-Acute COVID-19 Syndrome ; COVID-19/epidemiology ; SARS-CoV-2 ; Complement System Proteins/metabolism ; Complement C3b
Chemical Substances	Complement System Proteins (9007-36-7) ; Complement C3b (80295-43-8)
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Journal Article
ISSN	2666-6340
ISSN (online)	2666-6340
DOI	10.1016/j.medj.2024.01.011
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Article ; Online: Macrophage activation syndrome/haemophagocytic lymphohistiocytosis secondary to

Urriola, Nicolás / Williams, Andrew / Keat, Karuna

BMJ case reports

2019 Volume 12, Issue 8

Abstract: X-linked carriers of chronic granulomatous disease (CGD) may become phenotypically affected if substantial skewing from lyonisation occurs. We describe a 73-year-old female carrier with an overt CGD phenotype due to skewed lyonisation, complicated by ... ...

Abstract	X-linked carriers of chronic granulomatous disease (CGD) may become phenotypically affected if substantial skewing from lyonisation occurs. We describe a 73-year-old female carrier with an overt CGD phenotype due to skewed lyonisation, complicated by macrophage activation syndrome (MAS)/haemophagocytic lymphohistiocytosis (HLH) secondary to
MeSH term(s)	Acute Disease ; Aged ; Burkholderia Infections/complications ; Burkholderia Infections/genetics ; Burkholderia Infections/microbiology ; Burkholderia cepacia complex ; Female ; Granulomatous Disease, Chronic/genetics ; Granulomatous Disease, Chronic/microbiology ; Humans ; Lymphohistiocytosis, Hemophagocytic/genetics ; Lymphohistiocytosis, Hemophagocytic/microbiology ; Macrophage Activation Syndrome/genetics ; Macrophage Activation Syndrome/microbiology ; Sepsis/genetics ; Sepsis/microbiology ; Syndrome ; X Chromosome Inactivation
Language	English
Publishing date	2019-08-30
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2019-230434
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Article ; Online: Sex and the spondylitic.

Keat, Andrew

Rheumatology (Oxford, England)

2009 Volume 48, Issue 11, Page(s) 1337–1338

MeSH term(s)	Antirheumatic Agents/therapeutic use ; Humans ; Quality of Life ; Sexual Behavior ; Spondylitis, Ankylosing/drug therapy ; Spondylitis, Ankylosing/psychology ; Spondylitis, Ankylosing/rehabilitation ; Tumor Necrosis Factor-alpha/antagonists & inhibitors
Chemical Substances	Antirheumatic Agents ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2009-11
Publishing country	England
Document type	Comment ; Editorial
ZDB-ID	1464822-2
ISSN	1462-0332 ; 1462-0324
ISSN (online)	1462-0332
ISSN	1462-0324
DOI	10.1093/rheumatology/kep231
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Article ; Online: Clinical characteristics, treatment patterns, and outcomes among African American and White patients with multiple myeloma in the United States.

Saunders, Ashley / Slaff, Samantha / Subbiah, Krishnaveni / Gu, Tao / Ang, Kwan-Keat / Quan, Michelle Alyssa / Rosenberg, Aaron Seth

Leukemia & lymphoma

2024 Volume 65, Issue 1, Page(s) 109–117

Abstract: Multiple myeloma (MM) is more common among Black/African American (AA) patients than White patients, but survival rate improvements are less pronounced for AA patients. This study evaluated treatment patterns and survival among 1810 AA and 5904 White ... ...

Abstract	Multiple myeloma (MM) is more common among Black/African American (AA) patients than White patients, but survival rate improvements are less pronounced for AA patients. This study evaluated treatment patterns and survival among 1810 AA and 5904 White adults in the United States with ≥1 MM treatment and ≥3 months of follow-up. Median time from diagnosis to systemic treatment was longer (37 [0-3053] vs. 35 [0-3664] days) and median time to stem cell transplant (SCT) was longer for AA than White patients (255 [1-2352] vs. 225 [1-3094] days), and AA patients were less likely to receive SCT (odds ratio [OR]: 0.66; 95% confidence interval [CI]: 0.58-0.76). Despite disparities in treatment between AA and White patients, AA patients demonstrated lower risk of death (OR: 0.89; 95% CI: 0.81-0.96). These data highlight the value of equal access to care for the improvement of health outcomes in underserved populations.
MeSH term(s)	Adult ; Humans ; Black or African American ; Healthcare Disparities ; Multiple Myeloma/diagnosis ; Multiple Myeloma/epidemiology ; Multiple Myeloma/therapy ; United States/epidemiology ; White
Language	English
Publishing date	2024-01-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	1042374-6
ISSN	1029-2403 ; 1042-8194
ISSN (online)	1029-2403
ISSN	1042-8194
DOI	10.1080/10428194.2023.2273746
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Article ; Online: Atomic Force Microscopy and Molecular Dynamic Simulation of Adsorption of Polyacrylamide with Different Chemistries onto Calcium Carbonate.

Lew, Jin Hau / Hue, Keat Yung / Matar, Omar K / Müller, Erich A / Luckham, Paul F / Santos, Adrielle Sousa / Myo Thant, Maung Maung

Polymers

2024 Volume 16, Issue 4

Abstract: This study investigates the interaction of polyacrylamide (PAM) of different functional groups (sulfonate vs. carboxylate) and charge density (30% hydrolysed vs. 10% hydrolysed) with calcium carbonate ( ... ...

Abstract	This study investigates the interaction of polyacrylamide (PAM) of different functional groups (sulfonate vs. carboxylate) and charge density (30% hydrolysed vs. 10% hydrolysed) with calcium carbonate (CaCO
Language	English
Publishing date	2024-02-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym16040494
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