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  1. Article ; Online: A safer framework to evaluate characterization technologies of exhaled biologic materials using electrospun nanofibers.

    Evans, David T / Nelson, Dalton J / Pask, Megan E / Haselton, Frederick R

    Nanoscale

    2023  Volume 15, Issue 36, Page(s) 14822–14830

    Abstract: Exhaled biologic material is the source for the spread of many respiratory tract infections. To avoid the high-level of biosafety required to manage dangerous pathogens, we developed a safer framework using the endogenous surrogate targets RNase P ... ...

    Abstract Exhaled biologic material is the source for the spread of many respiratory tract infections. To avoid the high-level of biosafety required to manage dangerous pathogens, we developed a safer framework using the endogenous surrogate targets RNase P and
    MeSH term(s) Humans ; Exhalation ; Nanofibers ; Ribonuclease P ; Respiration ; Biological Products
    Chemical Substances Ribonuclease P (EC 3.1.26.5) ; Biological Products
    Language English
    Publishing date 2023-09-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d3nr01859h
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  2. Article: Synthesis and Biological Evaluation of Trehalose-based Bi-aryl Derivatives as C-type Lectin Ligands.

    Rasheed, Omer K / Buhl, Cassandra / Evans, Jay T / Holley, David / Ryter, Kendal T

    Tetrahedron

    2023  Volume 132

    Abstract: The identification of Mincle as the C-type lectin receptor on innate immune cells responsible for binding TDM and the realization that this receptor could be key to productive vaccines for mycobacterial infection has raised interest in the development of ...

    Abstract The identification of Mincle as the C-type lectin receptor on innate immune cells responsible for binding TDM and the realization that this receptor could be key to productive vaccines for mycobacterial infection has raised interest in the development of synthetic Mincle ligands as novel adjuvants. We recently reported on the synthesis and evaluation of Brartemicin analog UM-1024 that demonstrated Mincle agonist activity, exhibiting potent Th1/Th17 adjuvant activity that was greater than that of trehalose dibehenate (TDB). Our pursuit to understand Mincle/ligand relationships and improve the pharmacologic properties of the ligands has expanded and continues to reveal new and exciting structure activity relationships. Herein we report the synthesis of novel bi-aryl trehalose derivatives in good to excellent yields. These compounds were evaluated for their ability to engage the human Mincle receptor and tested for the induction of cytokines from human peripheral blood mononuclear cells. A preliminary structure-activity relationship (SAR) of these novel bi-aryl derivatives revealed that bi-aryl trehalose ligand
    Language English
    Publishing date 2023-01-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 204285-x
    ISSN 1464-5416 ; 0040-4020 ; 0563-2064
    ISSN (online) 1464-5416
    ISSN 0040-4020 ; 0563-2064
    DOI 10.1016/j.tet.2022.133241
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  3. Article ; Online: Substitutions in Nef That Uncouple Tetherin and SERINC5 Antagonism Impair Simian Immunodeficiency Virus Replication in Primary Rhesus Macaque Lymphocytes.

    Janaka, Sanath Kumar / Snow, Brian J / Behrens, Ryan T / Evans, David T

    Journal of virology

    2022  Volume 96, Issue 11, Page(s) e0017622

    Abstract: Most simian immunodeficiency viruses (SIVs) use Nef to counteract restriction by the tetherin proteins of their nonhuman primate hosts. In addition to counteracting tetherin, SIV Nef has a number of other functions, including the downmodulation of CD3, ... ...

    Abstract Most simian immunodeficiency viruses (SIVs) use Nef to counteract restriction by the tetherin proteins of their nonhuman primate hosts. In addition to counteracting tetherin, SIV Nef has a number of other functions, including the downmodulation of CD3, CD4, and major histocompatibility complex class I (MHC I) molecules from the surface of SIV-infected cells and the enhancement of viral infectivity by preventing the incorporation of SERINC5 into virions. Although these activities require different surfaces of Nef, they can be difficult to separate because of their dependence on similar interactions with AP-1 or AP-2 for clathrin-mediated endocytosis. We previously observed extensive overlap of the SIV Nef residues required for counteracting tetherin and SERINC5. Here, we define substitutions in Nef that separate anti-tetherin activity from SERINC5 antagonism and other activities of Nef. This information was used to engineer an infectious molecular clone of SIV (SIV
    MeSH term(s) Animals ; Bone Marrow Stromal Antigen 2/metabolism ; CD4-Positive T-Lymphocytes ; Gene Products, nef/genetics ; Histocompatibility Antigens Class I/genetics ; Histocompatibility Antigens Class I/metabolism ; Interferons/metabolism ; Lymphocytes/metabolism ; Lymphocytes/virology ; Macaca mulatta ; Membrane Proteins/metabolism ; Simian Immunodeficiency Virus/physiology ; Virus Replication
    Chemical Substances Bone Marrow Stromal Antigen 2 ; Gene Products, nef ; Histocompatibility Antigens Class I ; Membrane Proteins ; Interferons (9008-11-1)
    Language English
    Publishing date 2022-05-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/jvi.00176-22
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  4. Article ; Online: A SNP of lncRNA gives HIV-1 a boost.

    Janaka, Sanath Kumar / Evans, David T

    Nature immunology

    2019  Volume 20, Issue 7, Page(s) 778–780

    MeSH term(s) HIV Infections ; HIV-1/genetics ; Humans ; RNA, Long Noncoding/genetics ; Receptors, CCR5
    Chemical Substances CCR5 protein, human ; RNA, Long Noncoding ; Receptors, CCR5
    Language English
    Publishing date 2019-06-18
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-019-0422-1
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  5. Article ; Online: Uncovering the cognitive mechanisms underlying the gaze cueing effect.

    Alister, Manikya / McKay, Kate T / Sewell, David K / Evans, Nathan J

    Quarterly journal of experimental psychology (2006)

    2023  Volume 77, Issue 4, Page(s) 803–827

    Abstract: The gaze cueing effect is the tendency for people to respond faster to targets appearing at locations gazed at by others, compared with locations gazed away from by others. The effect is robust, widely studied, and is an influential finding within social ...

    Abstract The gaze cueing effect is the tendency for people to respond faster to targets appearing at locations gazed at by others, compared with locations gazed away from by others. The effect is robust, widely studied, and is an influential finding within social cognition. Formal evidence accumulation models provide the dominant theoretical account of the cognitive processes underlying speeded decision-making, but they have rarely been applied to social cognition research. In this study, using a combination of individual-level and hierarchical computational modelling techniques, we applied evidence accumulation models to gaze cueing data (three data sets total,
    MeSH term(s) Humans ; Cues ; Fixation, Ocular ; Reaction Time/physiology ; Attention/physiology ; Cognition
    Language English
    Publishing date 2023-06-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 219170-2
    ISSN 1747-0226 ; 0033-555X ; 1747-0218
    ISSN (online) 1747-0226
    ISSN 0033-555X ; 1747-0218
    DOI 10.1177/17470218231181238
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  6. Article: Adjuvanted Vaccine Induces Functional Antibodies against

    Román-Cruz, Valery C / Miller, Shannon M / Schoener, Roman A / Lukasiewicz, Chase / Schmidt, Amelia K / DeBuysscher, Blair L / Burkhart, David / Secor, Patrick R / Evans, Jay T

    Vaccines

    2024  Volume 12, Issue 2

    Abstract: Pseudomonas ... ...

    Abstract Pseudomonas aeruginosa
    Language English
    Publishing date 2024-01-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines12020115
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  7. Article ; Online: Prescription Drug Prices: An AAN Position Statement.

    Santoro, Jonathan D / Sico, Jason J / Burke, James F / Sarkar, Korak / Turbes, Madeline / Evans, David A / Jordan, Justin T

    Neurology

    2024  Volume 102, Issue 5, Page(s) e209132

    Abstract: This position statement serves to establish the AAN's stance on the methods to address the cost of prescription drugs being considered by state and federal policymakers so that the AAN can continue to advocate effectively for its members. Neurologists ... ...

    Abstract This position statement serves to establish the AAN's stance on the methods to address the cost of prescription drugs being considered by state and federal policymakers so that the AAN can continue to advocate effectively for its members. Neurologists seek to provide high-value care for patients with neurologic diseases at the lowest cost possible. However, many therapies for neurologic diseases are among the most expensive in the United States. The 3 major cost challenges include (1) unjustified increases in the pricing for drugs used to treat neurologic disorders, (2) the high cost of medications used to treat rare diseases where there are limited or no therapeutic options available, and (3) the high cost of noninnovative (already FDA-approved) therapies that used accelerated FDA approval pathways or Orphan Drug Act designated to expedite approvals in neurologic disorders. In each of these cases, AAN is concerned that the high cost does not deliver sufficient value to patients or society. The AAN's position is that action must be taken to ensure that effective prescription medications are accessible for patients with complex, chronic neurologic conditions. Potential solutions should be affordable, simple, and transparent. Cost-containment efforts must also address the burden on the entire healthcare system because high prescription drug prices may be shifted and absorbed in ways that negatively affect patient and prescriber access to important medications. AAN supports price negotiations, the cost saving potential of generics and biosimilars, development of novel therapeutics, price transparency, and importation.
    MeSH term(s) Humans ; United States ; Prescription Drugs ; Biosimilar Pharmaceuticals ; Orphan Drug Production ; Prescriptions ; Nervous System Diseases
    Chemical Substances Prescription Drugs ; Biosimilar Pharmaceuticals
    Language English
    Publishing date 2024-02-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000209132
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  8. Article ; Online: Implementing L-DNA analogs as mirrors of PCR reactant hybridization state: theoretical and practical guidelines for PCR cycle control.

    Spurlock, Nicholas / Gabella, William E / Nelson, Dalton J / Evans, David T / Pask, Megan E / Schmitz, Jonathan E / Haselton, Frederick R

    Analytical methods : advancing methods and applications

    2024  

    Abstract: In previous reports, we described a PCR cycle control approach in which the hybridization state of optically labeled L-DNA enantiomers of the D-DNA primers and targets determined when the thermal cycle was switched from cooling to heating and heating to ... ...

    Abstract In previous reports, we described a PCR cycle control approach in which the hybridization state of optically labeled L-DNA enantiomers of the D-DNA primers and targets determined when the thermal cycle was switched from cooling to heating and heating to cooling. A consequence of this approach is that it also "adapts" the cycling conditions to compensate for factors that affect the hybridization kinetics of primers and targets. It assumes, however, that the hybridization state of the labeled L-DNA analogs accurately reflects the hybridization state of the D-DNA primers and targets. In this report, the Van't Hoff equation is applied to determine the L-DNA concentration and ratio of L-DNA strands required by this assumption. Simultaneous fluorescence and temperature measurements were taken during L-DNA controlled cycling, and the optical and thermal switch points compared as a function of both total L-DNA concentration and ratio of strands. Based on the Van't Hoff relationship and these experimental results, L-DNA best mirrors the hybridization of PCR primers and targets when total L-DNA concentration is set equal to the initial concentration of the D-DNA primer of interest. In terms of strand ratios, L-DNA hybridization behavior most closely matches the behavior of their D-DNA counterparts throughout the reaction when one of the L-DNA strands is far in excess of the other. The L-DNA control algorithm was then applied to the practical case of the SARS-CoV-2 N2 reaction, which has been shown to fail or have a delayed Cq when PCR was performed without nucleic acid extraction. PCR Cq values for simulated "unextracted" PCR samples in a nasopharyngeal background and in an NaCl concentration similar to that of viral transport media were determined using either the L-DNA control algorithm (
    Language English
    Publishing date 2024-04-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515210-5
    ISSN 1759-9679 ; 1759-9660
    ISSN (online) 1759-9679
    ISSN 1759-9660
    DOI 10.1039/d4ay00083h
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  9. Article ; Online: Persistence of Contact Lens-Induced Corneal Parainflammation Following Lens Removal.

    Datta, Ananya / Lee, Ji Hyun / Truong, Tiffany / Flandrin, Orneika / Yang, Yujia / Evans, David J / Fleiszig, Suzanne M J

    Investigative ophthalmology & visual science

    2024  Volume 65, Issue 3, Page(s) 8

    Abstract: ... numbers after 24 hours' (CD11c+, Lyz2+, γδ-T cells) and six days' (Ly6G+ cells) wear. We investigated ...

    Abstract Purpose: Contact lens wear induces corneal parainflammation involving increased immune cell numbers after 24 hours' (CD11c+, Lyz2+, γδ-T cells) and six days' (Ly6G+ cells) wear. We investigated the time course of onset and resolution of these responses.
    Methods: LysMcre or C57BL/6J mice were fitted with a contact lens (four to 48 hours). Contralateral eyes did not wear lenses. After lens removal, Lyz2+, MHC-II+ or Ly6G+ cells were examined by quantitative imaging. RT-qPCR determined cytokine gene expression.
    Results: Lens wear for 24 hours increased corneal Lyz2+ cells versus contralateral eyes approximately two-fold. Corneas remained free of visible pathology. The Lyz2+ response was not observed after four or 12 hours' wear, nor after 12 hours' wear plus 12 hours' no wear. Lens removal after 24 hours' wear further increased Lyz2+ cells (∼48% after one day), which persisted for four days, returning to baseline by seven days. Lyz2+ cells in contralateral eyes remained at baseline. MHC-II+ cells showed a similar response but without increasing after lens removal. Lens wear for 48 hours showed reduced Lyz2+ cells versus 24 hours' wear with one day discontinuation, correlating with reduced IL-1β and IL-18 gene expression. Lens wear for 24 hours did not induce Ly6G+ responses six days after removal.
    Conclusions: Lens-induced corneal parainflammation involving Lyz2+ cells requires 24 hours' wear but persists after lens discontinuation, requiring seven days for reversal. Lens wear for 48 hours may suppress initial Lyz2+ cell and cytokine responses. The significance of parainflammation during and after lens wear remains to be determined.
    MeSH term(s) Mice ; Animals ; Mice, Inbred C57BL ; Lens, Crystalline ; Contact Lenses/adverse effects ; Cornea ; Cytokines/genetics
    Chemical Substances Cytokines
    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391794-0
    ISSN 1552-5783 ; 0146-0404
    ISSN (online) 1552-5783
    ISSN 0146-0404
    DOI 10.1167/iovs.65.3.8
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  10. Article: Field Resistance to Rose Rosette Disease as Determined by Multi-Year Evaluations in Tennessee and Delaware.

    Windham, Mark T / Evans, Thomas / Collins, Sara / Lake, Juniper A / Lau, Jeekin / Riera-Lizarazu, Oscar / Byrne, David H

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 3

    Abstract: Rose rosette disease (RRD) caused by the rose rosette emaravirus (RRV) and transmitted by the eriophyid ... ...

    Abstract Rose rosette disease (RRD) caused by the rose rosette emaravirus (RRV) and transmitted by the eriophyid mite
    Language English
    Publishing date 2023-03-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12030439
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